Receptor
PDB id Resolution Class Description Source Keywords
3gc4 1.8 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH INHIBITOR ZYMOMONAS MOBILIS DRUG DESIGN TIM BARREL TRNA MODIFICATION GLYCOSYLTRANSFERMETAL-BINDING QUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PR
Ref.: HOW TO REPLACE THE RESIDUAL SOLVATION SHELL OF POLA SITE RESIDUES TO ACHIEVE NANOMOLAR INHIBITION OF TRNA-GUANINE TRANSGLYCOSYLASE CHEMMEDCHEM V. 4 2012 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data Chemaxon Viewer Molecular Weight (Da) Formula SMILES
AAQ A:395;
Valid;
none;
Ki = 25 nM 363.416 C19 H21 N7 O CNc1[...
GOL A:400;
A:401;
A:402;
A:403;
A:404;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data 92.094 C3 H8 O3 C(C(C...
ZN A:399;
Part of Protein;
none;
submit data 65.409 Zn [Zn+2...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GE7 1.5 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH 6-AMINO-4-{2- [(CYCLOPENTYLMETHYL)AMINO]ETHYL}-2-(METHYLAMINO)-1,7-DIHYDRI MIDAZO[4,5-G]QUINAZOLIN-8-ONE ZYMOMONAS MOBILIS DRUG DESIGN TGT TIM BARREL GLYCOSYLTRANSFERASE METAL-BINDQUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PROCESSING
Ref.: HOW TO REPLACE THE RESIDUAL SOLVATION SHELL OF POLA SITE RESIDUES TO ACHIEVE NANOMOLAR INHIBITION OF TRNA-GUANINE TRANSGLYCOSYLASE CHEMMEDCHEM V. 4 2012 2009
Members (44)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
3 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
4 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
5 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
6 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
7 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
8 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
9 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
10 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
11 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
12 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
13 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
14 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
15 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
16 3C2N Ki = 6 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
17 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
18 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
19 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
20 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
21 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
22 3V0Y Ki = 4100 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
23 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
24 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
25 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
26 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
27 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
28 3GEV Ki = 2900 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
29 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
30 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
31 3C2Z Ki = 35 nM S98 C14 H12 N6 O S c1cc(sc1)C....
32 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
33 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
34 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
35 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
36 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
37 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
38 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
39 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
40 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
41 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
42 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
43 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
44 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....