MOAD release: 2013
Binding MOAD Statistics
23269 Protein-Ligand Structures
8156 Binding Data
11173 Different Ligands
6960 Different Families
Citing Binding MOAD
Nucl. Acids Res.
Welcome to Binding MOAD!
What is Binding MOAD?
We have created a subset of the Protein Data Bank (PDB), containing every high-quality example of ligand-protein binding. Hence, we call it the Mother of All Databases (MOAD).
Binding MOAD's goal is to be the largest collection of well resolved protein crystal structures with clearly identified biologically relevant ligands annotated with experimentally determined binding data extracted from literature.
Binding MOAD Criteria for inclusion:
...biologically relevant ligands...
Ligands may be a
peptide of 10 amino acids or less
oligonucleotide of 4 nucleotides or less
small organic molecule (e.g. ibuprofen)
cofactor (e.g. NADPH)
Ligands are not:
crystallographic additives (e.g. polythylene glycol)
buffers (e.g. Tris, CHAPS)
metals (e.g. Rb
metallic catalytic centers (e.g. FeS, NiFe)
solvents (e.g. DMSO)
has a resolution of 2.5 Å or better
...binding data extracted from literature
We've searched through the primary reference of each PDB entry looking for Kd, Ki, and IC50 data. If we've got something wrong or if you have something to add, Please let us know - we'll correct it, and give you credit.
NOTE: - We have gone through all the single HET group ligands and updated the SMILES to the current PDB Component Dictionary OpenEye Cannonical form. - In order to properly view the website, please make sure Java is installed on your system and java script is enabled on your browser (see FAQ).
Cite Binding MOAD:
L Hu, ML Benson, RD Smith, MG Lerner, HA Carlson. Binding MOAD (Mother Of All Databases).
A. Ahmed, RD Smith, JJ Clark, JB Dunbar, HA Carlson. Recent improvements to Binding MOAD: a resource for proteinligand binding affinities and structures.
Nucl. Acids Res.
ML Benson, RD Smith, NA Khazanov, B Dimcheff, J Beaver, P Dresslar, J Nerothin, and HA Carlson. Binding MOAD, A high-quality protein-ligand database.
Nucleic Acids Research
University of Michigan