-->
Receptor
PDB id Resolution Class Description Source Keywords
4ARE 2.19 Å EC: 3.4.24.3 CRYSTAL STRUCTURE OF THE COLLAGENASE UNIT OF COLLAGENASE G FROM CLOSTRIDIUM HISTOLYTICUM AT 2.19 ANGSTROM RESOLUTION. CLOSTRIDIUM HISTOLYTICUM HYDROLASE COLLAGEN PEPTIDASE COLLAGENOLYSIS METALLOPROTE
Ref.: STRUCTURAL BASIS FOR ACTIVITY REGULATION AND SUBSTR PREFERENCE OF CLOSTRIDIAL COLLAGENASES G, H, AND T. J.BIOL.CHEM. V. 288 20184 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
TRS A:1793;
Invalid;
none;
submit data
122.143 C4 H12 N O3 C(C(C...
P6G A:1791;
Invalid;
none;
submit data
282.331 C12 H26 O7 C(COC...
ZN A:1790;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
FLC A:1792;
Valid;
none;
submit data
189.1 C6 H5 O7 C(C(=...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4ARE 2.19 Å EC: 3.4.24.3 CRYSTAL STRUCTURE OF THE COLLAGENASE UNIT OF COLLAGENASE G FROM CLOSTRIDIUM HISTOLYTICUM AT 2.19 ANGSTROM RESOLUTION. CLOSTRIDIUM HISTOLYTICUM HYDROLASE COLLAGEN PEPTIDASE COLLAGENOLYSIS METALLOPROTE
Ref.: STRUCTURAL BASIS FOR ACTIVITY REGULATION AND SUBSTR PREFERENCE OF CLOSTRIDIAL COLLAGENASES G, H, AND T. J.BIOL.CHEM. V. 288 20184 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 4ARE - FLC C6 H5 O7 C(C(=O)[O-....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4ARE - FLC C6 H5 O7 C(C(=O)[O-....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4ARE - FLC C6 H5 O7 C(C(=O)[O-....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FLC; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 FLC 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4ARE; Ligand: FLC; Similar sites found with APoc: 245
This union binding pocket(no: 1) in the query (biounit: 4are.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 4O1P ANP 0.863309
2 3NT6 FAD 1.21951
3 2PX6 DH9 1.26582
4 3CGB FAD 1.45833
5 3CGD FAD 1.45833
6 3CGD COA 1.45833
7 3CGD NAD 1.45833
8 2D09 FLV 1.4742
9 4OYA 1VE 1.48936
10 5EHR 5OD 1.52091
11 4GYW UDP 1.58273
12 5OLZ T4E 1.6129
13 5WIU AQD 1.65877
14 1DJN ADP 1.72662
15 1PS9 FAD 1.78838
16 3ZCN ATP 1.85185
17 4D7E FAD 1.8648
18 5OHJ 9VE 1.90024
19 5A8E XTK 1.90476
20 6GEW SAH 1.95122
21 6GEW SFG 1.95122
22 2AX9 BHM 1.95312
23 4KCF AKM 1.98238
24 1U5R ATP 2.01149
25 2YBQ SAH 2.05479
26 3ZM6 2GN 2.15054
27 1ZGA HMK 2.2409
28 1KAE NAD 2.30415
