Receptor
PDB id Resolution Class Description Source Keywords
5JAL 2.06 Å EC: 3.1.1.47 EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN- PHOSPHOLIPASE A2 (LP-PLA2) DISCOVERED THROUGH X-F RAGMENT SCREENING HOMO SAPIENS PHOSPHOLIPASE LIPID METABOLISM HYDROLASE
Ref.: EXPLOITATION OF A NOVEL BINDING POCKET IN HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) D THROUGH X-RAY FRAGMENT SCREENING. J.MED.CHEM. V. 59 5356 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:501;
 Part of Protein;
 none;
 submit data
24.305 Mg [Mg+2...
DMS A:504;
 Invalid;
 none;
 submit data
78.133 C2 H6 O S CS(=O...
CL A:502;
A:503;
 Invalid;
Invalid;
 none;
none;
 submit data
35.453 Cl [Cl-]
6HO A:505;
 Valid;
 none;
 Kd = 980 uM
191.202 C11 H10 F N O c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LP1 1.91 Å EC: 3.1.1.47 CRYSTAL STRUCTURE OF HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIP COMPLEX WITH A [1.1.1]BICYCLOPENTANE-CONTAINING INHIBITOR AR ESOLUTION. HOMO SAPIENS PLASMA PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE SECRETED ALPHA/BETA-HYDROLASE-FOLD LDL-BOUND; LIPOPROTEIN ASSOCIATEPHOSPHOLIPASE A2 LP-PLA2 GROUP VIIA PLA2 GLYCOPROTEIN HLIPID DEGRADATION POLYMORPHISM SECRETED HYDROLASE-HYDROLINHIBITOR COMPLEX
Ref.: INVESTIGATION OF A BICYCLO[1.1.1]PENTANE AS A PHENY REPLACEMENT WITHIN AN LPPLA2 INHIBITOR. ACS MED CHEM LETT V. 8 43 2017
Members (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
70% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
50% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5YE8 ic50 ~ 1 mM 8U3 C7 H7 F2 N O2 S CS(=O)(=O)....
2 5JAH - 6HQ C6 H10 N2 O2 CC1(C(=O)N....
3 5JAP ic50 = 0.23 uM 6HZ C19 H19 N O Cc1ccccc1c....
4 5LZ4 Kd = 2 uM 7BW C15 H17 F N2 O2 CC1(CC(=O)....
5 5JAL Kd = 980 uM 6HO C11 H10 F N O c1cc(cc(c1....
6 5YE9 ic50 = 355 nM 8U6 C25 H19 N3 O4 S CC(=O)Nc1c....
7 5JAN - 6HP C10 H16 N2 O3 CC(C)COC1=....
8 5JAS ic50 = 1.7 uM 6HW C17 H16 N2 S Cc1ccccc1c....
9 5LZ9 ic50 = 0.12 uM 7BR C19 H23 F N2 O4 S CC1(CCS(=O....
10 5LZ2 ic50 ~ 1 mM 7BX C10 H10 N2 O2 S c1cc(cc(c1....
11 5YE7 ic50 = 3431 nM 8U0 C24 H20 N2 O4 S CC(=O)Nc1c....
12 5JAT ic50 = 0.23 uM 6HR C20 H22 N2 O S Cc1ccccc1c....
13 5LZ8 ic50 = 0.98 uM 7BP C17 H21 F N2 O2 CC(C)(C)[C....
14 5JAU ic50 = 0.0014 uM 6HU C23 H30 N4 O3 Cc1ccccc1c....
15 5LZ7 Kd = 0.53 uM 7BK C20 H19 F N2 O2 C[C@@]1(CC....
16 5YEA ic50 = 5 nM 8U9 C21 H12 Cl F3 N2 O5 S c1cc(ccc1C....
17 5LYY ic50 = 14 uM 7BJ C16 H19 F N2 O3 c1cc(ccc1O....
18 5LP1 ic50 = 0.398 nM 71H C35 H38 F4 N4 O2 S CCN(CC)CCN....
19 5JAR ic50 = 2 uM 6HV C18 H15 N O S Cc1ccccc1c....
