Receptor
PDB id Resolution Class Description Source Keywords
3Q47 1.71 Å EC: 6.3.2.- CRYSTAL STRUCTURE OF TPR DOMAIN OF CHIP COMPLEXED WITH PSEUDOPHOSPHORYLATED SMAD1 PEPTIDE MUS MUSCULUS E3 UBIQUITIN LIGASE LIGASE-TRANSCRIPTION COMPLEX
Ref.: MOLECULAR MECHANISM OF THE NEGATIVE REGULATION OF S PROTEIN BY CARBOXYL TERMINUS OF HSC70-INTERACTING P (CHIP). J.BIOL.CHEM. V. 286 15883 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER PRO HIS ASN PRO ILE SER ASP VAL ASP C:459;
Valid;
none;
submit data
756.767 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3Q49 1.54 Å EC: 6.3.2.- CRYSTAL STRUCTURE OF THE TPR DOMAIN OF CHIP COMPLEXED WITH H PEPTIDE MUS MUSCULUS E3 UBIQUITIN LIGASE LIGASE-CHAPERONE COMPLEX
Ref.: MOLECULAR MECHANISM OF THE NEGATIVE REGULATION OF S PROTEIN BY CARBOXYL TERMINUS OF HSC70-INTERACTING P (CHIP). J.BIOL.CHEM. V. 286 15883 2011
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 34 families.
1 3Q49 - GLY PRO THR ILE GLU GLU VAL ASP n/a n/a
2 3Q4A - SER PRO HIS ASN PRO ILE SER SEP VAL SEP n/a n/a
3 3Q47 - SER PRO HIS ASN PRO ILE SER ASP VAL ASP n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 23 families.
1 3Q49 - GLY PRO THR ILE GLU GLU VAL ASP n/a n/a
2 3Q4A - SER PRO HIS ASN PRO ILE SER SEP VAL SEP n/a n/a
3 3Q47 - SER PRO HIS ASN PRO ILE SER ASP VAL ASP n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 3Q49 - GLY PRO THR ILE GLU GLU VAL ASP n/a n/a
2 3Q4A - SER PRO HIS ASN PRO ILE SER SEP VAL SEP n/a n/a
3 3Q47 - SER PRO HIS ASN PRO ILE SER ASP VAL ASP n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER PRO HIS ASN PRO ILE SER ASP VAL ASP; Similar ligands found: 65
No: Ligand ECFP6 Tc MDL keys Tc
1 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 1 1
2 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.536364 0.919355
3 GLU PTR LEU GLY LEU ASP VAL PRO VAL 0.519231 0.836066
4 ASN ARG PRO ILE LEU SER LEU 0.508065 0.895522
5 GLU SER ASP PRO ILE VAL ALA GLN TYR 0.5 0.909091
6 GLN ASN TYR PRO ILE VAL GLN 0.496063 0.863636
7 ALA VAL PRO ILE ALA GLN 0.495495 0.852459
8 SER VAL PRO ILE 0.49505 0.885246
9 LEU ASN PHE PRO ILE SER PRO 0.491935 0.953125
10 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.486111 0.84058
11 SER ASP ILE LEU PHE PRO ALA ASP SER 0.476923 0.920635
12 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.465116 0.852941
13 SER PRO LEU ASP SER LEU TRP TRP ILE 0.460432 0.867647
14 ALA VAL PRO ILE 0.46 0.786885
15 PHE PRO THR LYS ASP VAL ALA LEU 0.455882 0.846154
16 VAL SER GLN ASN TYR PRO ILE VAL GLN ASN 0.455882 0.909091
17 ILE THR ASP GLN VAL PRO PHE SER VAL 0.453901 0.921875
18 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.453846 0.878788
19 LEU PRO PHE ASP LYS SER THR ILE MET 0.449664 0.84058
20 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.448529 0.855072
21 GLU GLU ILE ASP VAL VAL SER VAL 0.446429 0.721311
22 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.445946 0.816901
23 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.441379 0.833333
24 LYS PRO HIS SER ASP 0.44 0.846154
25 GLU LEU PRO LEU VAL LYS ILE 0.44 0.822581
26 ASN LEU VAL PRO SER VAL ALA THR VAL 0.4375 0.951613
27 ALA PRO SER PTR VAL ASN VAL GLN ASN 0.435714 0.797297
28 ILE MET ASP GLN VAL PRO PHE SER VAL 0.431507 0.880597
29 TRP MET ASP PHE ASP ASP ASP ILE PRO PHE 0.431034 0.793651
30 TRP ASP ILE PRO PHE 0.431034 0.793651
31 CYS THR PRO SER ARG 0.429752 0.782609
32 PHE ASN PHE PRO GLN ILE THR 0.428571 0.863636
33 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.428571 0.842857
34 LEU PRO PRO LEU ASP ILE THR PRO TYR 0.426573 0.835821
35 SER PRO LYS ARG ILE ALA 0.425197 0.808824
36 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.424658 0.830986
37 ALA VAL PRO ILE ALA GLN LYS SER GLU 0.422414 0.819672
38 LEU PRO PHE ASP LYS THR THR ILE MET 0.421769 0.811594
39 SER LEU ILE PRO TPO PRO ASP LYS 0.42029 0.842857
40 THR PRO TYR ASP ILE ASN GLN MET LEU 0.42 0.842857
41 ASN LEU VAL PRO THR VAL ALA THR VAL 0.417323 0.919355
42 GLY VAL VAL ALA SER GLN PRO ALA ARG VAL 0.417323 0.918033
43 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.416667 0.828571
44 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.416667 0.8125
45 SER HIS PRO ARG PRO ILE ARG VAL 0.415493 0.857143
46 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.415493 0.811594
47 ILE PRO ILE 0.414141 0.754098
48 ASN LEU VAL PRO VAL VAL ALA THR VAL 0.414062 0.919355
49 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.413333 0.842857
50 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.413043 0.823529
51 GLN VAL PRO SER ASP PRO TYR ASN TYR 0.410072 0.880597
52 GLU LYS PRO SER SER SER 0.408696 0.854839
53 LEU PRO PHE ASP ARG THR THR ILE MET 0.407895 0.773333
54 SER GLU CYS THR THR PRO CYS 0.406504 0.873016
55 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.40625 0.873016
56 GLU ARG THR ILE PRO ILE THR ARG GLU 0.406015 0.826087
57 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.40458 0.838235
58 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.404255 0.892308
59 GLU GLU PRO THR VAL ILE LYS LYS TYR 0.40411 0.835821
60 THR PRO GLN ASP LEU ASN THR MET LEU 0.402878 0.878788
61 LYS TYR TYR SER ILE ILE PRO HIS SER ILE 0.402778 0.816901
62 TYR TYR SER ILE ILE PRO HIS SER ILE 0.402778 0.816901
63 PHE SER HIS PRO GLN ASN THR 0.401408 0.838235
64 PRO GLN PRO VAL ASP SER TRP VAL 0.401316 0.865672
65 ALA VAL PRO ILE ALA GLN LYS 0.4 0.754098
Similar Binding Sites (Proteins are less than 50% similar to leader)
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