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Receptor
PDB id Resolution Class Description Source Keywords
6EZ6 2.04 Å EC: 2.7.1.153 PI3 KINASE DELTA IN COMPLEX WITH METHYL 5-(4-(5-((4- ISOPROPYLPIPERAZIN-1-YL)METHYL)OXAZOL-2-YL)-1H-INDAZOL-6-YLM ETHOXYNICOTINATE MUS MUSCULUS COVALENT INHIBITOR KINASE DRUG DISCOVERY COMPLEX TRANSFE
Ref.: SELECTIVELY TARGETING THE KINOME-CONSERVED LYSINE O DELTA AS A GENERAL APPROACH TO COVALENT KINASE INHI J. AM. CHEM. SOC. V. 140 932 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
C5Z A:1101;
Valid;
none;
submit data
490.554 C26 H30 N6 O4 CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6EZ6 2.04 Å EC: 2.7.1.153 PI3 KINASE DELTA IN COMPLEX WITH METHYL 5-(4-(5-((4- ISOPROPYLPIPERAZIN-1-YL)METHYL)OXAZOL-2-YL)-1H-INDAZOL-6-YLM ETHOXYNICOTINATE MUS MUSCULUS COVALENT INHIBITOR KINASE DRUG DISCOVERY COMPLEX TRANSFE
Ref.: SELECTIVELY TARGETING THE KINOME-CONSERVED LYSINE O DELTA AS A GENERAL APPROACH TO COVALENT KINASE INHI J. AM. CHEM. SOC. V. 140 932 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
18 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
50% Homology Family (41)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
18 4FUL - 0VU C22 H23 N5 O3 S c1cc(cc(c1....
19 4ANW ic50 = 18 nM O92 C18 H14 Cl F2 N5 O3 S CNC(=O)c1c....
20 4WWP ic50 = 0.12 uM 3VE C22 H18 Cl N7 Cc1c(cccn1....
21 6AUD - BWY C25 H34 N6 O2 S CC(C)n1c(n....
22 4ANV ic50 = 441 nM 751 C28 H28 N4 O4 S COc1ccc(cc....
23 5JHB Kd = 873 nM 6K5 C18 H21 Cl F3 N7 O2 c1c(c(cnc1....
24 5G55 - 3QH C20 H18 N4 O Cc1ccc(cc1....
25 1E7V - LY2 C19 H17 N O3 c1ccc(cc1)....
26 2CHX - 090 C18 H16 N5 O3 COc1ccc2c(....
27 4WWO ic50 = 0.038 uM 3VD C22 H16 Cl F N6 C[C@@H](c1....
28 1E8Z - STU C28 H26 N4 O3 C[C@@]12[C....
29 3R7Q ic50 = 0.108 uM FAV C19 H14 Cl N O2 S CN(c1ccccc....
30 4GB9 - 0WR C28 H39 N9 O2 CC(C)(C1CC....
31 3ENE Ki = 0.57 uM NPZ C16 H13 N5 Cn1c2c(c(n....
32 3LJ3 ic50 = 43 nM WYE C22 H22 N4 O4 Cn1cc(c2c1....
33 2V4L ic50 = 1.5 uM ABJ C14 H15 N5 O CC(C)n1c2c....
34 6C1S Ki = 0.004 uM EFV C19 H16 N6 O3 COc1cc(cnc....
35 4HVB - 19P C24 H26 N6 O3 Cc1ccc(cn1....
36 1E8W - QUE C15 H10 O7 c1cc(c(cc1....
37 1E8X - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
38 3ZVV ic50 = 915 uM XAZ C8 H10 N4 Cc1cc(n2c(....
39 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
40 5UBR - 85S C26 H30 N8 O2 CC(=O)N1CC....
