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Receptor
PDB id Resolution Class Description Source Keywords
6D5V 2.04 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY AND STRUCTURE-BASED OPTIMIZATION OF BENZIMIDAZOLE-DERIVED ACTIVATORS OF SOS1-MEDIATED N EXCHANGE ON RAS. J. MED. CHEM. V. 61 8875 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG Q:201;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
GNP Q:202;
Valid;
none;
submit data
522.196 C10 H17 N6 O13 P3 c1nc2...
FVY S:1101;
Valid;
none;
submit data
303.762 C16 H15 Cl F N3 Cc1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6D5V 2.04 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY AND STRUCTURE-BASED OPTIMIZATION OF BENZIMIDAZOLE-DERIVED ACTIVATORS OF SOS1-MEDIATED N EXCHANGE ON RAS. J. MED. CHEM. V. 61 8875 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 6D5V - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 6D5V - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 6D5V - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GNP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GNP 1 1
2 9GM 1 1
3 GDP 0.839506 0.973684
4 GP3 0.82716 0.948718
5 GTP 0.809524 0.973684
6 GNH 0.807229 0.986842
7 G1R 0.77907 0.961039
8 GCP 0.77907 0.948718
9 GSP 0.770115 0.925
10 5GP 0.756098 0.960526
11 G 0.756098 0.960526
12 G2R 0.747253 0.936709
13 GMV 0.747126 0.948718
14 GAV 0.714286 0.936709
15 GP2 0.712644 0.936709
16 G2P 0.711111 0.936709
17 Y9Z 0.708333 0.880952
18 GDC 0.690722 0.936709
19 GDD 0.690722 0.936709
20 GKE 0.690722 0.936709
21 G5P 0.686869 0.948718
22 GPG 0.684211 0.936709
23 GTG 0.683673 0.91358
24 GDR 0.683673 0.936709
25 GFB 0.683673 0.936709
26 JB2 0.68 0.936709
27 GKD 0.68 0.936709
28 6CK 0.676768 0.91358
29 G3A 0.676768 0.948718
30 GDX 0.673267 0.948718
31 ALF 5GP 0.67033 0.86747
32 YGP 0.663265 0.879518
33 GPD 0.656863 0.902439
34 ALF GDP 0.645833 0.86747
35 GDP AF3 0.645833 0.86747
36 GDP ALF 0.645833 0.86747
37 JB3 0.641509 0.925
38 DBG 0.640351 0.974359
39 G3D 0.638298 0.960526
40 G4P 0.625 0.960526
41 GMP 0.621951 0.857143
42 NGD 0.62037 0.936709
43 GGM 0.618182 0.925926
44 0O2 0.616162 0.960526
45 2MD 0.603604 0.870588
46 CAG 0.60177 0.904762
47 U2G 0.590909 0.91358
48 FEG 0.590909 0.858824
49 GDP 7MG 0.590476 0.888889
50 MGD 0.587719 0.870588
51 G G 0.586538 0.924051
52 ZGP 0.585586 0.848837
