-->
Receptor
PDB id Resolution Class Description Source Keywords
6BVM 1.8 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NA C:202;
Part of Protein;
none;
submit data
22.99 Na [Na+]
FMT B:2004;
B:2002;
B:2006;
C:201;
B:2005;
B:2003;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
46.025 C H2 O2 C(=O)...
EBV B:2001;
Valid;
none;
submit data
461.986 C26 H28 Cl N5 O c1ccc...
GNP A:201;
Valid;
none;
submit data
522.196 C10 H17 N6 O13 P3 c1nc2...
MG A:202;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
GOL B:2007;
B:2008;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6BVM 1.8 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 6BVM - EBV C26 H28 Cl N5 O c1ccc2c(c1....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 6BVM - EBV C26 H28 Cl N5 O c1ccc2c(c1....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 6BVM - EBV C26 H28 Cl N5 O c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: EBV; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 EBV 1 1
2 EAS 0.494949 0.859649
3 EC4 0.476636 0.859649
4 EBY 0.462264 0.844828
5 EAV 0.459459 0.844828
6 SMY 0.417391 0.686567
Ligand no: 2; Ligand: GNP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GNP 1 1
2 9GM 1 1
3 GDP 0.839506 0.973684
4 GP3 0.82716 0.948718
5 GTP 0.809524 0.973684
6 GNH 0.807229 0.986842
7 G1R 0.77907 0.961039
8 GCP 0.77907 0.948718
9 GSP 0.770115 0.925
10 5GP 0.756098 0.960526
11 G 0.756098 0.960526
12 G2R 0.747253 0.936709
13 GMV 0.747126 0.948718
14 GAV 0.714286 0.936709
15 GP2 0.712644 0.936709
16 G2P 0.711111 0.936709
17 Y9Z 0.708333 0.880952
18 GDC 0.690722 0.936709
19 GDD 0.690722 0.936709
20 GKE 0.690722 0.936709
21 G5P 0.686869 0.948718
22 GPG 0.684211 0.936709
23 GTG 0.683673 0.91358
24 GDR 0.683673 0.936709
25 GFB 0.683673 0.936709
26 JB2 0.68 0.936709
27 GKD 0.68 0.936709
28 6CK 0.676768 0.91358
29 G3A 0.676768 0.948718
30 GDX 0.673267 0.948718
31 ALF 5GP 0.67033 0.86747
32 YGP 0.663265 0.879518
33 GPD 0.656863 0.902439
34 ALF GDP 0.645833 0.86747
35 GDP AF3 0.645833 0.86747
36 GDP ALF 0.645833 0.86747
37 JB3 0.641509 0.925
38 DBG 0.640351 0.974359
39 G3D 0.638298 0.960526
40 G4P 0.625 0.960526
41 GMP 0.621951 0.857143
42 NGD 0.62037 0.936709
43 GGM 0.618182 0.925926
44 0O2 0.616162 0.960526
45 2MD 0.603604 0.870588
46 CAG 0.60177 0.904762
47 U2G 0.590909 0.91358
48 FEG 0.590909 0.858824
49 GDP 7MG 0.590476 0.888889
50 MGD 0.587719 0.870588
