Receptor
PDB id Resolution Class Description Source Keywords
3EF0 2.1 Å EC: 3.1.3.16 THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE II CTD PH SCHIZOSACCHAROMYCES POMBE PHOSPHATASE CTD FCPH BRCT HYDROLASE ALF4 TRANSITION STANALOG COBALT MAGNESIUM MANGANESE METAL-BINDING NUCLEUPROTEIN PHOSPHATASE
Ref.: THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE PHOSPHATASE. MOL.CELL V. 32 478 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALF A:600;
Valid;
none;
submit data
102.975 Al F4 F[Al-...
MG A:1;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3EF0 2.1 Å EC: 3.1.3.16 THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE II CTD PH SCHIZOSACCHAROMYCES POMBE PHOSPHATASE CTD FCPH BRCT HYDROLASE ALF4 TRANSITION STANALOG COBALT MAGNESIUM MANGANESE METAL-BINDING NUCLEUPROTEIN PHOSPHATASE
Ref.: THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE PHOSPHATASE. MOL.CELL V. 32 478 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 14 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 12 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALF; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ALF 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3EF0; Ligand: ALF; Similar sites found: 181
This union binding pocket(no: 1) in the query (biounit: 3ef0.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2CDC XYS 0.02545 0.44225 0.819672
2 2CDC NAP 0.02545 0.44225 0.819672
3 2CDC XYP 0.03184 0.43298 0.819672
4 2WPF WPF 0.04805 0.42948 1.34409
5 5FG3 GDP 0.01068 0.41216 1.34409
6 1DXY NAD 0.01258 0.42782 1.5015
7 3UOY NAP 0.0198 0.44085 1.6129
8 1MKY GDP 0.007333 0.4255 1.6129
9 1FP1 SAH 0.01637 0.40877 1.6129
10 3LAD FAD 0.04199 0.40632 1.6129
11 1L7E NAI 0.02529 0.40428 1.6129
12 4S3R 7SA 0.03418 0.40253 1.6129
13 4HGP KDO 0.006864 0.43253 1.66667
14 4I5I NAD 0.02617 0.41673 1.88172
15 1MV8 NAD 0.01538 0.41062 1.88172
16 4E13 NAD 0.01224 0.41581 2.12014
17 2XVF FAD 0.01271 0.43337 2.15054
18 2XVE FAD 0.02434 0.43277 2.15054
19 4PIO SAH 0.04138 0.40633 2.16718
20 4PIO AVI 0.04212 0.40069 2.16718
21 1RQL VSO 0.00005403 0.44598 2.24719
22 2P69 PLP 0.00009793 0.47171 2.28758
23 2HT6 GDP 0.01818 0.40066 2.29885
24 3WGT FAD 0.01537 0.43233 2.30548
25 3WGT QSC 0.01584 0.43233 2.30548
26 3ZNN 4WL 0.02465 0.42451 2.30548
27 3ZNN FAD 0.02465 0.42451 2.30548
28 1YJQ NAP 0.008166 0.43694 2.31023
29 4L2I NAD 0.03771 0.41788 2.31214
30 4L2I FAD 0.02767 0.41788 2.31214
31 2FCR FMN 0.01137 0.41596 2.31214
32 2CDU FAD 0.01412 0.42778 2.41935
33 3IHG FAD 0.01606 0.42123 2.41935
34 4NMC 2OP 0.02839 0.41755 2.41935
35 4NMC FAD 0.02948 0.41755 2.41935
36 2CDU ADP 0.01681 0.40785 2.41935
37 3OJO NAD 0.02252 0.40539 2.41935