53 CG2 0.580357 0.91358
54 ANP 0.568421 0.922078
55 PGD 0.567797 0.902439
56 MD1 0.567797 0.870588
57 3GP 0.56044 0.922078
58 TPG 0.558333 0.822222
59 GH3 0.55 0.948052
60 FE9 0.546219 0.778947
61 GPX 0.539216 0.922078
62 G4M 0.539062 0.860465
63 DGI 0.536082 0.9
64 BGO 0.535088 0.901235
65 IDP 0.53125 0.947368
66 DGT 0.53 0.9
67 2GP 0.526882 0.935065
68 G1R G1R 0.520325 0.901235
69 GCP G 0.518868 0.897436
70 A G 0.516949 0.911392
71 U A G G 0.512605 0.911392
72 G A A A 0.504202 0.9
73 AGO 0.504202 0.91358
74 P2G 0.5 0.860759
75 G1G 0.5 0.902439
76 R7I 0.49505 0.922078
77 MGP 0.49505 0.936709
78 R5I 0.49505 0.922078
79 PGD O 0.492063 0.831461
80 6G0 0.490196 0.936709
81 P1G 0.489796 0.85
82 AKW 0.483051 0.869048
83 DG 0.474227 0.8875
84 DGP 0.474227 0.8875
85 G U 0.466667 0.878049
86 IMP 0.463918 0.934211
87 G2Q 0.462963 0.936709
88 GPC 0.459677 0.858824
89 G C 0.459016 0.878049
90 GTA 0.448276 0.91358
91 G7M 0.444444 0.924051
92 MAP 0.439252 0.898734
93 G G G RPC 0.435484 0.853659
94 B4P 0.434343 0.871795
95 AP5 0.434343 0.871795
96 ADP 0.434343 0.896104
97 A2D 0.43299 0.871795
98 AT4 0.43 0.8625
99 G G G C 0.426357 0.890244
100 AU1 0.425743 0.922078
101 SGP 0.425743 0.807229
102 BA3 0.424242 0.871795
103 A G C C 0.423077 0.888889
104 35G 0.423077 0.909091
105 PCG 0.423077 0.909091
106 C2E 0.423077 0.897436
107 APC G U 0.421875 0.864198
108 HEJ 0.421569 0.896104
109 ATP 0.421569 0.896104
110 ACQ 0.419048 0.873418
111 5GP 5GP 0.419048 0.860759
112 5FA 0.417476 0.896104
113 AQP 0.417476 0.896104
114 01G 0.417391 0.880952
115 AN2 0.415842 0.909091
116 UNP 0.415842 0.810127
117 6AD 0.415094 0.821429
118 M33 0.411765 0.860759
119 ITT 0.411765 0.846154
120 G C C C 0.410448 0.901235
121 HFD 0.409524 0.851852
122 G U34 0.408 0.86747
123 ACP 0.407767 0.873418
124 6YZ 0.407407 0.873418
125 AR6 0.403846 0.871795
126 APR 0.403846 0.871795
127 DG DG 0.403509 0.845238
128 A4P 0.403226 0.848837
129 UCG 0.402985 0.888889
130 SAP 0.4 0.851852
131 AGS 0.4 0.851852
132 AD9 0.4 0.873418
Ligand no: 2; Ligand: FVY; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 FVY 1 1
2 FW4 0.545455 0.77193
3 HAN 0.405405 0.666667
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6D5V; Ligand: GNP; Similar sites found with APoc: 551
This union binding pocket(no: 1) in the query (biounit: 6d5v.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 2JDU MFU 1.73913
