Receptor
PDB id Resolution Class Description Source Keywords
5YE8 1.85 Å EC: 3.1.1.47 THE CRYSTAL STRUCTURE OF LP-PLA2 IN COMPLEX WITH A NOVEL INH HOMO SAPIENS HYDROLASE INHIBITOR HYDROLASE HYDROLASE-HYDROLASE INHIBITO
Ref.: STRUCTURE-GUIDED DISCOVERY OF NOVEL, POTENT, AND OR BIOAVAILABLE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2. J. MED. CHEM. V. 60 10231 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
8U3 B:501;
A:501;
 Valid;
Valid;
 none;
none;
 ic50 ~ 1 mM
207.198 C7 H7 F2 N O2 S CS(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LP1 1.91 Å EC: 3.1.1.47 CRYSTAL STRUCTURE OF HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIP COMPLEX WITH A [1.1.1]BICYCLOPENTANE-CONTAINING INHIBITOR AR ESOLUTION. HOMO SAPIENS PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE SECRETED ALPHA/BETA-HYDROLASE-FOLD LDL-BOUND; LIPOPROTEIN ASSOCIATEPHOSPHOLIPASE A2 LP-PLA2 GROUP VIIA PLA2 GLYCOPROTEIN HLIPID DEGRADATION POLYMORPHISM SECRETED HYDROLASE-HYDROLINHIBITOR COMPLEX
Ref.: INVESTIGATION OF A BICYCLO[1.1.1]PENTANE AS A PHENY REPLACEMENT WITHIN AN LPPLA2 INHIBITOR. ACS MED CHEM LETT V. 8 43 2017
Members (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
70% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
50% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 8U3; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 8U3 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 8U3; Similar ligands found: 744
No: Ligand Similarity coefficient
1 GWM 0.9610
2 DHY 0.9607
3 3C4 0.9570
4 IOS 0.9530
5 ABF 0.9478
6 B41 0.9434
7 HPS 0.9433
8 B85 0.9419
9 LDP 0.9398
10 AEG 0.9384
11 YTX 0.9361
12 YOF 0.9361
13 DAH 0.9350
14 TYL 0.9344
15 MP5 0.9341
16 CXH 0.9340
17 ZON 0.9338
18 RP5 0.9336
19 3HP 0.9328
20 1X4 0.9326
21 SYC 0.9321
22 QMP 0.9308
23 UA5 0.9305
24 EYV 0.9298
25 4HP 0.9297
26 HSX 0.9295
27 QBM 0.9293
28 TSR 0.9288
29 PMF 0.9274
30 DHC 0.9270
31 4SX 0.9270
32 IAC 0.9265
33 Q03 0.9256
34 SEP 0.9254
35 BZ2 0.9247
36 IYR 0.9245
37 MPV 0.9245
38 GO8 0.9233
39 FK8 0.9231
40 42J 0.9227
41 1FD 0.9226
42 PPY 0.9222
43 A29 0.9218
44 ESP 0.9218
45 HCI 0.9216
46 MQB 0.9216
47 BL0 0.9216
48 K7M 0.9215
49 PHE 0.9213
50 MMS 0.9208
51 9BF 0.9207
52 0HN 0.9206
53 4WL 0.9204
54 LNR 0.9203
55 3PG 0.9203
56 57O 0.9195
57 6NT 0.9190
58 61M 0.9190
59 1F1 0.9189
60 88L 0.9186
61 ENO 0.9180
62 ESX 0.9177
63 FWD 0.9177
64 TYR 0.9177
65 PO6 0.9174
66 4NS 0.9172
67 0HO 0.9172
68 MAJ 0.9168
69 OMD 0.9167
70 TYE 0.9166
71 6FZ 0.9161
72 3NY 0.9159
73 MES 0.9153
74 SBK 0.9153
75 CXP 0.9153
76 NVU 0.9153
77 TCA 0.9150