38 2CVZ NDP 0.02406 0.41682 2.42215
39 1N1G BCP 0.01996 0.42199 2.45902
40 3CTY FAD 0.04756 0.404 2.50784
41 3DAG FEG 0.01093 0.43399 2.51397
42 1LDN NAD 0.04045 0.40226 2.53165
43 1RE8 BD2 0.02933 0.42308 2.57143
44 2IV2 MGD 0.02924 0.4226 2.68817
45 2PQB GG9 0.03541 0.40207 2.68817
46 1KPH SAH 0.02557 0.40629 2.78746
47 2ZFU SAH 0.02136 0.40411 2.7907
48 2WK1 SAH 0.02394 0.40198 2.83688
49 2OD9 A1R NCA 0.04334 0.41038 2.92208
50 2QQF A1R 0.03855 0.4082 2.92208
51 1EZ0 NAP 0.02636 0.41258 2.94118
52 1VGR COA 0.02103 0.42344 2.95699
53 3GDN FAD 0.01849 0.42125 2.95699
54 3PT9 SAH 0.01799 0.40986 2.95699
55 3HQP ATP 0.0326 0.40035 2.95699
56 3ZG6 APR 0.0321 0.40008 3.04054
57 3BGD PM6 0.02313 0.41383 3.07692
58 3BGD SAH 0.0194 0.41182 3.07692
59 1TE2 PGA 0.0000007155 0.58565 3.09735
60 1L5Y BEF 0.0000023 0.58934 3.22581
61 1CT9 GLN 0.01741 0.40161 3.22581
62 1XHC FAD 0.02291 0.42153 3.26975
63 5T9E NAP 0.03804 0.40142 3.32103
64 4ZEV M6P 0.0002469 0.40671 3.37838
65 1QH9 LAC 0.00002751 0.54113 3.44828
66 1Q0S SAH 0.02354 0.4065 3.4749
67 4O8A FAD 0.02071 0.41633 3.49462
68 1X87 NAD 0.03538 0.40432 3.49462
69 1SBR VIB 0.005161 0.43001 3.5
70 2CHG ANP 0.02165 0.41229 3.53982
71 2Q46 NAP 0.02728 0.41323 3.55731
72 3E7O 35F 0.01765 0.41912 3.61111
73 4E5N NAD 0.02342 0.41251 3.63636
74 2VT3 ATP 0.005472 0.42455 3.72093
75 3L8G GMB 0.000007055 0.5046 3.74332
76 5E72 SAM 0.01558 0.41446 3.75723
77 3L9W GSH 0.01283 0.42558 3.76344
78 3L9W AMP 0.01416 0.42558 3.76344
79 3U4C NDP 0.02357 0.41375 3.76344
80 4AFK FLC 0.01381 0.40999 3.76344
81 2BP1 NDP 0.03434 0.40161 3.88889
82 4PNE SAH 0.003305 0.45482 3.97351
83 3JYN NDP 0.03283 0.41156 4
84 2Y6Q I7T 0.03045 0.41977 4.0201
85 2Y6Q FAD 0.01839 0.41977 4.0201
86 3VMF GTP 0.02796 0.40945 4.03226
87 3WXM GTP 0.03304 0.40367 4.03226
88 1GR0 NAD 0.03073 0.40651 4.08719
89 3H8V ATP 0.0002663 0.50311 4.10959
90 2V6G NAP 0.003695 0.46324 4.12088
91 2NU8 COA 0.02788 0.40307 4.16667
92 2IHT TPP 0.02733 0.40694 4.18848
93 4ONQ SFG 0.0218 0.4034 4.20168
94 2RBK VN4 0.000005008 0.56938 4.21456
95 2B82 ADN 0.03026 0.40157 4.2654
96 3UCL FAD 0.01103 0.4526 4.30108
97 3UCL NAP 0.01179 0.4526 4.30108
98 3UCL CYH 0.01103 0.4526 4.30108
99 3TKY SAH 0.01452 0.41379 4.61957
100 2F5Z FAD 0.0452 0.40381 4.6875
101 2GLX NDP 0.02046 0.41133 4.81928
102 2A92 NAI 0.03235 0.41423 4.83871
103 3GRU AMP 0.01612 0.40882 4.83871
104 5AYV KPL 0.02316 0.41898 4.85437
105 1TPY SAH 0.02226 0.41045 4.87805
106 3H2B SAH 0.01792 0.4126 4.92611
107 1LSS NAD 0.007991 0.42191 5
108 3CMC NAD 0.0149 0.45668 5.08982
109 3LCC SAH 0.01922 0.40284 5.10638
110 1H6C NDP 0.01728 0.43006 5.10753
111 1V59 FAD 0.04186 0.4083 5.10753
