Receptor
PDB id Resolution Class Description Source Keywords
5R0L 1.7 Å NON-ENZYME: OTHER PANDDA ANALYSIS GROUP DEPOSITION -- AAR2/RNASEH IN COMPLEX W FRAGMENT F2X-ENTRY H11, DMSO-FREE SACCHAROMYCES CEREVISIAE (STRAIN ATCC S288C) FRAGMAX FRAGMAXAPP FRAGMENT SCREENING RNASEH LIKE DOMAINDOMAIN U5 SNRNP ASSEMBLY SPLICING
Ref.: F2X-UNIVERSAL AND F2X-ENTRY: STRUCTURALLY DIVERSE C LIBRARIES FOR CRYSTALLOGRAPHIC FRAGMENT SCREENING. STRUCTURE V. 28 694 2020
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
TBJ A:2501;
 Valid;
 none;
 submit data
212.289 C11 H20 N2 O2 C1CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5R0D 1.27 Å NON-ENZYME: OTHER PANDDA ANALYSIS GROUP DEPOSITION -- AAR2/RNASEH IN COMPLEX W FRAGMENT F2X-ENTRY C11, DMSO-FREE SACCHAROMYCES CEREVISIAE (STRAIN ATCC S288C) FRAGMAX FRAGMAXAPP FRAGMENT SCREENING RNASEH LIKE DOMAINDOMAIN U5 SNRNP ASSEMBLY SPLICING
Ref.: F2X-UNIVERSAL AND F2X-ENTRY: STRUCTURALLY DIVERSE C LIBRARIES FOR CRYSTALLOGRAPHIC FRAGMENT SCREENING. STRUCTURE V. 28 694 2020
Members (35)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 5R09 - SYG C9 H13 N O CC[C@@H](c....
2 5R0G - SYJ C11 H10 F N O3 S c1ccc(c(c1....
3 5QY1 - R8A C6 H8 N2 O c1cc(c(nc1....
4 5QYB - R9G C12 H15 N O2 COc1cccc(c....
5 5R0B - SY7 C28 H30 N6 O4 COc1cc(ccn....
6 5QYK - SZA C12 H12 N2 O S c1cc(sc1)C....
7 5R0C - R8V C9 H9 N O2 CN1[C@H](c....
8 5QY7 - USJ C9 H11 N O2 CN1[C@H](c....
9 5QYD - R9S C9 H11 N O Cc1ccccc1C....
10 5R0M - SZA C12 H12 N2 O S c1cc(sc1)C....
11 5R0E - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
12 5QYC - SYJ C11 H10 F N O3 S c1ccc(c(c1....
13 5QYJ - TBJ C11 H20 N2 O2 C1CCC(C1)N....
14 5R0J - RBJ C8 H11 N O CNCc1ccc(c....
15 5QY4 - T9S C10 H12 N2 O2 CCOC(=O)N1....
16 5QYI - SZ7 C9 H10 N2 O S c1cc(sc1)/....
17 5R08 - R8A C6 H8 N2 O c1cc(c(nc1....
18 5QYE - USP C8 H10 N2 O2 CN1c2ccc(c....
19 5QY5 - SYA C8 H5 F3 O3 COc1c(c(cc....
20 5R0K - SZ7 C9 H10 N2 O S c1cc(sc1)/....
21 5R0L - TBJ C11 H20 N2 O2 C1CCC(C1)N....
22 5QY3 - SYG C9 H13 N O CC[C@@H](c....
23 5R0H - R9S C9 H11 N O Cc1ccccc1C....
24 5QYH - T9V C9 H11 N O2 CC(=O)Nc1c....
25 5QY6 - SY7 C28 H30 N6 O4 COc1cc(ccn....
26 5QY2 - TJ1 C5 H8 N2 O2 CC(C)C1=NO....
27 5R0D - R8Y C10 H13 N O3 S CCN(CCC(=O....
28 5QYG - RBJ C8 H11 N O CNCc1ccc(c....
29 5QY8 - TJV C8 H7 N O2 S c1cc2c(cc1....
30 5R0I - SYV C8 H8 N2 O2 CN1c2ccc(c....
31 5R0F - R9G C12 H15 N O2 COc1cccc(c....
32 5QY9 - R8Y C10 H13 N O3 S CCN(CCC(=O....