41 5DXT Ki = 0.2 nM 5H5 C19 H22 N6 O3 C[C@@H](C(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: C5Z; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 C5Z 1 1
2 VVX 0.4 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6EZ6; Ligand: C5Z; Similar sites found with APoc: 446
This union binding pocket(no: 1) in the query (biounit: 6ez6.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 4NMC FAD 1.09453
2 5VLQ ANP 1.18845
3 3UDZ ADP 1.41988
4 1KJ8 ATP 1.53453
5 1KJ8 GAR 1.53453
6 6GWR FEW 1.5873
7 2WSA MYA 1.59817
8 2WSA 646 1.59817
9 1OFZ FUC 1.60256
10 3EPO MP5 1.63399
11 1PK8 ATP 1.65877
12 2JLD AG1 1.66667
13 5MW8 ATP 1.69851
14 2ZWS PLM 1.70279
15 3K5I ADP 1.73697
16 3K5I AIR 1.73697
17 4BTK DTQ 1.78042
18 2CFM AMP 1.78253
19 4LS3 HIS 1.8018
20 4NM5 ADP 1.85676
21 5C4L 4XR 1.86916
22 5C4L SIS 1.86916
23 4EUU BX7 1.88088
24 3ZRM ZRM 1.88679
25 4Z87 GDP 1.90476
26 6FL8 ADP 1.91489
27 6FL8 TIY 1.91489
28 5N87 N66 1.91693
29 3TXO 07U 1.983
30 2XVD AS6 1.98676
31 2QK4 ATP 1.99115
32 4ORM ORO 1.99501
33 4ORM FMN 1.99501
34 4ORM 2V6 1.99501
35 2VPQ ANP 1.99557
36 2YRX AMP 1.99557
37 1O9U ADZ 2
38 3F7Z 34O 2
39 3HMO STU 2.04678
40 3PP0 03Q 2.07101
41 5ZTN CUR 2.0979
42 2WU6 DKI 2.09974
43 5KO1 6UY 2.12014
44 1CKN GTP 2.12121
45 1CKM GTP 2.12121
46 4OKD GLC GLC GLC 2.14286
47 2XK9 XK9 2.17391
48 6CMJ F6J 2.18069
49 3VSV XYS 2.19436
50 4CSD MFU 2.20588
51 4P5Z Q7M 2.21607
52 5CKW ANP 2.21729
53 2A1L PCW 2.22222
54 5TA6 79D 2.23464
55 1JPA ANP 2.24359
56 1AUX AGS 2.2508
57 3ETH ATP 2.25352
58 5A0U CHT 2.26415
59 5DZT AMP 2.28354
60 4NJH SAM 2.28354
61 4NJH 2K8 2.28354
62 5MJA 7O3 2.29508
63 1ZTH ADP 2.32558
64 3RE4 TO1 2.32558
65 1ZP9 ATP 2.32558
66 3E8N VRA 2.34604
67 3E8N ATP 2.34604
68 2QF7 AGS 2.37869
69 3ORQ ADP 2.38727
70 3KRL KRL 2.38806
71 4BHN BH9 2.39521
72 1Q8Y ADE 2.41287
73 6EOM ALA LYS 2.4735
74 4ONA UW1 2.47934
75 4UXL 5P8 2.48447
76 4GYI ADP 2.51889
77 3X01 AMP 2.54453
78 2WQN ADP 2.58065
79 3VOT ADP 2.58824
80 4LED XXR 2.61194
81 1OBD ATP 2.61438
82 3SLS ANP 2.63158
83 2PZI AXX 2.64317
84 3PE2 E1B 2.67062
85 3FHR P4O 2.67857
86 4XJ6 GH3 2.7027
87 5EH0 5NW 2.71318
88 5EQY 5RA 2.74314
89 6GQM F8H 2.7439
90 5VZ0 ADP 2.75928
91 5USZ SKE 2.76817
92 2YAB AMP 2.77008
93 4LH7 1X8 2.78638
94 5UIU 8CG 2.78638
95 5O5Y GLC 2.80172
96 5LI1 ANP 2.82486
97 3PN1 IVH 2.83019
98 4CC6 L5Y 2.83019
99 2B9H ADP 2.83286
100 4WHZ 3NL 2.85714
101 4FG8 ATP 2.85714
102 4D52 GXL 2.85714
103 5MY8 RXZ 2.87206
