Receptor
PDB id Resolution Class Description Source Keywords
6YPS 1.35 Å EC: 2.7.1.37 CRYSTAL STRUCTURE OF THE CAMP-DEPENDENT PROTEIN KINASE A IN WITH 4-HYDROXYBENZAMIDINE CRICETULUS GRISEUS PHOSPHOTRANSFERASE SIGNALLING PATHWAYS GLYCOGEN METABOLISMSERINE/THREONINE KINASE TRANSFERASE
Ref.: FRAGMENT BINDING TO KINASE HINGE: IF CHARGE DISTRIB LOCAL PK A SHIFTS MISLEAD POPULAR BIOISOSTERISM CON ANGEW.CHEM.INT.ED.ENGL. V. 60 252 2021
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
P72 A:402;
Valid;
none;
submit data
136.151 C7 H8 N2 O [H]/N...
DMS A:401;
Invalid;
none;
submit data
78.133 C2 H6 O S CS(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5IZF 2.1 Å EC: 2.7.1.37 COMPLEX OF PKA WITH THE BISUBSTRATE PROTEIN KINASE INHIBITOR HOMO SAPIENS PROTEIN KINASE INHIBITOR BISUBSTRATE OLIGOARGININE PKA TRANSFERASE
Ref.: BIFUNCTIONAL LIGANDS FOR INHIBITION OF TIGHT-BINDIN PROTEIN-PROTEIN INTERACTIONS. BIOCONJUG.CHEM. V. 27 1900 2016
Members (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 18 families.
1 1REK Ki = 200 nM B8L C32 H36 N2 O7 CC[C@H](C)....
2 6SOX - LQ2 C8 H7 N O3 c1cc(ccc1C....
3 3BWJ Kd = 0.319 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
4 6SPS - LR5 C8 H6 F3 N O c1cc(ccc1C....
5 6SPM - 3AE C8 H5 F3 O2 c1cc(ccc1C....
6 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
7 6SNX - UNU C7 H7 N O c1ccc(cc1)....
8 6ZN0 - NTN C6 H7 N3 c1cnccc1C(....
9 6SNN - BEZ C7 H6 O2 c1ccc(cc1)....
10 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
11 1SZM ic50 = 2.94 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
12 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
13 6SPY - LR8 C10 H13 N3 O2 c1cc(ncc1C....
14 6Z08 - NPO C6 H5 N O3 c1cc(ccc1[....
15 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
16 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
17 5IZF Kd = 0.18 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
18 6YPS - P72 C7 H8 N2 O [H]/N=C(c1....
19 6Z44 - IPH C6 H6 O c1ccc(cc1)....
20 6SPU - GAB C7 H7 N O2 c1cc(cc(c1....
70% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 1REK Ki = 200 nM B8L C32 H36 N2 O7 CC[C@H](C)....
2 6SOX - LQ2 C8 H7 N O3 c1cc(ccc1C....
3 3BWJ Kd = 0.319 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
4 6SPS - LR5 C8 H6 F3 N O c1cc(ccc1C....
5 6SPM - 3AE C8 H5 F3 O2 c1cc(ccc1C....
6 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
7 6SNX - UNU C7 H7 N O c1ccc(cc1)....
8 6ZN0 - NTN C6 H7 N3 c1cnccc1C(....
9 6SNN - BEZ C7 H6 O2 c1ccc(cc1)....
10 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
11 1SZM ic50 = 2.94 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
12 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
13 6SPY - LR8 C10 H13 N3 O2 c1cc(ncc1C....
14 6Z08 - NPO C6 H5 N O3 c1cc(ccc1[....
15 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
16 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
17 5IZF Kd = 0.18 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
18 6YPS - P72 C7 H8 N2 O [H]/N=C(c1....
19 6Z44 - IPH C6 H6 O c1ccc(cc1)....
20 6SPU - GAB C7 H7 N O2 c1cc(cc(c1....
50% Homology Family (663)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 6NG0 Ki = 10 nM B49 C22 H27 F N4 O2 CCN(CC)CCN....
5 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
6 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
7 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
8 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
9 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
10 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
11 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
12 5OQ7 Ki = 0.322 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
13 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
14 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
15 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
16 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
17 5OP5 Ki = 0.216 uM 3FE C17 H15 N5 O c1cc(cc(c1....
18 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
19 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
20 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
21 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
22 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
23 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
24 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
25 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
26 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
27 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
28 5OPR Ki = 2.56 uM A3E C21 H26 N6 O CC(C)n1cc(....
29 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
30 5OQ5 Ki = 0.02 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
31 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
32 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
33 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
34 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
35 5OQ8 Ki = 1.41 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
36 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
37 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
38 5OPS Ki = 0.863 uM A3Q C14 H9 N3 O c1cc(cc(c1....
39 3JVS Kd = 0.29 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
40 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
41 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
42 2C3L Ki = 8.58 uM IDZ C14 H10 N4 c1ccc2c(c1....
43 5OP2 Ki = 0.24 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
44 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
45 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
46 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
47 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
48 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
49 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
50 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
51 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
52 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
53 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
54 5R98 - SQG C10 H7 F3 N2 O2 c1cc(ccc1N....
55 5RA8 - 2O6 C8 H5 F3 N2 O c1cc2c(cc1....
56 5R9J - LXS C15 H16 N2 O4 CCN1C(=O)C....
57 4EH2 - IRG C17 H16 N4 c1ccc(cc1)....
58 3HA8 - 5JZ C36 H38 N8 O5 CCOc1nc(nc....
59 6Y7W Kd = 57.8 uM OFW C26 H35 N5 O6 S C[C@@]1(CN....
60 3HEG Kd = 0.18 uM BAX C21 H16 Cl F3 N4 O3 CNC(=O)c1c....
61 2ZAZ Ki = 0.4 uM GK1 C20 H15 N3 O2 S Cc1ccc(cc1....
62 5R9R - K3D C9 H17 N3 O2 CCNC(=O)N1....
63 3HP5 - I46 C14 H9 F2 N3 c1cc(ccc1c....
64 5ML5 ic50 = 10 nM 1VI C26 H25 F N4 O3 S COc1ccc(c(....
