Receptor
PDB id Resolution Class Description Source Keywords
6QEH 2.17 Å EC: 3.4.11.18 CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN CO AN INHIBITOR 5-CHLORO-QUINOLIN-8-OL HOMO SAPIENS HYDROLASE PEPTIDASE METAL ION BINDING PROTEOLYSIS HYDROLHYDROLASE INHIBITOR COMPLEX
Ref.: DISCOVERY AND STRUCTURE-BASED OPTIMIZATION OF NEXT-GENERATION REVERSIBLE METHIONINE AMINOPEPTIDAS (METAP-2) INHIBITORS. J.MED.CHEM. V. 62 5025 2019
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:503;
A:504;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
54.938 Mn [Mn+2...
GOL A:501;
 Invalid;
 none;
 submit data
92.094 C3 H8 O3 C(C(C...
HZQ A:502;
 Valid;
 none;
 submit data
179.603 C9 H6 Cl N O c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
7A16 1.9 Å EC: 3.4.11.18 CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN CO AN INHIBITOR GSK2229238A (COMPOUND 43) HOMO SAPIENS METHIONINE AMINOPEPTIDASE-2 HYDROLASE
Ref.: STRUCTURE-BASED OPTIMISATION OF ORALLY ACTIVE & REV METAP-2 INHIBITORS MAINTAINING A TIGHT 'MOLECULAR B BIOORG.MED.CHEM.LETT. V. 30 27533 2020
Members (26)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
70% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
27 1KQ9 - MET C5 H11 N O2 S CSCC[C@@H]....
28 1KQ0 - MED C5 H11 N O2 S CSCC[C@H](....
29 1QZY ic50 ~ 800 nM TDE C18 H32 N2 O7 CC(C)(C)C=....
50% Homology Family (29)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2GA2 ic50 = 3 uM A19 C13 H9 Br Cl N O4 S c1cc(ccc1S....
2 2ADU Ki = 18 nM R20 C9 H9 N3 Cc1cccc(c1....
3 7A14 ic50 = 0.00000001 M QVB C18 H16 Cl F N2 O2 CC(C)Oc1cc....
4 6QEI - HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
5 6QEF ic50 = 0.06 uM HZW C18 H16 Cl F N2 O3 c1ccc(cc1)....
6 6QEJ - HZT C14 H13 F N4 O2 S2 c1cc(sc1)S....
7 6QEH - HZQ C9 H6 Cl N O c1cc2c(ccc....
8 7A12 ic50 = 0.00000001 M QVK C15 H11 Cl N2 O c1ccc(cc1)....
9 7A16 ic50 = 0.00000001 M HZE C22 H24 F2 N4 O2 CC(C)Oc1cc....
10 1R58 - AO5 C15 H22 Cl N3 O3 S CC(C)SCC[C....
11 5JHU - 6KO C18 H19 N5 O3 COc1ccccc1....
12 1YW9 ic50 = 0.019 uM A84 C22 H25 F N2 O4 S CN(C)CC=C/....
13 2EA2 ic50 = 0.016 uM F77 C16 H16 F N O4 S CCc1ccc(c(....
14 7A15 ic50 = 0.00000001 M QV5 C22 H24 Cl F N4 O2 CC(C)Oc1cc....
15 6QEG ic50 = 0.05 uM K4K C17 H18 N2 O3 S c1ccc(cc1)....
16 5LYX ic50 = 0.038 uM 7BF C19 H18 N6 O c1cc2cnccc....
17 5JI6 ic50 = 0.011 uM 6KN C14 H10 F3 N3 Cc1cnccc1c....
18 5JFR ic50 = 5 nM 6KP C16 H11 F N6 Cc1c(cc2c(....
19 5LYW ic50 = 0.7 uM 7BH C17 H19 N5 O Cc1ccccc1O....
20 1R5H ic50 = 0.17 uM AO2 C17 H27 N3 O2 Cc1ccc(cc1....
21 1YW7 ic50 = 1.4 uM A41 C14 H13 N O4 S Cc1ccc(c(c....
22 7A13 - QW5 C16 H13 Cl N2 O2 COc1cccc(c....
23 2EA4 ic50 = 0.046 uM F79 C17 H19 F N2 O5 S CCc1ccc(c(....