51 G G 0.586538 0.924051
52 ZGP 0.585586 0.848837
53 CG2 0.580357 0.91358
54 ANP 0.568421 0.922078
55 PGD 0.567797 0.902439
56 MD1 0.567797 0.870588
57 3GP 0.56044 0.922078
58 TPG 0.558333 0.822222
59 GH3 0.55 0.948052
60 FE9 0.546219 0.778947
61 GPX 0.539216 0.922078
62 G4M 0.539062 0.860465
63 DGI 0.536082 0.9
64 BGO 0.535088 0.901235
65 IDP 0.53125 0.947368
66 DGT 0.53 0.9
67 2GP 0.526882 0.935065
68 G1R G1R 0.520325 0.901235
69 GCP G 0.518868 0.897436
70 A G 0.516949 0.911392
71 U A G G 0.512605 0.911392
72 G A A A 0.504202 0.9
73 AGO 0.504202 0.91358
74 P2G 0.5 0.860759
75 G1G 0.5 0.902439
76 R7I 0.49505 0.922078
77 MGP 0.49505 0.936709
78 R5I 0.49505 0.922078
79 PGD O 0.492063 0.831461
80 6G0 0.490196 0.936709
81 P1G 0.489796 0.85
82 AKW 0.483051 0.869048
83 DG 0.474227 0.8875
84 DGP 0.474227 0.8875
85 G U 0.466667 0.878049
86 IMP 0.463918 0.934211
87 G2Q 0.462963 0.936709
88 GPC 0.459677 0.858824
89 G C 0.459016 0.878049
90 GTA 0.448276 0.91358
91 G7M 0.444444 0.924051
92 MAP 0.439252 0.898734
93 G G G RPC 0.435484 0.853659
94 B4P 0.434343 0.871795
95 AP5 0.434343 0.871795
96 ADP 0.434343 0.896104
97 A2D 0.43299 0.871795
98 AT4 0.43 0.8625
99 G G G C 0.426357 0.890244
100 AU1 0.425743 0.922078
101 SGP 0.425743 0.807229
102 BA3 0.424242 0.871795
103 A G C C 0.423077 0.888889
104 35G 0.423077 0.909091
105 PCG 0.423077 0.909091
106 C2E 0.423077 0.897436
107 APC G U 0.421875 0.864198
108 HEJ 0.421569 0.896104
109 ATP 0.421569 0.896104
110 ACQ 0.419048 0.873418
111 5GP 5GP 0.419048 0.860759
112 5FA 0.417476 0.896104
113 AQP 0.417476 0.896104
114 01G 0.417391 0.880952
115 AN2 0.415842 0.909091
116 UNP 0.415842 0.810127
117 6AD 0.415094 0.821429
118 M33 0.411765 0.860759
119 ITT 0.411765 0.846154
120 G C C C 0.410448 0.901235
121 HFD 0.409524 0.851852
122 G U34 0.408 0.86747
123 ACP 0.407767 0.873418
124 6YZ 0.407407 0.873418
125 AR6 0.403846 0.871795
126 APR 0.403846 0.871795
127 DG DG 0.403509 0.845238
128 A4P 0.403226 0.848837
129 UCG 0.402985 0.888889
130 SAP 0.4 0.851852
131 AGS 0.4 0.851852
132 AD9 0.4 0.873418
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6BVM; Ligand: EBV; Similar sites found with APoc: 476
This union binding pocket(no: 1) in the query (biounit: 6bvm.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 2GSU AMP 1.79641
2 4Q6R 30J 1.86722
3 3LLI FAD 1.91571
4 4DR9 BB2 2.08333
5 2C43 COA 2.16718
6 4OAR 2S0 2.32558
7 2XSU PIE 2.39521
