Receptor
PDB id Resolution Class Description Source Keywords
1F3E 1.85 Å EC: 2.4.2.29 A NEW TARGET FOR SHIGELLOSIS: RATIONAL DESIGN AND CRYSTALLOG STUDIES OF INHIBITORS OF TRNA-GUANINE TRANSGLYCOSYLASE ZYMOMONAS MOBILIS TRNA-MODIFYING ENZYME GLYCOSYLTRANSFERASE TRANSFERASE
Ref.: A NEW TARGET FOR SHIGELLOSIS: RATIONAL DESIGN AND CRYSTALLOGRAPHIC STUDIES OF INHIBITORS OF TRNA-GUAN TRANSGLYCOSYLASE. J.MOL.BIOL. V. 306 455 2001
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DPZ A:400;
 Valid;
 none;
 Ki = 0.2 uM
192.175 C8 H8 N4 O2 c1c(c...
ZN A:500;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3GE7 1.5 Å EC: 2.4.2.29 TRNA-GUANINE TRANSGLYCOSYLASE IN COMPLEX WITH 6-AMINO-4-{2- [(CYCLOPENTYLMETHYL)AMINO]ETHYL}-2-(METHYLAMINO)-1,7-DIHYDRI MIDAZO[4,5-G]QUINAZOLIN-8-ONE ZYMOMONAS MOBILIS DRUG DESIGN TGT TIM BARREL GLYCOSYLTRANSFERASE METAL-BINDQUEUOSINE BIOSYNTHESIS TRANSFERASE TRNA PROCESSING
Ref.: HOW TO REPLACE THE RESIDUAL SOLVATION SHELL OF POLA SITE RESIDUES TO ACHIEVE NANOMOLAR INHIBITION OF TRNA-GUANINE TRANSGLYCOSYLASE CHEMMEDCHEM V. 4 2012 2009
Members (57)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
70% Homology Family (57)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
50% Homology Family (59)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1ENU Ki = 8.3 uM APZ C8 H7 N3 O2 c1cc2c(cc1....
2 2PWU - GUN C5 H5 N5 O c1[nH]c2c(....
3 4Q4S Kd = 111.6 nM S98 C14 H12 N6 O S c1cc(sc1)C....
4 2QII - PQ0 C7 H5 N5 O c1c(c2c([n....
5 1PXG - PRF C7 H9 N5 O c1c(c2c([n....
6 4KWO Ki = 353 nM 1UD C18 H24 N6 O5 CNc1[nH]c2....
7 2Z7K Ki = 77 nM BGU C9 H8 N6 O c1c2c(cc3c....
8 3SM0 Ki = 740 nM AEK C18 H24 N6 O CNc1[nH]c2....
9 6RKQ Ki = 48 uM K75 C13 H14 N6 CC#C[C@@H]....
10 4Q4P Kd = 407.4 nM 2YO C16 H20 N6 O c1c2c(cc3c....
11 1K4H Ki = 7.7 uM APQ C12 H16 N4 O S CCCSCc1cc(....
12 1EFZ - PRF C7 H9 N5 O c1c(c2c([n....
13 3C2Y Ki = 1.5 uM S60 C10 H9 N5 O Cc1[nH]c2c....
14 1Y5X Ki = 3.7 uM E89 C18 H17 N5 O2 COc1ccc(cc....
15 1R5Y Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
16 3RR4 Ki = 28050 nM HRD C11 H12 N6 O CNc1[nH]c2....
17 3EOU Ki = 97 nM PK3 C12 H14 N6 O2 CNc1[nH]c2....
18 6FMN Kd = 1120 nM E4E C15 H18 N6 O5 CO[C@H]1[C....
19 4Q4Q Kd = 1638.9 nM SAQ C14 H11 N5 O S c1cc(sc1)C....
20 4E2V - PRF C7 H9 N5 O c1c(c2c([n....
21 2Z1X - PRF C7 H9 N5 O c1c(c2c([n....