20 5LZ5 Kd = 0.45 uM 7K4 C20 H19 F N2 O2 C[C@]1(CC(....
21 5I8P Kd = 0.000000064 M VQ7 C23 H19 Cl F5 N3 O5 S CN1C(=CC(=....
22 5JAD Kd = 3.4 mM FB2 C6 H7 N O2 S c1ccc(cc1)....
23 5JAO - 6HX C13 H12 Cl N Cc1ccc(cc1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 6HO; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 6HO 1 1
2 6HZ 0.4 0.7
Similar Ligands (3D)
Ligand no: 1; Ligand: 6HO; Similar ligands found: 726
No: Ligand Similarity coefficient
1 R9G 0.9725
2 M5E 0.9674
3 3VW 0.9621
4 OA1 0.9596
5 GZ2 0.9567
6 BZQ 0.9549
7 TZM 0.9508
8 54F 0.9471
9 1ZC 0.9460
10 YIP 0.9425
11 YZM 0.9425
12 LL1 0.9422
13 CK1 0.9410
14 1VK 0.9410
15 0OL 0.9381
16 CK2 0.9378
17 0FR 0.9370
18 7VY 0.9365
19 9UL 0.9357
20 FCD 0.9352
21 5JT 0.9348
22 EQA 0.9347
23 MD6 0.9327
24 M6H 0.9312
25 C53 0.9306
26 1A7 0.9297
27 9W5 0.9294
28 DCZ 0.9288
29 X6P 0.9285
30 XI7 0.9274
31 EYJ 0.9270
32 0QW 0.9262
33 ONZ 0.9262
34 BQ2 0.9261
35 C82 0.9253
36 RA7 0.9253
37 4Z9 0.9248
38 MUK 0.9243
39 LZ5 0.9239
40 SQV 0.9236
41 TJM 0.9236
42 WVV 0.9225
43 TT4 0.9224
44 56D 0.9224
45 M74 0.9222
46 0OY 0.9220
47 FC2 0.9214
48 5O5 0.9213
49 YIH 0.9213
50 TRP 0.9213
51 RLG 0.9204
52 C0H 0.9201
53 XDK 0.9198
54 HA5 0.9196
55 SOJ 0.9195
56 D2G 0.9191
57 CTE 0.9190
58 CUQ 0.9186
59 G14 0.9184
60 AUV 0.9182
61 HIC 0.9181
62 9R5 0.9181
63 7MW 0.9178
64 GNW 0.9176
65 LVD 0.9176
66 A29 0.9175
67 AVA 0.9172
68 BNL 0.9168
69 JZA 0.9168
70 NFA 0.9165
71 X11 0.9162
72 61M 0.9159
73 6J9 0.9157
74 36M 0.9156
75 DHC 0.9154
76 CH9 0.9147
77 ARP 0.9147
78 RE4 0.9147
79 E35 0.9146
80 1L5 0.9146
81 KCH 0.9145
82 ZYV 0.9145
83 PDC 0.9144
84 ZZA 0.9141
85 JRB 0.9139
86 DEW 0.9137
87 HNL 0.9135
88 HNK 0.9135
89 I2E 0.9132
90 6L6 0.9129
91 HXY 0.9129
92 D3G 0.9126
93 J4K 0.9122
94 1BN 0.9122
95 KF5 0.9122
96 HNH 0.9120
97 2O6 0.9117
98 N9J 0.9117
99 YE6 0.9117
100 X48 0.9116
101 BP7 0.9115
102 4FP 0.9113
103 CH8 0.9112
104 0OO 0.9111
105 3QO 0.9110
106 GLR 0.9108
107 Q4G 0.9108
108 HX8 0.9108
109 L5D 0.9105
110 H35 0.9105
111 IQQ 0.9103
112 0NX 0.9103
113 363 0.9102
114 ITW 0.9102
115 NVU 0.9102
116 S8G 0.9100
117 L13 0.9099
118 46P 0.9099
119 DE3 0.9097
120 ODK 0.9095
121 BPY 0.9094
122 11X 0.9094
123 VM1 0.9094
124 3XH 0.9094
125 EXR 0.9094
126 795 0.9094
127 AMR 0.9092
128 SAF 0.9091
129 KTJ 0.9091
130 5C1 0.9089