8 5ZKC 3C0 2.39521
9 5EUD 5S6 2.39521
10 3P9T TCL 2.39521
11 4W4S B29 2.66667
12 3GN8 DEX 2.81124
13 5UFS 1TA 2.82258
14 5N9T 8QQ 2.99401
15 2UYT LRH 2.99401
16 2UYT ADP 2.99401
17 6EQ8 BQZ 2.99401
18 3WHB DCC 3.09278
19 3ZLR X0B 3.16456
20 2X5W K2B 3.18182
21 5JFS 6K0 3.24675
22 1MID LAP 3.2967
23 6F70 GSH 3.57143
24 3JZB 4HY 3.59281
25 3KJD 78P 3.59281
26 3T58 FAD 3.59281
27 3RY9 1CA 3.59281
28 4ZZE GLC GLC GLC 3.59281
29 3E7O 35F 3.61111
30 4NSQ COA 3.68421
31 5EK3 5PK 3.72208
32 4NAT ADP 3.75
33 4NAT 2W5 3.75
34 5SYN 71T 3.8961
35 5JF2 SF7 3.92157
36 2GTE VA 4.03226
37 2G3F IZC 4.038
38 1Y7I SAL 4.10448
39 5X5M 7YU 4.16667
40 2GJ3 FAD 4.16667
41 3V78 ET 4.19162
42 3ZS7 ATP 4.19162
43 3EWK FAD 4.19162
44 2ISJ FMN 4.19162
45 5NJI 8Z2 4.19162
46 2OBD PCW 4.20168
47 4EHU ANP 4.34783
48 3WYJ H78 4.34783
49 5CSD ACD 4.40252
50 6F68 4EU 4.47154
51 6F68 GSH 4.47154
52 3RV5 DXC 4.49438
53 1SBR VIB 4.5
54 3FAL REA 4.54545
55 5HGR 45D 4.61538
56 2OFV 242 4.69314
57 3KB9 BTM 4.71204
58 2JJK R15 4.73373
59 1Z8O DEB 4.79042
60 5L92 MLA 4.79042
61 5L92 C0R 4.79042
62 3HP9 CF1 4.79042
63 4F4S EFO 4.79042
64 2DSA HPX 4.79042
65 1FCH TYR GLN SER LYS LEU 4.79042
66 6F8A HIS 4.79042
67 2DSA GSH 4.79042
68 3FRQ ERY 4.79042
69 2OWZ CIT 4.79042
70 6BR8 6OU 4.79042
71 4EI7 GDP 4.79042
72 5KLP IHP 4.79042
73 1G27 BB1 4.79042
74 1JGS SAL 4.79042
75 6G5J EM8 4.84848
76 6ET8 BWH 4.95496
77 6H0B UDP 4.97925
78 3OKI OKI 5.15021
79 3UWB BB2 5.19481
80 4DXJ IPE 5.24862
81 5BV6 35G 5.26316
82 1W2Y DUN 5.38922
83 5UR1 YY9 5.38922
84 4OKZ 3E9 5.38922
85 3TGE TGE 5.38922
86 4L1F COS 5.38922
87 1M13 HYF 5.38922
88 3A51 VDY 5.38922
89 2CIX CEJ 5.38922
90 4F06 PHB 5.38922
91 3WCA FPS 5.38922
92 5UI2 EQ3 5.38922
93 4B74 1LH 5.38922
94 3W5N RAM 5.39419
95 2Q2Y ADP 5.44959
96 2Q2Y MKR 5.44959
97 2FTB OLA 5.6
98 2RH1 CLR 5.60166
99 1JF0 CZH 5.64103
100 4U0I 0LI 5.71429
101 5N8V KZZ 5.7971
102 5DY5 5GR 5.92105
103 4C2V YJA 5.96491
104 6BMS PLM 5.98802
105 3FWY ADP 5.98802
106 5K7H IVC 5.98802
107 4DSG UDP 5.98802
108 4DSG FAD 5.98802
109 2D4V FLC 5.98802
110 1NVM NAD 5.98802
111 2C9O ADP 5.98802
112 1DB1 VDX 5.98802
113 5F5N 5VD 5.98802
114 3ICT COA 5.98802
115 5IM3 DTP 5.98802
116 3UST FAD 5.99251
117 5YAP NAI 6.05263
118 5B0I BOG 6.12245
119 2B96 ANN 6.50407
120 3ET3 ET1 6.50685
121 2ALG HP6 6.52174
122 2ALG DAO 6.52174
123 6AYI C3G 6.53266
124 5OWC AYZ 6.55738
125 1Z3C SA8 6.58683
