Receptor
PDB id Resolution Class Description Source Keywords
3RR4 1.68 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH N-METHYL-LIN- BENZOGUANINE INHIBITOR ZYMOMONAS MOBILIS TIM BARREL GLYCOSYLTRANSFERASE METAL-BINDING QUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PROCESSING TRNA TRANSFERATRANSFERASE INHIBITOR COMPLEX
Ref.: FROM LIN-BENZOGUANINES TO LIN-BENZOHYPOXANTHINES AS FOR ZYMOMONAS MOBILIS TRNA-GUANINE TRANSGLYCOSYLASE REPLACEMENT OF PROTEIN-LIGAND HYDROGEN BONDING BY I WATER CLUSTERS. CHEMISTRY V. 18 9246 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:601;
A:701;
 Invalid;
Invalid;
 none;
none;
 submit data
92.094 C3 H8 O3 C(C(C...
HRD A:501;
 Valid;
 none;
 Ki = 28050 nM
244.253 C11 H12 N6 O CNc1[...
ZN A:401;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GE7 1.5 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH 6-AMINO-4-{2- [(CYCLOPENTYLMETHYL)AMINO]ETHYL}-2-(METHYLAMINO)-1,7-DIHYDRI MIDAZO[4,5-G]QUINAZOLIN-8-ONE ZYMOMONAS MOBILIS DRUG DESIGN TGT TIM BARREL GLYCOSYLTRANSFERASE METAL-BINDQUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PROCESSING
Ref.: HOW TO REPLACE THE RESIDUAL SOLVATION SHELL OF POLA SITE RESIDUES TO ACHIEVE NANOMOLAR INHIBITION OF TRNA-GUANINE TRANSGLYCOSYLASE CHEMMEDCHEM V. 4 2012 2009
Members (57)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
70% Homology Family (57)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
50% Homology Family (59)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
58 6H42 - GGL C5 H9 N O4 C(CC(=O)O)....
59 6H45 - QEI C12 H15 N5 O3 c1c(c2c([n....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: HRD; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 HRD 1 1
2 62D 0.545455 0.882353
3 ITE 0.53125 0.955556
4 2WU 0.492308 0.956522
5 BGU 0.41791 0.913043
Similar Ligands (3D)
Ligand no: 1; Ligand: HRD; Similar ligands found: 393
No: Ligand Similarity coefficient
1 S98 0.9761
2 S60 0.9599
3 RGK 0.9491
4 H4B 0.9479
5 NKI 0.9470
6 K7H 0.9443
7 08C 0.9420
8 A63 0.9397
9 A73 0.9368
10 1V1 0.9364
11 20D 0.9363
12 AGI 0.9355
13 PRL 0.9355
14 DFL 0.9354
15 1DR 0.9352
16 ZSP 0.9349
17 LUM 0.9341
18 GEN 0.9333
19 WLH 0.9322
20 NRA 0.9288
21 HRM 0.9282
22 27F 0.9281
23 25F 0.9274
24 5WT 0.9260
25 Q0K 0.9245
26 1UZ 0.9222
27 F40 0.9215
28 SZ5 0.9209
29 BMZ 0.9205
30 CX6 0.9203
31 1V3 0.9202
32 IDZ 0.9200
33 MBT 0.9193
34 AO 0.9191
35 3F4 0.9182
36 NIF 0.9168
37 AJG 0.9163
38 LFN 0.9157
39 7L4 0.9142
40 97K 0.9141
41 344 0.9139
42 NAR 0.9139
43 A9B 0.9138
44 1V0 0.9137
45 4UM 0.9137
46 9CE 0.9129
47 A8D 0.9127
48 A05 0.9126
49 F36 0.9122
50 2PK 0.9110
51 JRO 0.9110
52 KLV 0.9108
53 1FE 0.9095
54 0NJ 0.9090
55 JCZ 0.9087
56 91F 0.9084
57 2PV 0.9082
