Receptor
PDB id Resolution Class Description Source Keywords
2PEH 2.11 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE UHM DOMAIN OF HUMAN SPF45 IN COMPLE SF3B155-ULM5 HOMO SAPIENS RRM UHM PROTEIN BINDING
Ref.: U2AF-HOMOLOGY MOTIF INTERACTIONS ARE REQUIRED FOR ALTERNATIVE SPLICING REGULATION BY SPF45. NAT.STRUCT.MOL.BIOL. V. 14 620 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS ARG LYS SER ARG TRP ASP GLU THR PRO C:333;
D:334;
Valid;
Valid;
none;
none;
Kd = 1.1 uM
1246.37 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2PEH 2.11 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE UHM DOMAIN OF HUMAN SPF45 IN COMPLE SF3B155-ULM5 HOMO SAPIENS RRM UHM PROTEIN BINDING
Ref.: U2AF-HOMOLOGY MOTIF INTERACTIONS ARE REQUIRED FOR ALTERNATIVE SPLICING REGULATION BY SPF45. NAT.STRUCT.MOL.BIOL. V. 14 620 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar ligands found: 137
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 1 1
2 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.608187 0.90411
3 ACE TRP ARG VAL PRO 0.601351 0.861111
4 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.576923 0.75
5 GLU GLN ASP LYS TRP ALA SER 0.576159 0.771429
6 GLU ALA ASP LYS TRP GLN SER 0.555556 0.771429
7 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.55 0.847222
8 GLU ASN ASP LYS TRP ALA SER 0.54902 0.760563
9 GLU LEU ASP NRG TRP ALA SER 0.548781 0.7625
10 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.54023 0.932432
11 GLU LEU ASP LYS TRP ALA SER 0.538961 0.736111
12 ILE SER PRO ARG THR LEU ASP ALA TRP 0.538043 0.958904
13 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.527607 0.777778
14 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.526882 0.909091
15 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.52514 0.90411
16 GLU LEU ASP ORN TRP ALA SER 0.522293 0.722222
17 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.521739 0.915493
18 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.521212 0.847222
19 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.521053 0.897436
20 SER ARG TYR TRP ALA ILE ARG THR ARG 0.520468 0.813333
21 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.518919 0.907895
22 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.518293 0.777778
23 ASP SER LYS ASP VAL LYS GLU TRP TYR VAL ZN 0.51497 0.727273
24 SER ARG ASP HIS SER ARG THR PRO MET 0.514286 0.881579
25 GLU LEU GLU LYS TRP ALA SER 0.512987 0.722222
26 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.512953 0.897436
27 SER PRO LEU ASP SER LEU TRP TRP ILE 0.511905 0.837838
28 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.509091 0.944444
29 GLU LEU ASP LYS TRP ALA ASN 0.506329 0.69863
30 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.503311 0.819444
31 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.5 0.849315
32 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.5 0.833333
33 ARG ARG ARG ARG SER TRP TYR 0.5 0.794521
34 ALA LEU ASP LYS TRP ALA SER 0.5 0.736111
35 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.496815 0.887324
36 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.494845 0.864865
37 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.491429 0.706667
38 ALA SER ASN GLU ASN TRP GLU THR MET 0.487654 0.710526
39 GLU LEU ASP LYS TRP ALA GLY 0.487342 0.671233
40 SER TRP PHE PRO 0.486842 0.816901
41 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.486631 0.783784
42 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.484375 0.906667
43 SER ASN TRP SER HIS PRO GLN PHE GLU LYS 0.483696 0.847222
44 PRO GLN PRO VAL ASP SER TRP VAL 0.483146 0.887324
45 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.482353 0.914286
46 MET HIS PRO ALA GLN THR SER GLN TRP 0.478495 0.855263