131 QUS 0.9083
132 3VQ 0.9083
133 EYV 0.9081
134 7ZL 0.9077
135 7VP 0.9077
136 EYY 0.9076
137 4I8 0.9073
138 H4E 0.9072
139 1Z6 0.9072
140 5VL 0.9072
141 LJ4 0.9071
142 KYN 0.9070
143 ZME 0.9069
144 F16 0.9068
145 L22 0.9066
146 XDE 0.9066
147 ALE 0.9066
148 RJY 0.9065
149 FPL 0.9065
150 IAC 0.9063
151 A7Q 0.9061
152 EQW 0.9060
153 GGB 0.9060
154 92G 0.9058
155 5F8 0.9057
156 4AU 0.9057
157 DTR 0.9050
158 APS 0.9047
159 ENO 0.9047
160 MNP 0.9047
161 HX4 0.9046
162 YOF 0.9045
163 DAH 0.9044
164 JOV 0.9043
165 HNT 0.9043
166 LL2 0.9042
167 MJ5 0.9040
168 33S 0.9039
169 5GV 0.9038
170 FER 0.9036
171 FHC 0.9035
172 TIA 0.9035
173 28A 0.9034
174 H4B 0.9031
175 GZV 0.9030
176 6HX 0.9030
177 DHY 0.9029
178 531 0.9029
179 1WC 0.9028
180 9FE 0.9028
181 PPY 0.9027
182 JCZ 0.9025
183 XQI 0.9024
184 C2Y 0.9023
185 TCC 0.9023
186 IOP 0.9021
187 ATX 0.9021
188 5FL 0.9019
189 EN1 0.9016
190 9BF 0.9015
191 0QV 0.9015
192 1QP 0.9014
193 IOS 0.9014
194 FWD 0.9012
195 92P 0.9012
196 GO2 0.9005
197 6ZX 0.9005
198 CUT 0.9004
199 KMY 0.9002
200 K80 0.9001
201 R20 0.9001
202 5E5 0.8996
203 M5H 0.8996
204 ERZ 0.8993
205 2F6 0.8992
206 9FH 0.8990
207 1F1 0.8987
208 2FX 0.8985
209 FZM 0.8985
210 PJW 0.8985
211 DUR 0.8984
212 NCT 0.8984
213 D8Q 0.8984
214 THU 0.8983
215 FTV 0.8983
216 S2P 0.8982
217 SHI 0.8978
218 89J 0.8977
219 EGR 0.8976
220 5B2 0.8973
221 KLS 0.8972
222 5TZ 0.8972
223 54X 0.8972
224 B4O 0.8968
225 6C5 0.8967
226 4LV 0.8967
227 TSR 0.8965
228 ZIQ 0.8965
229 8G0 0.8963
230 HFA 0.8962
231 XRS 0.8962
232 R2P 0.8961
233 N1E 0.8960
234 NMM 0.8960
235 MMS 0.8960
236 HIS 0.8956
237 HBI 0.8953
238 TMG 0.8953
239 PHE 0.8952
240 8OZ 0.8952
241 XRX 0.8951
242 8XL 0.8950
243 HJH 0.8949
244 5DL 0.8948
245 IWT 0.8946
246 0JD 0.8946
247 4FF 0.8946
248 TYR 0.8945
249 DTY 0.8945
250 LTN 0.8945
251 TOH 0.8944
252 6KT 0.8943
253 CWD 0.8943
254 M4E 0.8942
255 B2T 0.8940
256 PFF 0.8940
257 848 0.8940
258 H7S 0.8939
259 5F5 0.8939
260 AWE 0.8938
261 4V2 0.8938
262 AAN 0.8936
263 SLS 0.8931
264 536 0.8931
265 CLU 0.8930
266 DDU 0.8928
267 BVS 0.8928
268 4LW 0.8927
269 HQJ 0.8927
270 GO8 0.8925
271 833 0.8924
272 AX4 0.8923
273 MSR 0.8923
274 PD2 0.8922
275 PRO GLY 0.8922
276 CS2 0.8922
277 HSX 0.8921
278 LSQ 0.8921
279 NAG 0.8920
280 12T 0.8920
281 BZJ 0.8919
282 50C 0.8918
283 FK8 0.8916