78 HFA 0.9148
79 8NB 0.9145
80 XDE 0.9144
81 ALE 0.9144
82 APS 0.9141
83 6DP 0.9136
84 36E 0.9134
85 4NP 0.9133
86 EXD 0.9132
87 2O6 0.9129
88 TRP 0.9128
89 E4P 0.9125
90 GO2 0.9124
91 NFA 0.9123
92 6NI 0.9122
93 JB8 0.9120
94 0JD 0.9120
95 AAN 0.9117
96 MNP 0.9115
97 ARP 0.9115
98 DTY 0.9115
99 2ZM 0.9114
100 15N 0.9111
101 2LT 0.9110
102 AKG 0.9110
103 PH3 0.9109
104 PLR 0.9107
105 ICO 0.9106
106 9B3 0.9106
107 EN1 0.9105
108 92P 0.9105
109 PAC 0.9104
110 JDN 0.9104
111 EVF 0.9100
112 H7Y 0.9099
113 HC4 0.9098
114 428 0.9098
115 4BY 0.9097
116 OGA 0.9097
117 657 0.9097
118 DPN 0.9096
119 SAF 0.9095
120 URS 0.9095
121 AHC 0.9094
122 KTW 0.9092
123 L99 0.9092
124 NPA 0.9085
125 TSS 0.9084
126 3VX 0.9083
127 4P5 0.9083
128 G6P 0.9083
129 3A9 0.9083
130 PLP 0.9083
131 BNF 0.9081
132 JAW 0.9081
133 R20 0.9077
134 RP3 0.9075
135 HHH 0.9074
136 M5H 0.9070
137 S24 0.9070
138 1L5 0.9069
139 X0V 0.9067
140 TYC 0.9067
141 CWD 0.9065
142 4FA 0.9065
143 PPT 0.9065
144 DTR 0.9061
145 EOL 0.9061
146 3ZB 0.9060
147 KTA 0.9060
148 XIZ 0.9059
149 7MX 0.9058
150 CFA 0.9058
151 CHB 0.9056
152 INO 0.9056
153 AX3 0.9054
154 LIP 0.9053
155 ICB 0.9053
156 0FK 0.9052
157 TZM 0.9052
158 6HP 0.9051
159 4Z9 0.9051
160 EKZ 0.9045
161 5OO 0.9045
162 HX4 0.9044
163 8XL 0.9043
164 HQJ 0.9042
165 H4E 0.9041
166 A5E 0.9040
167 SYE 0.9039
168 ABI 0.9039
169 P7Y 0.9038
170 DDU 0.9038
171 F4E 0.9037
172 P80 0.9035
173 SDF 0.9034
174 ESI 0.9033
175 GDE 0.9033
176 4MB 0.9033
177 4XV 0.9033
178 J6W 0.9032
179 NFM 0.9031
180 YPN 0.9031
181 MSR 0.9028
182 J9Q 0.9027
183 4ZA 0.9024
184 DGL 0.9023
185 HPP 0.9023
186 ZIQ 0.9022
187 AEH 0.9022
188 PHU 0.9020
189 N91 0.9019
190 NAG 0.9017
191 M3Q 0.9015
192 N7I 0.9015
193 C2Y 0.9012
194 4FH 0.9011
195 HA5 0.9010
196 8WT 0.9010
197 PFF 0.9009
198 DHB 0.9008
199 B40 0.9007
200 EGR 0.9005
201 SY4 0.9001
202 G1P 0.9001
203 IOP 0.8999
204 VXX 0.8999
205 M4T 0.8998
206 CPZ 0.8998
207 S7A 0.8996
208 4TU 0.8996
209 IPD 0.8995
210 1M2 0.8994
211 YRL 0.8994
212 RBJ 0.8993
213 HQ9 0.8991
214 XCG 0.8990
215 AEF 0.8990
216 PNP 0.8990
217 GLU 0.8989
218 L5V 0.8989
219 6KT 0.8989
220 TMG 0.8988
221 1A7 0.8986
222 R2P 0.8986
223 TZP 0.8981
224 3QM 0.8980
225 F52 0.8979
226 4NC 0.8977
227 L22 0.8975
228 FHC 0.8974
229 9TW 0.8973
230 BNL 0.8972
231 268 0.8971
232 IFP 0.8969
233 FTV 0.8967
234 IWD 0.8966
235 LAO 0.8966
236 Y4L 0.8965
237 M4E 0.8964
238 PD2 0.8964
239 1BN 0.8963
240 3IL 0.8963
241 I2E 0.8962
242 QMS 0.8961
243 OOG 0.8960
244 QY9 0.8958
245 BWD 0.8958
246 263 0.8958
247 173 0.8956
248 MYJ 0.8956
249 S0W 0.8954