2 2UVO NAG 1.75439
3 2HXW FLC 2.1097
4 2X77 GDP 2.1164
5 1B0U ATP 2.29008
6 2ZFI ADP 2.39521
7 3N5C GDP 2.46914
8 6C90 ADP 2.99401
9 1T3D CYS 2.99401
10 5D9G GLU ASN LEU TYR PHE GLN 2.99401
11 5FTB ANP 3.00231
12 5FHD ADP ALF 3.00231
13 1OSS BEN 3.13901
14 5EXT ADP 3.46154
15 4D81 ADP 3.53357
16 1M7G AV2 3.59281
17 4ZNL BEF ADP 3.59281
18 1IWE IMP 3.59281
19 2FSH ANP 3.59281
20 1M7G ADX 3.59281
21 2FPU HSO 3.59281
22 1M7G ADP 3.59281
23 3QDK QDK 3.59281
24 3H86 AP5 3.64583
25 6A20 ADP 3.73444
26 1FNZ A2G 3.79747
27 1G41 ADP 3.82883
28 3FJG 3PG 3.98406
29 3DKP ADP 4.08163
30 1TQ4 GDP 4.11622
31 2J5V PCA 4.19162
32 2PW0 TRC 4.19162
33 2IYL GDP 4.19162
34 1YXM ADE 4.19162
35 2O0J ADP 4.19162
36 2Z49 AMG 4.19162
37 1YTM ATP 4.19162
38 1MLY ACZ PLP 4.19162
39 2Z48 NGA 4.19162
40 5VHC BEF ADP 4.19162
41 4O48 ASP 4.19162
42 5HR5 ADP 4.19162
43 5J6Y GLC 4.25532
44 5J6Y BGC 4.25532
45 1HTW ADP 4.43038
46 2W58 ADP 4.45545
47 1C3X 8IG 4.51128
48 5ZB0 TYD 4.54545
49 5ZB0 ADP 4.54545
50 2KIN ADP 4.62185
51 3KC1 2T6 4.74777
52 1JI0 ATP 4.79042
53 3EZ2 ADP 4.79042
54 5M04 GDP 4.79042
55 3BOS CDP 4.79042
56 4PX9 ADP 4.79042
57 3B7G ANP 4.79042
58 4OHY ANP 4.79042
59 3ITJ CIT 4.79042
60 2OZE AGS 4.79042
61 3DC4 ADP 4.79042
62 2Q8M AMP 4.79042
63 5I34 GDP 4.79042
64 5XLS URA 4.79042
65 2HIM ASN 4.79042
66 4MZQ 1VU 4.86111
67 4WOP CTP 4.88889
68 4HE2 AMP 5.02959
69 3PUN FUC GAL NDG FUC 5.06329
70 3AI8 HNQ 5.07812
71 2XCU C5P 5.08021
72 2VOH CIT 5.09554
73 6AR9 3L4 5.14706
74 2Y65 ADP 5.20548
75 1A78 TDG 5.22388
76 2RGX AP5 5.33981
77 1T5C ADP 5.38922
78 5I0H ADP BEF 5.38922
79 1Z6T ADP 5.38922
80 1G8S MET 5.38922
81 4U60 SIA GAL NGA 5.38922
82 4U60 SIA 5.38922
83 4GOX A3P 5.38922
84 5H68 AGS 5.38922
85 4U60 SIA GAL BGC NGA GAL 5.38922
86 3F4F UMP 5.38922
87 1P9B GDP 5.38922
88 5AHO TLA 5.38922
89 2Q2Y ADP 5.44959
90 2Q2Y MKR 5.44959
91 3IO3 ADP 5.45977
92 3UIE ANP 5.5
93 6H5E ANP 5.57769
94 4KAX GTP 5.59006
95 1XXR MAN 5.59006
96 4YDS ATP 5.70175
97 3IUY AMP 5.70175
98 5UIV ADP 5.72687
99 5N69 ADP 5.80913
100 1G6H ADP 5.83658
101 5M7P ADP 5.94714
102 4FRZ ADP 5.95855
103 1VKJ A3P 5.96491
104 4RD0 GDP 5.98802
105 2A5F GTP 5.98802
106 3NHB ADP 5.98802
107 3FWY ADP 5.98802
108 5ZXD ATP 5.98802
109 3Q9L ATP 5.98802
110 2OBM ADP 5.98802
111 1F5N GNP 5.98802
112 5J1J ANP 5.98802
113 5Y6N ADP 5.98802
