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Receptor
PDB id Resolution Class Description Source Keywords
4KG9 1.7 Å EC: 3.1.2.15 CRYSTAL STRUCTURE OF USP7-NTD WITH MCM-BP HOMO SAPIENS TRAF DOMAIN DEUBIQUITINATION HYDROLASE
Ref.: A ROLE FOR USP7 IN DNA REPLICATION. MOL.CELL.BIOL. V. 34 132 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ARG VAL SER PRO SER THR SER TYR THR PRO B:153;
Valid;
none;
submit data
724.789 n/a O=C(N...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FOJ 1.6 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 364-367 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ARG VAL SER PRO SER THR SER TYR THR PRO; Similar ligands found: 97
No: Ligand ECFP6 Tc MDL keys Tc
1 ARG VAL SER PRO SER THR SER TYR THR PRO 1 1
2 PRO THR SEP PRO SER TYR 0.65 0.855072
3 SER TYR SEP PRO THR SEP PRO SEP TYR SER 0.580645 0.84058
4 GLY THR SER SER PRO SER ALA ASP 0.561404 0.857143
5 LEU SER SER PRO VAL THR LYS SER PHE 0.560606 0.920635
6 TYR SEP PRO THR SEP PRO SER 0.545455 0.842857
7 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.537879 0.938462
8 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.530303 0.833333
9 N7P THR SEP PRO SER TYR SET 0.51145 0.84507
10 PRO SER TYR SEP PRO THR SEP PRO SER 0.511278 0.842857
11 VAL SER GLN ASN TYR PRO ILE VAL GLN ASN 0.511111 0.938462
12 SER PRO THR SER PRO SEP TYR SER PRO PRO 0.5 0.855072
13 HIS SER ILE THR TYR LEU LEU PRO VAL 0.5 0.884058
14 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.489655 0.833333
15 TYR LEU GLU PRO ALA PRO VAL THR ALA 0.485294 0.893939
16 VAL PRO LEU ARG PRO MET THR TYR 0.482759 0.810811
17 LEU PRO PRO LEU ASP ILE THR PRO TYR 0.482269 0.878788
18 ASP ILE ALA TYR TYR THR SER GLU PRO 0.481203 0.895522
19 ARG THR PHE SER PRO THR TYR GLY LEU 0.47973 0.847222
20 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.47973 0.884058
21 TYR PRO SER LYS PRO ASP ASN PRO GLY GLU 0.479675 0.935484
22 VAL TYR PRO IAS HIS ALA 0.474074 0.838235
23 TYR TYR SER ILE ALA PRO HIS SER ILE 0.462069 0.857143
24 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.461538 0.907692
25 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.457516 0.857143
26 TYR LEU ALA PRO GLY PRO VAL THR ALA 0.456522 0.909091
27 GLN ASN TYR PRO ILE VAL GLN 0.455882 0.863636
28 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.453947 0.865672
29 TYR LEU GLU PRO GLY PRO VAL THR ALA 0.451389 0.923077
30 SER THR CYS PRO ALA ALA 0.451327 0.887097
31 ASP ILE ASN TYR TYR THR SER GLU PRO 0.450704 0.882353
32 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.450382 0.875
33 VAL PRO TYR SER SER ALA GLN NAG 0.446043 0.871429
34 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.444444 0.857143
35 TYR TYR SER ILE ILE PRO HIS SER ILE 0.444444 0.857143
36 TYR LEU GLU PRO GLY PRO VAL THR VAL 0.441379 0.923077
37 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.440298 0.863636
38 LEU PRO SER PHE GLU THR ALA LEU 0.439716 0.90625
39 SER SER TYR ARG ARG PRO VAL GLY ILE 0.436242 0.859155
40 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.435115 0.857143
41 ARG ARG ARG GLU ARG SER PRO THR ARG 0.434783 0.771429
42 ARG LEU TYR GLN ASN PRO THR THR TYR ILE 0.433121 0.810811
43 ILE THR ASP GLN VAL PRO PHE SER VAL 0.432432 0.892308
44 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.431655 0.865672
45 GLN MET PRO THR GLU ASP GLU TYR 0.431507 0.84058
46 LEU PHE GLY TYR PRO VAL TYR VAL 0.429577 0.848485
47 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.42953 0.805556
48 ASN TRP SER HIS PRO GLN PHE GLU LYS 0.428571 0.80597
49 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.428571 0.814286
50 LYS LEU TYR GLN ASN PRO THR THR TYR ILE 0.428571 0.882353