250 LSQ 0.8953
251 CTE 0.8953
252 SSC 0.8953
253 HMS 0.8953
254 OHP 0.8952
255 5LD 0.8950
256 P9P 0.8950
257 93K 0.8948
258 XIY 0.8948
259 R9J 0.8947
260 BGP 0.8946
261 97T 0.8946
262 9FL 0.8946
263 UFV 0.8945
264 2K8 0.8945
265 54Z 0.8945
266 4XS 0.8944
267 2HO 0.8943
268 NLA 0.8943
269 HWD 0.8943
270 6TZ 0.8940
271 HIS 0.8939
272 BG6 0.8939
273 258 0.8939
274 HG3 0.8939
275 VNL 0.8938
276 HL4 0.8937
277 YIE 0.8937
278 5NI 0.8936
279 S8V 0.8936
280 IC9 0.8935
281 4BF 0.8932
282 SHA 0.8932
283 36Y 0.8930
284 9FE 0.8930
285 CIY 0.8930
286 PBA 0.8928
287 NYL 0.8928
288 SKF 0.8928
289 36M 0.8927
290 ISA 0.8926
291 8OZ 0.8926
292 UNJ 0.8925
293 52C 0.8924
294 HNK 0.8924
295 0F9 0.8922
296 069 0.8922
297 EYJ 0.8921
298 5RN 0.8921
299 YF3 0.8920
300 DGN 0.8920
301 9ZE 0.8919
302 XRX 0.8919
303 C82 0.8918
304 R9S 0.8917
305 GZ2 0.8917
306 8ZE 0.8917
307 M3H 0.8917
308 SMN 0.8916
309 TSU 0.8916
310 2FX 0.8916
311 F06 0.8916
312 BRH 0.8914
313 PHI 0.8914
314 LTN 0.8912
315 9KH 0.8912
316 XX2 0.8912
317 UN1 0.8911
318 M6H 0.8909
319 S0E 0.8909
320 ALX 0.8909
321 2HG 0.8907
322 0LH 0.8907
323 6L6 0.8906
324 QH3 0.8904
325 33S 0.8901
326 N9J 0.8901
327 2BG 0.8900
328 P81 0.8900
329 DEW 0.8900
330 GZL 0.8899
331 JZA 0.8898
332 NIY 0.8898
333 GLP 0.8896
334 XQI 0.8896
335 PRA 0.8895
336 DEZ 0.8895
337 78U 0.8894
338 2BX 0.8893
339 S2G 0.8893
340 IHB 0.8892
341 KYN 0.8892
342 5XB 0.8891
343 0W1 0.8890
344 4OG 0.8889
345 AMS 0.8889
346 5LA 0.8888
347 Q02 0.8888
348 MCY 0.8887
349 DTE 0.8887
350 S2P 0.8886
351 AHN 0.8886
352 I4B 0.8886
353 X0U 0.8885
354 ISZ 0.8885
355 J0Z 0.8885
356 CCV 0.8885
357 SHI 0.8885
358 505 0.8884
359 DNF 0.8884
360 FP1 0.8884
361 GVG 0.8884
362 MS9 0.8882
363 ITW 0.8881
364 JND 0.8880
365 GRF 0.8879
366 PIM 0.8879
367 I4D 0.8879
368 PJW 0.8878
369 GRO 0.8878
370 GF4 0.8878
371 0A1 0.8877
372 ASC 0.8877
373 B86 0.8875
374 HF2 0.8874
375 2HC 0.8872
376 463 0.8870
377 2SX 0.8869
378 JRB 0.8869
379 LYL 0.8869
380 PRZ 0.8867
381 BPW 0.8865
382 1XA 0.8863
383 HJH 0.8862
384 SRO 0.8862
385 FA1 0.8862
386 9RW 0.8861
387 MR1 0.8861
388 CH9 0.8861
389 SAN 0.8858
390 NIZ 0.8858
391 4J8 0.8857
392 TOH 0.8856
393 8WO 0.8856
394 363 0.8856
395 ONR 0.8856
396 J9T 0.8855
397 DCZ 0.8853
398 0DN 0.8853
399 THU 0.8852
400 MPP 0.8852
401 HPT 0.8851
402 XDK 0.8851
403 3LJ 0.8851
404 THM 0.8850
405 Q06 0.8850
406 5XC 0.8850
407 XXG 0.8849
408 AMQ 0.8849
409 PBN 0.8849
410 FF2 0.8848
411 HNL 0.8847
412 92K 0.8846
413 BTM 0.8845
414 4NZ 0.8844
415 EXR 0.8843
416 EUE 0.8843
417 GLN 0.8843
418 6C5 0.8842
419 OTR 0.8842