114 2CE7 ADP 5.98802
115 2C9O ADP 5.98802
116 5MZN ADP 5.98802
117 5Z69 AGS 5.98802
118 3QKT ANP 5.98802
119 3FVQ ATP 5.98802
120 2Z5F A3P 5.98802
121 5Y0T TAT 5.98802
122 1OS1 PYR 6.0166
123 1OS1 ATP 6.0166
124 1I9G SAM 6.07143
125 4TQK NAG 6.15764
126 5TSH ADP 6.22407
127 5TSH ANP 6.22407
128 4JLV ADP 6.3197
129 5BQ5 ADP BEF 6.34921
130 5GOE GDP 6.3981
131 3WY9 GDP 6.45161
132 3WYA GDP 6.45161
133 4OWK NGA 6.52174
134 3LEK BCW 6.53595
135 3U6B GDP 6.58683
136 2BVN GNP 6.58683
137 3U6K GDP 6.58683
138 3WXM GTP 6.58683
139 3VMF GTP 6.58683
140 2PZE ATP 6.58683
141 4WZ6 ATP 6.58683
142 2HCJ GDP 6.58683
143 1D8T GDP 6.58683
144 5JBQ GDP 6.58683
145 4G5G GDP 6.58683
146 1FP6 ADP 6.58683
147 5WC2 ADP 6.58683
148 4WZA ACP 6.58683
149 2DPY ADP 6.58683
150 4WZA ADP 6.58683
151 4R43 GDP 6.58683
152 1EXF GLY 6.58683
153 2ZPA ADP 6.58683
154 4QOS ADP 6.58683
155 2FNA ADP 6.58683
156 4RZ3 ADP 6.58683
157 1E2K TMC 6.58683
158 3RC3 ANP 6.58683
159 4ZDJ UTP 6.58683
160 1ION ADP 6.58683
161 5NM7 GLY 6.58683
162 2BEK ATP 6.61479
163 1UPT GTP 6.66667
164 5K5Z ANP 6.6879
165 5L3W GDP 6.86275
166 5OCM 9RH 6.87285
167 4NU0 AP5 6.91244
168 5XDR ADP 7.05394
169 5VYQ FON 7.05882
170 1DAK ADP 7.14286
171 1DAK DPU 7.14286
172 5W7Q GDP 7.18563
173 5W76 GDP 7.18563
174 5W75 GDP 7.18563
175 3PCR GTP 7.18563
176 1WDT GTP 7.18563
177 1GOJ ADP 7.18563
178 3ZFD ANP 7.18563
179 3CNL GNP 7.18563
180 1SQ5 ADP 7.18563
181 2GK6 ADP 7.18563
182 1U0J ADP 7.18563
183 2XAU ADP 7.18563
184 1W5T ANP 7.18563
185 2X7I CIT 7.18563
186 1W5T ADP 7.18563
187 3BFX A3P 7.18563
188 5IRN ADP 7.18563
189 4DFU QUE 7.18563
190 1U2Z SAH 7.18563
191 4E03 ADP 7.28155
192 1W7J ADP BEF 7.28477
193 6EKZ SNP 7.31707
194 4PYA 2X3 7.45342
195 4YFY 1YJ 7.48031
196 5U32 GDP 7.62712
197 5LB3 ADP 7.64045
198 2VB6 ADP BEF 7.67635
199 4YS0 ADP 7.67635
200 4PFO ADP 7.67635
201 2XT3 ADP 7.78443
202 1LVG ADP 7.78443
203 2WHX ADP 7.78443
204 4V03 ADP 7.78443
205 4H1V GNP 7.78443
206 3E70 GDP 7.78443
207 1OXV ANP 7.78443
208 3TBK ANP 7.78443
209 5LTJ ADP 7.78443
210 3T34 GDP 7.78443
211 5LTJ BEF 7.78443
212 5AK0 8V1 7.78443
213 4X8O AP5 7.78443
214 4PJ3 ANP 7.78443
215 4OKD GLC GLC GLC 7.78443
216 1S3G AP5 7.78443
217 5MEX PAP 7.78443
218 2JLR ANP 7.78443
219 3QOX SAH 7.78443
220 1QAN SAH 7.78689
221 2Y7P SAL 7.79817
222 2C77 GNP 7.90123
223 2C78 GNP 7.90123
224 1NJF ADP 8