22 5JXQ Ki = 7 nM 6OK C19 H20 N6 O2 c1cc(ccc1C....
23 1Q66 Ki = 1.7 uM KMB C16 H16 N4 O S c1ccc(cc1)....
24 1N2V Ki = 83 uM BDI C9 H12 N4 O2 CCCCc1[nH]....
25 1Y5W Ki = 6.9 uM NEZ C18 H17 N5 O Cc1ccc(cc1....
26 1Q63 Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
27 4PUL Kd = 146.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
28 3GC4 Ki = 25 nM AAQ C19 H21 N7 O CNc1[nH]c2....
29 4LBU Kd = 276 nM 1WJ C18 H24 N6 O5 CNc1[nH]c2....
30 6RKT Ki = 17 uM K7H C10 H12 N6 CNc1[nH]c2....
31 2Z1W - BDI C9 H12 N4 O2 CCCCc1[nH]....
32 1K4G Ki = 1.4 uM AIQ C12 H12 N6 O S c1cnc([nH]....
33 1P0E - PRF C7 H9 N5 O c1c(c2c([n....
34 4LEQ Kd = 288 nM 1WK C17 H22 N6 O5 CNc1[nH]c2....
35 1P0B - PQ0 C7 H5 N5 O c1c(c2c([n....
36 2POT - GUN C5 H5 N5 O c1[nH]c2c(....
37 2QZR Ki = 55 nM S79 C20 H16 N6 O c1ccc2c(c1....
38 4Q4O Kd = 34.3 nM 2YM C16 H21 N7 O c1c2c(cc3c....
39 3S1G Ki = 6500 nM ITE C10 H9 N5 O CNc1[nH]c2....
40 4PUM Kd = 188.1 nM 2WU C10 H10 N6 O CNc1[nH]c2....
41 1S38 Ki = 7 uM MAQ C9 H9 N3 O Cc1cccc2c1....
42 1Q65 Ki = 3.5 uM BHB C13 H19 N5 O S CN(C)CCSCc....
43 3EOS Ki = 4 nM PK2 C19 H27 N7 O CNc1[nH]c2....
44 1F3E Ki = 0.2 uM DPZ C8 H8 N4 O2 c1c(cc(c2c....
45 1Y5V Ki = 1 uM NE8 C17 H15 N5 O c1ccc(cc1)....
46 1OZQ - PRF C7 H9 N5 O c1c(c2c([n....
47 4PUJ Kd = 35 nM CKR C15 H19 N7 O2 c1c2c(cc3c....
48 2BBF Ki = 7.9 uM 344 C9 H7 N5 O c1c2c(cc3c....
49 6FPU Kd = 321 nM E48 C21 H26 N6 O6 CC1(O[C@@H....
50 1S39 Ki = 20 nM AQO C8 H7 N3 O c1ccc2c(c1....
51 3TLL Ki = 40830 nM 62D C12 H14 N6 O CCNC1=Nc2c....
52 4PUK Kd = 52.4 nM 2WU C10 H10 N6 O CNc1[nH]c2....
53 2PWV - PQ0 C7 H5 N5 O c1c(c2c([n....
54 3GC5 Ki = 55 nM 2MQ C12 H15 N7 O CNc1[nH]c2....
55 3GE7 Ki = 2 nM AFQ C18 H25 N7 O CNc1[nH]c2....
56 4Q4R Kd = 369.2 nM SQO C15 H18 N6 O2 c1c2c(cc3c....
57 1Q4W Ki = 0.35 uM DQU C8 H8 N4 O c1cc2c(cc1....
58 6H42 - GGL C5 H9 N O4 C(CC(=O)O)....
