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Receptor
PDB id Resolution Class Description Source Keywords
3EF0 2.1 Å EC: 3.1.3.16 THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE II CTD PH SCHIZOSACCHAROMYCES POMBE PHOSPHATASE CTD FCPH BRCT HYDROLASE ALF4 TRANSITION STANALOG COBALT MAGNESIUM MANGANESE METAL-BINDING NUCLEUPROTEIN PHOSPHATASE
Ref.: THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE PHOSPHATASE. MOL.CELL V. 32 478 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALF A:600;
Valid;
none;
submit data
102.975 Al F4 F[Al-...
MG A:1;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3EF0 2.1 Å EC: 3.1.3.16 THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE II CTD PH SCHIZOSACCHAROMYCES POMBE PHOSPHATASE CTD FCPH BRCT HYDROLASE ALF4 TRANSITION STANALOG COBALT MAGNESIUM MANGANESE METAL-BINDING NUCLEUPROTEIN PHOSPHATASE
Ref.: THE STRUCTURE OF FCP1, AN ESSENTIAL RNA POLYMERASE PHOSPHATASE. MOL.CELL V. 32 478 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 3EF0 - ALF Al F4 F[Al-](F)(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALF; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ALF 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3EF0; Ligand: ALF; Similar sites found with APoc: 419
This union binding pocket(no: 1) in the query (biounit: 3ef0.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 2CDC XYS 0.819672
2 2CDC NAP 0.819672
3 2CDC XYP 0.819672
4 2O4C NAD 1.07527
5 4HA6 FAD 1.1811
6 9LDB NAD 1.20482
7 2WPF WPF 1.34409
8 5FG3 GDP 1.34409
9 1T7Q COA 1.34409
10 1T7Q 152 1.34409
11 4KXQ APR 1.42349
12 1CER NAD 1.51057
13 1GTE FAD 1.6129
14 3UOY NAP 1.6129
15 3UOY FAD 1.6129
16 1MKY GDP 1.6129
17 3LAD FAD 1.6129
18 1L7E NAI 1.6129
19 4S3R 7SA 1.6129
20 5OJL TXP 1.67785
21 5YU3 NAD 1.74419
22 5YU3 PRO 1.74419
23 3B20 NAD 1.76991
24 6FDF SAH 1.79641
25 1RHC F42 ACN 1.81818
26 2HJR APR 1.82927
27 1COY FAD 1.88172
28 2NPX NAD 1.88172
29 1MV8 NAD 1.88172
30 4I5I NAD 1.88172
31 5G3U ITW 1.88172
32 5HSA FAS 1.88172
33 4D7E FAD 1.88172
34 4D3F NAP 1.93548
35 4HGD KGT 2.05279
36 3C6K SPD 2.09974
37 3C6K MTA 2.09974
38 4E13 NAD 2.12014
39 2XVF FAD 2.15054
40 2XVE FAD 2.15054
41 1PN0 IPH 2.15054
42 5X62 SAH 2.15054
43 1MUU NAD 2.15054
44 5Y77 FAD 2.15054
45 4PIO SAH 2.16718
46 4MO2 FAD 2.17391
47 1RQL VSO 2.24719
48 2P69 PLP 2.28758
49 2HT6 GDP 2.29885
50 2O07 MTA 2.30263
51 2O07 SPD 2.30263
52 3WGT FAD 2.30548
53 3WGT QSC 2.30548
54 3ZNN FAD 2.30548
55 3ZNN 4WL 2.30548
56 1YJQ NAP 2.31023
57 4L2I FAD 2.31214