225 1NJF AGS 8
226 5GVR LMR 8.11966
227 1VHT BA3 8.25688
228 3LRE ADP 8.38323
229 5IRR GSP 8.38323
230 4CVN ADP 8.38323
231 2RCN GDP 8.38323
232 4IDN GNP 8.38323
233 2BIF SIN 8.38323
234 2BIF ANP 8.38323
235 1K6M AGS 8.38323
236 4MKF AP5 8.38323
237 3FYH ADP 8.38323
238 1DQN IMU 8.38323
239 1O8B ABF 8.38323
240 4PVR ASP 8.38323
241 5H4S RAM 8.38323
242 2JK0 ASP 8.38323
243 4Z7X 3CX 8.40336
244 5HCN GCP 8.42912
245 5EE5 GTP 8.4507
246 2CDN ADP 8.45771
247 1QF5 RPL 8.58469
248 1QF5 GDP 8.58469
249 1ZVX FIN 8.58896
250 1DCP HBI 8.65385
251 3HCH RSM 8.90411
252 1GPJ CIT 8.91089
253 2GNK ATP 8.92857
254 2VVG ADP 8.98204
255 1V8K ANP 8.98204
256 6AU6 GDP 8.98204
257 4LYA ATP 8.98204
258 1D2E GDP 8.98204
259 4ZG4 VO4 ADP 8.98204
260 1XKV ATP 8.98204
261 2R4V GSH 8.98204
262 5G3Y ADP 8.98204
263 6FAA ADP 8.98204
264 4MKG AP5 8.98204
265 4IOK ADP 8.98204
266 4IOK XPO 8.98204
267 5G41 AP5 8.98204
268 4QRH 0O2 9.04762
269 3P9Y N7P THR SEP PRO SER TYR SET 9.09091
270 3BFV ADP 9.22509
271 3FB4 AP5 9.25926
272 5TQZ GLC 9.33333
273 4P3Y GDP 9.34066
274 1ZEI CRS 9.43396
275 2YY8 MTA 9.45274
276 4J0Q GDP 9.58084
277 1KK1 GNP 9.58084
278 4PC3 GDP 9.58084
279 2NCD ADP 9.58084
280 3R7F CP 9.58084
281 6CS8 F9Y 9.58084
282 1ZIN AP5 9.58084
283 1AKY AP5 9.58084
284 2BQP GLC 9.58084
285 3DOE GTP 9.69697
286 2OG2 MLI 9.7493
287 3ZS9 ADP ALF 9.88701
288 2WOJ ADP ALF 9.88701
289 4XTR ATP 9.88701
290 4XVU ATP 9.88701
291 4XTR ADP 9.88701
292 2GMP NAG MAN 9.92064
293 2GMM MAN MAN 9.92064
294 2QZ4 ADP 9.92366
295 1APZ ASP 9.92908
296 2FAH GDP 9.95851
297 1PTR PRB 10
298 6B8B ADP 10.0402
299 2GWH A3P 10.0671
300 1SKQ GDP 10.1796
301 1BG2 ADP 10.1796
302 5IFS ADP 10.1796
303 1FNN ADP 10.1796
304 1IN4 ADP 10.1796
305 4A4Z ANP 10.1796
306 1D2N ANP 10.1796
307 1NST A3P 10.1796
308 2ODE ALF GDP 10.2857
309 1KO8 6PG 10.2857
310 3ZQ6 ADP ALF 10.4938
311 2CBZ ATP 10.5485
312 2OFW ADX 10.5769
313 1U3G ADP 10.582
314 1VBO MAN 10.7383
315 1VBO MAN MAN MAN 10.7383
316 3TK1 GDP 10.7784
317 3EWA ANP 10.7784
318 5VGR GDP 10.7784
319 1OYY AGS 10.7784
320 1F9V ADP 10.7784
321 1ZQ9 SAM 10.7784
322 3COB ADP 10.8401
323 1P4V GLY 10.8475
324 5O96 SAM 11.0204
325 5MVR ADP 11.1111
326 2WIC GNP 11.3772
327 4R98 GNH 11.3772
328 5ZBR ANP 11.3772
329 4XGU ADP 11.3772
330 1ZUI SKM 11.3772
331 1SVM ATP 11.3772
332 2J0W ASP 11.3772
333 2GUD MAN 11.3772
334 1SVK ALF GDP 11.6147