126 3PE2 E1B 6.58683
127 4U0S ADP 6.58683
128 2V95 HCY 6.58683
129 3COW 52H 6.58683
130 6F6E PLM 6.58683
131 4XRZ SI6 6.58683
132 4V24 GYR 6.58683
133 2UXI G50 6.58683
134 1W5F G2P 6.58683
135 1ION ADP 6.58683
136 4D7M TDC 6.58683
137 4KVL PLM 6.58683
138 1U8V FAD 6.58683
139 5NM7 GLY 6.58683
140 2FV5 541 6.58683
141 5X3R 7Y3 6.58683
142 3NJQ NJQ 6.58683
143 5N26 CPT 6.59341
144 4BFW ZVW 6.60377
145 2EW5 Y12 6.62983
146 5EEH SAH 6.64894
147 5EEH P9P 6.64894
148 1RDT 570 6.69014
149 3V49 PK0 6.76692
150 3KMR EQN 6.76692
151 3G4Q MCH 6.84932
152 1FM9 570 6.98529
153 1FM9 9CR 6.98529
154 2VDY HCY 7.18563
155 4KWD JF2 7.18563
156 3GST GPR 7.18563
157 1ESM COA 7.18563
158 4NE2 SH2 7.18563
159 4LY9 1YY 7.18563
160 3VRV YSD 7.18563
161 5OLZ T4E 7.18563
162 3RGA ILD 7.18563
163 3ROE THM 7.18563
164 5XPL 8C9 7.18563
165 2O4J VD4 7.18563
166 3RO7 TDR 7.18563
167 2IZ1 ATR 7.18563
168 2IZ1 RES 7.18563
169 1FP6 ADP 7.18563
170 4O1Z MXM 7.18563
171 1OQC FAD 7.2
172 2Q1H AS4 7.2
173 6A0S NDP 7.22892
174 4UCC ZKW 7.29614
175 3CEV ARG 7.35786
176 5HCV 60R 7.393
177 2A3I C0R 7.50988
178 1FK5 OLA 7.52688
179 1DKF OLA 7.65957
180 5OLK DTP 7.67442
181 1UVC STE 7.69231
182 1UHK CZN 7.78443
183 3NB0 G6P 7.78443
184 3F10 8HG 7.78443
185 5E4R NAP 7.78443
186 4NKW PLO 7.78443
187 1OPK MYR 7.78443
188 5NWI TYR PHE SER SEP ASN 7.78443
189 4JGX PLM 7.78443
190 2P4Q FLC 7.78443
191 5IQT AKG 7.78443
192 5IQT 6CU 7.78443
193 2VAP GDP 7.78443
194 3KFC 61X 7.78443
195 3WBF NAP 7.78443
196 4B7H NDP 7.78443
197 4O4Z N2O 7.79221
198 3T50 FMN 7.8125
199 4RKK GLC GLC GLC GLC GLC GLC 7.83133
200 4R38 RBF 7.85714
201 2LBD REA 7.86517
202 1XAP TTB 7.86517
203 4DM8 REA 7.86517
204 3RET PYR 7.92079
205 3RET SAL 7.92079
206 3V1V GST 8.08314
207 6B8O PSF 8.28402
208 4HBM 0Y7 8.33333
209 5GUE GGS 8.38323
210 5LIA 6XN 8.38323
211 3RDE OYP 8.38323
212 2D37 FMN 8.38323
213 5EIB GTP 8.38323
214 2YOO K2B 8.38323
215 5OSW AE4 8.38323
216 5XDT MB3 8.38323
217 5XDT GDP 8.38323
218 5OSW DIU 8.38323
219 5X20 AOT 8.38323
220 3IS2 FAD 8.44156
221 1JR8 FAD 8.54701
222 3JRS A8S 8.65385
223 3D72 FAD 8.72483
224 1IG3 VIB 8.74525
225 3RLB VIB 8.85417
226 3KDJ A8S 8.91089
227 3JQM GTP 8.9172
228 5Z1N PEF 8.92857
229 1FCZ 156 8.93617
230 1YOK P6L 8.98204
231 1S17 GNR 8.98204
232 4RC8 STE 8.98204
233 5LX9 OLB 8.98204
234 1YUC EPH 8.98204
235 4LH7 NMN 8.98204
236 3AAQ ARU 8.98204
237 5UNJ RJW 8.98204
238 6CB2 OLC 8.98204
239 2RHO GDP 8.98204
240 2RHO GSP 8.98204
241 4AIG FLX 8.98204
242 5IVX ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 9
243 1JQ9 PHE LEU SER TYR LYS 9.09091
244 4IS0 1R4 9.12863
245 4F7E 0SH 9.18367
246 1LQY BB2 9.23913
247 1N46 PFA 9.30233
248 4QJR PIZ 9.38776
249 3GYT DL4 9.42623
250 4WT2 3UD 9.52381
251 4ZBR DIF 9.54357
252 4ZBR NPS 9.54357
253 1ZDT PEF 9.54357
254 3LDW ZOL 9.58084
255 3LDW IPE 9.58084
256 4QWT ACD 9.58084
257 2QZZ EMF 9.58084
258 2QZZ NAP 9.58084
259 1NTV ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 9.58084
260 5UC9 MYR 9.58084
261 4WX0 HXD 9.58084
262 5J62 FMN 9.58084
263 5WRE 7TL 9.67742
264 5KAU RHQ 9.69697
265 2B3D FAD 9.80392
266 1N8V BDD 9.82143
267 3RUG DB6 9.93377
268 1NHZ 486 10
269 5G5W R8C 10
270 1OFU GDP 10.084
271 3QCP FAD 10.1796
272 1XKD ICT 10.1796
273 2R75 01G 10.1796
274 3RMK BML 10.1796
275 2AIB ERG 10.2041
276 1LRI CLR 10.2041
277 4HIA FMN 10.2273
278 2QM9 TDZ 10.3226
279 1JAY F42 10.3774
280 4H07 IPH 10.3896
281 4OAS 2SW 10.4167
282 5XJ8 NKO 10.4478
283 3G08 FEE 10.5263
284 5K53 STE 10.7784
285 1YMT DR9 10.7784
286 4IVG ANP 10.7784
287 1JQI CAA 10.7784
288 5U5G 7VD 10.7784
289 4ZM4 P3B 10.7784
290 5IF4 6AK 10.7784
291 4WRI OKA 10.7784
292 1M2Z DEX 10.8949
293 4V1T ADP 10.9375
294 3BQD DAY 10.9804
295 4P6X HCY 10.9804
296 2AEL SAZ 11.3772
297 5UC1 486 11.3772
298 3ND6 ATP 11.3772
299 3ANP DCC 11.3772
300 2AE2 PTO 11.3772
301 1QZR CDX 11.3772
302 1QZR ANP 11.3772
303 2F59 INI 11.465
304 2Z6D FMN 11.5385
305 3KPX CZH 11.6162
306 5DKK FMN 11.7241
307 5DUF G7A 11.7871
308 4EOX 0S5 11.8227
309 3GKJ HC3 11.976
310 3SCM LGN 11.976
311 6BMM OLB 11.976
312 4J24 EST 11.976
313 2NVA PL2 11.976
314 4MYD 164 11.976
315 3R9V DXC 11.976
316 3OLL EST 11.976
317 2YJD YJD 11.976
318 4J26 EST 11.976
319 1U3R 338 11.976
320 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 12
321 3QDJ ALA ALA GLY ILE GLY ILE LEU THR VAL 12
322 3OGN 3OG 12.0968
323 3HUJ AGH 12.1212
324 5C9J STE 12.1212
325 5C9J DAO 12.1212
326 4E90 7RG 12.1581
327 3VVY ET 12.3711
328 2PRG BRL 12.5
329 4CRL C1I 12.5749
330 3ET1 ET1 12.5749
331 1ITU CIL 12.5749
332 3D9F N6C 12.5749
333 3D9F FAD 12.5749
334 4AG8 AXI 12.5749
335 3SP6 IL2 12.5749
336 6IIU A8X 12.5749
337 3KDU NKS 12.5749
338 1IYK MYA 12.5749
339 1K7L 544 12.5749
340 2UW1 GVM 12.5749
341 2VPR TDC 12.5749
342 1X8J A3P 12.5749
343 2F5T MAL 12.5749
344 3S0E EOL 12.605
345 1T0S BML 12.7907
346 2A06 SMA 12.8205
347 1QV1 CZH 12.8205
348 2IYG FMN 12.9032
349 3BEJ MUF 13.0252
350 5BYK OAQ 13.1274
351 5BYK A3P 13.1274
352 3W54 RNB 13.1737
353 4XT8 TMQ 13.1737
354 3DCT 064 13.1915
355 1YRX FMN 13.2231
356 3P0K FAD 13.5338
357 3RUU 37G 13.5371
358 5MWE TCE 13.5802
359 6A5Y 9R0 13.5965
360 4OIV XX9 13.7168
361 3QUZ QUV 13.7725
362 1G3Q ADP 13.7725
363 3R9C ECL 13.7725
364 2YPO PHE 13.7725
365 3FWN ATR 13.7725
366 3FWN 6PG 13.7725
367 4MRP GSH 13.7725
368 4MRV HGD 13.7725
369 2VHW NAI 13.7725
370 4MRS GDS 13.7725
371 1GUX ASP LEU TYR CYS TYR GLU GLN LEU ASN 13.8158
372 3FZG SAM 14
373 5LWY OLB 14.0187
374 5TVI MYR 14.1304
375 3E3U NVC 14.2132
376 1YKD CMP 14.3713
377 5EW9 5VC 14.3713
378 1RX0 2MC 14.3713
379 4M4Q 21A 14.3713
380 3OA2 NAD 14.3713
381 1BWO LPC 14.4444
382 1XVB BHL 14.7059
383 5DJT FMN 14.7541
384 4EES FMN 14.7826
385 2BTO GTP 14.8148
386 5UR6 8KM 14.9171
387 5B4B LP5 14.9701
388 5C2H 4PX 14.9701
389 5C2H 4XU 14.9701
390 3N7H DE3 15.2
391 5MTE BB2 15.3285
392 4LNU GTP 15.3846
393 1CS4 FOK 15.566
394 1CS4 101 15.566
395 3IQE H4M 15.5689
396 3IQE F42 15.5689
397 5B25 4QJ 15.5689
398 4UOX PLP PUT 15.5689
399 4UOX PLP 15.5689
400 4XU6 TDA 15.5689
401 5IUY BOG 15.5689
402 2IFB PLM 16.0305
403 3QQA TCH 16.1677
404 2Z7I 742 16.1677
405 4EPL JAI 16.1677
406 2FP2 TSA 16.2651
407 5X13 HC4 16.4894
408 2W90 6PG 16.7665
409 4TMC FMN 16.7665
410 2HJ3 FAD 16.8
411 5ITZ GDP 17.0543
412 3AHQ FAD 17.3653
413 4ELG 52I 17.4699
414 4ELG 52J 17.4699
415 3GWL FAD 17.9245
416 1L0I PSR 17.9487
417 3BJC WAN 17.9641
418 3SHZ 5CO 17.9641
419 3GWN FAD 18.4211
420 3DST GRG 18.5629
421 2J8C SPO 18.5629
422 2J8C U10 18.5629
423 2E1A MSE 18.6667
424 4P4T GDP 19.1617
425 5LOF 70R 19.1617
426 4YV5 SVR 19.6721
427 1ZXM ANP 19.7605
428 5W3K 9TY 19.7605
429 3RYC GTP 20.2797
430 5U3B 7TD 20.3593
431 3CXH SMA 20.4301
432 3CX5 SMA 20.4301
433 5FOI MY8 20.9581
434 1XRO LEU 21.1604
435 1HBK COA 21.3483
436 4X7Q 3YR 21.5569
437 4BNU 9KQ 22.1557
438 1EZV SMA 22.973
439 2IBZ SMA 22.973
440 1Q1Y BB2 23.3533
441 5K52 OCD 23.9521
442 4MGB XDH 24.5509
443 2QE4 JJ3 24.5509
444 3UUA 0CZ 24.5509
445 4MGD 27N 24.5509
446 5WGD EST 24.5509
447 5WGQ EST 24.5509
448 4TV1 36M 24.5509
449 4MGA 27L 24.5509
450 2QA8 GEN 24.5509
451 3UUD EST 24.5509
452 4MG9 27K 24.5509
453 2BJ4 OHT 24.5509
454 5DXG EST 24.5509
455 5DXE EST 24.5509
456 4MG7 27H 24.5509
457 5HYR EST 24.5509
458 2QZO KN1 24.5509
459 5OM2 DXT 25