420 KOJ 0.8841
421 7VP 0.8840
422 ODO 0.8839
423 FBS 0.8838
424 MXD 0.8837
425 SNU 0.8837
426 790 0.8837
427 X48 0.8836
428 3LR 0.8835
429 DI6 0.8834
430 717 0.8832
431 FOM 0.8832
432 E0O 0.8832
433 HXY 0.8832
434 14W 0.8832
435 SG3 0.8831
436 FBM 0.8830
437 NCT 0.8830
438 5MD 0.8830
439 N2Z 0.8828
440 SG2 0.8828
441 DHS 0.8828
442 BPY 0.8826
443 2FY 0.8826
444 TZF 0.8825
445 AOT 0.8825
446 QUS 0.8824
447 X1P 0.8824
448 CLU 0.8823
449 QSB 0.8823
450 8W9 0.8821
451 2LP 0.8821
452 FA3 0.8821
453 EUH 0.8821
454 5BT 0.8821
455 6ZX 0.8820
456 2UB 0.8819
457 I1E 0.8819
458 Z5P 0.8818
459 NQH 0.8817
460 9UL 0.8817
461 4FP 0.8817
462 DUR 0.8813
463 2DL 0.8813
464 DHK 0.8812
465 B4O 0.8811
466 7MU 0.8810
467 M6P 0.8808
468 86L 0.8807
469 EUG 0.8806
470 2IT 0.8805
471 DER 0.8805
472 TGX 0.8805
473 PXP 0.8804
474 4XF 0.8803
475 AZM 0.8803
476 JTH 0.8803
477 GCO 0.8802
478 4V2 0.8801
479 N2M 0.8801
480 2O8 0.8801
481 N4B 0.8801
482 BQ2 0.8800
483 M1Z 0.8799
484 5WZ 0.8797
485 4LW 0.8796
486 JFJ 0.8795
487 GZQ 0.8795
488 GGL 0.8794
489 TT4 0.8793
490 BZE 0.8792
491 3VW 0.8792
492 XRS 0.8790
493 BSX 0.8790
494 FUD 0.8790
495 AC6 0.8790
496 M5E 0.8789
497 BP7 0.8788
498 BCU 0.8788
499 SKM 0.8787
500 261 0.8787
501 N2I 0.8786
502 XEN 0.8786
503 NOK 0.8785
504 EV0 0.8785
505 AMR 0.8784
506 HNH 0.8784
507 MPK 0.8783
508 LVD 0.8782
509 SOR 0.8782
510 F90 0.8781
511 HA7 0.8781
512 GLO 0.8781
513 PIY 0.8780
514 6HO 0.8779
515 YO5 0.8779
516 7C3 0.8778
517 M45 0.8777
518 GJZ 0.8777
519 ID2 0.8777
520 5WN 0.8775
521 2HU 0.8774
522 RQD 0.8773
523 1VK 0.8773
524 HDH 0.8773
525 23J 0.8773
526 DAL DAL 0.8773
527 9RH 0.8772
528 JF1 0.8771
529 ATX 0.8770
530 4TP 0.8769
531 DE3 0.8767
532 9R5 0.8766
533 1Z6 0.8765
534 HHT 0.8764
535 MTL 0.8764
536 CSN 0.8764
537 15L 0.8762
538 M6D 0.8760
539 DXP 0.8760
540 PZI 0.8760
541 4PN 0.8759
542 PEL 0.8759
543 CFI 0.8758
544 4RU 0.8758
545 NDG 0.8758
546 ZEC 0.8758
547 56D 0.8758
548 LX1 0.8757
549 4LV 0.8757
550 PH2 0.8757
551 BDP 0.8757
552 NNO 0.8755
553 4VY 0.8753
554 EDR 0.8753
555 V55 0.8753
556 SLS 0.8752
557 DHI 0.8751
558 JZ4 0.8751
559 F31 0.8751
560 KPA 0.8751
561 FHB 0.8750
562 APG 0.8750
563 HIC 0.8749
564 P84 0.8748
565 R9Y 0.8748
566 EMZ 0.8748
567 4A3 0.8746
568 C1M 0.8746
569 PMP 0.8746
570 GJP 0.8745
571 FER 0.8743
572 4TB 0.8742
573 STT 0.8742
574 92G 0.8741
575 DJN 0.8739
576 2CZ 0.8738
577 KTJ 0.8737
578 E35 0.8737
579 E1T 0.8736
580 PRO GLY 0.8736
581 1SV 0.8734
582 SME 0.8732
583 RLG 0.8732
584 4R1 0.8731
585 I3E 0.8731
586 LT1 0.8730
587 FBW 0.8730
588 PEA 0.8730
589 T9G 0.8729