335 1X6V ADP 11.6183
336 5KUT GDP 11.6402
337 2WJG GDP 11.976
338 1JJV ATP 11.976
339 4IEE AGS 11.976
340 4FCW ADP 11.976
341 4LJ9 ACP 11.976
342 1NY5 ADP 11.976
343 2WZF BGC 11.976
344 5XKT GNP 12
345 2WJH FLC 12.0482
346 2WJH GDP 12.0482
347 1F2U ATP 12.0805
348 3KTA AP5 12.1387
349 1B7T ADP 12.1795
350 3B9Q MLI 12.2517
351 1L2T ATP 12.3404
352 1Y3A GDP 12.462
353 1KSH GDP 12.5
354 5H67 ATP 12.5
355 4NON GDP 12.5749
356 3FKQ ATP 12.5749
357 4YJ1 ADP 12.5749
358 1LVK MNT BEF 12.5749
359 1Z03 OCH 12.5749
360 1P72 ADP 12.5749
361 3P4X ADP 12.5749
362 1R0X ATP 12.5874
363 2OM2 GDP 12.6154
364 1BH2 GSP 13.0159
365 1Y63 ADP 13.0435
366 4ZKD GDP 13.1737
367 1JJ7 ADP 13.1737
368 5J1S ATP 13.1737
369 2HF9 GSP 13.2743
370 2O66 FLC 13.3333
371 1KK8 BEF ADP 13.6691
372 4U00 ADP 13.7725
373 4YMU ATP 13.7725
374 3B5J 12D 13.7725
375 4MDB RLT 13.7725
376 1G3Q ADP 13.7725
377 3K5I AIR 13.7725
378 3BER AMP 14.0562
379 4Q1A 2XZ 14.2857
380 4Q1A UDP 14.2857
381 3PQC GDP 14.3713
382 4QM7 GTP 14.3713
383 2PL3 ADP 14.3713
384 5L3R GCP 14.3713
385 1WY7 SAH 14.4928
386 5C2N NAG 14.5833
387 3H4S ADP 14.8148
388 1RRC ADP 14.9701
389 2GKS ADP 14.9701
390 2IS6 ADP 14.9701
391 3UG4 AHR 14.9701
392 4R2I ANP 14.9701
393 1AQU A3P 14.9701
394 4BAS GNP 15.0754
395 3KIF GDL 15.0943
396 3AB4 THR 15.1685
397 6FMC DUE 15.1899
398 2XTZ GSP 15.2542
399 4XDY HIO 15.3846
400 1CS4 GSP 15.566
401 4NCN GTP 15.5689
402 4TMZ GSP 15.5689
403 3L6C MLI 15.5689
404 4UOX PUT 15.5689
405 1G7C 5GP 15.9574
406 3FSY SCA 15.9639
407 3CX8 GSP 16.1677
408 2AWN ADP 16.1677
409 3AB3 GDP 16.1677
410 1ZCB GDP 16.1677
411 1MKY GDP 16.1677
412 6CRK GDP 16.1677
413 2CHG ANP 16.1677
414 3RLF ANP 16.1677
415 1FQJ ALF 16.6667
416 1FQJ GDP 16.6667
417 1OFH ADP 16.6667
418 3IIJ ADP 16.6667
419 1RJ9 GCP 17
420 1PUJ GNP 17.3653
421 4IHQ ADP 17.3653
422 1LOB MMA 17.3653
423 5X40 ACP 17.3653
424 2ZTS ADP 17.3653
425 3KIH GDL 17.5258
426 1KJ8 GAR 17.9641
427 4G86 BNT 17.9641
428 4OI4 ATP 17.9641
429 3ZIA ADP 18.0328
430 3ZIA ATP 18.0328
431 5TWJ SAM 18.5185
432 5CK5 GDP 18.5629
433 1XP8 AGS 18.5629
434 6B4K ANP 18.5629
435 3TY3 GGG 18.5629
436 4HSE ADP 18.5629
437 1GXU 2HP 18.6813
438 4Y4V DAL 19.1617
439 4P4T GDP 19.1617
440 1TL2 NDG 19.1617
441 2W83 GTP 19.4805
442 5L3S GNP 19.7605
443 1IHU AF3 19.7605
444 1IHU ADP 19.7605
445 5L3V GDP 19.7605
446 4PPF FLC 20.3593