58 1UR 0.9080
59 O9T 0.9077
60 O9Z 0.9075
61 28A 0.9073
62 27M 0.9072
63 6FB 0.9070
64 YE7 0.9064
65 802 0.9060
66 HH6 0.9060
67 QIV 0.9060
68 OLU 0.9057
69 3Q0 0.9057
70 1UT 0.9055
71 CUE 0.9052
72 5VU 0.9052
73 BBP 0.9050
74 M83 0.9048
75 BIO 0.9046
76 47V 0.9045
77 W8L 0.9044
78 4CN 0.9042
79 7G2 0.9041
80 0UL 0.9039
81 YZ9 0.9038
82 L03 0.9038
83 5OR 0.9036
84 1V8 0.9034
85 CLI 0.9034
86 4ZF 0.9033
87 CDJ 0.9029
88 H2W 0.9029
89 H2B 0.9028
90 397 0.9024
91 6TJ 0.9023
92 DX7 0.9023
93 CR4 0.9020
94 5WW 0.9016
95 1V4 0.9013
96 J1K 0.9012
97 272 0.9009
98 Y3L 0.9004
99 P7V 0.9004
100 EQU 0.9003
101 1FL 0.9000
102 P4L 0.8996
103 4AU 0.8990
104 UN9 0.8990
105 II4 0.8986
106 MR6 0.8984
107 M3W 0.8983
108 EMO 0.8982
109 57D 0.8980
110 18E 0.8980
111 801 0.8978
112 ZEA 0.8974
113 2J1 0.8973
114 MR4 0.8972
115 A64 0.8971
116 120 0.8970
117 39Z 0.8970
118 P83 0.8962
119 S0D 0.8961
120 EST 0.8961
121 E9L 0.8960
122 0SY 0.8957
123 LU2 0.8954
124 7FU 0.8951
125 IQ5 0.8948
126 JF8 0.8934
127 TCR 0.8933
128 124 0.8931
129 N0Z 0.8930
130 AH6 0.8930
131 LZ7 0.8929
132 NDD 0.8927
133 9JT 0.8927
134 BHS 0.8925
135 ZRK 0.8920
136 EES 0.8917
137 HBI 0.8917
138 KMP 0.8916
139 YE6 0.8914
140 3D8 0.8912
141 8M5 0.8910
142 MR5 0.8910
143 ZHA 0.8909
144 2GQ 0.8909
145 4AB 0.8908
146 UAY 0.8907
147 6DQ 0.8906
148 WS7 0.8902
149 M3F 0.8902
150 3WL 0.8901
151 123 0.8900
152 DDC 0.8899
153 01I 0.8897
154 EAE 0.8896
155 N91 0.8896
156 BBY 0.8892
157 907 0.8891
158 29F 0.8886
159 SDN 0.8885
160 2D2 0.8885
161 FQX 0.8885
162 O53 0.8883
163 122 0.8883
164 MUK 0.8881
165 4FF 0.8881
166 2K8 0.8880
167 697 0.8880
168 338 0.8877
169 LI7 0.8877
170 6JM 0.8877
171 PIQ 0.8876
172 VT3 0.8876
173 PK3 0.8876
174 GNV 0.8875
175 P4T 0.8875
176 JTA 0.8872
177 ZAR 0.8871
178 BRY 0.8869
179 HNT 0.8868
180 NEU 0.8868
181 DXK 0.8867
182 GVI 0.8866
183 ZRL 0.8864
184 6QF 0.8864
185 5SJ 0.8863
186 334 0.8862
187 F18 0.8859
188 U13 0.8857
189 2MQ 0.8857
190 FSE 0.8855
191 QUE 0.8855
192 LC1 0.8853
193 CNI 0.8849
194 7EL 0.8849
195 6BK 0.8848
196 RSV 0.8847
197 A6W 0.8846
198 1XS 0.8846
199 7LU 0.8846
200 121 0.8843
201 AJ1 0.8843
202 JP2 0.8843
203 G2V 0.8843
204 3QV 0.8838
205 DFV 0.8837
206 A5Q 0.8836
207 FF2 0.8835
208 57U 0.8834
209 XAV 0.8832
210 3R4 0.8830
211 CG 0.8829
212 ANC 0.8829
213 GOE 0.8828
214 5E5 0.8827
215 5XL 0.8825
216 MRI 0.8822
217 DX8 0.8821
218 3JC 0.8820
219 BX4 0.8819
220 U4J 0.8817
221 6ZE 0.8817
222 RHN 0.8816
223 X2M 0.8815
224 9TF 0.8813
225 72G 0.8811
226 0FR 0.8810
227 8G6 0.8810
228 3VX 0.8809
229 X0U 0.8804
230 AQN 0.8802
231 DX2 0.8802
232 NU3 0.8800
233 0K7 0.8797
234 EY2 0.8796
235 HBO 0.8796
236 AXX 0.8795
237 DNQ 0.8794
238 78Y 0.8792
239 FNT 0.8784