590 W29 0.8729
591 CC5 0.8729
592 PPN 0.8727
593 N1E 0.8727
594 PRY 0.8724
595 MD6 0.8724
596 BB4 0.8719
597 FEH 0.8719
598 FBF 0.8719
599 MOK 0.8717
600 CS2 0.8717
601 9F8 0.8717
602 3YP 0.8714
603 S7G 0.8713
604 F6P 0.8712
605 M4S 0.8712
606 2LY 0.8711
607 P9E 0.8710
608 P58 0.8710
609 DQA 0.8710
610 CEE 0.8708
611 RMN 0.8708
612 F98 0.8708
613 JF6 0.8706
614 6J9 0.8705
615 NBG 0.8704
616 IP8 0.8703
617 EQW 0.8702
618 TAG 0.8702
619 4ME 0.8700
620 HBO 0.8699
621 FCR 0.8698
622 JLZ 0.8695
623 SQV 0.8694
624 264 0.8694
625 5DS 0.8693
626 PCS 0.8692
627 HHR 0.8692
628 AC2 0.8688
629 HSO 0.8687
630 3HM 0.8685
631 GL1 0.8685
632 3QO 0.8685
633 3N1 0.8684
634 XCZ 0.8684
635 9CA 0.8684
636 1IT 0.8682
637 94W 0.8682
638 11C 0.8681
639 LTT 0.8681
640 M2K 0.8680
641 1QP 0.8680
642 KDG 0.8679
643 B2J 0.8679
644 TPA 0.8677
645 1WC 0.8675
646 5WU 0.8675
647 PLP PMP 0.8674
648 5AD 0.8672
649 F4K 0.8671
650 41K 0.8669
651 JGB 0.8668
652 RAT 0.8666
653 4JC 0.8664
654 RES 0.8664
655 B3U 0.8663
656 I59 0.8662
657 TWO 0.8662
658 PJL 0.8661
659 5GT 0.8660
660 L21 0.8658
661 EE8 0.8658
662 LYS 0.8658
663 KP6 0.8658
664 SR1 0.8656
665 AY4 0.8656
666 A9P 0.8655
667 N3W 0.8655
668 DHM 0.8655
669 7AP 0.8654
670 2EC 0.8654
671 DZA 0.8652
672 EYY 0.8650
673 BIO 0.8647
674 13P 0.8647
675 2QC 0.8643
676 LDC 0.8640
677 AS3 0.8640
678 2UD 0.8640
679 3Y7 0.8639
680 AAS 0.8638
681 TB8 0.8637
682 HY1 0.8637
683 ZYQ 0.8633
684 HBI 0.8633
685 BK9 0.8632
686 NGA 0.8631
687 DIR 0.8630
688 4JT 0.8629
689 K82 0.8628
690 OQC 0.8627
691 MUC 0.8626
692 LFC 0.8625
693 A7H 0.8624
694 A2G 0.8624
695 TA6 0.8622
696 F9Y 0.8620
697 TU0 0.8619
698 HNM 0.8614
699 Q04 0.8614
700 TIH 0.8614
701 MZT 0.8613
702 F69 0.8612
703 5OF 0.8611
704 JYT 0.8610
705 GVM 0.8609
706 LLT 0.8608
707 ETV 0.8606
708 2F6 0.8602
709 QMR 0.8602
710 50C 0.8602
711 1SS 0.8602
712 GJK 0.8601
713 3TC 0.8599
714 9VQ 0.8599
715 XYH 0.8596
716 PA5 0.8595
717 SVD 0.8595
718 6VD 0.8594
719 8HC 0.8592
720 LL1 0.8590
721 NCV 0.8588
722 S3C 0.8587
723 S0G 0.8586
724 2FT 0.8584
725 K80 0.8582
726 YI6 0.8581
727 SOL 0.8580
728 A3M 0.8578
729 2KU 0.8578
730 1LN 0.8577
731 80G 0.8576
732 JXZ 0.8575
733 3EB 0.8572
734 3L1 0.8571
735 VOH 0.8568
736 C53 0.8563
737 3D1 0.8556
738 SYM 0.8553
739 ZXD 0.8543
740 DEE 0.8540
741 JG8 0.8537
742 YIH 0.8522
743 54X 0.8512
744 5O5 0.8504
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LP1; Ligand: 71H; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5lp1.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
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