Receptor
PDB id Resolution Class Description Source Keywords
6O7Y 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE TRYPANOSOMA CRUZI EIF4E5 TRANSLATION INITIATION FACTOR IN CO CAP-4 TRYPANOSOMA CRUZI RNA BINDING PROTEIN TRANSLATION INITIATION FACTOR TRYPANOSCAP-4
Ref.: CRYSTAL STRUCTURE OF THE TRYPANOSOMA CRUZI EIF4E5 TRANSLATION FACTOR HOMOLOGUE IN COMPLEX WITH MRNA C NUCLEIC ACIDS RES. V. 47 5973 2019
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:302;
A:303;
 Invalid;
Invalid;
 none;
none;
 submit data
96.063 O4 S [O-]S...
LRM A:301;
 Valid;
 none;
 Kd = 110 uM
1826.18 C56 H79 N20 O38 P6 C[n+]...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6O80 2.1 Å NON-ENZYME: TRANSCRIPT_TRANSLATE TRYPANOSOMA CRUZI EIF4E5 TRANSLATION INITIATION FACTOR IN CO M7GTP TRYPANOSOMA CRUZI RNA BINDING PROTEIN TRANSLATION INITIATION FACTOR
Ref.: CRYSTAL STRUCTURE OF THE TRYPANOSOMA CRUZI EIF4E5 TRANSLATION FACTOR HOMOLOGUE IN COMPLEX WITH MRNA C NUCLEIC ACIDS RES. V. 47 5973 2019
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 308 families.
1 6O7Y Kd = 110 uM LRM C56 H79 N20 O38 P6 C[n+]1cn(c....
2 6O80 Kd = 21 uM MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 266 families.
1 6O7Y Kd = 110 uM LRM C56 H79 N20 O38 P6 C[n+]1cn(c....
2 6O80 Kd = 21 uM MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 6O7Y Kd = 110 uM LRM C56 H79 N20 O38 P6 C[n+]1cn(c....
2 6O80 Kd = 21 uM MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LRM; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 LRM 1 1
2 UPA 0.428571 0.860465
3 GTA 0.424581 0.929412
4 UP5 0.409836 0.870588
5 CG2 0.404255 0.906977
6 25L 0.40113 0.835294
Similar Ligands (3D)
Ligand no: 1; Ligand: LRM; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6O80; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6o80.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
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