284 TIH 0.8915
285 D1G 0.8914
286 CUH 0.8914
287 DTE 0.8913
288 C9E 0.8912
289 15N 0.8911
290 5PV 0.8911
291 3A9 0.8910
292 2UB 0.8908
293 DXG 0.8908
294 BB4 0.8906
295 F4K 0.8906
296 3N1 0.8905
297 23J 0.8904
298 ARG 0.8904
299 4EU 0.8904
300 EV2 0.8904
301 EAJ 0.8903
302 49P 0.8903
303 DBE 0.8902
304 173 0.8902
305 PYU 0.8902
306 KDG 0.8901
307 5AD 0.8901
308 2UD 0.8900
309 2KU 0.8900
310 7MX 0.8899
311 78U 0.8899
312 B41 0.8898
313 THM 0.8898
314 EXG 0.8897
315 GOE 0.8897
316 4MP 0.8897
317 CC5 0.8896
318 HCI 0.8896
319 PH3 0.8895
320 REL 0.8893
321 0FK 0.8892
322 RK4 0.8892
323 97T 0.8891
324 ONR 0.8890
325 MXD 0.8890
326 LR2 0.8890
327 9ZE 0.8889
328 WOE 0.8886
329 5UD 0.8886
330 WS7 0.8884
331 5LD 0.8884
332 45L 0.8883
333 E9S 0.8882
334 3EB 0.8880
335 BP3 0.8880
336 1ER 0.8879
337 7O4 0.8879
338 OOG 0.8877
339 S7A 0.8876
340 GXG 0.8874
341 6NI 0.8874
342 263 0.8873
343 0F9 0.8873
344 30G 0.8872
345 TYC 0.8871
346 68B 0.8871
347 1AL 0.8870
348 5NI 0.8870
349 ZON 0.8870
350 QKU 0.8869
351 SSC 0.8867
352 TCA 0.8866
353 657 0.8865
354 6TZ 0.8864
355 4OG 0.8864
356 M78 0.8863
357 AZM 0.8860
358 92O 0.8859
359 ELH 0.8857
360 1SF 0.8856
361 HWD 0.8855
362 SV4 0.8853
363 6NT 0.8853
364 0HN 0.8852
365 SQ4 0.8852
366 C0W 0.8851
367 NIR 0.8851
368 7BX 0.8851
369 HF2 0.8851
370 CMU 0.8851
371 N2I 0.8850
372 4ZD 0.8850
373 ABF 0.8849
374 KYA 0.8848
375 YIE 0.8848
376 GJP 0.8848
377 S0F 0.8847
378 3ZB 0.8847
379 LNR 0.8845
380 2D2 0.8844
381 VJJ 0.8844
382 2K8 0.8844
383 1A5 0.8843
384 PO6 0.8843
385 J9Q 0.8842
386 NGA 0.8842
387 CPZ 0.8840
388 2ZM 0.8840
389 M45 0.8840
390 AX5 0.8840
391 0UL 0.8839
392 6FZ 0.8837
393 7Q1 0.8836
394 RNO 0.8836
395 NIY 0.8835
396 GXD 0.8835
397 KW8 0.8834
398 QIV 0.8833
399 3NY 0.8830
400 GVG 0.8830
401 M3E 0.8829
402 B2Y 0.8829
403 A5E 0.8828
404 4NS 0.8827
405 SOV 0.8827
406 3YP 0.8826
407 IYR 0.8825
408 5O6 0.8825
409 5GT 0.8824
410 9JT 0.8824
411 6FB 0.8822
412 U2Z 0.8819
413 CXP 0.8818
414 GAE 0.8817
415 MEX 0.8817
416 XEN 0.8817
417 22L 0.8816
418 F4E 0.8815
419 SYE 0.8815
420 B09 0.8815
421 47V 0.8814
422 HPP 0.8813
423 S0E 0.8813
424 JB8 0.8813
425 I3E 0.8813
426 IWD 0.8812
427 CBE 0.8812
428 DPN 0.8810
429 2B4 0.8810
430 J6W 0.8810
431 3C4 0.8810
432 0A9 0.8807
433 DC5 0.8807
434 MS0 0.8806
435 069 0.8806
436 GF4 0.8805