112 3Q9T FAY 0.0379 0.40727 5.10753
113 3TNF GNP 0.01452 0.42071 5.17241
114 2DBZ NAP 0.008773 0.43517 5.38922
115 4J75 TYM 0.03301 0.40557 5.62347
116 1I36 NAP 0.01265 0.4123 5.68182
117 1P18 7HP 0.02009 0.41196 5.88235
118 4EPL JAI 0.002715 0.45292 5.91398
119 1P1C SAH 0.02204 0.40491 6.03015
120 2GAG FOA 0.03029 0.41616 6.06061
121 2GAG FAD 0.03029 0.41616 6.06061
122 3E81 SLB 0.01719 0.40094 6.09756
123 4J36 1HR 0.00796 0.45203 6.1828
124 4J36 FAD 0.009881 0.4353 6.1828
125 1O97 AMP 0.0378 0.42244 6.25
126 5GXU FMN 0.00718 0.42589 6.45161
127 5H56 ADP 0.02246 0.4135 6.66667
128 5H56 TYD 0.02246 0.4135 6.66667
129 3Q3C NAD 0.02123 0.40922 6.68896
130 2VZ0 D64 0.04435 0.42902 6.71642
131 2VZ0 NAP 0.04435 0.42902 6.71642
132 1HFS L04 0.03835 0.40566 6.875
133 2HK9 ATR 0.01918 0.40259 6.90909
134 3FJO FMN 0.004628 0.44242 6.98925
135 4POO SAM 0.01771 0.4156 7
136 4FE3 U5P 0.00002299 0.43519 7.40741
137 2QZZ EMF 0.01675 0.42456 7.54717
138 2QZZ NAP 0.01612 0.42456 7.54717
139 1L7N ALF 0.000004488 0.54569 7.58294
140 1L7N AF3 0.00001771 0.49773 7.58294
141 1L7P SEP 0.00007877 0.45173 7.58294
142 2YN4 39J 0.00002215 0.51591 7.62712
143 2C5L GTP 0.03056 0.40682 7.69231
144 3Q85 GNP 0.02048 0.40137 7.69231
145 5AHO TLA 0.003013 0.41588 7.7381
146 2PT9 2MH 0.005807 0.45507 7.78816
147 2PT9 S4M 0.02259 0.41609 7.78816
148 2WCJ M21 0.02453 0.41083 7.80142
149 3ZQ6 ADP ALF 0.01584 0.4237 8.33333
150 4IF4 BEF 0.0000004267 0.62023 8.65385
151 2B4D COA 0.03708 0.40137 8.77193
152 1YNS HPO 0.003411 0.43514 9.1954
153 5DP2 NAP 0.02757 0.40082 9.35672
154 1N62 FAD 0.04905 0.40431 9.375
155 3A1C ACP 0.01019 0.41842 9.40767
156 2JAR UMP 0.00000007454 0.69644 9.5
157 3OCZ SRA 0.0000002158 0.47568 9.54198
158 4B74 1LH 0.0271 0.40489 9.67742
159 4ZOM 4Q3 0.02749 0.42186 9.77778
160 1V8B NAD 0.013 0.43668 9.94624
161 5W8V 9YP 0.007933 0.43333 10.2326
162 2HMT NAI 0.01579 0.41874 10.4167
163 4II2 ATP 0.001974 0.46228 10.4294
164 4L6C 0BT 0.00000002488 0.73276 10.8911
165 4RDI ATP 0.002357 0.4551 11.1111
166 4ZGS NAD 0.01572 0.41742 11.828
167 1E6E FAD 0.02664 0.40997 12.5
168 5UAO FAD 0.01459 0.43125 12.9032
169 2B8T THM 0.006578 0.44091 13.4529
170 2DJH 3PD UM3 0.008969 0.42399 13.913
171 4NTC FAD 0.03447 0.41015 14.0299
172 2BZG SAH 0.02416 0.4013 14.2241
173 2FKA BEF 0.000004222 0.56999 15.5039
174 3RNM FAD 0.04051 0.40739 15.5172
175 3FGZ BEF 0.000005789 0.55931 15.625
176 2DC1 NAD 0.02695 0.40656 15.678
177 2UZI GTP 0.03396 0.40159 15.7895
178 3KB6 NAD 0.02146 0.40893 17.3653
179 1NRJ GTP 0.02755 0.40564 18.8073
180 3F8K COA 0.02104 0.41962 22.5
181 2QTV GNP 0.03909 0.40134 26.5306
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