65 5R93 - SOJ C12 H12 N2 c1ccc(cc1)....
66 4DLI Kd = 2.4 uM IRG C17 H16 N4 c1ccc(cc1)....
67 3P78 ic50 = 0.11 uM P78 C24 H27 N3 O4 S2 CC(C)(C)c1....
68 5R9Y - SU7 C15 H18 N2 O c1ccc(cc1)....
69 4EH9 - IRG C17 H16 N4 c1ccc(cc1)....
70 1YWR ic50 = 32 nM LI9 C27 H29 F N6 O C[C@@H](c1....
71 3IW5 Kd = 0.839 uM DF3 C28 H24 F3 N3 O4 S c1ccc2c(c1....
72 5R9C - 7ZC C12 H16 N2 O CN(C)Cc1c[....
73 3HV3 ic50 = 900 nM R49 C30 H31 N7 O Cc1cccc(c1....
74 6HWV ic50 = 115 nM GEW C32 H28 F2 N6 O3 Cn1c(c(nc1....
75 5R8U - SLS C10 H11 N O2 c1cc2c(cc1....
76 4A9Y - AQZ C32 H37 N7 O4 Cc1ccc(cc1....
77 5R9Q - LVD C8 H10 N2 O2 c1ccc(cc1)....
78 3GCU - R48 C29 H30 N8 O Cc1ccc(cc1....
79 1OUY ic50 = 4.3 nM 094 C24 H18 Cl2 F2 N4 O S c1cc(c(c(c....
80 5R9L - SRJ C18 H25 N O2 c1ccc(cc1)....
81 3D7Z Ki = 12 nM GK5 C22 H24 N2 O2 Cc1ccc(cc1....
82 2YIS - YIS C35 H34 Cl N7 O3 S2 CC(C)(C)c1....
83 1OUK ic50 = 0.13 nM 084 C28 H29 F3 N6 C[C@@H](c1....
84 6YCW - OL8 C15 H10 N2 O4 c1cc(cc(c1....
85 3BV2 ic50 = 0.44 nM P38 C33 H32 N8 O3 Cc1ccc(cc1....
86 4R3C - GG5 C14 H10 F N3 c1cc(ccc1c....
87 4L8M ic50 = 0.001 uM F46 C33 H30 F N3 O5 c1ccc(cc1)....
88 4E6A - 0O9 C32 H65 O10 P CCCCCCCCCC....
89 1WBN ic50 = 0.35 uM L09 C20 H22 Cl N5 O2 CC(C)(C)c1....
90 6ZWR ic50 = 21.7 nM OEB C34 H39 N7 O3 c1ccc(cc1)....
91 2QD9 ic50 = 13 nM LGF C27 H24 F2 N6 O5 COc1c(cc2c....
92 3HUC Kd = 1030 nM G97 C20 H16 N6 O C=CC(=O)Nc....
93 3HL7 Ki = 0.023 uM I47 C20 H20 Cl N5 O2 c1cc(ccc1c....
94 4EHV - IRG C17 H16 N4 c1ccc(cc1)....
95 5R95 - SQ4 C10 H8 N2 O2 c1cc(ccc1N....
96 2GTN ic50 = 4 nM LIE C20 H16 F3 N5 O CC(C)n1c2c....
97 3HRB ic50 = 21 nM I39 C19 H14 F2 N2 O2 Cc1ccccc1c....
98 3BX5 ic50 = 3.5 nM 304 C17 H22 N4 O2 S CC[C@@H](C....
99 5R9V - SSY C10 H8 F3 N O2 CC(=O)c1cc....
100 3HVC ic50 = 600 nM GG5 C14 H10 F N3 c1cc(ccc1c....
101 2GFS ic50 = 0.7 uM PQB C19 H18 F N3 O4 c1cc(cc(c1....
102 5N63 - 8OW C21 H17 F N4 c1ccc(cc1)....
103 2NPQ Kd = 3.08 uM BOG C14 H28 O6 CCCCCCCCO[....
104 3IW6 Kd = 3.29 uM PP0 C23 H31 N3 O3 CCn1c(c(c(....
105 3S4Q ic50 = 4 nM NK0 C25 H23 N5 O2 Cc1ccc(cc1....
106 2BAJ Kd = 4 nM 1PP C20 H20 Cl2 N4 O CC(C)(C)c1....
107 3ROC - 29B C14 H10 F N3 c1cc(ccc1c....
108 5RA7 - SW7 C8 H9 N O Cc1ccc(cc1....
109 5R8Z - SN4 C7 H8 N2 O S COc1ccc(cn....
110 5R9D - N9J C8 H9 N O3 c1ccc(cc1)....
111 5R9P - SFY C11 H11 N3 O2 S c1ccnc(c1)....
112 3NWW ic50 = 7 nM 3NW C24 H34 N8 O S CCNC(=O)NC....
113 1W83 ic50 = 0.065 uM L11 C23 H25 Cl F N3 O3 c1cc(cnc1)....
114 3ZSH - 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
115 3IPH Ki = 0.0000251 mM G11 C21 H23 N3 O2 Cc1ccc(cc1....
116 5MZ3 ic50 = 0.0002 uM 8EN C24 H19 F3 N4 O2 Cc1ccc(cc1....
117 5R9W - STV C10 H13 N O4 S CCS(=O)(=O....
118 3P7B ic50 = 0.018 uM P7B C25 H28 N4 O3 S CC(C)(C)c1....
119 5RA1 - PO6 C8 H9 N O2 c1ccc(cc1)....
120 3GCQ Kd = 342 nM 1BU C29 H30 N8 O Cc1cccc(c1....
121 5RA5 - SVJ C8 H16 N2 CN1[C@@H]2....
122 5R9E - S7S C7 H13 N5 O CCCC(=O)Nc....
123 4F9Y Ki = 184 nM LM3 C21 H18 N4 CN(C)c1cc(....
124 5R92 - SO7 C14 H18 N2 O4 CN(C(=O)[C....
125 2BAL Kd = 490 nM PQA C21 H21 F N4 O2 c1cc(cc(c1....
