Receptor
PDB id Resolution Class Description Source Keywords
2IOY 1.9 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN SUGAR BINDING PROTEIN THERMOPHILIC PROTEINS
Ref.: THE BACKBONE STRUCTURE OF THE THERMOPHILIC THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN IS ESSENTIALLY IDENTICAL TO ITS MESOPHILIC E. COLI HOMOLOG. BMC STRUCT.BIOL. V. 8 20 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
RIP A:401;
B:402;
Valid;
Valid;
none;
none;
submit data
150.13 C5 H10 O5 C1[C@...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2IOY 1.9 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN SUGAR BINDING PROTEIN THERMOPHILIC PROTEINS
Ref.: THE BACKBONE STRUCTURE OF THE THERMOPHILIC THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN IS ESSENTIALLY IDENTICAL TO ITS MESOPHILIC E. COLI HOMOLOG. BMC STRUCT.BIOL. V. 8 20 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 473 families.
1 2IOY - RIP C5 H10 O5 C1[C@H]([C....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 166 families.
1 1DBP - RIP C5 H10 O5 C1[C@H]([C....
2 2DRI Kd = 0.13 uM RIP C5 H10 O5 C1[C@H]([C....
3 1DRK Kd = 0.15 uM RIP C5 H10 O5 C1[C@H]([C....
4 1DRJ Kd = 0.04 uM RIP C5 H10 O5 C1[C@H]([C....
5 2IOY - RIP C5 H10 O5 C1[C@H]([C....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 2FN8 - RIP C5 H10 O5 C1[C@H]([C....
2 1RPJ Kd = 0.33 uM ALL C6 H12 O6 C([C@@H]1[....
3 2DRI Kd = 0.13 uM RIP C5 H10 O5 C1[C@H]([C....
4 1DRK Kd = 0.15 uM RIP C5 H10 O5 C1[C@H]([C....
5 1DRJ Kd = 0.04 uM RIP C5 H10 O5 C1[C@H]([C....
6 2IOY - RIP C5 H10 O5 C1[C@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RIP; Similar ligands found: 14
No: Ligand ECFP6 Tc MDL keys Tc
1 XYP 1 1
2 0MK 1 1
3 RIP 1 1
4 LXC 1 1
5 ARA 1 1
6 ARB 1 1
7 XYS 1 1
8 HSY 1 1
9 BXP 0.414634 0.84375
10 XYP XYP 0.414634 0.84375
11 XYS XYP 0.414634 0.84375
12 XYS XYS 0.414634 0.84375
13 XYP XYS 0.414634 0.84375
14 FU4 0.4 0.896552
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2IOY; Ligand: RIP; Similar sites found: 12
This union binding pocket(no: 1) in the query (biounit: 2ioy.bio1) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4DXJ 0M9 0.02646 0.41087 4.24028
2 2RH1 CAU 0.01815 0.40909 4.59364
3 2ZX7 ZX7 0.02412 0.40409 6.36042
4 4UOH ADP 0.01411 0.40275 6.62252
5 5JO1 6LM 0.0104 0.42578 15.6757
6 3O75 F1X 0.0000002434 0.52273 31.6176
7 4Y9T PA1 0.00008506 0.48996 39.576
8 5XSS XYP 0.00001263 0.5137 40.636
9 2P9H IPT 0.00003491 0.47246 43.8662
10 2H3H BGC 0.000009713 0.49352 44.523
11 4IRX INS 0.00000001332 0.6013 48.0565
12 2VK2 GZL 0.00000001131 0.69819 48.4099
Pocket No.: 2; Query (leader) PDB : 2IOY; Ligand: RIP; Similar sites found: 3
This union binding pocket(no: 2) in the query (biounit: 2ioy.bio2) has 12 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1PIG GLC GLC 0.007677 0.40118 1.41343
2 1UOZ GLC SSG SSG SGC 0.0244 0.4071 4.24028
3 1SO0 GAL 0.005138 0.40063 13.0742
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