59 6H45 - QEI C12 H15 N5 O3 c1c(c2c([n....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: DPZ; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 DPZ 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: DPZ; Similar ligands found: 722
No: Ligand Similarity coefficient
1 BGC 0.9847
2 8S0 0.9824
3 G3F 0.9807
4 FLV 0.9801
5 GCS 0.9790
6 B60 0.9780
7 226 0.9757
8 APZ 0.9746
9 MAQ 0.9737
10 JUG 0.9713
11 NDM 0.9681
12 GLC 0.9668
13 G1O 0.9662
14 NTZ 0.9649
15 680 0.9647
16 ZVO 0.9632
17 0P6 0.9628
18 TEP 0.9604
19 BDP 0.9595
20 8CM 0.9581
21 CLZ 0.9579
22 CWS 0.9574
23 UFO 0.9568
24 3WA 0.9562
25 SHG 0.9559
26 KUF 0.9556
27 JBQ 0.9547
28 GAL 0.9542
29 LGC 0.9524
30 UNC 0.9518
31 9KT 0.9513
32 209 0.9507
33 3MG 0.9497
34 TOF 0.9485
35 EJZ 0.9476
36 8XQ 0.9471
37 LI6 0.9470
38 18N 0.9469
39 H33 0.9464
40 A7W 0.9464
41 PYQ 0.9462
42 HNQ 0.9455
43 32X 0.9455
44 PE0 0.9451
45 3Z8 0.9451
46 N8Y 0.9446
47 CFF 0.9441
48 15L 0.9440
49 12B 0.9433
50 B57 0.9433
51 9MG 0.9433
52 KT7 0.9429
53 BEA 0.9426
54 GCU 0.9423
55 MUA 0.9422
56 MEW 0.9419
57 DIN 0.9414
58 PFB 0.9412
59 AZ8 0.9407
60 X8D 0.9404
61 LKA 0.9399
62 FOT 0.9395
63 XHP 0.9395
64 3IT 0.9394
65 MRW 0.9394
66 5WY 0.9393
67 EVA 0.9393
68 AQO 0.9388
69 OA3 0.9385
70 M5K 0.9382
71 7VJ 0.9381
72 UAN 0.9381
73 C2U 0.9379
74 5WX 0.9377
75 0FO 0.9376
76 Q24 0.9373
77 IJZ 0.9370
78 AJ2 0.9369
79 Q7A 0.9369
80 2AK 0.9361
81 HJP 0.9352
82 6BL 0.9347
83 4HC 0.9341
84 0N7 0.9339
85 AZ9 0.9334
86 2FQ 0.9332
87 DQU 0.9332
88 7ZE 0.9329
89 MT0 0.9328
90 AJV 0.9327
91 ISE 0.9326
92 B62 0.9326
93 4KL 0.9325
94 OTW 0.9324
95 495 0.9324
96 RXA 0.9321
97 2ZQ 0.9321
98 7B3 0.9320
99 DHQ 0.9320
100 NQ 0.9310
101 Q77 0.9307
102 HLZ 0.9305
103 4MU 0.9304
104 39A 0.9300
105 44W 0.9298
106 7VS 0.9291
107 GCB 0.9291
108 M0W 0.9290
109 HZQ 0.9288
110 12Q 0.9285
111 DRL 0.9281
112 AEZ 0.9280
113 I6G 0.9279
114 5RG 0.9278
115 VK3 0.9276
116 YSO 0.9275
117 TIY 0.9274
118 SYA 0.9273
119 M0Q 0.9271
120 28N 0.9267
121 FDB 0.9264
122 MVN 0.9263
123 HQD 0.9261
124 PRF 0.9260
125 2H5 0.9257
126 TTY 0.9256
127 TTL 0.9254
128 KJH 0.9253
129 NID 0.9251
130 HQT 0.9251
131 4AN 0.9249
132 QX4 0.9248
133 GTQ 0.9247
134 HTP 0.9242
135 MT8 0.9242
136 37T 0.9241
137 IV2 0.9240
138 G5V 0.9240
139 M1H 0.9237
140 6CS 0.9235