447 1H65 GDP 20.3593
448 2ZR9 DTP 20.3593
449 6AIC AMP 20.3593
450 5ODQ 9SB 20.3593
451 4BQS K2Q 20.4545
452 4BQS ADP 20.4545
453 1UJ2 C5P 22.1557
454 2D7D ADP 22.5
455 4LPS GDP 22.7545
456 5BN3 ADP 22.7545
457 1CR1 TTP 22.7545
458 3A4M ADP 23.3533
459 2FH5 GTP 23.9521
460 1XMV ADP 23.9521
461 3DEF GDP 23.9521
462 5WRI A3P 24.5509
463 3W5J GDP 25.1497
464 1W0J ADP 25.1497
465 2CK3 ANP 25.1497
466 1W0J ADP BEF 25.1497
467 2CK3 ADP 25.1497
468 2V7Q ATP 25.1497
469 2V7Q ADP 25.1497
470 3DZD ADP 26.3473
471 4TL6 ANP 26.3473
472 1XX6 ADP 26.9461
473 4KVA GTP 26.9461
474 4JLS 3ZE 26.9461
475 4TTQ ATP 27.4419
476 4V0K GDP 27.5449
477 1DAR GDP 27.5449
478 4B47 GDP 28.1437
479 3KJI ADP 28.1437
480 4M9Q GNP 28.7425
481 1YRB GDP 29.3413
482 3T12 GDP ALF 29.3413
483 3T1O GDP 29.3413
484 1R4A GNP 29.4118
485 1G7S GDP 29.9401
486 3QF7 ANP 30
487 2PEZ GGZ 31.2849
488 2PEZ DAT 31.2849
489 5YT0 GDP 31.7365
490 5FG3 GDP 31.7365
491 2J59 GTP 31.7365
492 1J2J GTP 31.7365
493 1O3Y GTP 31.7365
494 4DCT GDP 32.3353
495 1RE0 GDP 32.3353
496 1ZD9 GDP 32.3353
497 1S9D GDP 32.3353
498 5H7K GDP 32.9341
499 5H7J GCP 32.9341
500 3AQ4 GDP 32.9341
501 2QN6 GDP 33.3333
502 1NRJ GTP 33.5329
503 1YZG GDP 33.5329
504 1ZJ6 G3D 34.1317
505 4YLG GDP 34.1317
506 5KSP GDP 37.7246
507 5KSZ GCP 37.7246
508 5KDO GDP 39.1892
509 2ZEJ GDP 39.521
510 4ZI2 GNP 40.1198
511 4GOJ GNP 40.1198
512 1FZQ GDP 40.1198
513 2QTV GNP 40.1198
514 1M2O GNP 41.3174
515 5DI3 GNP 41.9162
516 1F6B GDP 41.9162
517 3A1S GDP 43.7126
518 1MR3 G3D 44.3114
519 1GWN GTP 45.509
520 1M7B GTP 45.509
521 3M1I GTP 48.503
522 3GJX GTP 48.503
523 3WYF GTP 48.503
524 3WYG GTP 48.503
525 3GJ4 GDP 48.503
526 3GJ7 GDP 48.503
527 1Z0J GTP 48.503
528 3GJ5 GDP 48.503
529 3GJ8 GDP 48.503
530 1D5C GDP 48.7654
531 4HAT GNP 49.1018
532 5DHF GNP 49.1018
533 5UWP GNP 49.1018
534 6CIT GNP 49.1018
535 5UWQ GNP 49.1018
536 5UWJ GNP 49.1018
537 5UWO GNP 49.1018
538 5UWR GNP 49.1018
539 5UWW GNP 49.1018
540 5UWU GNP 49.1018
541 5UWT GNP 49.1018
542 5UWI GNP 49.1018
543 1WA5 GTP 49.1018
544 5UWS GNP 49.1018
545 5UWH GNP 49.1018
546 5DI9 GNP 49.1018
547 3GJ3 GDP 49.1018
548 3CH5 GDP 49.1018
549 5OEC GDP 49.1018
550 4HI0 GDP 49.1018
551 1YVD GNP 49.1124
Pocket No.: 2; Query (leader) PDB : 6D5V; Ligand: FVY; Similar sites found with APoc: 109