126 3HUB Kd = 8.2 nM 469 C27 H30 Cl F N4 O3 C[C@@H]1C[....
127 4F9W Ki = 114 nM LM4 C21 H18 N4 CN(C)c1cc(....
128 3P5K ic50 = 0.076 uM P5K C24 H27 N3 O4 S2 CC(C)(C)c1....
129 2I0H ic50 = 9 nM 222 C27 H19 Cl2 F N4 O3 c1ccc2c(c1....
130 5R9F - SQP C13 H11 N O2 c1ccc(c(c1....
131 1ZYJ ic50 = 1.5 uM BI5 C19 H16 N2 O2 c1ccc(cc1)....
132 6Y7X - OFQ C11 H19 N O C1C2CC3CC1....
133 3K3I - JZJ C18 H16 Br N3 c1ccc2c(c1....
134 1WBT ic50 = 0.34 uM WBT C26 H25 F N4 O2 c1cc(cc2c1....
135 1BMK - SB5 C17 H16 F N5 c1cc(ccc1c....
136 3E92 Ki = 10 nM G6A C21 H21 N3 O2 Cc1ccc(cc1....
137 3P7A ic50 = 0.52 uM P7A C23 H27 N3 O3 S2 CC(C)(C)c1....
138 6ANL ic50 = 240 nM T75 C24 H21 N3 O S CCc1nc(c(s....
139 3NNX ic50 = 11 nM EDD C22 H23 Cl2 N5 O2 CC(C)(C)C1....
140 4EH4 - IRG C17 H16 N4 c1ccc(cc1)....
141 1KV1 Kd = 1.16 uM BMU C15 H19 Cl N4 O CC(C)(C)c1....
142 5R9U - JMM C13 H16 N2 O3 c1cc(oc1)C....
143 3KF7 ic50 = 40 nM L9G C22 H18 F2 N4 O Cc1ccc(cc1....
144 4KIN ic50 = 4.8 nM 1M8 C22 H19 Cl N2 O2 S Cc1ccc(cc1....
145 5R9N - JFS C14 H12 N2 O c1ccc2c(c1....
146 4AA4 ic50 = 9 nM QC0 C25 H25 N5 O3 Cc1ccc(cc1....
147 5RA9 - SWD C6 H3 Cl N2 S c1csc2c1nc....
148 5XYY ic50 = 9.221 uM P0F C15 H12 Cl F N4 O c1cc(cc(c1....
149 5R97 - RUY C7 H12 N4 O C1CCN(CC1)....
150 3E93 Ki = 1.4 nM 19B C30 H32 N4 O3 Cc1ccc(cc1....
151 5R9O - 54F C11 H10 N2 O c1ccnc(c1)....
152 4AAC ic50 = 6.7 nM AAV C24 H24 N6 O3 Cc1ccc(cc1....
153 4AA0 ic50 = 35 nM AA0 C30 H33 N7 O3 Cc1ccc(cc1....
154 1OZ1 ic50 = 6.5 nM FPH C18 H12 F N3 O c1cc2c(c(c....
155 5N64 - 8OH C19 H16 N4 S c1ccc(cc1)....
156 3IW8 Kd = 13.4 uM HIZ C19 H18 Cl F N4 O2 S c1ccc(cc1)....
157 3LFN ic50 = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
158 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
159 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
160 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
161 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
162 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
163 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
164 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
165 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
166 6Q4K - HHW C16 H12 Cl N O3 c1cc(cc(c1....
167 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
168 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
169 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
170 2DS1 ic50 = 3.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
171 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
172 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
173 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
174 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
175 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
176 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
177 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
178 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
179 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
180 6Q4C - HH8 C8 H5 Br N2 c1cc2c(ccn....
181 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
182 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
183 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
184 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
185 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
186 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
187 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
188 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
189 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
190 6Q48 - HHQ C5 H4 I N O C1C(=CC=NC....
191 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
192 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
193 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
194 6Q4D - HHT C9 H9 Br O3 COc1cc(ccc....
195 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
196 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
197 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
198 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
199 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
200 6Q4F - 26D C5 H7 N3 c1cc(nc(c1....
201 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
202 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
203 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
204 6Q4I - HGK C13 H11 N O4 c1cc(ccc1C....
205 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
206 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
207 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
208 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
209 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
210 6Q4B - HHN C4 H3 Br N2 c1c(cncn1)....
211 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
212 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
213 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
214 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
215 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
216 6Q4J - HHB C12 H11 N3 O2 c1cc(cc(c1....
217 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
218 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
219 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
220 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
221 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
222 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
223 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
224 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
225 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
226 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
227 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
228 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
229 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
230 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
231 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
232 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
233 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
234 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
235 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
236 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
237 6Q4A - HGW C4 H3 I N2 c1c(cncn1)....
238 1H08 - BYP BWP n/a n/a
239 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
240 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
241 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
242 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
243 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
244 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
245 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
246 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
247 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
248 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
249 6Q3B - PYZ C3 H3 I N2 c1c(cn[nH]....
250 1PYE Ki = 386 nM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
251 6Q49 - HGQ C5 H4 Br N O C1=CNC(=O)....
252 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
253 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
254 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
255 6GUK Kd = 715 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
256 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
257 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
258 6Q4E Kd = 350 uM HH5 C5 H4 I N5 c1[nH]c2c(....
259 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
260 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
261 6Q4G Kd = 50 uM HJK C13 H11 N5 O2 c1cc(cc(c1....
262 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
263 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
264 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
265 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
266 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
267 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
268 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
269 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
270 5VED - STU C28 H26 N4 O3 C[C@@]12[C....
271 2X4Z Kd = 2.7 nM 7KC C25 H30 N8 O S Cc1nc2ccsc....
272 5XVA Ki = 0.051 uM 8FU C18 H20 Cl N7 O Cc1cc(n[nH....
273 2CDZ - 23D C19 H24 Cl N7 CCn1cnc2c1....
274 4JDI - ARG ARG ARG ARG SER TRP TYR n/a n/a
275 6WLX - LYS LYS ARG LEU SER VAL GLU n/a n/a
276 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
277 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
278 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
279 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
280 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
281 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
282 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
283 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
284 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
285 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
286 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
287 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
288 3V5P Ki = 0.0011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
289 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
290 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
291 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
292 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
293 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
294 6HME - FXB C21 H21 N O3 CC(C)n1c2c....