240 NAG 0.8784
241 06R 0.8782
242 IQZ 0.8780
243 DRG 0.8778
244 HHS 0.8776
245 O9Q 0.8773
246 4HB 0.8772
247 9OF 0.8772
248 K75 0.8772
249 AZN 0.8771
250 FHV 0.8770
251 B21 0.8770
252 K8W 0.8770
253 CWE 0.8768
254 BVS 0.8767
255 VUP 0.8766
256 FBC 0.8764
257 31F 0.8764
258 4I8 0.8763
259 EZL 0.8762
260 5NN 0.8762
261 GNY 0.8761
262 E1K 0.8752
263 IK1 0.8751
264 6ZW 0.8748
265 92O 0.8745
266 ADL 0.8742
267 041 0.8739
268 0DF 0.8739
269 3Y7 0.8738
270 KU1 0.8737
271 LR2 0.8735
272 IXM 0.8732
273 DT7 0.8730
274 549 0.8729
275 26C 0.8729
276 NPS 0.8726
277 FYR 0.8722
278 EE8 0.8722
279 1ZC 0.8720
280 6P3 0.8720
281 WG8 0.8720
282 LIG 0.8719
283 8SK 0.8714
284 363 0.8714
285 NPX 0.8713
286 XCG 0.8713
287 J38 0.8711
288 BPU 0.8708
289 1EL 0.8706
290 1EB 0.8706
291 3GX 0.8705
292 8HH 0.8705
293 TID 0.8703
294 6B5 0.8701
295 AVX 0.8700
296 C4E 0.8700
297 F2W 0.8699
298 5TY 0.8699
299 PH2 0.8699
300 F08 0.8698
301 20N 0.8695
302 TMG 0.8693
303 5H6 0.8690
304 2PW 0.8690
305 4HG 0.8687
306 RKV 0.8687
307 4GU 0.8684
308 6T5 0.8683
309 0LA 0.8680
310 4NR 0.8680
311 49P 0.8680
312 8NB 0.8680
313 NOM 0.8680
314 108 0.8678
315 2P3 0.8678
316 WS6 0.8677
317 JL7 0.8677
318 7EH 0.8676
319 5TZ 0.8674
320 T21 0.8673
321 1HP 0.8673
322 XM5 0.8672
323 W2E 0.8671
324 GN5 0.8670
325 2JK 0.8670
326 3J8 0.8663
327 38E 0.8662
328 833 0.8658
329 AN3 0.8656
330 6VW 0.8655
331 WV7 0.8653
332 HFT 0.8652
333 LR8 0.8645
334 609 0.8645
335 5AD 0.8644
336 2UV 0.8639
337 28B 0.8637
338 BPY 0.8636
339 8V8 0.8636
340 AH9 0.8635
341 GNJ 0.8635
342 4QX 0.8632
343 ZYQ 0.8630
344 NEO 0.8629
345 4BL 0.8628
346 WUB 0.8626
347 0LO 0.8626
348 SU9 0.8623
349 3DE 0.8622
350 4BY 0.8622
351 7FZ 0.8620
352 U14 0.8619
353 79X 0.8618
354 BZJ 0.8618
355 3ZB 0.8617
356 8NX 0.8615
357 X48 0.8612
358 TXQ 0.8609
359 68A 0.8607
360 SAK 0.8602
361 6FX 0.8599
362 5E1 0.8598
363 15Q 0.8597
364 GNM 0.8595
365 SGW 0.8594
366 Q9T 0.8594
367 Z21 0.8592
368 DPT 0.8590
369 UNJ 0.8585
370 V1T 0.8582
371 QUG 0.8580
372 1R5 0.8580
373 CK2 0.8580
374 M78 0.8580
375 LWA 0.8580
376 P9I 0.8579
377 K4T 0.8578
378 7KE 0.8576
379 DT9 0.8574
380 5GT 0.8572
381 517 0.8571
382 8CC 0.8571
383 3VQ 0.8571
384 IQW 0.8567
385 1AJ 0.8560
386 JWS 0.8560
387 5TU 0.8555
388 3VS 0.8548
389 ZIP 0.8540
390 Z3R 0.8538
391 537 0.8538
392 ANF 0.8525
393 1YL 0.8512
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3GE7; Ligand: AFQ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3ge7.bio1) has 34 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3GE7; Ligand: AFQ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3ge7.bio1) has 34 residues
No: Leader PDB Ligand Sequence Similarity
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