This union binding pocket(no: 2) in the query (biounit: 6d5v.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 2XHK AKG 2.25225
2 1SR7 MOF 2.3166
3 1BGQ RDC 2.66667
4 5DH3 5BS 2.85714
5 1GVE NAP 2.99401
6 5AEW BNL 3.19149
7 2XKO AKG 3.37079
8 3HKW IX6 3.52697
9 3F3E LEU 3.52697
10 3RY9 1CA 3.59281
11 3G5D 1N1 3.59281
12 2J4D FAD 3.59281
13 4NAT ADP 3.75
14 4XB4 45D 3.94737
15 2GJ3 FAD 4.16667
16 3P3G 3P3 4.19162
17 3P3G UKW 4.19162
18 2FLI DX5 4.19162
19 5N2I NAP 4.31034
20 2JJK R15 4.73373
21 4ORM ORO 4.79042
22 4ORM 2V6 4.79042
23 4ORM FMN 4.79042
24 4CJX NAP 5.01567
25 3GGO NAI 5.09554
26 3OKI OKI 5.15021
27 1E3I CXF 5.38922
28 4JBI NDP 5.40541
29 5W99 A1V 5.65476
30 1D6H COA 5.98802
31 4AQL TXC 5.98802
32 5J6A P46 5.98802
33 3FWY ADP 5.98802
34 5B0I BOG 6.12245
35 6C74 PC 6.30631
36 4D7M TDC 6.58683
37 5X3R 7Y3 6.58683
38 3WXB NDP 6.58683
39 5LNQ CAA 6.58683
40 1NP7 FAD 6.58683
41 3RI1 3RH 6.58683
42 3H0A D30 6.98529
43 1FM9 570 6.98529
44 5TWO 7MV 6.98529
45 3G9E RO7 7.01107
46 2XFH CL6 7.18563
47 2R40 20E 7.18563
48 3KJS DQ1 7.18563
49 1Z83 AP5 7.18563
50 1EU1 GLC 7.18563
51 3BF1 ADP 7.18563
52 1OQC FAD 7.2
53 4UX9 ANP 7.78443
54 2C91 NAP 7.78443
55 4OKD GLC GLC GLC 7.78443
56 4O4Z N2O 7.79221
57 5XDT ZI7 8.38323
58 4CMI NAP 8.38323
59 3RDE OYP 8.38323
60 5LX9 OLB 8.38323
61 4CM8 NAP 8.38323
62 5Z1N PEF 8.92857
63 5IVX ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 8.98204
64 1OLM VTQ 8.98204
65 4OMJ 2TX 8.98204
66 1YUC EPH 8.98204
67 1JQ9 PHE LEU SER TYR LYS 9.09091
68 4V1F BQ1 9.30233
69 2GOU FMN 9.58084
70 4WX0 HXD 9.58084
71 6DWD HDV 9.58084
72 5WRE 7TL 9.67742
73 2VSS ACO 10.1449
74 3RMK BML 10.1796
75 5WP4 SAH 10.1796
76 1JAY NAP 10.3774
77 5CG1 NAD BBN 10.7784
78 5K53 STE 10.7784
79 1GT4 UNA 11.3208
80 5A4W QCT 11.976
81 3D9F N6C 12.5749
82 2O3Z AI7 12.5749
83 1K7L 544 12.5749
84 1T0S BML 12.7907
85 3BEJ MUF 13.0252
86 4UMJ BFQ 13.1737
87 4XT8 TMQ 13.1737
88 3DCT 064 13.1915
89 3RUU 37G 13.5371
90 6A5Y 9R0 13.5965
91 2TPS TPS 13.7725
92 4J7Q B7N 14.3713
93 5CJH 522 14.3713
94 5A89 FMN 14.7436
95 3N7H DE3 15.2
96 3LA3 2FT 16.1677
97 2HJ3 FAD 16.8
98 5TBM 79A 18.8034
99 5LXT GDP 20.2797
100 5U3B 7TD 20.3593
101 1N5D NDP 21.5278
102 5K52 OCD 22.1557
103 5MT9 SRO 23.8095
104 5MT9 ARG 23.8095
105 5AAV GW5 24.5509
106 6CB2 OLC 25.7485
107 3FPF MTA 25.7485
108 3FPF TNA 25.7485
109 5HZ9 5M8 33.3333
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