295 6HOP - FER C10 H10 O4 COc1cc(ccc....
296 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
297 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
298 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
299 6RFF ic50 = 0.37 uM K1B C12 H6 Br N5 O4 S c1cc(c(cc1....
300 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
301 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
302 5H8E Kd = 6.33 pM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
303 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
304 6L1Z - E3U C16 H12 O6 c1cc(c(c2c....
305 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
306 5MOE Kd = 520 uM OQC C11 H10 Cl N O c1cc(c(cc1....
307 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
308 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
309 6RB1 ic50 = 1.37 uM JWQ C14 H9 F3 N4 O3 S COc1cc(ccc....
310 6TEI - N4N C15 H11 N3 O2 S c1ccnc(c1)....
311 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
312 6HBN - FXB C21 H21 N O3 CC(C)n1c2c....
313 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
314 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
315 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
316 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
317 5N9N Ki = 0.41 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
318 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
319 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
320 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
321 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
322 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
323 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
324 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
325 6YPK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
326 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
327 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
328 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
329 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
330 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
331 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
332 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
333 6YPH - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
334 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
335 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
336 6RCM ic50 = 0.36 uM K0N C17 H18 N4 O3 S CC(C)(C)c1....
337 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
338 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
339 6SPX ic50 = 44 uM DAS ASP ASP ASP ASP ASP LYS 9AB n/a n/a
340 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
341 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
342 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
343 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
344 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
345 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
346 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
347 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
348 6RFE ic50 = 0.28 uM K0Z C13 H9 Br N4 O3 S COc1cc(ccc....
349 6YPG - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
350 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
351 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
352 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
353 3PE1 Ki = 0.223 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
354 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
355 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
356 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
357 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
358 2ZJW Ki = 0.02 uM REF C14 H6 O8 c1c2c-3c(c....
359 6HOU - V55 C8 H8 O3 COc1cc(ccc....
360 7A4C ic50 = 3.82 uM QWW C5 H Br3 N4 c12c(c(c(n....
361 6YPN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
362 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
363 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
364 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
365 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
366 6L24 - E3U C16 H12 O6 c1cc(c(c2c....
367 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
368 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
369 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
370 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
371 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
372 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
373 6HNY - GHT C19 H19 N O4 CN1CCc2cc(....
374 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
375 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
376 4XP0 - 42A C8 H5 N3 c1cc2c(c[n....
377 4QP2 Kd = 940 uM 36R C7 H5 Cl N2 O c1cc2c(cc1....
378 5NHF ic50 < 0.00032 uM 8X5 C23 H25 N5 O2 c1ccc(cc1)....
379 5BUJ ic50 = 0.005 uM 4VB C16 H15 N5 O c1cnccc1c2....
380 6G9J ic50 = 4.1 nM ERK C27 H28 Cl N5 O3 C[C@H](c1c....
381 5BUI ic50 = 0.089 uM 4V9 C17 H15 F N4 c1ccnc(c1)....
382 4QP7 ic50 = 5.9 uM 363 C9 H7 N5 c1c[nH]c2c....
383 3ERK ic50 = 18 uM SB4 C18 H19 F N6 c1cc(ccc1c....
384 6GDQ - EVK C21 H22 Cl2 N4 O2 CC(C)Nc1cc....
385 5V60 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
386 6QA1 - HVK C5 H6 N2 c1ccnc(c1)....
387 1TVO Ki = 0.14 uM FRZ C18 H13 N7 c1ccc(cc1)....
388 6G9A ic50 = 21 nM ESQ C23 H28 Cl N5 O3 c1cc2c(cc1....
389 5BVD ic50 = 0.16 nM 4VF C24 H26 Cl N5 O3 c1cc(cc(c1....
390 4ZZN ic50 = 0.26 uM CQ8 C18 H21 Cl N4 O2 CNC(=O)c1c....
391 3SA0 - NRA C13 H8 O6 c1c(cc2c(c....
392 4ERK ic50 = 27 uM OLO C15 H18 N6 O Cn1cnc2c1n....
393 6GJD ic50 = 0.022 uM F0E C46 H55 N11 O5 c1cnc(nc1)....
394 5U6I - 81Y C19 H22 N4 O2 CC(C)Oc1cc....
395 5NHV ic50 = 0.0028 uM 8QB C16 H19 N5 O2 c1cnc(nc1c....
396 6QAL - HV2 C3 H6 O3 S C1C(CS1(=O....
397 3I5Z Ki = 2 nM Z48 C24 H23 N5 O2 Cc1cnc(nc1....
398 6QA4 - HRZ C5 H5 N O C1=CC(=O)N....
399 4N0S - DHC C9 H8 O4 c1cc(c(cc1....
400 5NHP ic50 = 0.023 uM 8XK C19 H23 N7 O2 Cn1c(ccn1)....
401 3I60 Ki < 2 nM E86 C24 H22 Cl N5 O2 Cc1cnc(nc1....
402 4XP2 - TT4 C8 H9 N5 c1ccc(cc1)....
403 1PME Ki = 0.76 nM SB2 C21 H16 F N3 O S C[S@](=O)c....
404 6Q7T - HOW C3 H4 N2 O c1conc1N
405 5NHL ic50 < 0.0003 uM 8XB C20 H25 N7 O2 Cc1cnc(nc1....
406 5HD4 - 38Z C33 H33 N9 O2 c1cnc(nc1)....
407 6G97 ic50 = 4.2 nM EQZ C20 H23 Cl N4 O3 COCCN1Cc2c....
408 6G92 ic50 = 76000 nM ERZ C10 H13 N5 Cc1cnc(nc1....
409 5K4I ic50 = 3.1 nM 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
410 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
411 1JNK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
412 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
413 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
414 5IZF Kd = 0.18 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
415 6YPS - P72 C7 H8 N2 O [H]/N=C(c1....
416 6Z44 - IPH C6 H6 O c1ccc(cc1)....
