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Receptor
PDB id Resolution Class Description Source Keywords
2IOY 1.9 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THERMOANAEROBACTER TENGCONGENSIS RIBOSE PROTEIN THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN SUGAR BINDING PROTEIN THERMOPHILIC
Ref.: THE BACKBONE STRUCTURE OF THE THERMOPHILIC THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PRO ESSENTIALLY IDENTICAL TO ITS MESOPHILIC E. COLI HOM BMC STRUCT.BIOL. V. 8 20 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
RIP A:401;
B:402;
Valid;
Valid;
none;
none;
submit data
150.13 C5 H10 O5 C1[C@...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2IOY 1.9 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THERMOANAEROBACTER TENGCONGENSIS RIBOSE PROTEIN THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PROTEIN SUGAR BINDING PROTEIN THERMOPHILIC
Ref.: THE BACKBONE STRUCTURE OF THE THERMOPHILIC THERMOANAEROBACTER TENGCONGENSIS RIBOSE BINDING PRO ESSENTIALLY IDENTICAL TO ITS MESOPHILIC E. COLI HOM BMC STRUCT.BIOL. V. 8 20 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 2IOY - RIP C5 H10 O5 C1[C@H]([C....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 175 families.
1 1DBP - RIP C5 H10 O5 C1[C@H]([C....
2 2DRI Kd = 0.13 uM RIP C5 H10 O5 C1[C@H]([C....
3 1DRK Kd = 0.15 uM RIP C5 H10 O5 C1[C@H]([C....
4 1DRJ Kd = 0.04 uM RIP C5 H10 O5 C1[C@H]([C....
5 2IOY - RIP C5 H10 O5 C1[C@H]([C....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 2FN8 - RIP C5 H10 O5 C1[C@H]([C....
2 1RPJ Kd = 0.33 uM ALL C6 H12 O6 C([C@@H]1[....
3 2DRI Kd = 0.13 uM RIP C5 H10 O5 C1[C@H]([C....
4 1DRK Kd = 0.15 uM RIP C5 H10 O5 C1[C@H]([C....
5 1DRJ Kd = 0.04 uM RIP C5 H10 O5 C1[C@H]([C....
6 2IOY - RIP C5 H10 O5 C1[C@H]([C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RIP; Similar ligands found: 12
No: Ligand ECFP6 Tc MDL keys Tc
1 RIP 1 1
2 XYS 1 1
3 ARB 1 1
4 HSY 1 1
5 ARA 1 1
6 XYP 1 1
7 LXC 1 1
8 0MK 1 1
9 XYP XYS 0.414634 0.84375
10 BXP 0.414634 0.84375
11 XYS XYP 0.414634 0.84375
12 FU4 0.4 0.896552
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2IOY; Ligand: RIP; Similar sites found with APoc: 87
This union binding pocket(no: 1) in the query (biounit: 2ioy.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 4WT2 3UD None
2 4DK7 0KS 1.21457
3 4JZX 476 1.41343
4 6EQS BV8 1.45455
5 5HTX ADP 1.76678
6 2SIM DAN 2.12014
7 1PK8 ATP 2.4735
8 2P1C GG3 2.4735
9 2QV6 GTP 2.61194
10 5MWY YNU 2.82686
11 5L7G 6QE 2.82686
12 2J62 GSZ 2.82686
13 4UDB CV7 2.94118
14 5HCV 60R 3.11284
15 4CYI ATP 3.18021
16 3OND NAD 3.53357
17 3OND ADN 3.53357
18 3KF3 FRU 3.53357
19 5D2R 56W 3.53357
20 5W10 CMP 3.58974
21 5K8P 6R8 3.88693
22 1GZ4 ATP 3.88693
23 1GQ2 NAP 3.88693
24 4DXJ 0M9 4.24028
25 5ZCE MTT 4.24028
26 3PB9 1BN 4.24028
27 3EKK GS2 4.24028
28 5UFS 1TA 4.43548
29 5Y6Q MCN 4.59364
30 2RH1 CAU 4.59364
31 3AXI GLC 4.59364
32 6HKE MLT 4.59364
33 3C3Y SAH 4.64135
34 3KDJ A8S 4.9505
35 1IZE IVA VAL VAL STA ALA STA 4.95356
36 1AJ0 PH2 4.96454
37 1AJ0 SAN 4.96454
38 4YZ5 DAN 5.30035
39 3QXV MTX 5.55556
40 3NJ4 AFX 5.65371
41 5ZKC 3C0 5.65371
42 3CXO 3LR 5.65371
43 3CXO 1N5 5.65371
44 4X7Q 3YR 5.65371
45 4ELG 52I 6.0241
46 2MAS PIR 6.36042
47 2ZX7 ZX7 6.36042
48 4UOH ADP 6.62252
49 3PVT 3HC 7.06714
50 3AMN CBI 7.54717
51 3AMN CBK 7.54717
52 4E2J MOF 7.6
53 1SR7 MOF 7.72201
54 3KRU FMN 8.12721
55 1GA8 UPF 8.12721
56 1GA8 DEL 8.12721
57 4MLN ODV 8.16327
58 2O7B HC4 8.48057
59 6DVH FMN 8.62944
60 4P6W MOF 8.73016
61 4EI7 GDP 9.18728
62 2HI4 BHF 9.54064
63 3SI2 PBD 9.54064
64 1JNQ EGT 9.54064
65 4JR7 GNP 9.89399
66 4Q86 AMP 10.6007
67 4PIO SAH 10.9541
68 4PIO AVI 10.9541
69 5DLY SAH 11.6541
70 3BL6 FMC 13.0435
71 1SO0 GAL 13.0742
72 2YVK MRU 13.7809
73 3OJI PYV 15.3439
74 5JO1 6LM 15.6757
75 4R57 ACO 19.8864
76 5Z84 CHD 21.9178
77 4XXH T6P 30.9804
78 3O75 F1X 31.6176
79 4V1T ADP 37.5
80 4Y9T PA1 39.576
81 5XSS XYP 40.636
82 5XSJ XYP 40.636
83 2P9H IPT 43.8662
84 5YSZ CBI 44.523
85 2H3H BGC 44.523
86 4IRX INS 48.0565
87 2VK2 GZL 48.4099
Pocket No.: 2; Query (leader) PDB : 2IOY; Ligand: RIP; Similar sites found with APoc: 25
This union binding pocket(no: 2) in the query (biounit: 2ioy.bio2) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 1PIG GLC GLC 1.41343
2 2B4Q NAP 2.12014
3 2FP2 TSA 2.40964
4 1Z45 GAL 2.82686
5 3WR7 COA 2.94118
6 6G1P CIT 3.18021
7 2UXI G50 3.33333
8 3UXL CFI 3.53357
9 4OKZ 3E9 3.53357
10 4Z87 GDP 4.24028
11 1UOZ GLC SSG SSG SGC 4.24028
12 1UPF URF 4.46429
13 6HKE LMR 4.59364
14 6F3M ADN 4.947
15 4QHP 32Q 5.30035
16 1QPB PYM 5.30035
17 1QPB TPP 5.30035
18 4ELG 52J 6.0241
19 1SIV PSI 7.07071
20 2PVN P63 7.42049
21 4U7W NDP 7.42049
22 3T3C 017 8.08081
23 2Q46 NAP 10.2767
24 4TVD BGC 10.6007
25 2NX1 PEP 12.7341
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