Receptor
PDB id Resolution Class Description Source Keywords
2FOP 2.1 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH MDM2 PEPTIDE 147-150 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU LYS PRO SER SER SER B:142;
Valid;
none;
submit data
633.656 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FOJ 1.6 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 364-367 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLU LYS PRO SER SER SER; Similar ligands found: 61
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU LYS PRO SER SER SER 1 1
2 GLU LEU PRO LEU VAL LYS ILE 0.547826 0.816667
3 LYS PRO LYS 0.533333 0.854545
4 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.527273 0.868852
5 VAL LYS PRO GLY 0.515464 0.844828
6 SER SER GLY LYS VAL PRO LEU SER 0.5 0.932203
7 LYS PRO HIS SER ASP 0.5 0.916667
8 GLY SER ASP PRO PHE LYS 0.5 0.964912
9 SER SER CYS PRO LEU SER LYS 0.5 0.883333
10 GLU GLU PRO THR VAL ILE LYS LYS TYR 0.488889 0.80303
11 ASN ARG PRO ILE LEU SER LEU 0.47541 0.80597
12 1IP CYS PHE SER LYS PRO ARG 0.474074 0.820895
13 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.472868 0.746269
14 THR LYS PRO ARG 0.470588 0.770492
15 GLU PHE SER PRO 0.466667 0.912281
16 SER SER GLY LYS VAL PRO LEU 0.465517 0.915254
17 SER PRO LYS ARG ILE ALA 0.461538 0.8125
18 GLY GLY CYS PHE SER LYS PRO LYS MYR 0.460993 0.873016
19 LYS THR PHE PRO PRO THR GLU PRO LYS 0.458647 0.885246
20 GLU PRO GLY GLY SER ARG 0.456897 0.885246
21 CYS THR PRO SER ARG 0.452174 0.828125
22 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.448529 0.887097
23 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.445312 0.731343
24 GLY SER ASP PRO TRP LYS 0.445312 0.901639
25 LYS ARG ARG ARG HIS PRO SER GLY 0.442748 0.830769
26 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.442029 0.819672
27 LYS SER LYS 0.436782 0.745455
28 SER MET PRO GLU LEU SER PRO VAL LEU 0.434426 0.859375
29 LEU SER SER PRO VAL THR LYS SER PHE 0.432836 0.854839
30 ALA GLY SER VAL GLU GLN TPO PRO LYS LYS 0.432624 0.820895
31 LYS LEU THR PRO LEU CYS VAL THR LEU 0.432 0.868852
32 ARG PRO LYS PRO LEU VAL ASP PRO 0.428571 0.712121
33 SER GLU CYS THR THR PRO CYS 0.42735 0.915254
34 GLY PRO SER SER GLY GLY 0.427184 0.981818
35 LEU PRO PHE GLU LYS SER THR VAL MET 0.426573 0.833333
36 5JP PRO LYS ARG ILE ALA 0.421053 0.772727
37 SER ALA PRO ASP THR ARG PRO ALA 0.418605 0.833333
38 SER LEU ILE PRO TPO PRO ASP LYS 0.41791 0.797101
39 MAA LYS PRO PHE 0.417391 0.766667
40 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.417323 0.916667
41 GLU SER ASP PRO ILE VAL ALA GLN TYR 0.415493 0.818182
42 ARG ARG ARG GLU ARG SER PRO THR ARG 0.415385 0.873016
43 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.412214 0.859375
44 LYS ARG ARG ARG HIS PRO SER 0.412214 0.784615
45 PRO SER ILE ASP ARG SER THR LYS PRO 0.411348 0.820895
46 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.410448 0.846154
47 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.40678 0.870968
48 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.406061 0.733333
49 ARG PRO LYS ARG ILE ALA 0.404762 0.753846
50 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.404412 0.84375
51 PRO LEU SER LYS 0.403846 0.79661
52 GLY VAL VAL ALA SER GLN PRO ALA ARG VAL 0.403226 0.913793
53 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.403226 0.790323
54 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.403101 0.791045
55 ACE ILE GLU PRO ASJ 0.401786 0.847458
56 GLY THR SER SER PRO SER ALA ASP 0.401709 0.913793
57 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.401361 0.833333
58 ILE LEU LYS GLU PRO VAL HIS GLY VAL 0.4 0.753846
59 SER SER CYS SER SER CYS PRO LEU SER LYS 0.4 0.80597
60 LEU PRO SER PHE GLU THR ALA LEU 0.4 0.870968
61 LEU PRO PHE ASP LYS SER THR ILE MET 0.4 0.820895
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FOJ; Ligand: GLY ALA ARG ALA HIS SER SER; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2foj.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
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