417 6SPU - GAB C7 H7 N O2 c1cc(cc(c1....
418 3DA6 - BZ9 C28 H23 N7 O Cc1cc(c2cc....
419 2R9S ic50 = 0.15 uM 255 C24 H24 N4 O2 S CC(C)(C)NS....
420 4Y5H ic50 = 15 nM 519 C20 H30 N6 O2 CC(C)NC(=O....
421 4X21 Kd = 36 nM 3WH C20 H23 I N6 O CCNC(=O)N1....
422 3RTP ic50 = 7 nM 34I C18 H14 N6 O2 S c1ccc2c(c1....
423 3PZE - CFK C12 H11 N3 O2 S c1ccc(cc1)....
424 4Z9L ic50 = 1.6 nM 880 C27 H34 Cl2 N6 CCCn1c(c(n....
425 4WHZ ic50 < 1 nM 3NL C24 H23 Cl N8 O2 c1ccc(c(c1....
426 4W4Y ic50 = 3034 nM 3HQ C24 H22 N6 O2 Cc1ccc(cc1....
427 4W4W ic50 = 6630 nM 3HJ C23 H20 N6 O2 Cc1cc(ccn1....
428 3G90 Ki = 0.44 uM J72 C17 H12 F2 N2 O4 c1cc2c(cc1....
429 1PMV ic50 = 150 nM 537 C14 H8 N2 O c1ccc2c(c1....
430 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
431 2Z7R ic50 ~ 0.4 nM STU C28 H26 N4 O3 C[C@@]12[C....
432 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
433 5ORO - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
434 6HJJ ic50 = 1.7 uM G7T C26 H24 F4 N6 O2 Cc1cc(ccc1....
435 5ORS - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
436 5ORL - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
437 5DR9 - 5E2 C16 H9 Br Cl N O2 c1cc(cc(c1....
438 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
439 5DN3 Kd = 3.77 uM 5DN C16 H9 Br F N O2 c1cc(cc(c1....
440 6C2T - EGJ C27 H26 Cl F N4 O2 S C[C@H]1C[C....
441 5ORP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
442 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
443 5OSE Kd = 681 uM A98 C6 H9 N3 O2 S2 CCSc1nnc(s....
444 6R4B - JSN C14 H15 F2 N3 O2 CC1=NC(=O)....
445 5DNR - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
446 6VPJ - GLC GLC n/a n/a
447 6VPL - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
448 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
449 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
450 5DT0 - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
451 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
452 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
453 5ORX ic50 = 308 uM A6H C11 H8 Cl2 N2 O c1cc(c(c(c....
454 6VPI - MLA C3 H4 O4 C(C(=O)O)C....
455 5ORN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
456 5OS5 Kd = 410 uM A8K C12 H10 O2 S c1cc(ccc1O....
457 5DR2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
458 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
459 6R4D - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
460 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
461 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
462 5OSD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
463 5OS2 Kd = 1821 uM A7K C13 H21 N2 O c1ccc(c(c1....
464 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
465 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
466 5ORR Kd = 170 uM A5Q C9 H6 F3 N3 S c1cc(ccc1c....
467 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
468 5OS3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
469 5DRD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
470 5DPV - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
471 5ORZ Kd = 432 uM A6W C10 H9 N O2 S2 COC(=O)c1c....
472 4UYN ic50 = 4 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
473 5DT3 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
474 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
475 6HJK ic50 = 25 nM G7W C25 H20 F4 N6 O2 CC(C)n1c2c....
476 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
477 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
478 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
479 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
480 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
481 5ORW Kd = 796 uM A6E C13 H16 F N O2 S c1cc(ccc1O....
482 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
483 5OS0 Kd = 2792 uM A6Z C12 H15 Cl N3 c1cc(cc(c1....
484 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
485 3GC9 - B45 C28 H27 Cl3 F N3 O CC(C)N1CCC....
486 4KS7 - 7KC C25 H30 N8 O S Cc1nc2ccsc....
487 4KS8 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
488 6TE2 - N4N C15 H11 N3 O2 S c1ccnc(c1)....
489 6HMB - 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
490 7A22 ic50 = 1.98 uM QWW C5 H Br3 N4 c12c(c(c(n....
491 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
492 6HMC - FXB C21 H21 N O3 CC(C)n1c2c....
493 5YF9 - NIO C6 H5 N O2 c1cc(cnc1)....
494 6TGU - N92 C16 H11 Cl N2 O3 S c1cc(ccc1c....
495 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
496 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
497 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
498 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
499 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
500 6QS5 ic50 = 0.57 uM JGB C10 H8 N2 O3 c1cc(c(cc1....
501 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
502 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
503 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
504 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
505 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
506 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
507 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
508 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
509 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
510 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
511 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
512 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
513 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
514 5BYZ ic50 = 0.042 uM 4WE C25 H32 F N7 O Cc1ncc(n1C....
515 6HKN ic50 = 0.051 uM G9E C22 H21 F3 N4 O3 COc1ccc2c(....
516 4ZSJ ic50 = 2.3 uM 4R0 C13 H17 Cl N6 O Cc1cc(ccc1....
517 4ZSG - 4QX C12 H15 Cl N6 O CC(C)NC(=O....
518 6HKM ic50 = 270 nM G92 C23 H22 F3 N3 O4 COc1cc2c(c....
519 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
520 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
521 5AUW ic50 = 8.9 uM QUE C15 H10 O7 c1cc(c(cc1....
522 5AV2 - KMP C15 H10 O6 c1cc(ccc1C....
523 5AUU ic50 = 21 uM LU2 C15 H10 O6 c1cc(c(cc1....
524 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
525 5AV3 - KMP C15 H10 O6 c1cc(ccc1C....
526 5AUT Kd = 6.7 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
527 5AV0 ic50 = 280 uM 47X C15 H10 O5 c1cc(c(cc1....
528 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
529 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
530 5AV4 - GEN C15 H10 O5 c1cc(ccc1C....
531 5AUX ic50 = 10 uM KMP C15 H10 O6 c1cc(ccc1C....
532 5AUV ic50 = 31 uM AGI C15 H10 O5 c1cc(ccc1C....