58 4L2I NAD 2.31214
59 2FCR FMN 2.31214
60 3N8K D1X 2.32558
61 3ITJ FAD 2.36686
62 2A8X FAD 2.37069
63 4ZCC FAD 2.38095
64 2CDU FAD 2.41935
65 3IHG FAD 2.41935
66 4NMC 2OP 2.41935
67 4NMC FAD 2.41935
68 3WQQ NDP 2.41935
69 3WQQ IB3 2.41935
70 2CDU ADP 2.41935
71 4JDR FAD 2.41935
72 1G7S GDP 2.41935
73 3OJO NAD 2.41935
74 3SSO SAH 2.41935
75 2CVZ NDP 2.42215
76 1WP4 NDP 2.42215
77 1ZQ9 SAM 2.45614
78 1YQD NAP 2.45902
79 1N1G BCP 2.45902
80 3CTY FAD 2.50784
81 3DAG FEG 2.51397
82 1LDN NAD 2.53165
83 5CAE SIN 2.55591
84 5CAE COA 2.55591
85 1RE8 BD2 2.57143
86 2CUL FAD 2.58621
87 4JJF FE9 2.61628
88 5EIN NAP 2.61628
89 1RPN NDP 2.68657
90 5NMX NAP 2.68817
91 5NMX FAD 2.68817
92 2IV2 MGD 2.68817
93 3OND NAD 2.68817
94 3OND ADN 2.68817
95 6EL3 NAP 2.68817
96 3EUT DCR 2.68817
97 2PQB GG9 2.68817
98 2ZKJ ADP 2.68817
99 2XB8 XNW 2.73973
100 1G63 FMN 2.76243
101 6APV 3L4 2.77778
102 1KPH SAH 2.78746
103 1KPG SAH 2.78746
104 2ZFU SAH 2.7907
105 2WK1 SAH 2.83688
106 2VDV SAM 2.84553
107 5DX9 T6P 2.8481
108 1PN4 HDC 2.85714
109 5N9Z CAP 2.8777
110 3VPH NAD 2.90323
111 2OD9 A1R NCA 2.92208
112 2QQF A1R 2.92208
113 1EZ0 NAP 2.94118
114 5VN0 FAD 2.95699
115 5VN0 NAI 2.95699
116 2JHP SAH 2.95699
117 4M52 M52 2.95699
118 1VGR COA 2.95699
119 3GDN FAD 2.95699
120 4M52 FAD 2.95699
121 1FEC FAD 2.95699
122 3AXB FAD 2.95699
123 3AXB PRO 2.95699
124 5GSN FAD 2.95699
125 3WY9 GDP 2.95699
126 3PT9 SAH 2.95699
127 5J7X FAD 2.95699
128 6ECU SAH 2.95699
129 3HQP ATP 2.95699
130 4M73 M72 2.96736
131 4M73 SAH 2.96736
132 1JXZ BCA 2.97398
133 6HOY TSN 2.98013
134 1SZD APR 3.0303
135 3ZG6 APR 3.04054
136 5O74 GDP 3.04569
137 5LD5 NAD 3.07263
138 3BGD PM6 3.07692
139 3BGD SAH 3.07692
140 1TE2 PGA 3.09735
141 5ZI2 NAD 3.18841
142 2Q0L FAD 3.21543
143 1L5Y BEF 3.22581
144 4DMG SAM 3.22581
145 5U5N NAD 3.22581
146 1CT9 GLN 3.22581
147 5A04 NDP 3.24484
148 5A04 BGC 3.24484
149 1XHC FAD 3.26975
150 5T9E NAP 3.32103
151 5Z21 NAI 3.35196
152 4ZEV M6P 3.37838
153 5L3S GNP 3.37838
154 1QH9 LAC 3.44828
155 5WP5 SAH 3.46232
156 1Q0S SAH 3.4749
157 6ECW SAH 3.49206
158 5WS9 AMP 3.49462
159 4O8A FAD 3.49462
160 2ZXI FAD 3.49462
161 1X87 NAD 3.49462
162 1SBR VIB 3.5
163 1FK8 NAD 3.50195
164 2CHG ANP 3.53982
165 2Q46 NAP 3.55731
166 1Z82 NDP 3.58209
167 3E7O 35F 3.61111
168 1HDG NAD 3.61446
169 1WVG APR 3.62117
170 4YRY FAD 3.62319
171 4YRY NAD 3.62319
172 4E5N NAD 3.63636
173 5GM1 SAH 3.7037
174 5OCG GNP 3.7037
175 2VT3 ATP 3.72093
176 3L8G GMB 3.74332
177 5E72 SAM 3.75723
178 4MOP 2H5 3.76344
179 5KMS FAD 3.76344
