-->
Receptor
PDB id Resolution Class Description Source Keywords
6I0T 2 Å EC: 2.7.7.52 CRYSTAL STRUCTURE OF DMTAILOR IN COMPLEX WITH GPU DROSOPHILA MELANOGASTER TERMINAL URIDYL TRANSFERASE NUCLEOTIDYL TRANSFERASE TRANSF
Ref.: STRUCTURAL BASIS FOR ACCEPTOR RNA SUBSTRATE SELECTI THE 3' TERMINAL URIDYLYL TRANSFERASE TAILOR. NUCLEIC ACIDS RES. 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
G U B:1;
Valid;
Atoms found LESS than expected: % Diff = 0.091;
submit data
588.403 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5Z4A 1.64 Å EC: 2.7.7.52 STRUCTURE OF TAILOR IN COMPLEX WITH AGU RNA DROSOPHILA MELANOGASTER TERMINAL URIDYLYLTRANSFERASE TRANSFERASE-RNA COMPLEX
Ref.: STRUCTURAL INSIGHTS INTO A UNIQUE PREFERENCE FOR 3' GUANINE OF MIRTRON IN DROSOPHILA TUTASE TAILOR. NUCLEIC ACIDS RES. 2018
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5Z4M - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
2 5Z4J - U U U U n/a n/a
3 5Z4A - A G U n/a n/a
4 6I0S - 2KH C9 H16 N3 O14 P3 C1=CN(C(=O....
5 6I0T - G U n/a n/a
6 5Z4D - A G U U n/a n/a
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5Z4M - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
2 5Z4J - U U U U n/a n/a
3 5Z4A - A G U n/a n/a
4 6I0S - 2KH C9 H16 N3 O14 P3 C1=CN(C(=O....
5 6I0T - G U n/a n/a
6 5Z4D - A G U U n/a n/a
50% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5Z4M - UTP C9 H15 N2 O15 P3 C1=CN(C(=O....
2 5Z4J - U U U U n/a n/a
3 5Z4A - A G U n/a n/a
4 6I0S - 2KH C9 H16 N3 O14 P3 C1=CN(C(=O....
5 6I0T - G U n/a n/a
6 5Z4D - A G U U n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: G U ; Similar ligands found: 134
No: Ligand ECFP6 Tc MDL keys Tc
1 G U 1 1
2 A G U 0.818182 0.987342
3 G C 0.801802 1
4 A G U U 0.785714 0.987342
5 G U34 0.721739 0.987342
6 A U 0.689655 0.924051
7 G G G C 0.688525 0.9625
8 A G C C 0.682927 0.987179
9 G C C C 0.661417 0.974684
10 U2G 0.628099 0.9625
11 G G 0.626087 0.925
12 G G G RPC 0.612903 0.949367
13 A U C C 0.6 0.949367
14 G A A A 0.595238 0.949367
15 U A A U 0.586466 0.9125
16 3GP 0.576923 0.898734
17 U U 0.5625 0.822785
18 A G 0.55814 0.936709
19 U A G G 0.553846 0.936709
20 U A 0.545455 0.9125
21 UCG 0.544118 0.9375
22 G3D 0.54386 0.8875
23 ALF 5GP 0.539823 0.869048
24 GPC 0.537879 0.927711
25 GCP G 0.525 0.898734
26 5GP 0.522936 0.911392
27 G 0.522936 0.911392
28 G4P 0.521368 0.8875
29 CG2 0.519084 0.9625
30 UDP UDP 0.514286 0.807692
31 GP2 0.513274 0.86747
32 GDP 0.513274 0.9
33 GDP AF3 0.512605 0.869048
34 ALF GDP 0.512605 0.869048
35 GDP ALF 0.512605 0.869048