47 GLY SER ASP PRO TRP LYS 0.475309 0.857143
48 MET TRP ARG PRO TRP 0.473373 0.776316
49 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.472826 0.863014
50 ASN ASP TRP LEU LEU PRO SER TYR 0.469613 0.842105
51 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.466292 0.942857
52 ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 0.465241 0.893333
53 GLU LEU ASP HOX TRP ALA SER 0.463855 0.68
54 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.461111 0.797297
55 GLU LEU ASP HIS TRP ALA SER 0.461078 0.712329
56 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.460674 0.835616
57 VAL ASP SER LYS ASN THR SER SER TRP 0.460606 0.777778
58 ARG LEU TRP SER 0.460526 0.777778
59 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.460227 0.75
60 LEU PRO PHE GLU ARG ALA THR VAL MET 0.459459 0.842105
61 ALA TRP ARG HIS PRO GLN PHE GLY GLY 0.457895 0.861111
62 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.457831 0.666667
63 ARG PHE PRO LEU THR PHE GLY TRP 0.457447 0.931507
64 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.457317 0.756757
65 PRO SER ILE ASP ARG SER THR LYS PRO 0.457143 0.902778
66 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.456853 0.932432
67 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.455446 0.894737
68 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.454054 0.734177
69 TRP GLU TYR ILE PRO ASN VAL 0.453039 0.779221
70 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.451429 0.684932
71 ARG TYR PRO LEU THR PHE GLY TRP 0.450777 0.906667
72 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.450495 0.907895
73 ARG ARG ARG GLU ARG SER PRO THR ARG 0.448485 0.9
74 ALA PRO ALA TRP LEU PHE GLU ALA 0.446927 0.743243
75 LEU GLU LYS ALA ARG GLY SER THR TYR 0.446328 0.77027
76 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.446328 0.810811
77 LEU PRO PHE GLU ARG ALA THR ILE MET 0.444444 0.831169
78 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.442623 0.842857
79 ASP GLU ASP LYS TRP ASP ASP PHE 0.442308 0.661972
80 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.441718 0.743243
81 ALA LEU ASP LYS TRP ASP 0.441558 0.680556
82 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.441489 0.75641
83 SER SER THR ARG GLY ILE SER GLN LEU TRP 0.440217 0.849315
84 LYS ARG ARG ARG HIS PRO SER GLY 0.43787 0.887324
85 ASP ASN TRP GLN ASN GLY THR SER 0.43787 0.760563
86 FME ASP VAL GLU ALA TRP LEU 0.436782 0.605263
87 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.434286 0.88
88 THR LEU PRO TRP ASP LEU TRP THR THR 0.434286 0.835616
89 ASP TRP GLU ILE VAL 0.433121 0.60274
90 PHE SER ASP PRO TRP GLY GLY 0.431818 0.84507
91 ACE PRO TRP ALA THR CYS ASP SER NH2 0.429379 0.863014
92 SER ASP PTR MET ASN MET THR PRO 0.428571 0.72619
93 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.425641 0.780822
94 GLU PRO GLN ALA PRO TRP MET GLU 0.425414 0.75
95 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.424419 0.72
96 01W ARG TRP THR DAB MET LEU GLY 0.42328 0.696629
97 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.423077 0.723684
98 ASP ASP TRP ASN TRP GLU VAL GLU ASP 0.421384 0.657534
99 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.420765 0.88
100 LYS ARG ARG ARG HIS PRO SER 0.420118 0.84507
101 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.42 0.866667
102 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.419355 0.746667
103 GLN GLU GLU TRP SEP THR VAL MET 0.417143 0.658537
104 LEU PRO PHE ASP ARG THR THR ILE MET 0.417112 0.844156
105 LYS PRO VAL LEU ARG THR ALA 0.416667 0.847222
106 PLM GLN THR ALA ARG LYS SER THR GLY GLY TRP 0.416667 0.851351
107 LYS GLN GLU PRO GLN GLU ILE ASP PHE 0.416667 0.736111
