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Receptor
PDB id Resolution Class Description Source Keywords
4I67 2.33 Å EC: 3.6.4.13 CRYSTAL STRUCTURE OF THE RRM DOMAIN OF RNA HELICASE HERA FRO THERMOPHILUS IN COMPLEX WITH GGGC RNA THERMUS THERMOPHILUS UNWINDING ATPASE HEAT RESISTANT RNA RECOGNITION MOTIF RNBINDING DEAD BOX PROTEIN HYDROLASE-RNA COMPLEX
Ref.: RECOGNITION OF TWO DISTINCT ELEMENTS IN THE RNA SUB THE RNA-BINDING DOMAIN OF THE T. THERMOPHILUS DEAD HELICASE HERA. NUCLEIC ACIDS RES. V. 41 6259 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
G G G RPC B:1;
Valid;
none;
submit data
1431.74 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4I67 2.33 Å EC: 3.6.4.13 CRYSTAL STRUCTURE OF THE RRM DOMAIN OF RNA HELICASE HERA FRO THERMOPHILUS IN COMPLEX WITH GGGC RNA THERMUS THERMOPHILUS UNWINDING ATPASE HEAT RESISTANT RNA RECOGNITION MOTIF RNBINDING DEAD BOX PROTEIN HYDROLASE-RNA COMPLEX
Ref.: RECOGNITION OF TWO DISTINCT ELEMENTS IN THE RNA SUB THE RNA-BINDING DOMAIN OF THE T. THERMOPHILUS DEAD HELICASE HERA. NUCLEIC ACIDS RES. V. 41 6259 2013
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 4I67 - G G G RPC n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 4I67 - G G G RPC n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 4I67 - G G G RPC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: G G G RPC; Similar ligands found: 87
No: Ligand ECFP6 Tc MDL keys Tc
1 G G G RPC 1 1
2 A G C C 0.882883 0.961538
3 G C C C 0.789916 0.949367
4 G G G C 0.762712 0.962025
5 G C 0.756522 0.949367
6 G U 0.612903 0.949367
7 U A G G 0.606299 0.935897
8 G G 0.601695 0.924051
9 A G 0.598425 0.935897
10 U A C C 0.596899 0.935897
11 CG2 0.595238 0.91358
12 GCP G 0.594828 0.922078
13 A G U U 0.587413 0.962025
14 A G U 0.574468 0.962025
15 APC G U 0.572519 0.935897
16 C C 0.567568 0.846154
17 G A A A 0.561538 0.924051
18 GPC 0.55303 0.880952
19 A C A C 0.548872 0.924051
20 G3D 0.547826 0.886076
21 G4P 0.538462 0.886076
22 C C C C 0.525862 0.835443
23 A U C C 0.524476 0.924051
24 CTP C C C C 0.519685 0.881579
25 DC DG 0.518797 0.914634
26 3GP 0.509091 0.897436
27 0O2 0.508197 0.886076
28 G U34 0.492537 0.9375
29 ALF 5GP 0.491525 0.845238
30 DG DC 0.485915 0.902439
31 U2G 0.485075 0.91358
32 5GP 0.473684 0.886076
33 DC DG DA DC 0.473684 0.925926
34 G 0.473684 0.886076
35 UCG 0.472222 0.936709
36 ALF GDP 0.467742 0.845238
37 GDP AF3 0.467742 0.845238
38 GDP ALF 0.467742 0.845238
39 GDP 0.466102 0.875
40 GNH 0.462185 0.864198
41 GPG 0.460317 0.888889
42 GSP 0.459016 0.833333
43 GP3 0.457627 0.9
44 CGP 0.456522 0.891566
45 2GP 0.45614 0.8625
46 GP2 0.453782 0.843373
47 GMP 0.453704 0.7875
48 U A A U 0.44898 0.911392
49 GTP 0.442623 0.875
50 GMV 0.442623 0.853659
51 DC DG DT DA 0.440476 0.904762
52 DG DA DC DG 0.440252 0.926829
53 GAV 0.44 0.843373
54 G1R 0.439024 0.864198
55 GCP 0.439024 0.853659
56 U U U U 0.438017 0.807692
57 GDP 7MG 0.43609 0.9125
58 DA DC DG DA 0.435583 0.914634
59 GNP 0.435484 0.853659
60 G2P 0.435484 0.843373
61 9GM 0.435484 0.853659
62 DT DA DC DG 0.434524 0.904762
63 G2R 0.429688 0.843373
64 DG DG 0.426357 0.890244
65 GDC 0.424242 0.865854