24 1R5G - AO1 C19 H26 N2 O2 S CCSCC[C@@H....
25 6QED ic50 = 0.015 uM HZK C21 H19 Cl F N3 O4 c1cc2c(cc1....
26 2OAZ Ki = 2 nM I96 C16 H18 N4 S2 CC(C)c1ccc....
27 1KQ9 - MET C5 H11 N O2 S CSCC[C@@H]....
28 1KQ0 - MED C5 H11 N O2 S CSCC[C@H](....
29 1QZY ic50 ~ 800 nM TDE C18 H32 N2 O7 CC(C)(C)C=....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: HZQ; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 HZQ 1 1
2 8XQ 0.469388 0.7
Similar Ligands (3D)
Ligand no: 1; Ligand: HZQ; Similar ligands found: 875
No: Ligand Similarity coefficient
1 MT0 1.0000
2 495 0.9996
3 HH8 0.9759
4 GLC 0.9723
5 5Q0 0.9714
6 HQY 0.9713
7 4XH 0.9712
8 GIO 0.9703
9 ES1 0.9696
10 24W 0.9692
11 5SG 0.9691
12 1NP 0.9690
13 1LQ 0.9689
14 1SQ 0.9682
15 G6D 0.9681
16 BGC 0.9681
17 JUG 0.9673
18 G1O 0.9670
19 ADK 0.9669
20 JPZ 0.9668
21 5IQ 0.9668
22 N5J 0.9665
23 4YS 0.9662
24 NQ 0.9653
25 G3F 0.9652
26 RXA 0.9651
27 3MA 0.9640
28 HLZ 0.9636
29 25W 0.9632
30 VK3 0.9629
31 JBH 0.9617
32 HQT 0.9604
33 O72 0.9602
34 1LM 0.9600
35 12Q 0.9592
36 5WX 0.9580
37 1XN 0.9579
38 ISE 0.9573
39 BTE 0.9572
40 APZ 0.9571
41 6MP 0.9565
42 NTZ 0.9562
43 R8V 0.9561
44 39A 0.9560
45 HPA 0.9544
46 7NI 0.9544
47 3WA 0.9534
48 KJH 0.9533
49 JBQ 0.9531
50 GCS 0.9530
51 7WA 0.9528
52 EQT 0.9526
53 TTL 0.9526
54 ADE 0.9525
55 YSO 0.9524
56 37T 0.9517
57 BP1 0.9513
58 ES4 0.9513
59 XXR 0.9513
60 5QX 0.9511
61 9KT 0.9505
62 AZA 0.9504
63 SKA 0.9502
64 PM6 0.9501
65 GUN 0.9500
66 9DG 0.9497
67 10L 0.9496
68 7W1 0.9494
69 HJP 0.9494
70 0P6 0.9493
71 CFP 0.9489
72 AZ8 0.9484
73 PE0 0.9481
74 67N 0.9480
75 8S0 0.9479
76 Q88 0.9478
77 M1A 0.9478
78 XAN 0.9476
79 PXL 0.9475
80 F5B 0.9472
81 7HP 0.9471
82 A7W 0.9471
83 DBJ 0.9470
84 2D0 0.9467
85 5M0 0.9465
86 IGA 0.9458
87 290 0.9457
88 9DA 0.9455
89 DX4 0.9455
90 CWS 0.9454
91 9HX 0.9453
92 NTM 0.9452
93 TEP 0.9452
94 M0W 0.9451
95 XYP 0.9451
96 12B 0.9450
97 SVN 0.9449
98 SAL 0.9448
99 PHT 0.9448
100 A2F 0.9441
101 6GU 0.9441
102 AJ2 0.9441
103 PYQ 0.9440
104 M5K 0.9437
105 ES0 0.9431
106 Q6T 0.9431
107 M6N 0.9430
108 141 0.9428
109 UNC 0.9425
110 3MG 0.9423
111 AZ9 0.9421
112 6AP 0.9421
113 HH5 0.9411
114 LI6 0.9411
115 AKH 0.9408
116 8CM 0.9403
117 9MG 0.9403
118 J9W 0.9402
119 CWM 0.9401
120 3IT 0.9401
121 Q24 0.9400
122 LXC 0.9400
123 7HQ 0.9399
124 MEW 0.9398
125 CFF 0.9397