29 5W7R 9Z7 2.331
30 5HCV 60R 2.33463
31 2A3I C0R 2.37154
32 3ICT FAD 2.38095
33 4V24 GYR 2.42588
34 2XFH CL6 2.43309
35 4EMI FAD 2.43902
36 5M8T 0TR 2.46637
37 3RG9 NDP 2.5
38 4IJP 1EH 2.51397
39 2W90 6PG 2.54777
40 5N5U 7N8 2.54777
41 6EOP F15 2.58993
42 1ZPD CIT 2.64085
43 3LPF Z77 2.64463
44 6C8T EQJ 2.65957
45 1Q8Y ADP 2.68097
46 3K87 FAD 2.7027
47 1V59 FAD 2.71967
48 5HTX ADP 2.73349
49 5J6A P46 2.75
50 1U59 STU 2.78746
51 4NKW PLO 2.83401
52 2UXI G50 2.85714
53 1ORR NAD 2.88184
54 4GA6 AMP 2.92398
55 3WQM B29 2.99003
56 4POJ 2VP 3.0303
57 2ZB4 5OP 3.08123
58 2ZB4 NAP 3.08123
59 3ZLR X0B 3.16456
60 4LSJ LSJ 3.16547
61 2W1A TSA 3.17797
62 2RH1 CAU 3.2
63 5B4B LP5 3.22581
64 2YPO PHE 3.24675
65 1SFF IK2 3.28639
66 3WCA FPS 3.28767
67 1NJF AGS 3.30935
68 1TIQ COA 3.33333
69 5U3B 7TD 3.34448
70 5DLY 5D7 3.38346
71 3TTI KBI 3.44828
72 2YB9 HA0 3.45324
73 1SG4 CO8 3.46154
74 4XRQ 1B0 3.4632
75 5V13 JH3 3.47222
76 4AFH L0B 3.47826
77 5WKC FAD 3.54505
78 6EMU SAM 3.5533
79 1GQY ACP 3.57895
80 5LX9 OLB 3.58306
81 3QWB NDP 3.59281
82 1KEV NDP 3.7037
83 2CNT COA 3.75
84 3V49 PK0 3.7594
85 1CS4 101 3.77358
86 1CS4 FOK 3.77358
87 4C9G CXT 3.77358
88 2A14 SAH 3.80228
89 4KVX ACO 3.84615
90 4OIC A8S 3.86473
91 3FHR P4O 3.86905
92 4ONA UW1 3.92562
93 1GHE ACO 3.9548
94 4R57 ACO 3.97727
95 2OBD PCW 3.9916
96 4W97 UCA 4
97 1PMO PLR 4.02878
98 4Q9M 2ZW 4.06504
99 5DM1 5D7 4.11985
100 5DM1 SAH 4.11985
101 4UA3 COA 4.12371
102 3SVL FMN 4.14508
103 5IFS ADP 4.158
104 4WRI OKA 4.16667
105 5ORG 6DB 4.18251
106 2GQS ADP 4.21941
107 5FM0 WAQ 4.23077
108 3ZQE DXC 4.2623
109 1TT8 PHB 4.26829
110 1YUC EPH 4.31373
111 2GJ5 VD3 4.32099
112 5DP2 NAP 4.38596
113 3SQP 3J8 4.39331
114 4OB6 S2T 4.39883
115 4K49 HFQ 4.41176
116 5UR6 8KM 4.41989
117 5G57 6M5 4.44444
118 6BR9 PGV 4.45682
119 6AYH C3G 4.47761
120 2GBB CIT 4.48718
121 6BXI ANP 4.5045
122 3S2Y FMN 4.52261
123 2ZB3 NDP 4.53258
124 2OQ2 A3P 4.5977
125 4FE2 ADP 4.70588
126 1YKD CMP 4.77387
127 3ZLM ANP 4.78723
128 2IBN I1N 4.8
129 5GSN NAP 4.85651
130 1XMU ROF 4.89209
131 6EXS C3H 4.92813
132 1E5F PLP 4.9505
133 6C7D EOJ 4.97076
134 2CE7 ADP 5.04202
135 2RIO ADP 5.06912
136 2B4Q NAP 5.07246
137 5X2Z 3LM 5.27638
138 5X30 7XF 5.27638
139 1MI3 NAD 5.2795
140 4RI1 ACO 5.37634
141 4Y9J FAD 5.39629
142 2O3Z AI7 5.53506