533 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
534 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
535 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
536 6SK9 ic50 = 1.42 uM F9N C23 H33 N7 O3 S CN(C)CCCNS....
537 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
538 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
539 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
540 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
541 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
542 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
543 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
544 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
545 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
546 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
547 5HKM ic50 = 0.013 uM 61Y C16 H15 N7 CCc1cc(nc(....
548 3QD0 ic50 = 3.16 nM 3Q4 C24 H26 N8 O C[C@@H]1CC....
549 3ORZ - BI4 C27 H26 N4 O2 C[N@]1CCC[....
550 5LVN Kd = 20 uM ADN C10 H13 N5 O4 c1nc(c2c(n....
551 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
552 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
553 3OTU - BI4 C27 H26 N4 O2 C[N@]1CCC[....
554 3QCX ic50 = 63 nM 3Q2 C16 H19 N7 O C[C@@H]1CO....
555 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
556 5LVL Kd = 1.25 uM 537 C14 H8 N2 O c1ccc2c(c1....
557 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
558 3QCY ic50 = 20 nM 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
559 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
560 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
561 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1[....
562 2X39 ic50 = 2.2 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
563 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
564 4QNA ic50 = 0.023 uM X11 C9 H9 N5 O c1ccc(c(c1....
565 4QMO ic50 = 0.019 uM 34L C13 H8 N4 O S c1cc2c(c3c....
566 4QMW ic50 = 0.086 uM KS1 C17 H17 N7 c1c[nH]c2c....
567 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
568 4QML - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
569 4QO9 ic50 = 0.16 uM 627 C26 H30 N6 O3 CN1CCN(CC1....
570 4QMQ ic50 = 0.26 uM 34U C24 H27 N5 O2 COCCOc1ccc....
571 4QMY ic50 = 0.004 uM STU C28 H26 N4 O3 C[C@@]12[C....
572 3A7J - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
573 4W8D - 3JA C14 H16 N6 O Cn1cc(cn1)....
574 4QMN ic50 = 0.003 uM DB8 C26 H29 Cl2 N5 O3 CN1CCN(CC1....
575 4QMS ic50 = 7.4 uM 1N1 C22 H26 Cl N7 O2 S Cc1cccc(c1....
576 4QMV ic50 = 0.023 uM 34W C23 H25 F3 N6 O2 CC(=O)NCC(....
577 3A7I - ADE C5 H5 N5 c1[nH]c2c(....
578 6ISJ - 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
579 4EL9 - AFE C21 H20 O10 C[C@H]1[C@....
580 5D9L ic50 = 0.024 uM 583 C15 H12 N2 O2 c1cc(ccc1c....
581 6YG2 - 8E8 C25 H26 N6 O2 CCC(=O)N1C....
582 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
583 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
584 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
585 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
586 2XBJ ic50 = 0.003 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
587 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
588 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
589 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
590 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
591 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
592 5K00 ic50 = 7 nM 6PV C32 H34 N6 O4 COc1cccc(c....
593 5MAG - 7KC C25 H30 N8 O S Cc1nc2ccsc....
594 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
595 2F57 - 23D C19 H24 Cl N7 CCn1cnc2c1....
596 5L2S - 6ZV C27 H32 F2 N8 CCN1CCN(CC....
597 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
598 6YLC - OXW C20 H19 F N10 CN1CCC(CC1....
599 6BUU - GLY ARG PRO ARG THR THR ZXW PHE ALA GLU n/a n/a
600 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(C[C....
601 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
602 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
603 4EYJ - N61 C20 H23 N5 O2 CC(C)(C)c1....
604 3C0G - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
605 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
606 4OTI ic50 = 43 nM MI1 C16 H20 N6 O C[C@@H]1CC....
607 6QF4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
608 6SPW ic50 = 4.5 uM DAS ASP ASP ASP ASP ASP LYS A0Z n/a n/a
609 5ONI - 9YE C23 H25 N O3 CC(C)n1c2c....
610 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
611 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
612 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
613 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
614 6B16 Ki = 32 nM C7Y C19 H20 N8 C[C@@H](c1....
615 5DFP Ki = 22 nM 59U C28 H32 Cl N7 O CCN1c2c(cn....
616 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
617 5IME Ki = 4.6 nM 6BZ C22 H22 Cl N7 O2 CC1=NC=CN(....
618 4ZY6 Ki = 5 nM 4T6 C18 H17 Cl N8 c1cc2c(c(c....
619 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
620 4EQC ic50 = 8 nM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
621 4ZJJ Kd = 9.9 nM 4OR C24 H29 Cl F N5 O CCN1c2ccc(....
622 5KBR ic50 = 260 nM IPW C22 H20 Cl N5 O c1cc(ccc1C....
623 4ZLO ic50 = 12 uM 4PV C18 H18 F2 N4 CN1CCN(CC1....
624 4ZJI Kd = 340 nM 4OQ C20 H22 Cl F N4 CCN1c2ccc(....
625 5DEY Ki = 3.7 nM 59T C25 H25 Cl N6 O3 Cc1cccc(n1....
626 3Q4Z - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
627 4ZY5 Ki = 26 nM 4T5 C17 H25 N7 c1cnc(nc1N....
628 5JZJ - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
629 3SLS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
630 5AX9 ic50 = 8 nM 4KT C24 H24 N4 O3 COc1ccc(cc....
631 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
632 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
633 4MWH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
634 4LFI - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
635 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
636 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
637 4RVT ic50 = 1.9 uM 3XM C17 H19 N O4 CCCCCC(=O)....
638 4OBO ic50 = 0.077 uM 2QV C14 H10 Cl N3 c1cc(cc(c1....
639 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
640 1CM8 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
641 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
642 3EQC - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
643 3EQI - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
644 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
645 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
646 3M2W ic50 < 0.003 uM L8I C23 H21 F N4 O CN1CC2(C1)....
647 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
648 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
649 5VJA - DUK C14 H12 Cl N5 O2 S C[C@H](C(=....
650 5A6N ic50 = 52 uM U7E C7 H7 N5 O2 S c1cc(cc(c1....