126 I3A 0.9395
127 M0Q 0.9394
128 D07 0.9394
129 C2U 0.9393
130 7VS 0.9392
131 3Z8 0.9392
132 AIN 0.9391
133 4HC 0.9390
134 M1H 0.9390
135 AQO 0.9388
136 32X 0.9384
137 FOT 0.9382
138 7WV 0.9380
139 BDP 0.9379
140 AZG 0.9378
141 2ZQ 0.9375
142 BE2 0.9373
143 7B4 0.9364
144 JBE 0.9361
145 KJY 0.9361
146 ISN 0.9361
147 ZVO 0.9357
148 QPR 0.9357
149 6CS 0.9356
150 HQD 0.9354
151 KLW 0.9351
152 GAL 0.9350
153 DHQ 0.9350
154 M1Q 0.9349
155 1XM 0.9348
156 5RG 0.9344
157 FUL 0.9343
158 SWA 0.9342
159 KYD 0.9341
160 7ZE 0.9340
161 JIF 0.9339
162 INS 0.9335
163 GTQ 0.9334
164 ADZ 0.9333
165 3F0 0.9333
166 7VJ 0.9331
167 HFB 0.9330
168 5MK 0.9328
169 EXO 0.9327
170 BOA 0.9326
171 LSA 0.9325
172 6M1 0.9325
173 7MH 0.9324
174 LGC 0.9323
175 NPY 0.9323
176 1WD 0.9321
177 BCP 0.9320
178 QUZ 0.9320
179 3HA 0.9319
180 5WY 0.9318
181 URC 0.9317
182 42C 0.9316
183 GRE 0.9316
184 HNQ 0.9316
185 NDM 0.9315
186 QX2 0.9314
187 T6C 0.9313
188 KKN 0.9311
189 VNL 0.9311
190 B57 0.9308
191 4SV 0.9307
192 2ZV 0.9306
193 IJZ 0.9305
194 KUF 0.9303
195 B53 0.9300
196 54G 0.9298
197 0CU 0.9293
198 KT7 0.9291
199 EA1 0.9291
200 YH7 0.9290
201 3RK 0.9290
202 JKE 0.9289
203 DPZ 0.9288
204 0N7 0.9287
205 PFB 0.9285
206 PX7 0.9284
207 6F0 0.9282
208 IV2 0.9276
209 UAN 0.9276
210 FDB 0.9275
211 3U4 0.9268
212 7WR 0.9268
213 680 0.9268
214 DHK 0.9267
215 M1E 0.9266
216 MRW 0.9260
217 DBH 0.9260
218 ES7 0.9258
219 7W4 0.9258
220 ES6 0.9257
221 DIN 0.9257
222 329 0.9257
223 5WV 0.9256
224 F05 0.9255
225 GTR 0.9251
226 3C2 0.9250
227 0W8 0.9247
228 JBK 0.9242
229 209 0.9242
230 9EW 0.9238
231 G5V 0.9234
232 3M0 0.9231
233 PCI 0.9231
234 DQN 0.9231
235 FE DB1 0.9230
236 3C1 0.9230
237 15L 0.9230
238 23A 0.9229
239 9TZ 0.9229
240 GDE 0.9227
241 H33 0.9223
242 06B 0.9220
243 XYS 0.9219
244 B60 0.9216
245 QBK 0.9216
246 B55 0.9213
247 NID 0.9211
248 149 0.9210
249 BTY 0.9210
250 KIB 0.9210
251 PHH 0.9209
252 JFD 0.9209
253 2CK 0.9206
254 5CL 0.9203
255 5RN 0.9203
256 YIO 0.9201
257 DIU 0.9200
258 TBS 0.9200
259 HHA 0.9200
260 NOJ 0.9197
261 K17 0.9191
262 OXC 0.9189
263 CTS 0.9188
264 BCF 0.9188
265 I6G 0.9183
266 SHG 0.9183
267 ORO 0.9177
268 DRL 0.9175
269 BBF 0.9175
270 RPQ 0.9174
271 6M4 0.9174
272 MAQ 0.9167
273 HLR 0.9166
274 8TX 0.9166
275 XAZ 0.9164
276 4CS 0.9163
277 6M9 0.9161
278 2H5 0.9161
279 F3B 0.9160