143 1KPG 16A 5.57491
144 4B7X NAP 5.65476
145 1W2Y DUN 5.67686
146 6MJF SAH 5.69948
147 5GUE GGS 5.74018
148 4USI ATP 5.84416
149 5N7O 69Y 5.88235
150 4J56 FAD 6.14035
151 1AFS NAP 6.19195
152 2PVN P63 6.25
153 4CJX 9L9 6.26959
154 1OJ4 ANP 6.36042
155 5GM1 SAH 6.39731
156 4EKQ NPO 6.41711
157 3WR7 COA 6.47059
158 1SBR VIB 6.5
159 4EMJ FAD 6.54206
160 3ZCB ATP 6.56566
161 2VBU CDP 6.61765
162 4XPL ACO 6.74847
163 2Z9I GLY ALA THR VAL 6.79012
164 1T57 FMN 6.79612
165 3P9T TCL 6.84932
166 6CR2 LFV 6.91824
167 2NPX FAD 7.15884
168 6ECT SAM 7.16511
169 3V78 ET 7.21154
170 3ZJ0 ACO 7.28155
171 4D9C PMP 7.30994
172 2R3A SAM 7.33333
173 4RVU NDP 7.53012
174 6BR8 PGV 7.53968
175 6BR8 6OU 7.53968
176 5JCM ISD 7.76053
177 5JCM FAD 7.76053
178 5JCM NAD 7.76053
179 4QLX KTC 7.76256
180 2F5Z FAD 7.8125
181 5USZ SKE 7.95848
182 4GOX A3P 7.98722
183 2PI8 NAG NAG NAG NAG NAG NAG 8.11594
184 5I3B HQE 8.36237
185 5BYK A3P 8.49421
186 5BYK OAQ 8.49421
187 5EFQ ADP 8.58209
188 4NST ADP 8.58209
189 1DKF OLA 8.58369
190 1DKF BMS 8.58369
191 4I6G FAD 8.59375
192 5K7H IVC 9.09091
193 3D78 NBB 9.2437
194 5Y6Q FAD 9.25926
195 1OKC CXT 9.42761
196 4IA6 EIC 9.47547
197 1GZ6 NAI 9.71787
198 3SFI 3SF 9.74576
199 2G37 FAD 9.78593
200 3H8V ATP 9.93151
201 4O6M C5P 9.94624
202 5UR1 YY9 9.96785
203 1SR7 MOF 10.0386
204 3K9U ACO 10.0629
205 3BEJ MUF 10.084
206 5OYH T99 10.3627
207 2BNE U5P 10.3734
208 3QLM PLM 10.4839
209 1O94 ADP 10.625
210 5ECP JAA 10.7623
211 2EV1 OLA 10.8108
212 4OIV XX9 11.0619
213 2J8C U10 11.1538
214 3FAL LO2 11.157
215 3FAL REA 11.157
216 1GUX ASP LEU TYR CYS TYR GLU GLN LEU ASN 11.1842
217 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 11.5646
218 2R5T ANP 12.0643
219 5TIV A3P 12.253
220 2QJY SMA 12.2677
221 2WAT COA 12.2951
222 1WWZ ACO 12.5786
223 1T8U UAP SGN IDS SGN 13.2353
224 2Y69 CHD 13.75
225 2IBZ SMA 14.1732
226 4DRI RAP 14.2857
227 4DRJ RAP 14.2857
228 1EZV SMA 14.4
229 2A06 SMA 14.5455
230 3FAP ARD 14.8936
231 5GPG RAP 15.0538
232 5F1R 42O 16.0338
233 1N8V BDD 16.0714
234 6AYI C3G 17.0854
235 3CX5 SMA 17.5926
236 3CXH SMA 18.75
237 4N3A UDP 19.2308
238 2F99 AKV 19.6078
239 5LXM ADP 21.0526
240 3RNM FAD 22.4138
241 5A89 ADP 25
242 5A89 FMN 25
243 3S0E EOL 25.2101
244 5M36 9SZ 26.3158
245 1M2Z DEX 33.3333
246 1YOK P6L 50
247 4P6X HCY 50
APoc FAQ
Feedback