651 6CMJ ic50 = 5 nM F6J C24 H22 N2 O2 CC(C)Cc1cc....
652 3E7O ic50 = 120 nM 35F C20 H14 N6 O2 c1cc(cc(c1....
653 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
654 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
655 4WNO ic50 = 160 nM 3RF C20 H19 N7 c1ccc2c(c1....
656 4WNP ic50 = 8 nM 3RJ C22 H20 N8 c1ccc2c(c1....
657 6QAS - 34W C23 H25 F3 N6 O2 CC(=O)NCC(....
658 6MNH - JVD C12 H16 N4 O C[C@H](C(C....
659 5CI7 ic50 = 120 nM 51W C18 H24 I N7 O c1cc(cc(c1....
660 2V7O - DRN C25 H23 N5 O2 S [H]/N=C(/N....
661 2UV2 - GVD C22 H19 N7 c1ccc2c(c1....
662 2JFL - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
663 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: P72; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 P72 1 1
2 HBD 0.517241 0.607143
3 4BZ 0.483871 0.703704
4 BEN 0.413793 0.695652
Similar Ligands (3D)
Ligand no: 1; Ligand: P72; Similar ligands found: 1098
No: Ligand Similarity coefficient
1 SW7 1.0000
2 PBZ 1.0000
3 NPO 1.0000
4 PHB 1.0000
5 1Y6 1.0000
6 4MA 1.0000
7 PAB 1.0000
8 826 1.0000
9 AC6 0.9981
10 Z82 0.9974
11 174 0.9936
12 BEZ 0.9818
13 HBA 0.9759
14 NCA 0.9755
15 PBC 0.9754
16 DHB 0.9742
17 JLZ 0.9737
18 ANN 0.9737
19 BAM 0.9733
20 4NC 0.9730
21 4M0 0.9714
22 6PC 0.9710
23 FA0 0.9708
24 NIO 0.9692
25 INO 0.9685
26 2HO 0.9680
27 P9P 0.9678
28 NTN 0.9675
29 MYJ 0.9671
30 4VP 0.9667
31 DOB 0.9667
32 4P5 0.9667
33 XX2 0.9659
34 BPN 0.9659
35 UNU 0.9659
36 AC0 0.9658
37 E5X 0.9647
38 SN4 0.9645
39 CFI 0.9645
40 SS1 0.9644
41 NNO 0.9640
42 5CU 0.9640
43 FHB 0.9637
44 4A3 0.9637
45 BNS 0.9633
46 QSB 0.9633
47 CHB 0.9630
48 YCP 0.9626
49 QSC 0.9624
50 93K 0.9622
51 NBZ 0.9620
52 OTR 0.9612
53 BHA 0.9610
54 4JL 0.9608
55 GUA 0.9603
56 FCR 0.9602
57 PZA 0.9601
58 IHB 0.9597
59 AAS 0.9592
60 HDH 0.9591
61 JAE 0.9591
62 4J8 0.9591
63 TH7 0.9590
64 FBS 0.9585
65 TSU 0.9584
66 VGL 0.9584
67 FQI 0.9583
68 PHU 0.9582
69 AX7 0.9582
70 ABV 0.9576
71 9TW 0.9573
72 JZ7 0.9561
73 5NU 0.9559
74 HIO 0.9555
75 4JM 0.9554
76 SAN 0.9549
77 BE7 0.9545
78 SRT 0.9542
79 TYL 0.9540
80 8WO 0.9539
81 AEF 0.9537
82 HMH 0.9526
83 270 0.9526
84 RSO 0.9525
85 ISZ 0.9524
86 H42 0.9523
87 MLT 0.9520
88 H8N 0.9515
89 OAA 0.9514
90 FAN 0.9511
91 4NM 0.9510
92 717 0.9507
93 BHO 0.9503
94 P92 0.9502
95 IT2 0.9493
96 DHR 0.9486
97 5OB 0.9484
98 03V 0.9479
99 TPA 0.9476
100 OK7 0.9474
101 2K4 0.9472
102 4FS 0.9472
103 AMS 0.9470
104 2CK 0.9470
105 ET2 0.9467
106 M58 0.9466
107 5H1 0.9461
108 F60 0.9459
109 XQ0 0.9458
110 BE2 0.9457
111 5WV 0.9456
112 2AQ 0.9454
113 4SV 0.9453
114 COU 0.9452
115 SAL 0.9449
116 14O 0.9449
117 11S 0.9446
118 0HO 0.9444
119 JB5 0.9441
120 K34 0.9441
121 ES5 0.9439
122 FBA 0.9438
123 6AI 0.9438
124 FEH 0.9437
125 OCH 0.9436
126 HC4 0.9435
127 XM0 0.9435
128 6NT 0.9433
129 MSR 0.9431
130 YRL 0.9427
131 BZX 0.9425
132 14J 0.9425
133 NIZ 0.9420
134 PAC 0.9418
135 VGD 0.9418
136 I3E 0.9417
137 FBB 0.9416
138 7WG 0.9414
139 1PT 0.9414
140 3U4 0.9413
141 5MB 0.9412
142 5XC 0.9411
143 0HN 0.9409
144 173 0.9408
145 S2G 0.9405
146 SKM 0.9405
147 6RQ 0.9402
148 DYA 0.9400
149 3NY 0.9399
150 ES2 0.9399
151 36R 0.9398
152 IPB 0.9395
153 JKE 0.9395
154 K2T 0.9393
155 M4T 0.9392
156 1P8 0.9387
157 OVV 0.9387
158 XIY 0.9386
159 67N 0.9382
160 C2B 0.9381
161 C21 0.9377
162 D48 0.9373
163 H4N 0.9372
164 5VM 0.9372
165 FK1 0.9371
166 4JT 0.9369
167 F9P 0.9366
168 3AB 0.9365
169 NPY 0.9362
170 ODO 0.9362
171 CLW 0.9362
172 4XR 0.9360
173 UGC 0.9358
174 X0V 0.9357