104 4WTV ATP 2.91829
105 4RDL FUC GAL NDG FUC 2.92208
106 1ULE GLA GAL NAG 2.94957
107 6CGD AKN 2.95082
108 6CGD GNP 2.95082
109 4UX9 ANP 3.02198
110 2PUL ACP 3.02267
111 3PTG 932 3.0303
112 5AWM ANP 3.04569
113 4UAL 3FV 3.10263
114 6FE1 V14 3.11284
115 2PVN P63 3.125
116 4IX4 ADP 3.14286
117 5UR1 YY9 3.21543
118 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 3.21637
119 2JDR L20 3.21637
120 3OPT AKG 3.21716
121 4OTH DRN 3.22581
122 5H9Q TD2 3.22581
123 5YF9 NIO 3.24484
124 4GLW 0XT 3.27869
125 1MEX RAC 3.28639
126 2X34 UQ8 3.31492
127 6A1G 9OL 3.33333
128 5WXU FLC 3.34029
129 3ALN ANP 3.36391
130 3LXK MI1 3.36391
131 1KKR 2AS 3.38983
132 1Z2P I3S 3.39506
133 1Z2P ACP 3.39506
134 3DNT ATP 3.40909
135 3TPV ADE 3.40909
136 1M0W ANP 3.46232
137 4WNP 3RJ 3.48432
138 4YZN 4K5 3.48432
139 5KBE IPH 3.49345
140 6AC9 ANP 3.51351
141 4X7Q 3YR 3.52564
142 4F9U PBD 3.52564
143 4EN4 ATP 3.52564
144 4EN4 GT1 3.52564
145 4EN4 GT0 3.52564
146 1OS7 AKG 3.53357
147 3ORK AGS 3.53698
148 2IO8 ADP 3.55412
149 5OMY 9YE 3.58056
150 3DLS ADP 3.58209
151 5NBW 8SK 3.6036
152 3KAL ADP 3.60721
153 4L3L 5FI 3.61842
154 5CEO 50D 3.66667
155 4UWJ 7L5 3.6855
156 4UWJ MYA 3.6855
157 1T27 PCW 3.69004
158 5DEY 59T 3.7037
159 6F3G CJN 3.72881
160 4U98 ACP 3.74449
161 4ZGP ADP 3.75427
162 5X8I SQZ 3.75723
163 2AQX ATP 3.80623
164 4U0I 0LI 3.80952
165 5HVJ ANP 3.80952
166 2X2M X2M 3.82166
167 3RI1 3RH 3.83387
168 2YGN PCF 3.84615
169 2BMB PMM 3.85321
170 3TTI KBI 3.87931
171 3FC2 IBI 3.8806
172 4AUA 4AU 3.90879
173 1VJY 460 3.9604
174 5JSP DQY 3.9801
175 1OIJ AKG 3.98671
176 3GGF GVD 3.98671
177 1RE8 BD2 4
178 6GZD LCI 4.01069
179 4DFU QUE 4.03727
180 2Q7D ANP 4.04624
181 5COU ATP 4.11765
182 5DRB 5FJ 4.12371
183 6FYL 3NG 4.13223
184 4RFM 3P6 4.13534
185 3DAK ANP 4.13793
186 3CY2 MB9 4.14013
187 2V7O DRN 4.16667
188 4QMN DB8 4.19355
189 4PU5 ANP 4.19426
190 4NFN 2KC 4.20712
191 5AX9 4KT 4.22078
192 5GLT BGC GAL NAG GAL 4.22535
193 2V58 LZJ 4.23163
194 5HES 032 4.23453
195 4E93 GUI 4.24403
196 5ISY NAD 4.2471
197 3VPC ADP 4.25532
198 4N70 2HX 4.26829
199 4USF 6UI 4.27632
200 5T8O 76Z 4.29799
201 3GC8 B45 4.32432
202 3HAV ATP 4.34783
203 3BZ3 YAM 4.34783
204 5M06 ADP 4.34783
205 4OWK NGA 4.34783
206 5A5W GUO 4.34783
207 3TY5 ATP 4.35835
208 3TY5 ADP 4.35835
209 3PLS ANP 4.36242
210 4CSV STI 4.36364
211 5LPB ADP 4.39189
212 2QX0 PH2 4.40252
213 3I0O ADP 4.42478
214 3DRW AMP 4.43038
215 4O4F IHP 4.43548
216 4O4F ATP 4.43548
217 5XVG 8FX 4.43686