33 5QYF - T9Y C7 H7 F3 N2 O2 CCOC(=O)c1....
34 5QYA - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
35 5R0A - SYA C8 H5 F3 O3 COc1c(c(cc....
70% Homology Family (35)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 5R09 - SYG C9 H13 N O CC[C@@H](c....
2 5R0G - SYJ C11 H10 F N O3 S c1ccc(c(c1....
3 5QY1 - R8A C6 H8 N2 O c1cc(c(nc1....
4 5QYB - R9G C12 H15 N O2 COc1cccc(c....
5 5R0B - SY7 C28 H30 N6 O4 COc1cc(ccn....
6 5QYK - SZA C12 H12 N2 O S c1cc(sc1)C....
7 5R0C - R8V C9 H9 N O2 CN1[C@H](c....
8 5QY7 - USJ C9 H11 N O2 CN1[C@H](c....
9 5QYD - R9S C9 H11 N O Cc1ccccc1C....
10 5R0M - SZA C12 H12 N2 O S c1cc(sc1)C....
11 5R0E - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
12 5QYC - SYJ C11 H10 F N O3 S c1ccc(c(c1....
13 5QYJ - TBJ C11 H20 N2 O2 C1CCC(C1)N....
14 5R0J - RBJ C8 H11 N O CNCc1ccc(c....
15 5QY4 - T9S C10 H12 N2 O2 CCOC(=O)N1....
16 5QYI - SZ7 C9 H10 N2 O S c1cc(sc1)/....
17 5R08 - R8A C6 H8 N2 O c1cc(c(nc1....
18 5QYE - USP C8 H10 N2 O2 CN1c2ccc(c....
19 5QY5 - SYA C8 H5 F3 O3 COc1c(c(cc....
20 5R0K - SZ7 C9 H10 N2 O S c1cc(sc1)/....
21 5R0L - TBJ C11 H20 N2 O2 C1CCC(C1)N....
22 5QY3 - SYG C9 H13 N O CC[C@@H](c....
23 5R0H - R9S C9 H11 N O Cc1ccccc1C....
24 5QYH - T9V C9 H11 N O2 CC(=O)Nc1c....
25 5QY6 - SY7 C28 H30 N6 O4 COc1cc(ccn....
26 5QY2 - TJ1 C5 H8 N2 O2 CC(C)C1=NO....
27 5R0D - R8Y C10 H13 N O3 S CCN(CCC(=O....
28 5QYG - RBJ C8 H11 N O CNCc1ccc(c....
29 5QY8 - TJV C8 H7 N O2 S c1cc2c(cc1....
30 5R0I - SYV C8 H8 N2 O2 CN1c2ccc(c....
31 5R0F - R9G C12 H15 N O2 COc1cccc(c....
32 5QY9 - R8Y C10 H13 N O3 S CCN(CCC(=O....
33 5QYF - T9Y C7 H7 F3 N2 O2 CCOC(=O)c1....
34 5QYA - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
35 5R0A - SYA C8 H5 F3 O3 COc1c(c(cc....
50% Homology Family (35)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 5R09 - SYG C9 H13 N O CC[C@@H](c....
2 5R0G - SYJ C11 H10 F N O3 S c1ccc(c(c1....
3 5QY1 - R8A C6 H8 N2 O c1cc(c(nc1....
4 5QYB - R9G C12 H15 N O2 COc1cccc(c....
5 5R0B - SY7 C28 H30 N6 O4 COc1cc(ccn....
6 5QYK - SZA C12 H12 N2 O S c1cc(sc1)C....
7 5R0C - R8V C9 H9 N O2 CN1[C@H](c....
8 5QY7 - USJ C9 H11 N O2 CN1[C@H](c....
9 5QYD - R9S C9 H11 N O Cc1ccccc1C....
10 5R0M - SZA C12 H12 N2 O S c1cc(sc1)C....
11 5R0E - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
12 5QYC - SYJ C11 H10 F N O3 S c1ccc(c(c1....
13 5QYJ - TBJ C11 H20 N2 O2 C1CCC(C1)N....
14 5R0J - RBJ C8 H11 N O CNCc1ccc(c....
15 5QY4 - T9S C10 H12 N2 O2 CCOC(=O)N1....
16 5QYI - SZ7 C9 H10 N2 O S c1cc(sc1)/....