280 GYE 0.9160
281 RM4 0.9159
282 SX1 0.9158
283 F0J 0.9158
284 INE 0.9157
285 18N 0.9155
286 MVL 0.9155
287 RNS 0.9154
288 MO8 0.9153
289 3Z7 0.9151
290 RAM 0.9150
291 75K 0.9149
292 DIE 0.9149
293 DOR 0.9148
294 XQG 0.9147
295 0RW 0.9145
296 FLV 0.9144
297 TOF 0.9143
298 5JQ 0.9143
299 SRO 0.9141
300 4MU 0.9140
301 CTL 0.9139
302 92K 0.9139
303 FBG 0.9139
304 GOX 0.9138
305 BEA 0.9137
306 MUA 0.9136
307 B62 0.9134
308 GLA 0.9131
309 4ME 0.9131
310 FA0 0.9131
311 TBP 0.9130
312 1PT 0.9130
313 MFB 0.9129
314 5CU 0.9128
315 GCU 0.9128
316 SOE 0.9127
317 UFO 0.9125
318 AHR 0.9124
319 1P7 0.9121
320 0FO 0.9120
321 5NU 0.9118
322 3ID 0.9118
323 8IG 0.9118
324 XHP 0.9116
325 GOG 0.9115
326 X09 0.9113
327 2FG 0.9111
328 PXM 0.9110
329 GIM 0.9110
330 4M4 0.9108
331 DOB 0.9107
332 2AK 0.9107
333 FGZ 0.9107
334 COU 0.9106
335 QAT 0.9105
336 OTW 0.9101
337 ARB 0.9100
338 8GC 0.9097
339 4NC 0.9096
340 FCB 0.9093
341 QX4 0.9092
342 IBF 0.9090
343 03V 0.9089
344 GCB 0.9088
345 4AA 0.9088
346 34D 0.9088
347 AW5 0.9086
348 V55 0.9084
349 226 0.9084
350 BHO 0.9084
351 MAN 0.9084
352 IND 0.9082
353 BZX 0.9080
354 KBG 0.9079
355 FUC 0.9077
356 4FS 0.9076
357 SXS 0.9074
358 86J 0.9074
359 44W 0.9073
360 12M 0.9073
361 X05 0.9071
362 QSH 0.9071
363 DEN 0.9070
364 K6X 0.9070
365 BMA 0.9070
366 NDH 0.9070
367 MBG 0.9068
368 DQU 0.9067
369 BZI 0.9067
370 ASO 0.9064
371 4M0 0.9062
372 XQ0 0.9061
373 GJS 0.9061
374 BZF 0.9060
375 S76 0.9058
376 AEZ 0.9057
377 EVA 0.9057
378 GAB 0.9057
379 K32 0.9055
380 2AQ 0.9054
381 BSP 0.9051
382 D1X 0.9051
383 GM7 0.9049
384 LKA 0.9049
385 5JL 0.9048
386 K22 0.9048
387 DHB 0.9047
388 QAS 0.9045
389 IDM 0.9045
390 H42 0.9043
391 GIV 0.9043
392 TTY 0.9042
393 0R1 0.9041
394 ASC 0.9040
395 MPI 0.9039
396 42A 0.9038
397 ICO 0.9038
398 HTP 0.9037
399 JKZ 0.9037
400 NMJ 0.9035
401 LZ1 0.9034
402 3NT 0.9034
403 AX7 0.9033
404 I1N 0.9033
405 3PF 0.9032
406 14O 0.9031
407 OCH 0.9031
408 KFH 0.9031
409 270 0.9030
410 DMD 0.9030
411 LZM 0.9028
412 1X7 0.9027
413 3MB 0.9027
414 E7Z 0.9024
415 1GN 0.9024
416 5H1 0.9021
417 GTZ 0.9021
418 3FH 0.9020
419 ES5 0.9020
420 EYK 0.9019
421 FBT 0.9018
422 MVN 0.9017
423 GVH 0.9016
424 0FN 0.9015
425 2A7 0.9014
426 K8X 0.9013
427 6AI 0.9012
428 0TR 0.9012
429 44V 0.9010
430 ABV 0.9009
431 G3E 0.9007
432 MBD 0.9007
433 3AB 0.9005