36 APC G U 0.511111 0.888889
37 GPG 0.504132 0.91358
38 0O2 0.504132 0.8875
39 3PD UM3 0.5 0.938272
40 A C A C 0.5 0.949367
41 GCP 0.495726 0.878049
42 GNH 0.495652 0.888889
43 GSP 0.491525 0.857143
44 G2P 0.491525 0.86747
45 GP3 0.491228 0.901235
46 UPU 0.491071 0.810127
47 GMP 0.490385 0.835443
48 GKE 0.488 0.91358
49 GDC 0.488 0.91358
50 GDD 0.488 0.91358
51 CSV 0.487805 0.829268
52 CSQ 0.487805 0.829268
53 GTP 0.487179 0.9
54 GAV 0.483333 0.86747
55 2GP 0.477477 0.8875
56 4TC 0.477273 0.855422
57 GDP 7MG 0.476562 0.91358
58 GMV 0.474576 0.878049
59 UP5 0.473282 0.876543
60 UDP 0.472222 0.7875
61 U5P 0.471154 0.797468
62 U 0.471154 0.797468
63 G1R 0.470588 0.888889
64 DA DU DG DA 0.470149 0.880952
65 U U U U 0.470085 0.810127
66 GNP 0.466667 0.878049
67 9GM 0.466667 0.878049
68 APU 0.462687 0.9
69 JB2 0.461538 0.890244
70 G2R 0.459677 0.86747
71 C C C C 0.458333 0.884615
72 U A C C 0.457143 0.936709
73 DU DU DU DU BRU DG DU 0.455782 0.883721
74 GKD 0.450382 0.91358
75 GDR 0.449612 0.890244
76 GFB 0.449612 0.890244
77 DC DG 0.449275 0.939024
78 UTP 0.446429 0.7875
79 6CK 0.446154 0.869048
80 YGP 0.445312 0.903614
81 44P 0.444444 0.759036
82 DG DG 0.444444 0.891566
83 Y9Z 0.44186 0.83908
84 UTP U U U 0.441667 0.794872
85 UPG 0.441667 0.790123
86 GUD 0.441667 0.790123
87 URM 0.441667 0.780488
88 UFM 0.441667 0.790123
89 660 0.441667 0.780488
90 GDU 0.441667 0.790123
91 TPG 0.441379 0.824176
92 G1R G1R 0.441379 0.902439
93 3UC 0.44 0.752941
94 GDX 0.43609 0.901235
95 G3A 0.435115 0.901235
96 UNP 0.434783 0.768293
97 C C 0.433333 0.871795
98 G5P 0.431818 0.901235
99 P2G 0.431034 0.839506
100 UPF 0.430894 0.752941
101 U2F 0.430894 0.752941
102 UFG 0.430894 0.752941
103 JB3 0.430657 0.879518
104 2KH 0.429825 0.768293
105 CAG 0.429577 0.840909
106 PGD O 0.428571 0.853933
107 GTG 0.427481 0.891566
108 Y6W 0.42623 0.752941
109 GPD 0.425373 0.858824
110 ZGP 0.42446 0.829545
111 P1G 0.423729 0.829268
112 UPA 0.423358 0.888889
113 DG DC 0.421769 0.903614
114 UDH 0.421488 0.735632
115 2MD 0.41844 0.872093
116 BGO 0.417266 0.857143
117 FEG 0.417266 0.83908
118 NGD 0.417266 0.91358
119 URI 0.415842 0.721519
120 USQ 0.412698 0.684783
121 UPP 0.409836 0.790123
122 G3N 0.409449 0.771084
123 GPX 0.409449 0.851852
124 UAD 0.408 0.768293
125 UDX 0.408 0.768293
126 UDM 0.407692 0.771084
127 UA3 0.407407 0.78481
128 U3P 0.407407 0.78481
129 EPZ 0.402878 0.771084
130 DGI 0.401639 0.833333
131 UD1 0.401515 0.780488
132 UD2 0.401515 0.780488
133 EEB 0.4 0.761905
134 MGD 0.4 0.872093
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback