Receptor
PDB id Resolution Class Description Source Keywords
3gc4 1.8 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH INHIBITOR ZYMOMONAS MOBILIS DRUG DESIGN TIM BARREL TRNA MODIFICATION GLYCOSYLTRANSFERMETAL-BINDING QUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PR
Ref.: HOW TO REPLACE THE RESIDUAL SOLVATION SHELL OF POLA SITE RESIDUES TO ACHIEVE NANOMOLAR INHIBITION OF TRNA-GUANINE TRANSGLYCOSYLASE CHEMMEDCHEM V. 4 2012 2009
Ligand Information
Ligand Validity Binding Data Ligand Warnings Chemaxon Viewer Molecular Weight (Da) Formula SMILES
AAQ Valid Ki = 25 nM none 363.416
C19 H21 N7 O
CNc1[nH]c2cc3c(c(c2n1)CCNCc4ccccc4)N=C(NC3=O)N
GOL Invalid - none 92.094
C3 H8 O3
C(C(CO)O)O
ZN Part of Protein - none 65.409
Zn
[Zn+2]
90% Homology Family

The Class containing this family consists of a total of 2 families.

Leader:    3GE7     TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH 6-AMINO-4-{2- [(CYCLOPENTYLMETHYL)AMINO]ETHYL}-2-(METHYLAMINO)-1,7-DIHYDRI MIDAZO[4,5-G]QUINAZOLIN-8-ONE
No: PDB id Binding Data Representative ligand
1 1ENU Ki = 8.3 uM APZ
2 1Q63 Ki = 1.4 uM AIQ
3 3GC4 Ki = 25 nM AAQ
4 2PWU - GUN
5 2Z1W - BDI
6 1K4G Ki = 1.4 uM AIQ
7 1P0E - PRF
8 2QII - PQ0
9 1PXG - PRF
10 1P0B - PQ0
11 2Z7K Ki = 77 nM BGU
12 2POT - GUN
13 3SM0 Ki = 740 nM AEK
14 2QZR Ki = 55 nM S79
15 3S1G Ki = 6500 nM ITE
16 3C2N Ki = 6 nM CKR
17 1K4H Ki = 7.7 uM APQ
18 1EFZ - PRF
19 1S38 Ki = 7 uM MAQ
20 1Q65 Ki = 3.5 uM BHB
21 3EOS Ki = 4 nM PK2
22 3V0Y Ki = 4100 nM SQO
23 1F3E Ki = 0.2 uM DPZ
24 1Y5V Ki = 1 uM NE8
25 3C2Y Ki = 1.5 uM S60
26 1OZQ - PRF
27 1Y5X Ki = 3.7 uM E89
28 3GEV Ki = 2900 nM SAQ
29 2BBF Ki = 7.9 uM 344
30 1R5Y Ki = 0.35 uM DQU
31 3C2Z Ki = 35 nM S98
32 3RR4 Ki = 28050 nM HRD
33 3EOU Ki = 97 nM PK3
34 1S39 Ki = 20 nM AQO
35 3TLL Ki = 40830 nM 62D
36 2Z1X - PRF
37 1Q66 Ki = 1.7 uM KMB
38 2PWV - PQ0
39 3GC5 Ki = 55 nM 2MQ
40 1N2V Ki = 83 uM BDI
41 3GE7 Ki = 2 nM AFQ
42 1Y5W Ki = 6.9 uM NEZ
43 1Q4W Ki = 0.35 uM DQU
More Information
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