434 GTL 0.9003
435 GZ8 0.9001
436 YQA 0.9001
437 SKM 0.9000
438 3HB 0.9000
439 UEG 0.9000
440 ZWZ 0.9000
441 6BL 0.8999
442 BR8 0.8999
443 Z5P 0.8996
444 VNJ 0.8994
445 AMG 0.8991
446 BHA 0.8989
447 8WT 0.8989
448 0MK 0.8989
449 GT0 0.8987
450 SOR 0.8986
451 DNC 0.8982
452 F60 0.8982
453 P9P 0.8981
454 5QY 0.8981
455 KIA 0.8980
456 0CT 0.8979
457 5HN 0.8979
458 2FQ 0.8978
459 FUF 0.8978
460 JB5 0.8977
461 53C 0.8977
462 2K4 0.8976
463 35C 0.8975
464 YCP 0.8973
465 X8D 0.8973
466 5B1 0.8973
467 M2K 0.8972
468 AJV 0.8969
469 G2F 0.8969
470 1U1 0.8966
471 WOO 0.8966
472 L3Q 0.8964
473 PRF 0.8964
474 F12 0.8964
475 2HQ 0.8962
476 23J 0.8962
477 1WG 0.8959
478 2MN 0.8958
479 JAE 0.8957
480 5MB 0.8957
481 GBD 0.8956
482 RM1 0.8956
483 173 0.8956
484 JXN 0.8956
485 MT5 0.8955
486 RSF 0.8952
487 DUB 0.8952
488 SWD 0.8951
489 60P 0.8949
490 HXX 0.8949
491 URF 0.8947
492 6ME 0.8944
493 1U6 0.8942
494 MYJ 0.8941
495 SHA 0.8941
496 13X 0.8941
497 CLZ 0.8939
498 PQ0 0.8939
499 6VD 0.8938
500 JZ3 0.8938
501 5MI 0.8938
502 39O 0.8938
503 FLC 0.8936
504 FCA 0.8935
505 SE2 0.8934
506 JLZ 0.8934
507 IPZ 0.8933
508 SYV 0.8933
509 TFU 0.8930
510 5OB 0.8927
511 GAG 0.8926
512 5AN 0.8926
513 2AL 0.8924
514 FHB 0.8924
515 BEZ 0.8921
516 MZB 0.8921
517 JZ9 0.8920
518 4A3 0.8920
519 CHB 0.8918
520 NVU 0.8917
521 FLM 0.8917
522 DEE 0.8916
523 GOO 0.8916
524 2DR 0.8915
525 OMD 0.8914
526 QSB 0.8914
527 D48 0.8914
528 EJZ 0.8914
529 XX2 0.8913
530 OXQ 0.8913
531 AX2 0.8913
532 BEN 0.8912
533 11S 0.8912
534 NNO 0.8912
535 QWW 0.8911
536 WCE 0.8911
537 SYA 0.8910
538 FB1 0.8910
539 INO 0.8909
540 3TJ 0.8909
541 PYG 0.8908
542 X6X 0.8908
543 ES9 0.8906
544 LT2 0.8906
545 5RO 0.8904
546 J5I 0.8903
547 MFU 0.8903
548 MCT 0.8902
549 4Z4 0.8901
550 TDR 0.8901
551 DBX 0.8900
552 4JP 0.8900
553 PDC 0.8899
554 FYU 0.8898
555 MWM 0.8897
556 G4D 0.8896
557 NIO 0.8896
558 GMN 0.8895
559 4XV 0.8894
560 7B3 0.8893
561 H4N 0.8892
562 NCA 0.8891
563 82I 0.8890
564 NBZ 0.8890
565 3MC 0.8890
566 4PW 0.8890
567 JTH 0.8890
568 J9Q 0.8889
569 6UA 0.8888
570 94B 0.8888
571 6PC 0.8887
572 FK1 0.8886
573 QWN 0.8886
574 1P3 0.8886
575 DNF 0.8885
576 4ZE 0.8885
577 7ME 0.8885
578 8GK 0.8884
579 MWP 0.8883
580 97T 0.8882
581 H6B 0.8882
582 WBU 0.8881
583 ERH 0.8880
584 MT8 0.8879
585 BNT 0.8878
586 XM0 0.8878
587 3AY 0.8878