180 1VQW FAD 3.76344
181 3L9W GSH 3.76344
182 3L9W AMP 3.76344
183 5H81 NAP 3.76344
184 1UWK NAD 3.76344
185 1UWK URO 3.76344
186 4ZA8 4LU 3.76344
187 4ZA8 F5C 3.76344
188 4ZA8 FZZ 3.76344
189 2GVC FAD 3.76344
190 6HH6 A3R 3.76344
191 4QS9 BGC 3.76344
192 1G55 SAH 3.79009
193 3WDM ADN 3.83142
194 3A8T ATP 3.83481
195 3P9C SAH 3.84615
196 2WZM NA7 3.88693
197 5K9B FMN 3.88889
198 2BP1 NDP 3.88889
199 3VYW SAM 3.8961
200 3MB5 SAM 3.92157
201 3CKJ CIT 3.95137
202 4PNE SAH 3.97351
203 5Z75 NAD 3.97554
204 2HF9 GSP 3.9823
205 3JYN NDP 4
206 5N6C NAD 4
207 6EQS BV8 4
208 2Y6Q FAD 4.0201
209 5EOW FAD 4.03226
210 3VMF GTP 4.03226
211 3WXM GTP 4.03226
212 1GR0 NAD 4.08719
213 1W4R TTP 4.10256
214 3H8V ATP 4.10959
215 5TKJ ALA VAL GLY ILE GLY ALA VAL PHE 4.10959
216 2V6G NAP 4.12088
217 3U31 NAD 4.13793
218 2DVZ GLU 4.14013
219 4UME KDO 4.14508
220 2NU8 COA 4.16667
221 2IHT TPP 4.18848
222 5MW4 5JU 4.19162
223 4ONQ SFG 4.20168
224 2RBK VN4 4.21456
225 2I7C AAT 4.24028
226 2B82 ADN 4.2654
227 5UR0 NAD 4.29799
228 3UCL CYH 4.30108
229 3UCL FAD 4.30108
230 1P3D UMA 4.30108
231 5ESO ISC 4.30108
232 5ESO TDP 4.30108
233 2HVW DDN 4.34783
234 3ABI NAD 4.38356
235 5FUW THM 4.3956
236 2FK8 SAM 4.40252
237 6GNC FAD 4.42177
238 2CJF RP4 4.4586
239 1H5Q NAP 4.5283
240 2WOX NDP 4.56989
241 3TKY SAH 4.61957
242 2F5Z FAD 4.6875
243 1OBV FMN 4.73373
244 3OII SAH 4.74308
245 5OCM NAP 4.811
246 2GLX NDP 4.81928
247 1BZL GCG 4.83871
248 2A92 NAI 4.83871
249 3GRU AMP 4.83871
250 4BLW SAH 4.84429
251 4H2D FMN 4.84848
252 5AYV KPL 4.85437
253 1TPY SAH 4.87805
254 5MIT FAD 4.89297
255 5MIT NAP 4.89297
256 3H2B SAH 4.92611
257 4USQ FAD 4.98615
258 1LSS NAD 5
259 1F6B GDP 5.05051
260 5AOV NAP 5.05952
261 5U5G NAP 5.08475
262 3CMC NAD 5.08982
263 2Q1W NAD 5.1051
264 3LCC SAH 5.10638
265 1H6C NDP 5.10753
266 1RYD NDP 5.10753
267 6F97 FAD 5.10753
268 1V59 FAD 5.10753
269 3Q9T FAY 5.10753
270 1J5P NAD 5.13834
271 3TNF GNP 5.17241
272 5EJ2 NAD 5.19481
273 6BR7 BEF 5.26316
274 2IXB A2G 5.37634
275 2IXB NAD 5.37634
276 4ZAC 4LU 5.37634
277 4XQC NAD 5.37634
278 4XQC 13D 5.37634
279 1UZH CAP 5.37634
280 5KOK SAH 5.37634
281 5KOK R9T 5.37634
282 1TDF FAD 5.37975
283 2DBZ NAP 5.38922
284 1Y8Q ATP 5.49133
285 3T6E UQ9 5.49451
286 3T6E MQ9 5.49451
287 3WLE NAD 5.57185
288 4J75 TYM 5.62347
289 1CDO NAD 5.64516
290 1I36 NAP 5.68182
291 4RVU NDP 5.72289
292 3QJ4 FAD 5.84795
293 3B1F NAD 5.86207
294 5JY6 NAD 5.89888
295 4EPL JAI 5.91398
296 3OA2 NAD 5.97484
297 3G89 SAM 6.0241
298 1P1C SAH 6.03015
299 2WC1 FMN 6.04396