108 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.416667 0.876712
109 GLN THR ALA ARG MYK SER THR GLY GLY TRP 0.416667 0.851351
110 TYR PRO LYS ARG ILE ALA 0.416185 0.824324
111 MET ASP TRP ASN MET HIS ALA ALA 0.416185 0.671053
112 MET TYR TRP TYR PRO TYR 0.416185 0.705128
113 PHE PRO THR LYS ASP VAL ALA LEU 0.414773 0.791667
114 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.413793 0.821918
115 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.413043 0.657895
116 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.412791 0.68
117 ILE ASP TRP PHE GLU GLY LYS GLU 0.412429 0.69863
118 ILE ASP TRP PHE ASP GLY LYS GLU 0.412429 0.69863
119 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.411765 0.732394
120 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.411168 0.864865
121 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.409357 0.777778
122 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 0.407609 0.756757
123 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.407216 0.917808
124 LYS GLN TRP ASP ASN TYR GLU PTR ILE TRP 0.407216 0.646341
125 SER SER ILE GLU PHE ALA ARG LEU 0.406977 0.712329
126 SER PRO LYS ARG ILE ALA 0.406061 0.833333
127 SER GLU ILE GLU PHE ALA ARG LEU 0.405882 0.69863
128 LEU PRO PHE ASP LYS SER THR ILE MET 0.405263 0.766234
129 ACE ASN TRP GLU THR PHE 0.403509 0.684932
130 LEU PRO PHE GLU LYS SER THR VAL MET 0.403226 0.776316
131 LYS TRP LYS 0.402778 0.642857
132 LYS ILE LEU HIS ARG LEU LEU GLN ASP SER 0.402174 0.77027
133 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.402174 0.805556
134 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.402116 0.766234
135 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.40201 0.759036
136 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.401042 0.864865
137 ARG PRO LYS ARG ILE ALA 0.4 0.791667
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2PEH; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar sites found: 141
This union binding pocket(no: 1) in the query (biounit: 2peh.bio3) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2I0D MUT 0.005842 0.4664 None
2 5LGA 6VH 0.00278 0.46039 None
3 5DRB 5FJ 0.006119 0.4521 None
4 5BYZ 4WE 0.008045 0.43192 None
5 3VRV YSD 0.01685 0.4314 None
6 3WYJ H78 0.02831 0.42891 None
7 2P3B 3TL 0.01384 0.42779 None
8 3EKK GS2 0.01292 0.42727 None
9 2P3C 3TL 0.01794 0.42194 None
10 3TGE TGE 0.03113 0.42083 None
11 3V49 PK0 0.01006 0.42012 None
12 1XCL SAH 0.01732 0.4174 None
13 1ZUI SKM 0.02202 0.41424 None
14 2VWA PTY 0.01047 0.41315 None
15 5DJU FMN 0.01044 0.41277 None
16 2AX9 BHM 0.03072 0.41161 None
17 1QJC PNS 0.02806 0.40879 None
18 2FKW RG1 0.01939 0.40871 None
19 4LSJ LSJ 0.01377 0.40863 None
20 4IEH 1E9 0.01831 0.40569 None
21 3PE2 E1B 0.04854 0.40444 None
22 1N8V BDD 0.032 0.40369 None
23 3MBG FAD 0.02339 0.40326 None
24 3EEL 53T 0.04659 0.40291 None
25 1M2Z DEX 0.01757 0.40176 None
26 2QZT PLM 0.02859 0.40149 None
27 4NJS G08 0.03377 0.40137 None
28 5TO8 7FM 0.01882 0.42085 2.85714
29 2Q1H AS4 0.008954 0.41419 2.85714
30 5IH9 6BF 0.02363 0.41265 2.85714
31 5FVJ ACO 0.01791 0.41045 2.85714
32 1ZPT FAD 0.03762 0.40605 2.85714
33 5EYK 5U5 0.02621 0.40212 2.85714
34 1G8S MET 0.01603 0.40074 2.85714
35 4BNU 9KQ 0.008457 0.42068 3.80952
36 5IF4 6AK 0.01521 0.41536 3.80952
37 1GHE ACO 0.01428 0.41104 3.80952
38 2ZCQ B65 0.03544 0.41093 3.80952
39 1QRP HH0 0.01943 0.40731 3.80952
40 1T27 PCW 0.0164 0.42776 4.7619
41 1OW4 2AN 0.004297 0.42087 4.7619
42 2E3N 6CM 0.01551 0.41985 4.7619
43 4NKW PLO 0.007733 0.41727 4.7619
44 1U3D FAD 0.01593 0.41434 4.7619
45 4RLT FSE 0.00837 0.40723 4.7619
46 2Q0D ATP 0.02512 0.4068 4.7619
47 4HIA FMN 0.03072 0.40675 4.7619
48 4P6X HCY 0.0143 0.40612 4.7619
49 4ZW3 4S9 0.04129 0.40006 4.7619