141 GJS 0.9233
142 6ME 0.9233
143 K3Q 0.9231
144 M1Q 0.9230
145 7NI 0.9230
146 NOJ 0.9227
147 DIU 0.9226
148 5NE 0.9226
149 5M0 0.9225
150 44V 0.9223
151 8HC 0.9219
152 QAS 0.9218
153 SRO 0.9218
154 PQ0 0.9216
155 SOR 0.9215
156 HHR 0.9215
157 GIM 0.9215
158 39O 0.9215
159 PXL 0.9214
160 URC 0.9213
161 J9W 0.9210
162 PH2 0.9210
163 1SQ 0.9209
164 MXX 0.9208
165 HKD 0.9208
166 GM7 0.9206
167 24W 0.9205
168 4ME 0.9201
169 ZYR 0.9198
170 54G 0.9197
171 1NP 0.9196
172 PHH 0.9196
173 0FK 0.9196
174 5QX 0.9192
175 R8V 0.9190
176 K32 0.9188
177 ES1 0.9187
178 EXO 0.9186
179 GZ8 0.9185
180 5Q0 0.9185
181 KJY 0.9184
182 SXS 0.9184
183 UEG 0.9181
184 G6D 0.9180
185 HQY 0.9178
186 R9Y 0.9177
187 PXM 0.9177
188 QAT 0.9177
189 DNC 0.9176
190 2KA 0.9174
191 GOX 0.9174
192 2HQ 0.9173
193 G12 0.9170
194 2D0 0.9170
195 DBJ 0.9167
196 K17 0.9167
197 D07 0.9164
198 7W1 0.9160
199 5MK 0.9159
200 GOG 0.9158
201 1X7 0.9158
202 1P7 0.9158
203 EA1 0.9157
204 QBK 0.9157
205 INE 0.9157
206 2LY 0.9157
207 1LQ 0.9155
208 5SG 0.9155
209 86J 0.9155
210 Q6T 0.9153
211 DNA 0.9152
212 5WU 0.9149
213 ADZ 0.9146
214 N5J 0.9145
215 8W9 0.9144
216 4AA 0.9139
217 TBS 0.9138
218 GRE 0.9135
219 COU 0.9134
220 5RO 0.9134
221 4YS 0.9132
222 537 0.9130
223 06B 0.9128
224 OCH 0.9128
225 K22 0.9126
226 JBH 0.9124
227 JU2 0.9123
228 MO8 0.9122
229 5IQ 0.9122
230 SX1 0.9118
231 FDR 0.9117
232 1KP 0.9117
233 82I 0.9116
234 RPQ 0.9115
235 JPZ 0.9114
236 F12 0.9113
237 JTH 0.9112
238 DQN 0.9111
239 GCW 0.9110
240 LDR 0.9109
241 HFB 0.9109
242 XXR 0.9107
243 3HA 0.9104
244 MVL 0.9104
245 2EC 0.9103
246 8TX 0.9099
247 PEY 0.9098
248 1LM 0.9097
249 IBM 0.9097
250 1XN 0.9095
251 7B4 0.9090
252 92K 0.9089
253 AZA 0.9088
254 B55 0.9087
255 9TZ 0.9086
256 AKH 0.9085
257 BMA 0.9085
258 03V 0.9084
259 O72 0.9078
260 I3A 0.9078
261 9AP 0.9077
262 2AQ 0.9075
263 HH8 0.9075
264 ISN 0.9075
265 64C 0.9074
266 4VS 0.9073
267 SYV 0.9071
268 Z5P 0.9069
269 SKA 0.9067
270 DEE 0.9067
271 KIA 0.9067
272 KIB 0.9067
273 7ME 0.9065
274 CWM 0.9065
275 F5B 0.9064
276 3GQ 0.9063
277 XAZ 0.9062
278 4XH 0.9062
279 SWA 0.9062
280 RM1 0.9062
281 GLA 0.9061
282 4FS 0.9061
283 6VD 0.9060
284 E7Z 0.9057
285 DBH 0.9057
286 INS 0.9055
287 GDE 0.9055
288 JBK 0.9055
289 AIN 0.9053
290 6F0 0.9052
291 Q88 0.9052
292 B53 0.9052