300 3E81 SLB 6.09756
301 4J36 1HR 6.1828
302 4J36 FAD 6.1828
303 1DLJ UGA 6.1828
304 1DLJ NAI 6.1828
305 1UP7 NAD 6.1828
306 3EWP APR 6.21469
307 1O97 FAD 6.25
308 1O97 AMP 6.25
309 1O94 AMP 6.25
310 5DF1 58X 6.25
311 5DF1 NAP 6.25
312 1O94 ADP 6.25
313 4CM8 IZ9 6.25
314 4CMI M4V 6.25
315 5L3R GCP 6.31229
316 1S7G NAD 6.32411
317 1Z4O GL1 6.33484
318 1C0I FAD 6.33609
319 1C0I BE2 6.33609
320 5GXU FMN 6.45161
321 5KF6 FAD 6.45161
322 3TWO NDP 6.6092
323 4QTU SAM 6.66667
324 3Q3C NAD 6.68896
325 2VZ0 D64 6.71642
326 2VZ0 NAP 6.71642
327 1BW9 NAD 6.74157
328 2Q7V FAD 6.76923
329 1HFS L04 6.875
330 2HK9 ATR 6.90909
331 3FJO FMN 6.98925
332 2JLD AG1 6.98925
333 4PYW ACE THR THR ALA ILE NH2 6.98925
334 4POO SAM 7
335 4H6Q FAD 7.05128
336 4H6Q TFB 7.05128
337 4YDU ADP 7.173
338 3QV1 NAD 7.31707
339 4RR7 A3S 7.35294
340 1NL5 MAL 7.37705
341 4FE3 U5P 7.40741
342 1HYH NAD 7.44337
343 5VKT NAP 7.45856
344 2QZZ NAP 7.54717
345 2QZZ EMF 7.54717
346 1L7N ALF 7.58294
347 1L7N AF3 7.58294
348 1L7P SEP 7.58294
349 4D79 ATP 7.6087
350 2YN4 39J 7.62712
351 4A6D SAM 7.64873
352 5O4J SAH 7.66423
353 2C5L GTP 7.69231
354 3Q85 GNP 7.69231
355 5AHO TLA 7.7381
356 2PT9 S4M 7.78816
357 2PT9 2MH 7.78816
358 5OC1 FAD 7.7957
359 4Y9J UCC 7.7957
360 2WCJ M21 7.80142
361 4QC6 30N 7.82123
362 5OEC GDP 8.19672
363 3ZQ6 ADP ALF 8.33333
364 4IF4 BEF 8.65385
365 2B4D COA 8.77193
366 1H0H MGD 8.8785
367 1JQ3 AAT 9.12162
368 5ERG SAM 9.13978
369 5A3B APR 9.24092
370 5DP2 NAP 9.35672
371 1N62 FAD 9.375
372 3A1C ACP 9.40767
373 2JAR UMP 9.5
374 3OCZ SRA 9.54198
375 1M2K APR 9.63855
376 4B74 1LH 9.67742
377 1V8B NAD 9.94624
378 5L95 AMP 10
379 2ISJ FMN 10
380 1BZY IMU 10.1382
381 2HMT NAI 10.4167
382 4II2 ATP 10.4294
383 1RJ9 GCP 10.6667
384 6BQ6 TER 10.8761
385 4L6C 0BT 10.8911
386 6ECT SAM 10.9034
387 4RDH AMP 11.1111
388 4RDI ATP 11.1111
389 5JE8 NAD 11.2583
390 3GGO NAI 11.465
391 4ZGS NAD 11.828
392 6F3M NAD 12.0968
393 5XNC MTA 12.1294
394 5YEC ATP 12.3529
395 1E6E FAD 12.5
396 3L4S 3PG 12.7976
397 3L4S NAD 12.7976
398 5UAO FAD 12.9032
399 2B8T THM 13.4529
400 2DJH 3PD UM3 13.913
401 4NTC FAD 14.0299
402 2BZG SAH 14.2241
403 2FKA BEF 15.5039
404 3RNM FAD 15.5172
405 3FGZ BEF 15.625
406 2DC1 NAD 15.678
407 2QQ0 ANP 15.7609
408 2QQ0 THM 15.7609
409 2UZI GTP 15.7895
410 3NJ4 NAD 16.129
411 3KB6 NAD 17.3653
412 5WLB GNP 17.6471
413 1NRJ GTP 18.8073
414 5MGZ SAH 19.9153
415 3F8K COA 22.5
416 2A06 SMA 24.359
417 2QTV GNP 26.5306
418 3B1J NAD 36
419 5YT0 GDP 38.0952
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