437 ODO 0.8804
438 BZE 0.8802
439 JF6 0.8802
440 AHC 0.8802
441 BWD 0.8800
442 SBK 0.8799
443 ZEA 0.8798
444 52C 0.8798
445 XEV 0.8797
446 492 0.8797
447 TYE 0.8795
448 4GU 0.8795
449 ZYW 0.8794
450 RQD 0.8793
451 2J2 0.8793
452 PQT 0.8791
453 MAJ 0.8791
454 PH2 0.8791
455 OQC 0.8790
456 2DL 0.8790
457 D8Y 0.8789
458 PPT 0.8789
459 NK5 0.8787
460 XFE 0.8787
461 HHS 0.8785
462 GVY 0.8785
463 AOJ 0.8784
464 EV3 0.8784
465 JAW 0.8784
466 ZEC 0.8782
467 V15 0.8782
468 TAG 0.8782
469 OGA 0.8781
470 8U3 0.8779
471 HHH 0.8779
472 DX5 0.8778
473 X29 0.8777
474 S46 0.8775
475 STX 0.8775
476 4Z3 0.8775
477 TYL 0.8775
478 EVF 0.8774
479 SNO 0.8774
480 LDC 0.8774
481 28B 0.8773
482 JFM 0.8773
483 FNA 0.8773
484 FUD 0.8772
485 G1P 0.8770
486 14W 0.8769
487 AX3 0.8769
488 54Z 0.8769
489 1XA 0.8769
490 HLP 0.8768
491 LTT 0.8767
492 SLY 0.8767
493 9FL 0.8767
494 A3M 0.8766
495 SNU 0.8766
496 8CC 0.8766
497 JF2 0.8766
498 DNB 0.8766
499 27M 0.8765
500 CFA 0.8764
501 2HG 0.8763
502 49O 0.8762
503 1YO 0.8762
504 LLT 0.8761
505 VXX 0.8761
506 LDP 0.8761
507 XCG 0.8760
508 1PS 0.8760
509 F63 0.8759
510 FYR 0.8759
511 SKF 0.8759
512 6J5 0.8759
513 8ZE 0.8758
514 ESP 0.8758
515 E7S 0.8757
516 7R4 0.8757
517 5V7 0.8757
518 HL4 0.8757
519 M6Z 0.8756
520 7PJ 0.8754
521 ESX 0.8753
522 2SX 0.8753
523 NPA 0.8753
524 GCO 0.8753
525 ARJ 0.8752
526 0ON 0.8752
527 4BY 0.8751
528 1KN 0.8750
529 MPK 0.8750
530 CSN 0.8748
531 3TC 0.8747
532 0HO 0.8746
533 7MU 0.8745
534 4XF 0.8745
535 PBN 0.8745
536 4BF 0.8745
537 P80 0.8744
538 4WF 0.8744
539 A7K 0.8742
540 GC2 0.8741
541 FMQ 0.8740
542 428 0.8738
543 PQZ 0.8737
544 86L 0.8736
545 9PL 0.8735
546 SNI 0.8734
547 M2E 0.8733
548 QME 0.8733
549 S1D 0.8732
550 ADN 0.8732
551 6PB 0.8731
552 5WZ 0.8731
553 L2K 0.8730
554 3IB 0.8729
555 AKG 0.8727
556 C0Y 0.8726
557 TSS 0.8726
558 AOT 0.8724
559 92K 0.8724
560 QH3 0.8724
561 61O 0.8722
562 S7G 0.8722
563 NDG 0.8720
564 7QS 0.8720
565 TIZ 0.8718
566 G6P 0.8716
567 A9P 0.8715
568 LEL 0.8714
569 SWX 0.8713
570 DIR 0.8711
571 JDN 0.8709
572 PLP 0.8709
573 WCU 0.8709
574 SQ7 0.8708
575 Z13 0.8707
576 8NX 0.8707
577 CLT 0.8706
578 QMS 0.8705
579 BY5 0.8704
580 L15 0.8703
581 E1T 0.8703
582 MP5 0.8703
583 EAT 0.8702
584 7UC 0.8702
585 2MR 0.8701
586 T03 0.8696
587 96Z 0.8696
588 4TP 0.8695
589 P81 0.8694