51 GLN ASN GLY PTR VAL ASN PRO THR TYR 0.427586 0.821918
52 ARG VAL ALA SER PRO THR SER GLY VAL 0.427536 0.811594
53 THR PRO PRO SER PRO PHE 0.42623 0.888889
54 SER THR SEP PRO THR PHE ASN LYS 0.424837 0.802817
55 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.424658 0.850746
56 ACE TYR PRO ILE GLN GLU THR 0.42446 0.833333
57 GLU SER ASP PRO ILE VAL ALA GLN TYR 0.423841 0.938462
58 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.423358 0.8
59 ILE SER PRO ARG THR LEU ASP ALA TRP 0.422619 0.786667
60 ALA THR PRO PHE GLN GLU 0.422414 0.868852
61 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.421769 0.746667
62 PRO THR SER TYR ALA GLY ASP ASP SER GLY 0.41958 0.84375
63 ACE PRO ALA PRO TYR 0.418803 0.815385
64 LEU ASN PHE PRO ILE SER PRO 0.41791 0.865672
65 TYR PRO PHE PHE NH2 0.416667 0.825397
66 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.41573 0.8
67 GLU ALA ASP PRO THR GLY HIS SER TYR 0.415094 0.882353
68 ASN LEU VAL PRO SER VAL ALA THR VAL 0.414815 0.861538
69 GLU GLU PRO THR VAL ILE LYS LYS TYR 0.414474 0.893939
70 CYS THR PRO SER ARG 0.414062 0.782609
71 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.413793 0.850746
72 VAL MET ALA PRO ARG THR LEU PHE LEU 0.412903 0.746667
73 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.412903 0.791667
74 ARG SEP PRO VAL PHE SER 0.412162 0.767123
75 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.412162 0.848485
76 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.412162 0.848485
77 ARG PRO MET THR TYR LYS GLY ALA LEU 0.412121 0.776316
78 PHE SER ALA PTR PRO SER GLU GLU ASP 0.411348 0.842857
79 SER ASP ILE LEU PHE PRO ALA ASP SER 0.411348 0.876923
80 SER SER CYS PRO LEU SER LYS 0.410853 0.859375
81 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.410072 0.8
82 TYR PRO LYS ARG ILE ALA 0.409722 0.774648
83 ALA PRO ASP THR ARG PRO 0.409091 0.774648
84 ALA ARG SER HIS SEP TYR PRO ALA 0.408805 0.779221
85 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.408805 0.882353
86 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.408284 0.8
87 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.408163 0.780822
88 SER ALA PRO ASP THR ARG PRO ALA 0.407143 0.788732
89 ALA PRO GLN PRO ALA PRO GLU ASN ALA TYR 0.406897 0.863636
90 SER TYR SER PRO THR SEP PRO SER 0.406504 0.797101
91 LEU PRO PHE GLU LYS SER THR VAL MET 0.406452 0.84058
92 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.405405 0.814286
93 LYS THR PHE PRO PRO THR GLU PRO LYS 0.405405 0.890625
94 PRO LYS ARG PRO THR THR LEU ASN LEU PHE 0.404908 0.816901
95 VAL TYR ILE HIS PRO PHE 0.404412 0.808824
96 PHE ASN PHE PRO GLN ILE THR 0.404255 0.808824
97 SER GLU CYS THR THR PRO CYS 0.403101 0.859375
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FOJ; Ligand: GLY ALA ARG ALA HIS SER SER; Similar sites found with APoc: 28
This union binding pocket(no: 1) in the query (biounit: 2foj.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 3A6T 8OG None
2 4USI ATP None
3 4UZI IMD 1.93548
4 5FPE 3TR 3.22581
5 5EJ2 NAD 3.22581
6 5ZI2 ADP 3.47826
7 5GWT NAD 3.59712
8 5GWT SIN 3.59712
9 6HTO MET 3.87097
10 6HTO 5AD 3.87097
11 1QSC ACE TYR PRO ILE GLN GLU THR 4.51613
12 2PKA BEN 4.60526
13 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 5.26316
14 1XOC VAL ASP SER LYS ASN THR SER SER TRP 5.80645
15 2W68 SIA GAL BGC 5.80645
16 5C5H 4YB 5.80645
17 3L8W XAN 7.09677
18 1LSH PLD 7.74194
19 2IRY DGT 7.74194
20 2B6N ALA PRO THR 7.74194
21 5ECP MET 10.3226
22 5ECP JAA 10.3226
23 5ECP ATP 10.3226
24 4O9S 2RY 12.2581
25 1D01 ACE MET LEU SER VAL GLU GLU GLU GLY 14.8387
26 4AFH L0B 16.129
27 1JYQ MAZ PTR PTM ASN 18.75
28 3IVV ASP GLU VAL THR SER THR THR SER SER SER 20
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