588 93K 0.8877
589 UFV 0.8877
590 RIP 0.8874
591 ZZ8 0.8874
592 N8Y 0.8873
593 PA1 0.8872
594 BK9 0.8870
595 4AN 0.8870
596 PRZ 0.8870
597 8W9 0.8869
598 4XR 0.8868
599 7CZ 0.8868
600 2HO 0.8868
601 2MI 0.8867
602 FFP 0.8867
603 HY3 0.8866
604 ADA 0.8866
605 XBZ 0.8866
606 OVV 0.8866
607 FBV 0.8864
608 HMH 0.8864
609 MSN 0.8864
610 TH7 0.8863
611 3HM 0.8861
612 2C9 0.8860
613 2EC 0.8860
614 EUG 0.8859
615 3CU 0.8859
616 BRT 0.8854
617 2YU 0.8852
618 BAM 0.8851
619 C2Y 0.8851
620 2CQ 0.8851
621 3FA 0.8848
622 K5W 0.8847
623 4HO 0.8845
624 2LY 0.8844
625 O2A 0.8844
626 R9Y 0.8843
627 PZA 0.8842
628 4XS 0.8841
629 ALL 0.8841
630 HMU 0.8841
631 E3D 0.8839
632 OA3 0.8839
633 4JT 0.8839
634 28N 0.8838
635 5ZE 0.8837
636 261 0.8836
637 GAF 0.8833
638 UNU 0.8833
639 9TW 0.8833
640 3BZ 0.8833
641 NOY 0.8832
642 F81 0.8831
643 150 0.8831
644 Q7A 0.8831
645 3DM 0.8830
646 ET2 0.8829
647 ICP 0.8829
648 L7T 0.8827
649 8NY 0.8827
650 ARA 0.8825
651 TM7 0.8824
652 KGK 0.8821
653 2CM 0.8820
654 IHB 0.8820
655 HT4 0.8819
656 1DW 0.8819
657 2AC 0.8819
658 1P8 0.8819
659 A13 0.8819
660 NK 0.8819
661 3SK 0.8818
662 2ZX 0.8814
663 R8A 0.8812
664 N7P 0.8811
665 DFB 0.8811
666 43M 0.8811
667 MMA 0.8810
668 P92 0.8810
669 IFL 0.8809
670 KJU 0.8809
671 PYD 0.8808
672 WDL 0.8808
673 R8S 0.8808
674 MHK 0.8807
675 A1U 0.8807
676 275 0.8806
677 FP1 0.8805
678 HLD 0.8804
679 0JD 0.8803
680 2MY 0.8802
681 CLW 0.8802
682 RIB 0.8800
683 ENL 0.8800
684 948 0.8797
685 EKZ 0.8796
686 FBB 0.8794
687 ES2 0.8794
688 1MC 0.8793
689 IFM 0.8792
690 GZL 0.8792
691 286 0.8790
692 34A 0.8790
693 PEY 0.8788
694 GCW 0.8787
695 4HM 0.8785
696 RHU 0.8784
697 M5N 0.8783
698 NPO 0.8782
699 2MP 0.8782
700 3CE 0.8780
701 PZI 0.8779
702 LDR 0.8778
703 ZZ3 0.8778
704 0F9 0.8778
705 36R 0.8777
706 LDP 0.8775
707 XYD 0.8773
708 JND 0.8772
709 GXL 0.8772
710 5NE 0.8770
711 SJ5 0.8769
712 PHB 0.8768
713 VGD 0.8768
714 GV9 0.8768
715 MZG 0.8766
716 4YO 0.8765
717 6MH 0.8764
718 K2T 0.8763
719 5JC 0.8762
720 TH0 0.8762
721 4JQ 0.8761
722 5MH 0.8759
723 VGL 0.8755
724 QXW 0.8755
725 FHN 0.8755
726 4ZC 0.8753
727 3XX 0.8752
728 94N 0.8750
729 NIZ 0.8750
730 4JJ 0.8749
731 BZ3 0.8746
732 UQ 0.8745
733 Q71 0.8744
734 45C 0.8744
735 92P 0.8744
736 4CL 0.8742
737 1KP 0.8741
738 5VM 0.8740
739 X0V 0.8739
740 0TU 0.8739
741 GLT 0.8738
742 GLF 0.8738