460 5DX3 EST 25.1497
461 5G57 6M5 25.7485
462 2PR5 FMN 26.5152
463 3CR4 PNT 27.1739
464 2Y69 CHD 28.5714
465 3EE4 MYR 30.5389
466 5ZCO PSC 33.8983
467 2DYR PSC 33.8983
468 5Z84 PSC 33.8983
469 2DYS PSC 33.8983
470 5Z84 CHD 33.8983
471 5ZCO CHD 33.8983
472 2DYS TGL 33.8983
473 5Z84 TGL 33.8983
474 5ZCO TGL 33.8983
475 5W97 CHD 33.8983
476 4LSJ LSJ 46.1538
Pocket No.: 2; Query (leader) PDB : 6BVM; Ligand: GNP; Similar sites found with APoc: 560
This union binding pocket(no: 2) in the query (biounit: 6bvm.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 2JDU MFU 1.73913
2 2UVO NAG 1.75439
3 2HXW FLC 2.1097
4 2X77 GDP 2.1164
5 1B0U ATP 2.29008
6 2ZFI ADP 2.39521
7 3N5C GDP 2.46914
8 6C90 ADP 2.99401
9 1T3D CYS 2.99401
10 5D9G GLU ASN LEU TYR PHE GLN 2.99401
11 5FHD ADP ALF 3.00231
12 5FTB ANP 3.00231
13 1OSS BEN 3.13901
14 5EXT ADP 3.46154
15 4D81 ADP 3.53357
16 1M7G AV2 3.59281
17 4ZNL BEF ADP 3.59281
18 2FSH ANP 3.59281
19 1M7G ADX 3.59281
20 2FPU HSO 3.59281
21 1M7G ADP 3.59281
22 3QDK QDK 3.59281
23 3H86 AP5 3.64583
24 6A20 ADP 3.73444
25 1FNZ A2G 3.79747
26 1G41 ADP 3.82883
27 3DKP ADP 4.08163
28 1TQ4 GDP 4.11622
29 2J5V PCA 4.19162
30 2IYL GDP 4.19162
31 2PW0 TRC 4.19162
32 1YXM ADE 4.19162
33 2Z49 AMG 4.19162
34 2O0J ADP 4.19162
35 1MLY ACZ PLP 4.19162
36 1YTM ATP 4.19162
37 5VHC BEF ADP 4.19162
38 1F0X FAD 4.19162
39 5HR5 ADP 4.19162
40 5ZW3 SAH 4.19162
41 2F5X ASP 4.19162
42 1BO4 COA 4.19162
43 5J6Y BGC 4.25532
44 5J6Y GLC 4.25532
45 1HTW ADP 4.43038
46 2W58 ADP 4.45545
47 5ZB0 TYD 4.54545
48 5ZB0 ADP 4.54545
49 2KIN ADP 4.62185
50 3KC1 2T6 4.74777
51 1JI0 ATP 4.79042
52 5M04 GDP 4.79042
53 4PX9 ADP 4.79042
54 3BOS CDP 4.79042
55 3B7G ANP 4.79042
56 4OHY ANP 4.79042
57 3ITJ CIT 4.79042
58 2OZE AGS 4.79042
59 3DC4 ADP 4.79042
60 2Q8M AMP 4.79042
61 5I34 GDP 4.79042
62 6GSG RCO 4.79042
63 3EZ2 ADP 4.79042
64 4MZQ 1VU 4.86111
65 4WOP CTP 4.88889
66 4HE2 AMP 5.02959
67 3PUN FUC GAL NDG FUC 5.06329
68 3AI8 HNQ 5.07812
69 2XCU C5P 5.08021
70 6AR9 3L4 5.14706
71 2Y65 ADP 5.20548
72 2RGX AP5 5.33981
73 1T5C ADP 5.38922
74 5I0H ADP BEF 5.38922
75 1XP8 AGS 5.38922
76 1IWE IMP 5.38922
77 1Z6T ADP 5.38922
78 1G8S MET 5.38922
79 5H68 AGS 5.38922
80 4U60 SIA GAL NGA 5.38922
81 4GOX A3P 5.38922
82 4U60 SIA 5.38922
83 2BO4 FLC 5.38922
84 3F4F UMP 5.38922
85 4U60 SIA GAL BGC NGA GAL 5.38922
86 2Q2Y ADP 5.44959
87 2Q2Y MKR 5.44959
88 3IO3 ADP 5.45977
89 6H5E ANP 5.57769