590 NBB 0.8694
591 ABI 0.8693
592 S8V 0.8691
593 5TO 0.8691
594 27K 0.8690
595 0K7 0.8690
596 54E 0.8690
597 L99 0.8689
598 EWG 0.8688
599 SOR 0.8688
600 36Y 0.8686
601 535 0.8686
602 HC4 0.8686
603 A08 0.8685
604 XIZ 0.8685
605 PSJ 0.8684
606 A5P 0.8684
607 MTL 0.8684
608 6SD 0.8683
609 J9T 0.8683
610 LJ3 0.8683
611 GOJ 0.8682
612 27B 0.8681
613 80G 0.8677
614 MZM 0.8677
615 4HP 0.8677
616 EUE 0.8675
617 5WN 0.8674
618 W29 0.8674
619 JXZ 0.8674
620 4NP 0.8671
621 2LY 0.8671
622 5SP 0.8669
623 2BG 0.8669
624 P9E 0.8668
625 BGP 0.8668
626 B86 0.8667
627 OW7 0.8665
628 8MO 0.8663
629 BL0 0.8662
630 Y3L 0.8661
631 N4E 0.8661
632 E4P 0.8659
633 ZEB 0.8658
634 3VX 0.8657
635 PIM 0.8656
636 RVE 0.8655
637 ILO 0.8653
638 0DN 0.8653
639 EE8 0.8653
640 API 0.8652
641 THA 0.8652
642 DBS 0.8652
643 11C 0.8650
644 4VY 0.8649
645 HHR 0.8648
646 DI6 0.8648
647 4MB 0.8647
648 CXH 0.8647
649 BGU 0.8647
650 BCU 0.8645
651 WUB 0.8645
652 PLR 0.8645
653 YTX 0.8644
654 44V 0.8641
655 F06 0.8641
656 BNF 0.8640
657 OJD 0.8639
658 12R 0.8639
659 5S9 0.8638
660 JXK 0.8636
661 NYL 0.8635
662 FF2 0.8634
663 XYP XIF 0.8633
664 XIF XYP 0.8633
665 JYT 0.8632
666 DHZ 0.8629
667 87L 0.8629
668 Q03 0.8628
669 0J5 0.8624
670 JAH 0.8624
671 F69 0.8621
672 16Z 0.8620
673 DGN 0.8619
674 BK9 0.8618
675 RP5 0.8616
676 S8D 0.8614
677 CIR 0.8614
678 A2G 0.8612
679 DNA 0.8611
680 T2D 0.8610
681 3D1 0.8604
682 2FY 0.8604
683 8OE 0.8601
684 M1Z 0.8601
685 Q02 0.8599
686 4A5 0.8596
687 NWD 0.8596
688 PMP 0.8595
689 Z5P 0.8595
690 BIO 0.8593
691 GLU 0.8592
692 2JX 0.8589
693 3AK 0.8588
694 J9N 0.8588
695 NOS 0.8586
696 DEE 0.8585
697 4TB 0.8584
698 A8K 0.8582
699 BHO 0.8580
700 K48 0.8579
701 NFM 0.8578
702 TXW 0.8576
703 3AD 0.8575
704 4ME 0.8575
705 N2M 0.8574
706 PXP 0.8574
707 K97 0.8571
708 1OH 0.8570
709 9F8 0.8566
710 S2G 0.8565
711 3L1 0.8565
712 A7H 0.8564
713 ID2 0.8562
714 8NB 0.8561
715 5DS 0.8558
716 MCY 0.8557
717 YPN 0.8552
718 S8A 0.8549
719 8OB 0.8545
720 5BT 0.8540
721 6DP 0.8537
722 36E 0.8533
723 T1N 0.8532
724 LPK 0.8528
725 5OO 0.8521
726 IM4 0.8520
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LP1; Ligand: 71H; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5lp1.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
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