218 3A7R LAQ 4.45104
219 4KS7 X4Z 4.45205
220 3HCN CHD 4.45682
221 2Y6O 1N1 4.46735
222 2X32 OTP 4.46927
223 5IH9 6BF 4.47761
224 1TIW FAD 4.48505
225 1TIW TFB 4.48505
226 4NZN 2OU 4.54545
227 4NZN ANP 4.54545
228 5C1P ADP 4.57516
229 5ZCT ANP 4.57516
230 5C1P DAL DAL 4.57516
231 4JGP PYR 4.60829
232 4H6B 10X 4.61538
233 4H6B 10Y 4.61538
234 2AE2 NAP 4.61538
235 2AE2 PTO 4.61538
236 2J7T 274 4.63576
237 4GJ3 0XP 4.63576
238 2HGS ADP 4.64135
239 2OFV 242 4.69314
240 2XMY CDK 4.69799
241 3WVR AMP 4.69799
242 2CSN CKI 4.7138
243 3NBC LAT 4.72973
244 5L9B AKG 4.7619
245 5OKT 9XK 4.77707
246 4XYM A12 4.78261
247 4XZ3 ACP 4.78261
248 4BFM ANP 4.79042
249 1UNH IXM 4.79452
250 5JKG 6LF 4.82315
251 1OPK P16 4.84848
252 6GUE FB8 4.85075
253 4OPC FDA 4.85651
254 1UPR 4IP 4.87805
255 1QPR PHT 4.92958
256 2BSA NAP 4.9505
257 2BSA FAD 4.9505
258 3TKI S25 4.95356
259 2HY0 306 4.96894
260 2XOC ADP 4.98084
261 4WW7 AMP 4.98084
262 6E2O S0L 5.08475
263 3W0O HY0 5.15759
264 3W0O ADP 5.15759
265 3V4S ADP 5.16796
266 3V4S ATP 5.16796
267 5VC5 96M 5.19031
268 5NKB 8ZT 5.22876
269 2IF8 ADP 5.23416
270 5H2U 1N1 5.24345
271 4CYI ATP 5.25114
272 3SJK LYS PRO VAL LEU ARG THR ALA 5.26316
273 3VHE 42Q 5.29248
274 5IH1 GDP 5.29801
275 5IH1 6BQ 5.29801
276 6CZ3 FLJ 5.30303
277 2VN9 GVD 5.31561
278 3VPD ANP 5.33808
279 3NX2 FER 5.35714
280 4ASE AV9 5.38244
281 2PYW ADP 5.47619
282 1T36 ADP 5.49738
283 4F9C 0SX 5.55556
284 1EHI ADP 5.57029
285 4YMJ 4EJ 5.59211
286 2BPM 529 5.66038
287 4WOV 3SM 5.67823
288 4AT3 LTI 5.68562
289 4XH0 ADP 5.7072
290 4BCM T7Z 5.72519
291 4BCQ TJF 5.72519
292 4BCN T9N 5.72519
293 2YNE NHW 5.72917
294 2YNE YNE 5.72917
295 4OCJ NDG 5.80475
296 3E7O 35F 5.83333
297 3NW7 LGV 5.86319
298 4YLZ LAT NAG GAL 5.88235
299 2BOS GLA GAL 5.88235
300 5IGI GMP 5.98007
301 5IGI ZIT 5.98007
302 4AG8 AXI 6.01266
303 3O0G 3O0 6.04027
304 3TII ANP 6.05263
305 4Y93 746 6.05381
306 2VZ6 FEF 6.07029
307 3GC0 AMP 6.07903
308 5TT6 ATP 6.09137
309 5VCV 1N1 6.10932
310 1I7L ATP 6.14887
311 3AKK ADP 6.15385
312 4EWH T77 6.18182
313 2HK5 1BM 6.2963
314 4DC2 ADE 6.31313
315 2YAK OSV 6.31579
316 3E85 BSU 6.32911
317 4OCV ANP 6.33245
318 5ODT ADP 6.36042
319 1DZK PRZ 6.36943
320 3WO0 ADP 6.38298
321 3WO0 ALA 6.38298
322 2WEL K88 6.42202
323 4Y8D 49J 6.42857
324 4PZ6 GMP 6.45161
325 4IDT T28 6.46067
326 3KN5 ANP 6.46154
327 4IZY 1J2 6.50407
328 2WA4 069 6.59026
329 1U59 STU 6.62021
330 5BVE 4VG 6.6482
331 4YZC STU 6.66667
332 5JGA 6KC 6.66667
333 6F7X MFU 6.66667