17 5R08 - R8A C6 H8 N2 O c1cc(c(nc1....
18 5QYE - USP C8 H10 N2 O2 CN1c2ccc(c....
19 5QY5 - SYA C8 H5 F3 O3 COc1c(c(cc....
20 5R0K - SZ7 C9 H10 N2 O S c1cc(sc1)/....
21 5R0L - TBJ C11 H20 N2 O2 C1CCC(C1)N....
22 5QY3 - SYG C9 H13 N O CC[C@@H](c....
23 5R0H - R9S C9 H11 N O Cc1ccccc1C....
24 5QYH - T9V C9 H11 N O2 CC(=O)Nc1c....
25 5QY6 - SY7 C28 H30 N6 O4 COc1cc(ccn....
26 5QY2 - TJ1 C5 H8 N2 O2 CC(C)C1=NO....
27 5R0D - R8Y C10 H13 N O3 S CCN(CCC(=O....
28 5QYG - RBJ C8 H11 N O CNCc1ccc(c....
29 5QY8 - TJV C8 H7 N O2 S c1cc2c(cc1....
30 5R0I - SYV C8 H8 N2 O2 CN1c2ccc(c....
31 5R0F - R9G C12 H15 N O2 COc1cccc(c....
32 5QY9 - R8Y C10 H13 N O3 S CCN(CCC(=O....
33 5QYF - T9Y C7 H7 F3 N2 O2 CCOC(=O)c1....
34 5QYA - SY4 C9 H12 F2 N2 O2 S CCCS(=O)(=....
35 5R0A - SYA C8 H5 F3 O3 COc1c(c(cc....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: TBJ; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 TBJ 1 1
2 REG 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: TBJ; Similar ligands found: 89
No: Ligand Similarity coefficient
1 BSU 0.9275
2 S0B 0.9256
3 RDV 0.9180
4 JF5 0.9135
5 KPV 0.9118
6 CT0 0.9106
7 MKN 0.9098
8 6C8 0.9097
9 OJD 0.9058
10 JON 0.9044
11 BZM 0.9041
12 Q86 0.9040
13 1PB 0.9004
14 6C5 0.8999
15 HL6 0.8981
16 3CX 0.8955
17 5TO 0.8940
18 MGB 0.8929
19 6FR 0.8926
20 N9M 0.8924
21 G8V 0.8917
22 A5P 0.8912
23 FZ0 0.8909
24 ARG 0.8909
25 P93 0.8903
26 6FG 0.8898
27 HSA 0.8896
28 HAR 0.8888
29 JP5 0.8882
30 F6R 0.8881
31 N0H 0.8870
32 ZE7 0.8861
33 3VR 0.8853
34 3KJ 0.8815
35 4AF 0.8814
36 9OD 0.8811
37 FZ3 0.8807
38 PAN 0.8805
39 JGY 0.8804
40 HPZ 0.8802
41 E8U 0.8801
42 HLP 0.8782
43 S2C 0.8781
44 8V8 0.8773
45 6PG 0.8771
46 DA2 0.8763
47 5TT 0.8759
48 DKA 0.8758
49 KNA 0.8758
50 9JH 0.8754
51 S8P 0.8754
52 9VQ 0.8751
53 YI6 0.8750
54 M28 0.8748
55 1PS 0.8742
56 0OM 0.8741
57 JP8 0.8741
58 ALY 0.8722
59 ABH 0.8716
60 3GC 0.8712
61 2O8 0.8710
62 SZ7 0.8710
63 5KJ 0.8702
64 PML 0.8701
65 5SP 0.8698
66 LPA 0.8691
67 R10 0.8686
68 PA5 0.8684
69 11X 0.8680
70 UN3 0.8673
71 GVA 0.8660
72 AGP 0.8657
73 IBP 0.8650
74 EG0 0.8648
75 S7D 0.8632
76 00G 0.8623
77 4Z0 0.8618
78 4FP 0.8616
79 EFR 0.8616
80 PTR 0.8608
81 DMA 0.8605
82 5WK 0.8604
83 M25 0.8588
84 TFQ 0.8569
85 MLY 0.8563
86 XRX 0.8559
87 3IP 0.8546
88 C5F 0.8537
89 22F 0.8534
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5R0D; Ligand: R8Y; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5r0d.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
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