Receptor
PDB id Resolution Class Description Source Keywords
2G30 1.6 Å NON-ENZYME: OTHER BETA APPENDAGE OF AP2 COMPLEXED WITH ARH PEPTIDE HOMO SAPIENS ALPHA-HELICAL ARH PEPTIDE PLATFORM DOMAIN SANDWICH DOMAINENDOCYTOSIS ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MOLECULAR SWITCHES INVOLVING THE AP-2 BETA2 APPENDAGE REGULATE ENDOCYTIC CARGO SELECTION AND CLATHRIN COAT ASSEMBLY DEV.CELL V. 10 329 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA ALA PHE S:6;
Valid;
none;
submit data
292.359 n/a O=C(N...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2G30 1.6 Å NON-ENZYME: OTHER BETA APPENDAGE OF AP2 COMPLEXED WITH ARH PEPTIDE HOMO SAPIENS ALPHA-HELICAL ARH PEPTIDE PLATFORM DOMAIN SANDWICH DOMAINENDOCYTOSIS ADAPTOR ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: MOLECULAR SWITCHES INVOLVING THE AP-2 BETA2 APPENDAGE REGULATE ENDOCYTIC CARGO SELECTION AND CLATHRIN COAT ASSEMBLY DEV.CELL V. 10 329 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1579 families.
1 2G30 - ALA ALA PHE n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1312 families.
1 2G30 - ALA ALA PHE n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1130 families.
1 2G30 - ALA ALA PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ALA ALA PHE; Similar ligands found: 24
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA ALA PHE 1 1
2 LYS LEU LEU PHE 0.513514 0.725
3 ASP PHE THR CYS SER GLN ILE SER PRO 0.507937 0.657143
4 PHE ALA 0.483333 0.84375
5 ALA VAL GLY ILE GLY ALA VAL PHE LEU 0.482759 0.725
6 ALA PHE THR 0.470588 0.828571
7 ALA PHE 0.459016 0.870968
8 NMM ILE PHE SER 0.45679 0.617021
9 ARG GLN ALA ASN PHE LEU GLY LYS ILE ASN 0.453488 0.690476
10 ALA PHE THR SER 0.453333 0.725
11 ASP SER GLY PHE SER PHE GLY SER LYS 0.452055 0.613636
12 PHE ALA GLN 0.444444 0.8
13 THR GLU ASP ASN ASP ASP ASP LEU TYR GLY 0.432836 0.736842
14 LEU SER PRO ASP SER PHE LEU ASN ASP 0.432432 0.707317
15 ALA ALA ALA ALA ALA 0.421053 0.766667
16 ALA ALA ALA ALA 0.421053 0.766667
17 ARG GLN ALA ASN PHE LEU GLY LYS 0.419355 0.644444
18 TRP LEU PHE VAL GLN ARG ASP SER LYS GLU 0.418605 0.674419
19 ALA VAL GLY ILE GLY ALA VAL PHE 0.417582 0.7
20 VAL ALA PHE ARG SER 0.417582 0.604167
21 LYS PHE LYS 0.407895 0.710526
22 ARG GLN VAL ASN PHE LEU GLY LYS ILE ASN 0.404255 0.690476
23 ALA ALA ALA 0.4 0.71875
24 SER PHE ALA ASN GLY 0.4 0.622222
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2G30; Ligand: ALA ALA PHE; Similar sites found with APoc: 2
This union binding pocket(no: 1) in the query (biounit: 2g30.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 6HMR GE5 8.91473
2 6HMR GE5 8.91473
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