66 GKE 0.424242 0.865854
67 GDD 0.424242 0.865854
68 UTP U U U 0.422764 0.815789
69 JB2 0.422222 0.865854
70 BGO 0.421429 0.878049
71 U A 0.42069 0.911392
72 C3P 0.418182 0.833333
73 6CK 0.41791 0.845238
74 Y9Z 0.413534 0.795455
75 CSV 0.412214 0.783133
76 CSQ 0.412214 0.783133
77 NGD 0.411348 0.9125
78 GFB 0.410448 0.865854
79 GDR 0.410448 0.865854
80 GDX 0.408759 0.876543
81 3PD UM3 0.408451 0.9375
82 YGP 0.406015 0.879518
83 A U 0.404255 0.898734
84 GGM 0.402778 0.857143
85 GKD 0.40146 0.865854
86 DA DU DG DA 0.401408 0.902439
87 GTG 0.4 0.890244
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4I67; Ligand: G G G RPC; Similar sites found with APoc: 262
This union binding pocket(no: 1) in the query (biounit: 4i67.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 5TVI MYR None
2 5MT9 ARG None
3 5MT9 SRO None
4 4QC6 30N None
5 2WOR 2AN None
6 3KPE TM3 None
7 2JJK R15 None
8 5F1R 42O None
9 3LLI FAD None
10 4ORM FMN None
11 4ORM 2V6 None
12 4ORM ORO None
13 4WH9 3M8 None
14 2CNT COA None
15 4OYA 1VE None
16 4XPL ACO None
17 5AZC PGT None
18 4I90 CHT None
19 1E4I NFG None
20 4WG0 CHD None
21 4R57 ACO None
22 5V4R MGT None
23 4LWU 20U None
24 5IF4 6AK None
25 6CS9 PIO None
26 4F4S EFO None
27 3X1M COA None
28 4YDQ ANP None
29 4YDQ HFG None
30 1TV5 N8E None
31 1Q7E MET None
32 4UCC ZKW None
33 2QHD DAO None
34 4IBF 1D5 None
35 1LNX URI None
36 1BGQ RDC None
37 5HGZ ACO None
38 4KVX ACO None
39 1JQ9 PHE LEU SER TYR LYS None
40 1I0B PEL None
41 1YKI FMN None
42 1YKI NFZ None
43 5DUF G7A None
44 4DXJ IPE None
45 3R96 AMP None
46 3R96 ACO None
47 3WCA FPS None
48 4UA3 COA None
49 6BJO DUY None
50 5M37 9SZ None
51 3GWL FAD None
52 2E3N 6CM None
53 3WR7 COA None
54 4WGF HX2 2.29885
55 5YZC 95C 2.29885
56 3KDU NKS 3.44828
57 6BR8 6OU 3.44828
58 3ZLR X0B 3.44828
59 3FUR Z12 3.44828
60 1XQP 8HG 3.44828
61 3QKD HI0 3.44828
62 3SP6 IL2 3.44828
63 2GWH PCI 3.44828
64 6BA2 7KM 3.44828
65 5TWO 7MV 3.44828
66 1ATL 0QI 3.44828
67 2JBZ COA 3.44828
68 3FEI CTM 3.44828
69 5OSW AE4 3.44828
70 1K7L 544 3.44828
71 4QVX 3CQ 3.44828
72 5D9G GLU ASN LEU TYR PHE GLN 3.44828
73 1TIQ COA 3.44828
74 1NU4 MLA 4.5977
75 6GL8 F3Q 4.5977
76 4ELG 52J 4.5977
77 4ELG 52I 4.5977
78 3TGE TGE 4.5977
79 2VZZ SCA 4.5977
80 1TMX HGX 5.46075
81 4RYV ZEA 5.74713
82 3B6C SDN 5.74713
83 4YV5 SVR 5.74713
84 1P0H ACO 5.74713
85 1P0H COA 5.74713
86 3G5N PB2 5.74713
87 4NB5 2JT 5.74713
88 1EWF PC1 5.74713
89 1YRE COA 5.74713
90 2WZV FMN 5.74713
91 5IBE 69M 5.74713
92 4X6F 3XU 5.74713
93 3TDC 0EU 6.89655
94 1GNI OLA 6.89655
95 3L9R L9Q 6.89655
96 3L9R L9R 6.89655
97 1NF8 BOG 6.89655
98 3W5N RAM 6.89655
99 2QB8 ATP 6.89655
100 2OBD PCW 6.89655
101 2BHW NEX 6.89655
102 1U25 IHS 6.89655
103 1U72 MTX 6.89655
104 1U72 NDP 6.89655
105 1T8U UAP SGN IDS SGN 6.89655
106 4Z87 GDP 6.89655
107 1S8G DAO 6.89655
108 4M0R 644 6.89655
109 3LN0 52B 6.89655
110 6GD6 EVB 6.89655
111 5TIV A3P 6.89655
112 1Y7P RIP 6.89655
113 3T58 FAD 6.89655
114 2HHP FLC 8.04598
115 6CB2 OLC 8.04598
116 4LPG 1MV 8.04598
117 5WL1 CUY 8.04598
118 5WL1 D3D 8.04598
119 3SCM LGN 8.04598
120 4LY9 1YY 8.04598
121 5NTP 98E 8.04598
122 5EW9 5VC 8.04598
123 3ZJ0 ACO 8.04598