175 PIM 0.9357
176 AMC 0.9355
177 QUZ 0.9355
178 MS9 0.9352
179 ES9 0.9352
180 4JQ 0.9351
181 KKN 0.9351
182 4WL 0.9350
183 5MI 0.9348
184 BP9 0.9346
185 3HA 0.9346
186 MZW 0.9346
187 8ZE 0.9345
188 ES6 0.9344
189 COI 0.9343
190 8GC 0.9342
191 ISN 0.9341
192 ES7 0.9340
193 SS2 0.9340
194 1SA 0.9339
195 JBE 0.9339
196 SYV 0.9337
197 2MI 0.9336
198 HX3 0.9336
199 FYU 0.9335
200 2BG 0.9333
201 GDE 0.9332
202 MNN 0.9332
203 IFP 0.9332
204 2A9 0.9331
205 G3E 0.9331
206 QY9 0.9327
207 JAW 0.9326
208 3M0 0.9325
209 ABI 0.9323
210 2RH 0.9322
211 WCE 0.9322
212 CXF 0.9319
213 DEN 0.9318
214 AKG 0.9318
215 FBM 0.9317
216 EKZ 0.9315
217 MQN 0.9315
218 TZF 0.9315
219 LMR 0.9312
220 PYF 0.9312
221 M4S 0.9310
222 M1A 0.9309
223 2FY 0.9309
224 QWN 0.9309
225 LNR 0.9305
226 4SX 0.9305
227 PRO 0.9304
228 FB2 0.9304
229 GJZ 0.9303
230 FPI 0.9300
231 3ID 0.9299
232 IDM 0.9299
233 7W1 0.9298
234 AHR 0.9298
235 DBH 0.9297
236 3NT 0.9297
237 12Q 0.9294
238 SNU 0.9294
239 7WV 0.9293
240 6M9 0.9293
241 DHK 0.9292
242 OXZ 0.9288
243 NMJ 0.9288
244 3PF 0.9288
245 L99 0.9288
246 NDH 0.9287
247 PZM 0.9286
248 1MR 0.9286
249 M3H 0.9285
250 ZXD 0.9285
251 3BZ 0.9285
252 KJH 0.9285
253 AL0 0.9282
254 RHU 0.9282
255 BRT 0.9281
256 HBX 0.9279
257 1DJ 0.9278
258 4JC 0.9276
259 8H8 0.9276
260 SKA 0.9275
261 5QX 0.9274
262 PEA 0.9274
263 NSP 0.9271
264 SMV 0.9271
265 GLU 0.9268
266 F4E 0.9268
267 CPZ 0.9267
268 PMB 0.9264
269 ESP 0.9264
270 ASP 0.9263
271 HY1 0.9262
272 3OC 0.9261
273 4FH 0.9261
274 JA8 0.9261
275 I1E 0.9260
276 4JU 0.9260
277 TZC 0.9260
278 TP5 0.9256
279 LDP 0.9256
280 TIU 0.9255
281 SE2 0.9255
282 3SK 0.9254
283 1DV 0.9252
284 OKG 0.9252
285 5QY 0.9250
286 QXW 0.9250
287 SYN 0.9249
288 PZI 0.9249
289 ABN 0.9248
290 PY7 0.9248
291 FOA 0.9248
292 4FA 0.9247
293 36Y 0.9246
294 1M2 0.9246
295 PIY 0.9244
296 SHA 0.9243
297 BCU 0.9243
298 QSH 0.9242
299 F05 0.9240
300 IND 0.9239
301 4NB 0.9238
302 B57 0.9238
303 BZI 0.9236
304 HMU 0.9235
305 CN0 0.9235
306 6M4 0.9231
307 282 0.9231
308 XYL 0.9230
309 LQ2 0.9230
310 RB5 0.9230
311 F9Y 0.9229
312 BZ3 0.9229
313 LZ1 0.9228
314 3F0 0.9226
315 0TU 0.9226
316 1WD 0.9226
317 2MH 0.9226
318 XUL 0.9225
319 2HQ 0.9225
320 L14 0.9224
321 PKU 0.9224
322 DMD 0.9224
323 JDN 0.9221
324 J9N 0.9219
325 HQT 0.9217
326 3A9 0.9217
327 PXL 0.9217
328 2PC 0.9215
329 JBN 0.9215
330 NBE 0.9214
331 FE DB1 0.9213
332 4JP 0.9212
333 R8V 0.9211
334 LT2 0.9209
335 OGA 0.9209
336 2FT 0.9207
337 FUD 0.9207
338 BZ2 0.9207
339 1AB 0.9206
340 HYP 0.9206
341 MR1 0.9206
342 4YO 0.9205
343 4ZA 0.9205
344 M6W 0.9205
345 NOJ 0.9205
346 0RW 0.9204
347 RBJ 0.9201
348 JZ5 0.9201
349 BSX 0.9200
350 URS 0.9200
351 54D 0.9198
352 TZL 0.9197
353 ZBT 0.9197
354 265 0.9192
355 PCA 0.9191
356 RIB 0.9191
357 268 0.9191
358 ZZT 0.9189
359 FGZ 0.9189
360 E7Z 0.9188
361 KBZ 0.9188
362 ICB 0.9188
363 8K2 0.9187
364 GLC 0.9187
365 273 0.9186
366 BML 0.9183
367 J9T 0.9182
368 HIS 0.9181
369 LG4 0.9181
370 PNZ 0.9180
371 FP1 0.9177
372 1DW 0.9175
373 ASN 0.9174
374 R2B 0.9172
375 GYE 0.9172
376 SEP 0.9171
377 JZ9 0.9170
378 3QM 0.9169
379 SVN 0.9169
380 8OZ 0.9168
381 KJU 0.9168
382 IFL 0.9167
383 PXY 0.9167
384 PCR 0.9166
385 2LP 0.9165
386 DE5 0.9162
387 MRZ 0.9162
388 DS0 0.9160
389 RAT 0.9158
390 LDU 0.9155
391 ASO 0.9155
392 9CL 0.9154
393 VNL 0.9153
394 9EW 0.9152
395 4CH 0.9151
396 RMN 0.9150
397 XRG 0.9150
398 KOJ 0.9149
399 PYC 0.9148
400 3DO 0.9146
401 HQE 0.9146
402 MPI 0.9145
403 MAE 0.9145
404