293 5B1 0.9051
294 PCI 0.9050
295 ES5 0.9049
296 6M1 0.9049
297 B56 0.9048
298 FBG 0.9048
299 GTR 0.9047
300 5NS 0.9047
301 JB5 0.9044
302 EQT 0.9043
303 GUN 0.9043
304 XAN 0.9041
305 9DG 0.9041
306 G3E 0.9041
307 H5B 0.9040
308 ES0 0.9040
309 42C 0.9039
310 GIO 0.9037
311 3M0 0.9037
312 Q71 0.9036
313 L7T 0.9034
314 G2F 0.9034
315 M2K 0.9027
316 QPR 0.9025
317 BCF 0.9024
318 KBG 0.9023
319 FA0 0.9022
320 92P 0.9020
321 ICO 0.9019
322 5QY 0.9018
323 C2Y 0.9018
324 M1E 0.9015
325 LZM 0.9015
326 8WT 0.9015
327 KJU 0.9014
328 H42 0.9014
329 2ZV 0.9014
330 BTY 0.9013
331 IGA 0.9013
332 AJY 0.9009
333 BBF 0.9009
334 GTZ 0.9008
335 ZZ8 0.9007
336 DHK 0.9006
337 ADK 0.9005
338 0XT 0.9004
339 141 0.9003
340 KFH 0.9003
341 V55 0.9002
342 KKN 0.9002
343 M6N 0.9001
344 DNF 0.9001
345 N2I 0.9000
346 3F0 0.8999
347 42A 0.8996
348 MWP 0.8994
349 PX7 0.8993
350 NTM 0.8992
351 YQA 0.8991
352 F1A 0.8990
353 IBF 0.8990
354 3RK 0.8989
355 F0J 0.8987
356 3PF 0.8987
357 5RN 0.8986
358 XM5 0.8985
359 8IG 0.8984
360 4M4 0.8984
361 SOE 0.8984
362 BNT 0.8983
363 67N 0.8983
364 BPU 0.8982
365 3TJ 0.8981
366 GCV 0.8981
367 7W4 0.8980
368 4M0 0.8980
369 25W 0.8979
370 YH7 0.8978
371 7HQ 0.8976
372 ALL 0.8976
373 75K 0.8975
374 AP4 0.8972
375 7WR 0.8971
376 JR2 0.8970
377 DOB 0.8968
378 R6T 0.8967
379 30G 0.8966
380 SE2 0.8966
381 5WV 0.8965
382 A2F 0.8965
383 NVU 0.8964
384 8ZE 0.8963
385 1XM 0.8963
386 BOA 0.8961
387 4Z4 0.8960
388 BHA 0.8960
389 MQN 0.8960
390 M1A 0.8958
391 CTS 0.8958
392 FE DB1 0.8958
393 ROI 0.8956
394 LT2 0.8956
395 ES7 0.8952
396 KYA 0.8951
397 VNL 0.8950
398 5CU 0.8947
399 WOO 0.8947
400 C9E 0.8946
401 NAG 0.8945
402 6AP 0.8945
403 LSA 0.8945
404 XQ0 0.8945
405 20J 0.8944
406 DX4 0.8942
407 JXN 0.8940
408 F3B 0.8940
409 5JQ 0.8940
410 6GU 0.8938
411 ZB1 0.8938
412 GLT 0.8937
413 D48 0.8937
414 BCP 0.8936
415 JG8 0.8935
416 J5I 0.8934
417 CTL 0.8934
418 1GN 0.8933
419 8GK 0.8929
420 5NU 0.8929
421 V1T 0.8925
422 MT5 0.8924
423 LZ2 0.8924
424 4JQ 0.8923
425 BK9 0.8922
426 0TU 0.8921
427 XQG 0.8921
428 HHA 0.8920
429 UQ 0.8920
430 2K8 0.8920
431 PHT 0.8918
432 290 0.8917
433 23J 0.8917
434 149 0.8916
435 GXY 0.8914
436 GIV 0.8914
437 B5D 0.8912
438 3MA 0.8911
439 7I2 0.8911
440 FSW 0.8909
441 5OB 0.8908
442 CFP 0.8907
443 2JK 0.8906
444 EYK 0.8906