743 AC0 0.8738
744 LCN 0.8737
745 D3M 0.8737
746 KOJ 0.8736
747 MS9 0.8736
748 AZF 0.8735
749 F31 0.8735
750 OXZ 0.8735
751 HKD 0.8734
752 NGO 0.8733
753 8H8 0.8732
754 MQN 0.8732
755 3R6 0.8730
756 PBR 0.8730
757 DMJ 0.8730
758 5UC 0.8730
759 HX3 0.8729
760 NCD 0.8725
761 3OC 0.8724
762 SYR 0.8723
763 KBB 0.8722
764 FA3 0.8722
765 FBW 0.8721
766 DFU 0.8721
767 TCZ 0.8721
768 CN0 0.8720
769 0GZ 0.8714
770 5GU 0.8714
771 DGJ 0.8713
772 4TU 0.8712
773 SS1 0.8709
774 YTB 0.8708
775 JZ2 0.8707
776 9AP 0.8706
777 MWJ 0.8705
778 4KL 0.8704
779 4JO 0.8704
780 FDK 0.8704
781 24B 0.8703
782 JR2 0.8702
783 IFP 0.8702
784 FPK 0.8700
785 BR9 0.8700
786 9FL 0.8698
787 PBC 0.8698
788 QSC 0.8698
789 TLD 0.8697
790 PAB 0.8694
791 PH2 0.8693
792 AUD 0.8693
793 8WO 0.8691
794 3MH 0.8690
795 F4Z 0.8689
796 SF9 0.8687
797 B5D 0.8687
798 ZZT 0.8686
799 NTN 0.8685
800 IPB 0.8680
801 VXX 0.8678
802 51R 0.8678
803 3DO 0.8678
804 NLA 0.8677
805 6KX 0.8673
806 ZYR 0.8673
807 GLY PRO 0.8671
808 7M6 0.8669
809 FBU 0.8666
810 Y8I 0.8665
811 FA6 0.8660
812 HA7 0.8660
813 FH2 0.8658
814 260 0.8658
815 K37 0.8657
816 II6 0.8656
817 ONR 0.8654
818 GCV 0.8651
819 27Y 0.8650
820 TC7 0.8650
821 IP0 0.8647
822 HHR 0.8647
823 TWO 0.8646
824 6RQ 0.8644
825 SVD 0.8643
826 0R0 0.8642
827 HBD 0.8642
828 64C 0.8641
829 G12 0.8639
830 VOH 0.8638
831 826 0.8638
832 5NS 0.8636
833 PBZ 0.8635
834 FDR 0.8633
835 ISZ 0.8629
836 1Y6 0.8628
837 FAN 0.8627
838 GYP 0.8624
839 MNM 0.8624
840 TIU 0.8624
841 4MA 0.8621
842 BPU 0.8620
843 XYL 0.8620
844 JA8 0.8619
845 MXX 0.8619
846 174 0.8612
847 XCZ 0.8601
848 7D2 0.8601
849 SFU 0.8600
850 8OZ 0.8594
851 FRU 0.8593
852 KIF 0.8593
853 2J9 0.8591
854 LRH 0.8590
855 PBA 0.8589
856 0LH 0.8587
857 0HO 0.8587
858 GXY 0.8587
859 LZ2 0.8581
860 LYL 0.8580
861 IUR 0.8575
862 P72 0.8573
863 47J 0.8572
864 9CA 0.8569
865 EV0 0.8564
866 9PY 0.8560
867 5PX 0.8550
868 5WU 0.8547
869 H5B 0.8544
870 EOL 0.8540
871 6LW 0.8537
872 P3K 0.8530
873 IBM 0.8530
874 BDF 0.8527
875 1IT 0.8519
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 7A16; Ligand: HZE; Similar sites found with APoc: 2
This union binding pocket(no: 1) in the query (biounit: 7a16.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 3L24 GOA 2.42588
2 3L24 GOA 2.42588
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