334 3OYW TDG 6.71642
335 4CLI 5P8 6.72783
336 5B09 4MX 6.73077
337 3WG3 A2G GAL NAG FUC 6.74157
338 2P7Q GG6 6.76692
339 4AZW ATP 6.79405
340 4ITH RCM 6.80272
341 3E5A VX6 6.81818
342 1S68 AMP 6.82731
343 5OES ADP 6.8323
344 2YW2 ATP 6.83962
345 3EKK GS2 6.84039
346 4QTB 38Z 6.84211
347 3VV1 GAL FUC 6.875
348 3GM5 CIT 6.91824
349 2QL9 CIT 6.93642
350 1DKU AP2 6.94006
351 3VRY B43 7.04846
352 3HZT J60 7.06638
353 3RWP ABQ 7.07396
354 5LVP ATP 7.07396
355 2RIO ADP 7.14286
356 4A4X JUP 7.16846
357 4JH6 FCN 7.24638
358 3G5D 1N1 7.34266
359 3M2W L8I 7.35786
360 2F2U M77 7.46269
361 5HCY 60D 7.55287
362 3V8S 0HD 7.56098
363 1MDC PLM 7.57576
364 3QH2 3NM 7.69231
365 5A6N U7E 7.77385
366 5TO8 7FM 7.80142
367 4Q5H ANP 8.04598
368 4TWP AXI 8.11808
369 5YK1 ANP 8.18584
370 1IA9 ANP 8.21429
371 1NU4 MLA 8.24742
372 3SRV S19 8.30325
373 4WVW SLT 8.33333
374 2BKK ADP 8.33333
375 3TM0 ANP 8.36502
376 3TM0 B31 8.36502
377 5YW5 ADE 8.37989
378 5I35 ANP 8.39695
379 4R78 AMP 8.41424
380 4F4P 0SB 8.42491
381 4CQE CQE 8.63309
382 5XQW 8EU 8.75576
383 4Y0X ADP 8.8
384 1XE7 GUN 8.86699
385 4XV1 904 8.90411
386 2R5V HHH 8.96359
387 2I8T GDD 8.98204
388 5U98 1KX 9.09091
389 1AE1 NAP 9.15751
390 4WUP 3UF 9.23077
391 1XJD STU 9.27536
392 4E1Z 0MX 9.27835
393 5FU3 BGC BGC BGC 9.43396
394 3PVW QRX 9.45946
395 4IJP 1EH 9.49721
396 1JBU BEN 9.52381
397 1OUK 084 9.56284
398 1TQP ATP 9.57447
399 4NW6 2NS 9.59752
400 3THR C2F 9.89761
401 4G17 0VN 10
402 1CBK ROI 10
403 3H9R TAK 10.0917
404 3VPB ADP 10.7143
405 6ES0 BW8 10.7256
406 1GSA ADP 10.7595
407 5NEA 8V8 10.7692
408 5W4W 9WG 10.8761
409 4KBA 1QM 10.8761
410 2YG2 S1P 11.0465
411 1E4E ADP 11.0787
412 1BYG STU 11.1511
413 5K2M ADP 11.3208
414 5Y86 HRM 11.3946
415 2A19 ANP 11.4286
416 4JR7 GNP 11.4973
417 5EOB 5QQ 11.5987
418 5T7I LAT NAG GAL 11.6129
419 5NLD LBT 12.2302
420 5TBM 79A 13.0435
421 5V3D FCN 13.1034
422 5WO4 B7V 13.9073
423 5Y80 IRE 14.1892
424 5HQ0 LZ9 14.2857
425 1TZD ADP 14.5455
426 5KK4 44E 14.5833
427 5KEW 6SB 14.8936
428 5A89 ADP 16.0256
429 5A89 FMN 16.0256
430 4ZS4 ATP 16.6124
431 4CQK PIO 17.0213
432 1W2D 4IP 17.3585
433 1W2D ADP 17.3585
434 3LQV ADE 17.9487
435 3PDT ADP 18.5455
436 2ZV2 609 19.4631
437 4LRJ ANP 19.5266
438 4AU8 Z3R 19.9324
439 1BHX ASP PHE GLU GLU ILE 23.3333
440 2GU8 796 25
441 5LXT ACP 28.6713
442 5EYK 5U5 30.5085
443 4UWH JXM 34.609
444 4C2W ANP 34.6154
445 1K3A ACP 35.7143
446 4C2V YJA 36.3636
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