Receptor
PDB id Resolution Class Description Source Keywords
6GX6 2 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF IMP3 RRM12 IN COMPLEX WITH RNA (ACAC) HOMO SAPIENS RNA RECOGNITION MOTIF (RRM) IMP3 IGF2BP3 CRYSTAL STRUCTURBINDING PROTEIN
Ref.: STRUCTURAL BASIS OF IMP3 RRM12 RECOGNITION OF RNA. RNA V. 24 1659 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:203;
A:201;
A:204;
A:202;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
PO4 A:205;
Invalid;
none;
submit data
94.971 O4 P [O-]P...
A C A C B:1;
Valid;
Atoms found LESS than expected: % Diff = 0.047;
Kd = 4.7 uM
1203.8 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6GX6 2 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF IMP3 RRM12 IN COMPLEX WITH RNA (ACAC) HOMO SAPIENS RNA RECOGNITION MOTIF (RRM) IMP3 IGF2BP3 CRYSTAL STRUCTURBINDING PROTEIN
Ref.: STRUCTURAL BASIS OF IMP3 RRM12 RECOGNITION OF RNA. RNA V. 24 1659 2018
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: A C A C ; Similar ligands found: 108
No: Ligand ECFP6 Tc MDL keys Tc
1 A C A C 1 1
2 U A C C 0.926606 0.986842
3 A U C C 0.865546 1
4 A U 0.697479 0.973684
5 A G U U 0.686131 0.962025
6 U A A U 0.682171 0.935897
7 C C C C 0.675926 0.907895
8 A G U 0.661765 0.962025
9 A G C C 0.638462 0.936709
10 G C 0.634921 0.949367
11 C C 0.633027 0.894737
12 G C C C 0.619403 0.925
13 U A 0.590909 0.935897
14 A A 0.584746 0.871795
15 G G G C 0.58209 0.9375
16 G A A A 0.580153 0.924051
17 ATP A A A 0.578512 0.907895
18 G G G RPC 0.548872 0.924051
19 U A G G 0.540741 0.911392
20 A A A 0.53719 0.860759
21 A G 0.533333 0.911392
22 APU 0.530303 0.923077
23 A3P 0.508929 0.846154
24 G U 0.5 0.949367
25 PAP 0.495726 0.835443
26 APC G U 0.489362 0.864198
27 3AM 0.481818 0.833333
28 PAX 0.479452 0.857143
29 0WD 0.478571 0.876543
30 C5P 0.477064 0.846154
31 C 0.477064 0.846154
32 CAR 0.477064 0.846154
33 GAP 0.475 0.897436
34 UP5 0.474074 0.923077
35 PPS 0.471074 0.75
36 4TC 0.467153 0.9
37 CDP 0.464912 0.835443
38 7XL 0.462185 0.8375
39 CTP C C C C 0.459259 0.857143
40 CSV 0.453846 0.85
41 CSQ 0.453846 0.85
42 ADP BMA 0.453125 0.897436
43 ADP PO3 0.446281 0.894737
44 UPA 0.446043 0.935897
45 MYR AMP 0.442748 0.802326
46 PUA 0.442177 0.865854
47 C3P 0.441441 0.833333
48 C5G 0.440945 0.860759
49 HF4 0.440678 0.835443
50 CTP 0.440678 0.835443
51 ADP VO4 0.44 0.860759
52 VO4 ADP 0.44 0.860759
53 AMP 0.438596 0.846154
54 A 0.438596 0.846154
55 CPA 0.435714 0.901235
56 DAL AMP 0.433071 0.884615
57 ADP ALF 0.432 0.829268
58 ALF ADP 0.432 0.829268
59 GPC 0.431507 0.880952
60 PO4 PO4 A A A A PO4 0.430769 0.881579
61 ADP 0.428571 0.848101
62 NMN AMP PO4 0.427586 0.923077
63 UDP ALA FGA CYS DAL DAL MUB C C A9Z 0.426667 0.817204
64 CDC 0.425197 0.761364
65 A12 0.420168 0.817073
66 AP2 0.420168 0.817073
67 TYR AMP 0.419118 0.875
68 4TA 0.417808 0.879518
69 NAJ PYZ 0.417219 0.857143
70 C2G 0.416 0.848101
71 CXY 0.415385 0.8375
72 A2D 0.415254 0.871795
73 ABM 0.415254 0.825
74 PRX 0.414634 0.804878
75 AN2 0.413223 0.8375
76 NAI 0.411348 0.8875
77 AGS 0.41129 0.807229
78 SAP 0.41129 0.807229
79 AR3 0.411215 0.779221
80 CTN 0.411215 0.779221
81 CDM 0.410853 0.797619
82 A22 0.410853 0.860759
83 SRA 0.410256 0.804878
84 NAJ PZO 0.409396 0.9
85 AMP DBH 0.408759 0.85
86 A2P 0.408333 0.833333
87 BA3 0.408333 0.871795
88 25A 0.407692 0.871795
89 ACP 0.406504 0.82716
90 ATP 0.406504 0.848101
91 HEJ 0.406504 0.848101
92 AP5 0.404959 0.871795
93 B4P 0.404959 0.871795
94 T99 0.404762 0.817073
95 TAT 0.404762 0.817073
96 LPA AMP 0.404255 0.802326
97 DG DA DC DG 0.403614 0.903614
98 APC 0.403226 0.817073
99 AQP 0.403226 0.848101
100 5FA 0.403226 0.848101
101 U U 0.403101 0.820513
102 AR6 AR6 0.402878 0.896104
103 ARG AMP 0.402878 0.857143
104 Z5A 0.402597 0.870588
105 AT4 0.401639 0.817073
106 SON 0.401639 0.839506
107 7D5 0.4 0.790123
108 ATR 0.4 0.822785
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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