445 0W8 0.8905
446 9R5 0.8896
447 E7R 0.8894
448 K6X 0.8894
449 MBG 0.8894
450 SKM 0.8893
451 ZWZ 0.8891
452 SVN 0.8889
453 MAN 0.8888
454 582 0.8886
455 AMG 0.8885
456 GT0 0.8882
457 5CL 0.8882
458 TQU 0.8882
459 FGZ 0.8881
460 VXX 0.8879
461 HHS 0.8879
462 1QP 0.8877
463 FBT 0.8877
464 G1P 0.8875
465 PRZ 0.8874
466 5JL 0.8874
467 HH5 0.8873
468 3J8 0.8872
469 DX3 0.8872
470 AZG 0.8871
471 MIG 0.8871
472 PQK 0.8870
473 4JT 0.8869
474 BSP 0.8866
475 KLW 0.8865
476 ESI 0.8863
477 JKZ 0.8860
478 F6P 0.8859
479 0CU 0.8857
480 6M9 0.8857
481 1U6 0.8855
482 2SX 0.8853
483 IFL 0.8852
484 X05 0.8851
485 NDH 0.8850
486 DBX 0.8849
487 PDC 0.8849
488 KIF 0.8846
489 68A 0.8845
490 CCV 0.8844
491 TSS 0.8844
492 SYR 0.8843
493 BZ3 0.8842
494 GHM 0.8841
495 ASO 0.8840
496 2FG 0.8840
497 1HN 0.8839
498 0FN 0.8835
499 9FL 0.8835
500 ZZZ 0.8834
501 3R6 0.8834
502 DK1 0.8833
503 GSY 0.8833
504 ORO 0.8832
505 4YO 0.8832
506 MS9 0.8831
507 5GU 0.8831
508 O2A 0.8831
509 15N 0.8829
510 4RU 0.8826
511 GJP 0.8825
512 3C1 0.8825
513 KDV 0.8825
514 QUZ 0.8823
515 SHA 0.8822
516 K37 0.8822
517 ADA 0.8820
518 4TU 0.8817
519 F05 0.8816
520 KBB 0.8814
521 4XV 0.8812
522 X09 0.8810
523 3C2 0.8806
524 NPY 0.8806
525 GNM 0.8805
526 0RW 0.8804
527 329 0.8803
528 I1N 0.8802
529 NOY 0.8802
530 J9Q 0.8801
531 0JD 0.8797
532 9PY 0.8797
533 P3K 0.8795
534 NBG 0.8795
535 MHK 0.8794
536 GAF 0.8793
537 BTE 0.8793
538 QSH 0.8792
539 SAL 0.8792
540 GTL 0.8791
541 AY4 0.8790
542 5VL 0.8788
543 5VJ 0.8788
544 TWO 0.8788
545 GV9 0.8783
546 JF2 0.8783
547 ASC 0.8782
548 8MO 0.8780
549 HBO 0.8780
550 3ID 0.8779
551 X6X 0.8778
552 HPA 0.8778
553 97T 0.8776
554 JP2 0.8773
555 OXC 0.8770
556 3FH 0.8769
557 091 0.8769
558 PA1 0.8768
559 THA 0.8768
560 CN0 0.8768
561 9EW 0.8768
562 7MX 0.8767
563 0F9 0.8763
564 NLA 0.8762
565 27B 0.8761
566 MMA 0.8760
567 SWD 0.8757
568 8VE 0.8756
569 4NO 0.8755
570 4V6 0.8754
571 DMD 0.8754
572 GXL 0.8752
573 3DO 0.8749
574 E1T 0.8748
575 XFE 0.8748
576 DOR 0.8748
577 MFU 0.8746
578 15E 0.8745
579 KGK 0.8742
580 KTW 0.8742
581 OMD 0.8742
582 BE2 0.8741
583 67X 0.8739
584 JBE 0.8738
585 4XS 0.8737
586 3RI 0.8736
587 TT4 0.8736
588 6M4 0.8735
589 4NC 0.8735
590 23A 0.8735
591 QWW 0.8733
592 AA 0.8732
593 2AL 0.8732
594 BZX 0.8731
595 EUG 0.8730
596 54X 0.8726
597 9CA 0.8724
598 1DW 0.8724
599 1U1 0.8720
600 EMZ 0.8720
601 6X9 0.8719
602 FBB 0.8719
603 ADE 0.8719
604 64E 0.8718
605 VOH 0.8716
606 E1K 0.8714
607 JF1 0.8713
608 6MP 0.8713
609 2J9 0.8711
610 3DM 0.8709
611 5XC 0.8707
612 JND 0.8706
613 9ZE 0.8705
614 LAO 0.8701
615 7HP 0.8701
616 14O 0.8700
617 NGO 0.8700
618 XQK 0.8699
619 3U4 0.8699
620 TFU 0.8698
621 FDK 0.8698
622 CKA 0.8697
623 TGX 0.8692
624 1IT 0.8691
625 0W1 0.8691
626 1WG 0.8690
627 5H1 0.8690
628 VGD 0.8689
629 9DA 0.8688
630 ES6 0.8688
631 7WA 0.8687
632 RAM 0.8687
633 ABV 0.8686
634 9HX 0.8685
635 10L 0.8684
636 7WV 0.8681
637 BP1 0.8681
638 2BG 0.8680
639 5TY 0.8679
640 AW5 0.8679
641 NBV 0.8676
642 TNF 0.8674
643 4SV 0.8674
644 5PX 0.8671
645 3Z7 0.8670
646 HA5 0.8668
647 5OF 0.8668
648 CBF 0.8667
649 7M6 0.8665
650 EGR 0.8663
651 JAE 0.8660
652 ES2 0.8659
653 5MB 0.8658
654 DHB 0.8656
655 UFV 0.8656
656 SG2 0.8656
657 6E8 0.8655
658 BZJ 0.8655
659 1A7 0.8654
660 3MB 0.8654
661 ANF 0.8653
662 JKE 0.8653
663 TH7 0.8652
664 344 0.8649
665 D3M 0.8648
666 173 0.8646
667 FH2 0.8646
668 MB1 0.8644
669 6RQ 0.8644
670 K2T 0.8644
671 1P8 0.8644
672 BA5 0.8642
673 0HO 0.8642
674 N0Z 0.8642
675 F60 0.8641
676 IPB 0.8640
677 7D2 0.8637
678 ET2 0.8636
679 1WD 0.8636
680 9LI 0.8635
681 HXX 0.8635
682 5MI 0.8633
683 2CK 0.8629
684 ONR 0.8628
685 FYU 0.8627
686 INO 0.8626
687 F9Y 0.8624
688 CLW 0.8621
689 ES4 0.8621
690 NNO 0.8617
691 4HM 0.8613
692 1X8 0.8611
693 36R 0.8611
694 0HN 0.8611
695 6AI 0.8610
696 DRG 0.8604
697 39U 0.8600
698 X0W 0.8597
699 FHB 0.8597
700 4A3 0.8594
701 FHN 0.8591
702 DMJ 0.8590
703 GYE 0.8590
704 6QF 0.8588
705 150 0.8585
706 9FE 0.8582
707 93K 0.8578
708 SLS 0.8576
709 S3B 0.8575
710 94W 0.8574
711 MYJ 0.8566
712 DPT 0.8566
713 P9P 0.8563
714 293 0.8562
715 7FF 0.8561
716 3HM 0.8550
717 8NX 0.8550
718 HLD 0.8548
719 2HO 0.8543
720 948 0.8532
721 774 0.8530
722 LYL 0.8513
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3GE7; Ligand: AFQ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3ge7.bio1) has 34 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3GE7; Ligand: AFQ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3ge7.bio1) has 34 residues
No: Leader PDB Ligand Sequence Similarity
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