50 4YEF 4CQ 0.03556 0.40022 5.61798
51 2A3I C0R 0.002185 0.44768 5.71429
52 2PX6 DH9 0.00183 0.44314 5.71429
53 5CSD ACD 0.007966 0.43808 5.71429
54 5L7G 6QE 0.004806 0.43273 5.71429
55 1NP7 FAD 0.007315 0.4327 5.71429
56 2YJD YJD 0.004926 0.42263 5.71429
57 5B4B LP5 0.01213 0.42161 5.71429
58 2I0G I0G 0.03268 0.41753 5.71429
59 2AMV BIN 0.03567 0.41621 5.71429
60 4L6H MTX 0.02082 0.40973 5.71429
61 4GCZ FMN 0.01246 0.40724 5.71429
62 5HCV 60R 0.01454 0.40577 5.71429
63 5LJ0 6XX 0.02408 0.40123 5.71429
64 3C6K MTA 0.04294 0.40115 5.71429
65 3C6K SPD 0.04294 0.40115 5.71429
66 5B0W 22B 0.004068 0.44821 6.66667
67 3H0A D30 0.008495 0.42669 6.66667
68 4J6C STR 0.002237 0.42342 6.66667
69 3FUR Z12 0.02987 0.41654 6.66667
70 5C03 AGS 0.009023 0.41211 6.66667
71 2HFP NSI 0.01663 0.40777 6.66667
72 5IR4 ZPE 0.04794 0.4031 6.66667
73 3LN0 52B 0.04739 0.40164 6.66667
74 4XRZ SI6 0.01934 0.40139 6.66667
75 2P1C GG3 0.03094 0.40098 6.66667
76 5HGR 45D 0.01032 0.43005 7.61905
77 1P1M MET 0.007473 0.42332 7.61905
78 4GBD MCF 0.007029 0.42292 7.61905
79 2EVL GAL SPH EIC 0.03722 0.41592 7.61905
80 3QWI CUE 0.03 0.41392 7.61905
81 1K3A ACP 0.006564 0.41221 7.61905
82 5UR1 YY9 0.0497 0.40141 7.61905
83 3S7O LBV 0.034 0.40122 7.61905
84 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 0.03302 0.41501 8
85 5C0C ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.04186 0.40869 8
86 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 0.0388 0.40534 8
87 5LXT 7AK 0.04764 0.42551 8.57143
88 1EYQ NAR 0.002553 0.42434 8.57143
89 4RQL SNE 0.002593 0.42242 8.57143
90 5FBN 5WF 0.02052 0.41473 8.57143
91 3V66 D3A 0.02933 0.41266 8.57143
92 3QFJ LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.03656 0.41021 8.57143
93 1XON PIL 0.02105 0.40823 8.57143
94 1UOU CMU 0.009235 0.40747 8.57143
95 5A8E XTK 0.01717 0.40709 8.57143
96 3JSZ UPG 0.01486 0.40701 8.57143
97 3R1V AZB 0.02 0.40526 8.57143
98 5BVE 4VG 0.01792 0.43726 9.52381
99 4RC8 STE 0.005731 0.42899 9.52381
100 1J78 OLA 0.001991 0.42146 9.52381
101 4RHP PEF 0.005905 0.41888 9.52381
102 5T67 JHZ 0.04195 0.40942 9.52381
103 5T67 SAH 0.04008 0.40639 9.52381
104 3SVJ 4LI 0.0158 0.4057 9.52381
105 3GWT 066 0.02955 0.40436 9.52381
106 2HQM FAD 0.04762 0.40408 9.52381
107 3ZJX BOG 0.01554 0.40366 9.52381
108 4COL DTP 0.01464 0.40002 9.52381
109 1XVB BHL 0.04389 0.40251 10.4762
110 5K7K 6RJ 0.007411 0.42821 11.4286
111 2C78 PUL 0.02431 0.42805 11.4286
112 4PJT 2YQ 0.01409 0.4208 11.4286
113 1EWF PC1 0.04731 0.40168 11.4286
114 3E8T UQ8 0.004149 0.46867 12.381
115 2OBD PCW 0.005227 0.44139 12.381
116 2FDW D3G 0.002007 0.42737 12.381
117 2OBD 2OB 0.01873 0.41893 12.381
118 3KXC PLM 0.01589 0.41024 12.381
119 5U98 1KX 0.0373 0.41922 13.3333
120 1J0D 5PA 0.02108 0.40553 13.3333
121 4PYW ACE THR THR ALA ILE NH2 0.001702 0.45662 14.2857
122 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.01164 0.42961 14.2857
123 5K53 STE 0.007465 0.41987 14.2857
124 4WVO 3UZ 0.02012 0.40791 14.2857
125 2VBA P4T 0.02332 0.40193 14.2857
126 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 0.02133 0.41161 15.2381
127 4GU5 FAD 0.003147 0.44972 16.1905
128 4ZOM 4Q3 0.03956 0.42476 16.1905
129 5IXK 6EW 0.01502 0.41939 16.1905
130 5NTW 98N 0.02559 0.40639 16.1905
131 3B9Z CO2 0.01974 0.41966 20
132 3GN8 DEX 0.01215 0.40957 21.9048
133 4DR9 BB2 0.009874 0.40821 22.8571
134 1SR7 MOF 0.0327 0.40209 22.8571
135 1EZV SMA 0.02144 0.40651 24.7619
136 4G31 0WH 0.0174 0.41729 25.7143
137 5I96 69Q 0.02135 0.40918 25.7143
138 5TA6 79D 0.02107 0.40689 25.7143
139 3Q8G PEE 0.02128 0.42977 33.3333
140 5K52 OCD 0.008778 0.41821 33.3333
141 3MDV CL6 0.007948 0.43468 37.1429
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