124 5IXK 6EW 8.04598
125 2X5W K2B 8.04598
126 3GZ9 D32 8.04598
127 4XDA ADP 8.04598
128 4LY9 S6P 8.04598
129 5W7D PX8 8.04598
130 2WPX ACO 8.04598
131 1F0X FAD 8.04598
132 2O1V ADP 8.04598
133 5LGD PLM 8.04598
134 5FVJ ACO 8.04598
135 3UR0 SVR 8.04598
136 3RUG DB6 8.04598
137 3W54 RNB 8.04598
138 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 9.1954
139 5UGW GSH 9.1954
140 4MNS 2AX 9.1954
141 6BMS POV 9.1954
142 1V0C KNC 9.1954
143 1V0C ACO 9.1954
144 2I0G I0G 9.1954
145 5UR6 8KM 9.1954
146 2P1C GG3 9.1954
147 5XQL C2E 9.1954
148 1UBY DMA 9.1954
149 4XU6 TDA 9.1954
150 3B9Z CO2 9.1954
151 6BR9 6OU 9.1954
152 3LDW ZOL 9.1954
153 4HBM 0Y7 10
154 2BCG GER 10.3448
155 1FM9 570 10.3448
156 1GEG GLC 10.3448
157 1RDT 570 10.3448
158 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 10.3448
159 5LX9 OLB 10.3448
160 4JD3 PLM 10.3448
161 4JD3 COA 10.3448
162 4OAR 2S0 10.3448
163 3QCP FAD 10.3448
164 1WWZ ACO 10.3448
165 2GMH UQ5 10.3448
166 5LWY OLB 10.3448
167 1SJD NPG 10.3448
168 1SR7 MOF 10.3448
169 1CMC SAM 10.3448
170 3SFI 3SF 10.3448
171 5K53 STE 10.3448
172 3H0A D30 10.3448
173 2EIX FAD 10.3448
174 4V1F BQ1 10.4651
175 4WT2 3UD 11.4286
176 3AI3 SOE 11.4943
177 1DTL BEP 11.4943
178 5J6A P46 11.4943
179 5UC1 486 11.4943
180 1ZED PNP 11.4943
181 4OAS 2SW 12.5
182 5LXT GDP 12.6437
183 5LXT 7AK 12.6437
184 4OIV XX9 12.6437
185 1M2Z BOG 12.6437
186 4ZBR DIF 12.6437
187 3OKI OKI 12.6437
188 6A5Y 9R0 12.6437
189 4ZBR NPS 12.6437
190 2JEV NHQ 12.6437
191 1PZO CBT 12.6437
192 3QUZ QUV 12.6437
193 5IVX ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 12.6437
194 3DCT 064 12.6437
195 1NHZ 486 12.6437
196 4U03 GTP 12.6437
197 4U03 TLL 12.6437
198 5OLK DTP 12.6437
199 4P6X HCY 12.6437
200 4EIL FOL 12.6437
201 5M36 9SZ 13.1579
202 2VL8 UDP 13.7931
203 1ZPD CIT 13.7931
204 2VBQ BSJ 13.7931
205 1H9G COA MYR 13.7931
206 4YSX E23 13.7931
207 2VL8 CTS 13.7931
208 4EKQ NPO 13.7931
209 2EV1 OLA 13.7931
210 1DB1 VDX 13.7931
211 5IM3 DTP 13.7931
212 3AQT RCO 13.7931
213 2P4Y C03 14.9425
214 4TV1 36M 14.9425
215 2GJ5 VD3 14.9425
216 3VHZ L2P GLC MAN SGA 14.9425
217 2E2R 2OH 16.092
218 3X01 AMP 16.092
219 1DKF BMS 17.2414
220 3KMZ EQO 17.2414
221 2XSU PIE 17.2414
222 1GHE ACO 17.2414
223 1DMH LIO 17.2414
224 1HK8 DGT 17.2414
225 2YPO PHE 17.2414
226 4B5P ACO 17.2414
227 5AAV GW5 18.3908
228 1FX8 BOG 18.3908
229 5B4B LP5 18.3908
230 2BJ4 OHT 18.3908
231 5OLZ T4E 18.3908
232 2Z7I 742 18.3908
233 2QE4 JJ3 18.3908
234 4AVB ACO 18.3908
235 5G48 1FL 18.3908
236 5BQI GSH 19.5402
237 5BQI 4UL 19.5402
238 4TMK T5A 19.5402
239 3HRD FAD 20.6897
240 2Y69 CHD 21.8391
241 4NTO 1PW 21.8391
242 3HUJ AGH 21.8391
243 4OGQ 7PH 22.5806
244 4OGQ 2WM 22.5806
245 4OGQ 1O2 22.5806
246 4OGQ SQD 22.5806
247 4IA6 EIC 22.9885
248 3NB0 G6P 22.9885
249 4ZB8 GDS 22.9885
250 1BUC CAA 22.9885
251 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 22.9885
252 3T6E UQ9 24.1379
253 6DIO CIT 24.1379
254 5K04 COA 24.1379
255 5Z84 CHD 25
256 5W97 CHD 25
257 5ZCO CHD 25
258 5ZCO TGL 25
259 2D5Z L35 26.4368
260 3RWP ABQ 27.5862
261 2J8C U10 29.8851
262 4V24 GYR 29.8851
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