Receptor
PDB id Resolution Class Description Source Keywords
2FN8 2.15 Å NON-ENZYME: TRANSPORT THERMOTOGA MARITIMA RIBOSE BINDING PROTEIN RIBOSE BOUND FORM THERMOTOGA MARITIMA RBP RIBOSE BINDING PROTEIN PERIPLASMIC BINDING PROTEIN THERMOPHILIC PROTEIN SUGAR BINDING PROTEIN
Ref.: LIGAND-INDUCED CONFORMATIONAL CHANGES IN A THERMOPH RIBOSE-BINDING PROTEIN. BMC STRUCT.BIOL. V. 8 50 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
RIP A:303;
Valid;
none;
submit data
150.13 C5 H10 O5 C1[C@...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FN8 2.15 Å NON-ENZYME: TRANSPORT THERMOTOGA MARITIMA RIBOSE BINDING PROTEIN RIBOSE BOUND FORM THERMOTOGA MARITIMA RBP RIBOSE BINDING PROTEIN PERIPLASMIC BINDING PROTEIN THERMOPHILIC PROTEIN SUGAR BINDING PROTEIN
Ref.: LIGAND-INDUCED CONFORMATIONAL CHANGES IN A THERMOPH RIBOSE-BINDING PROTEIN. BMC STRUCT.BIOL. V. 8 50 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 199 families.
1 2FN8 - RIP C5 H10 O5 C1[C@H]([C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 166 families.
1 2FN8 - RIP C5 H10 O5 C1[C@H]([C....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 2FN8 - RIP C5 H10 O5 C1[C@H]([C....
2 1RPJ Kd = 0.33 uM ALL C6 H12 O6 C([C@@H]1[....
3 2DRI Kd = 0.13 uM RIP C5 H10 O5 C1[C@H]([C....
4 1DRK Kd = 0.15 uM RIP C5 H10 O5 C1[C@H]([C....
5 1DRJ Kd = 0.04 uM RIP C5 H10 O5 C1[C@H]([C....
6 2IOY - RIP C5 H10 O5 C1[C@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RIP; Similar ligands found: 14
No: Ligand ECFP6 Tc MDL keys Tc
1 XYP 1 1
2 0MK 1 1
3 RIP 1 1
4 LXC 1 1
5 ARA 1 1
6 ARB 1 1
7 XYS 1 1
8 HSY 1 1
9 BXP 0.414634 0.84375
10 XYP XYP 0.414634 0.84375
11 XYS XYP 0.414634 0.84375
12 XYS XYS 0.414634 0.84375
13 XYP XYS 0.414634 0.84375
14 FU4 0.4 0.896552
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FN8; Ligand: RIP; Similar sites found: 32
This union binding pocket(no: 1) in the query (biounit: 2fn8.bio1) has 13 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4DXJ 0M9 0.03621 0.40587 1.9802
2 1ELU PDA 0.008743 0.42607 2.31023
3 1ELU CSS 0.01091 0.42407 2.31023
4 1FEC FAD 0.04064 0.41911 2.9703
5 4LZJ 22H 0.02575 0.4085 2.9703
6 3EYA TDP 0.03692 0.40178 2.9703
7 5HX8 66P 0.03381 0.40411 3.31126
8 5ECP ATP 0.02645 0.42532 3.63036
9 4ZL4 4PK 0.02251 0.41372 3.9604
10 4RLT FSE 0.009025 0.41711 4.08163
11 1V7C HEY 0.02047 0.41789 4.29043
12 2VJ8 HA2 0.04532 0.4115 4.29043
13 3CGB FAD 0.04582 0.40887 4.62046
14 4WT2 3UD 0.04014 0.40278 5.71429
15 3QWI CUE 0.02552 0.42753 5.92593
16 2Q46 NAP 0.03647 0.40597 5.92885
17 4OAS 2SW 0.02168 0.41996 6.25
18 4CYI ATP 0.01135 0.42045 6.27063
19 4UCI SAM 0.02198 0.40781 7.59076
20 2D0V PQQ 0.02522 0.40366 8.33333
21 4IIL RBF 0.00628 0.43325 9.24092
22 4L2I FAD 0.04942 0.40566 14.0684
23 3O75 F1X 0.0000005782 0.63213 14.7059
24 3JRS A8S 0.02558 0.40046 14.9038
25 5DLY 5D7 0.04198 0.41332 17.2932
26 3EJW PAV 0.01207 0.40447 28.5714
27 3MA0 XYP 0.0001035 0.5028 34.6535
28 2GBP BGC 0.000003357 0.59586 34.9835
29 5XSS XYP 0.000005707 0.56678 39.934
30 9ABP GAL 0.00003011 0.54362 40.264
31 9ABP GLA 0.00003011 0.54362 40.264
32 2P9H IPT 0.0003323 0.48525 44.9814
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