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Receptor
PDB id Resolution Class Description Source Keywords
1LOX 2.4 Å EC: 1.13.11.33 RABBIT RETICULOCYTE 15-LIPOXYGENASE ORYCTOLAGUS CUNICULUS OXIDOREDUCTASE 15LO_DEPOT2
Ref.: THE STRUCTURE OF MAMMALIAN 15-LIPOXYGENASE REVEALS SIMILARITY TO THE LIPASES AND THE DETERMINANTS OF S SPECIFICITY. NAT.STRUCT.BIOL. V. 4 1003 1997
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FE2 A:840;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
RS7 A:841;
Valid;
none;
Ki = 3 uM
256.339 C17 H20 O2 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LOX 2.4 Å EC: 1.13.11.33 RABBIT RETICULOCYTE 15-LIPOXYGENASE ORYCTOLAGUS CUNICULUS OXIDOREDUCTASE 15LO_DEPOT2
Ref.: THE STRUCTURE OF MAMMALIAN 15-LIPOXYGENASE REVEALS SIMILARITY TO THE LIPASES AND THE DETERMINANTS OF S SPECIFICITY. NAT.STRUCT.BIOL. V. 4 1003 1997
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
2 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
2 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
3 3RDE - OYP C23 H34 O3 CCCCCCCCCC....
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3FG4 - ACD C20 H32 O2 CCCCCC=C/C....
2 4QWT - ACD C20 H32 O2 CCCCCC=C/C....
3 2P0M - RS7 C17 H20 O2 CCCCCCC#Cc....
4 1LOX Ki = 3 uM RS7 C17 H20 O2 CCCCCCC#Cc....
5 3RDE - OYP C23 H34 O3 CCCCCCCCCC....
6 3V99 - ACD C20 H32 O2 CCCCCC=C/C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: RS7; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 RS7 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LOX; Ligand: RS7; Similar sites found with APoc: 132
This union binding pocket(no: 1) in the query (biounit: 1lox.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 2AIB ERG None
3 4ZBR DIF 0.857633
4 4ZBR NPS 0.857633
5 3HYW DCQ 1.16279
6 6BMS PLM 1.46628
7 2R0N TGC 1.52284
8 4NWJ 3PG 1.55945
9 2YIV YIV 1.82927
10 2Z9I GLY ALA THR VAL 1.85185
11 3EE4 MYR 1.85759
12 4UIB GWX 1.9544
13 2W92 NGT 1.99081
14 1RJW ETF 2.0649
15 6F1J EDG 2.15385
16 3VRV YSD 2.21402
17 3B9Z CO2 2.31959
18 6CB2 OLC 2.38908
19 1XRO LEU 2.38908
20 1I0B PEL 2.40964
21 4OB6 S2T 2.6393
22 5UR6 8KM 2.76243
23 3WYJ H78 2.7668
24 2C6Q NDP 2.849
25 4IA6 EIC 2.87648
26 5AZC PGT 3
27 2QCX PF1 3.04183
28 6BMM OLB 3.07167
29 3T58 FAD 3.08285
30 4X8D AVI 3.13199
31 6BR8 PGV 3.1746
32 5AAV GW5 3.1746
33 2Q0L FAD 3.21543
34 2QE4 JJ3 3.22581
35 3IS2 FAD 3.24675
36 5IUY BOG 3.31126
37 2X32 OTP 3.35196
38 3D72 FAD 3.3557
39 3IPQ 965 3.53357
40 3SQP 3J8 3.55649
41 5OSW DIU 3.77358
42 3PVT 3HC 3.85852
43 2X34 UQ8 3.8674
44 4EHU ANP 3.98551
45 5C1M OLC 4
46 6G5Q EMZ 4.01003
47 6CAY ERG 4.14201
48 4JGP PYR 4.14747
49 4V3I ASP LEU THR ARG PRO 4.28016
50 6GG9 FMN 4.32099
51 5B0I BOG 4.37318
52 5CHR 4NC 4.37956
53 5N26 CPT 4.3956
54 4YMU ARG 4.58333
55 4DXD 9PC 4.68278
56 1E1M NAP 4.78261
57 1E1M FAD 4.78261
58 1W2D 4IP 4.90566
59 1W2D ADP 4.90566
60 5LXB 7A9 4.95868
61 4R38 RBF 5
62 1K7L 544 5.20833
63 2O4C NAD 5.26316
64 4G8R 96P 5.31915
65 5U75 SIA GAL NDG FUC 5.35714
66 3EWC MCF 5.39084
67 5J5R 6G1 5.39846
68 5J5R IMP 5.39846
69 3KDU NKS 5.41516
70 3W54 RNB 5.47112
71 3P9T TCL 5.47945
72 4Q0A 4OA 5.62914
73 4RC8 STE 5.85586
74 4I9B 1KA 5.99613
75 6GH1 ARG LEU PRO ALA LYS ALA PRO LEU LEU 6
76 1KQR MNA 6.14525
77 4JX1 CAM 6.19469
78 1DTL BEP 6.21118
79 4M51 BEZ 6.32318
80 5C9J DAO 6.40569
81 5X20 AOT 6.41026
82 1VR0 3SL 6.47773
83 2ALG DAO 6.52174
84 5NI5 8YB 6.59722
85 1X8D RNS 6.73077
86 2V95 HCY 7.00809
87 6ESN BWE 7.11611
88 2C43 COA 7.12074
89 5APK 76E 7.16981
90 5SVV FMN 7.29927
91 5NTW 98N 7.393
92 1L0I PSR 7.69231
93 4N2R AHR 8.08383
94 3OKI OKI 8.15451
95 5EXA 5SO 8.26087
96 4WGF HX2 8.29268
97 5K53 STE 8.39695
98 3KP6 SAL 8.60927
99 5CSD ACD 8.80503
100 1XVB BHL 8.82353
101 1HBK COA 8.98876
102 1KJM ALA GLN PHE SER ALA SER ALA SER ARG 9
103 5LX9 OLB 9.50704
104 3VVY ET 9.79381
105 2AQX ATP 10.7266
106 5KAX RHQ 10.8434
107 5EK3 5PK 10.9181
108 1E6E FAD 11.7188
109 2GTE VA 12.0968
110 4EXO PYR 12.3288
111 5X80 SAL 12.5
112 2YAJ 4HP 12.7907
113 2GBB CIT 12.8205
114 5K52 OCD 12.8302
115 5BV6 35G 13.1579
116 5N5U AMP 13.3758
117 5N5U 7N8 13.3758
118 1XX4 BAM 13.7931
119 5TDU PCR 15.4762
120 1S9D AFB 15.8537
121 1ZDU P3A 16.3265
122 2YLD CMO 16.5354
123 2Z6C FMN 17.8295
124 3RUG DB6 20.202
125 3G08 FEE 20.202
126 1ZEI CRS 20.7547
127 5LWY OLB 25.2336
128 4RJD TFP 25.7576
129 5MWE TCE 27.1429
130 5X8Q 82R 27.2727
131 5Z84 CHD 28.2609
132 1JNQ EGT 34.8943
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