90 4KAX GTP 5.59006
91 1XXR MAN 5.59006
92 4YDS ATP 5.70175
93 3IUY AMP 5.70175
94 5UIV ADP 5.72687
95 5N69 ADP 5.80913
96 1G6H ADP 5.83658
97 5M7P ADP 5.94714
98 4FRZ ADP 5.95855
99 1VKJ A3P 5.96491
100 4RD0 GDP 5.98802
101 2A5F GTP 5.98802
102 3NHB ADP 5.98802
103 5ZXD ATP 5.98802
104 2OBM ADP 5.98802
105 1F5N GNP 5.98802
106 2CE7 ADP 5.98802
107 5Y6N ADP 5.98802
108 5MZN ADP 5.98802
109 3FWY ADP 5.98802
110 5J1J ANP 5.98802
111 3Q9L ATP 5.98802
112 5Z69 AGS 5.98802
113 2C9O ADP 5.98802
114 3FVQ ATP 5.98802
115 2Z5F A3P 5.98802
116 3QKT ANP 5.98802
117 5Y0T TAT 5.98802
118 1OS1 PYR 6.0166
119 1OS1 ATP 6.0166
120 1I9G SAM 6.07143
121 2ZL4 ALA ALA ALA ALA 6.12245
122 4TQK NAG 6.15764
123 4GBM A3P 6.19195
124 5TSH ADP 6.22407
125 5TSH ANP 6.22407
126 4JLV ADP 6.3197
127 5BQ5 ADP BEF 6.34921
128 5GOE GDP 6.3981
129 3WY9 GDP 6.45161
130 3WYA GDP 6.45161
131 4OWK NGA 6.52174
132 3U6B GDP 6.58683
133 2BVN GNP 6.58683
134 3WXM GTP 6.58683
135 3VMF GTP 6.58683
136 2PZE ATP 6.58683
137 4WZ6 ATP 6.58683
138 2HCJ GDP 6.58683
139 1D8T GDP 6.58683
140 5JBQ GDP 6.58683
141 4G5G GDP 6.58683
142 3U6K GDP 6.58683
143 2DPY ADP 6.58683
144 4WZA ACP 6.58683
145 4WZA ADP 6.58683
146 4R43 GDP 6.58683
147 1EXF GLY 6.58683
148 2ZPA ADP 6.58683
149 4QOS ADP 6.58683
150 4RZ3 ADP 6.58683
151 1E2K TMC 6.58683
152 5WC2 ADP 6.58683
153 3RC3 ANP 6.58683
154 2FNA ADP 6.58683
155 1ION ADP 6.58683
156 4ZDJ UTP 6.58683
157 5NM7 GLY 6.58683
158 2BEK ATP 6.61479
159 1UPT GTP 6.66667
160 5K5Z ANP 6.6879
161 5L3W GDP 6.86275
162 5OCM 9RH 6.87285
163 4NU0 AP5 6.91244
164 4KJU 1RH 6.97674
165 5XDR ADP 7.05394
166 5VYQ FON 7.05882
167 1DAK ADP 7.14286
168 1DAK DPU 7.14286
169 5W76 GDP 7.18563
170 5W75 GDP 7.18563
171 3PCR GTP 7.18563
172 1WDT GTP 7.18563
173 5W7Q GDP 7.18563
174 3ZFD ANP 7.18563
175 3CNL GNP 7.18563
176 1SQ5 ADP 7.18563
177 1U0J ADP 7.18563
178 2GK6 ADP 7.18563
179 2XAU ADP 7.18563
180 2X7I CIT 7.18563
181 1FP6 ADP 7.18563
182 1W5T ADP 7.18563
183 3BFX A3P 7.18563
184 4DFU QUE 7.18563
185 5IRN ADP 7.18563
186 5KXE 6Y2 7.18563
187 2ZJ5 ADP 7.18563
188 1GOJ ADP 7.18563
189 1W5T ANP 7.18563
190 4E03 ADP 7.28155
191 6EKZ SNP 7.31707
192 4PYA 2X3 7.45342
193 4YFY 1YJ 7.48031
194 5U32 GDP 7.62712
195 5LB3 ADP 7.64045
196 2VB6 ADP BEF 7.67635
197 4YS0 ADP 7.67635
198 4PFO ADP 7.67635
199 2XT3 ADP 7.78443
200 1LVG ADP 7.78443
201 3E70 GDP 7.78443
202 1OXV ANP 7.78443
203 5LTJ ADP 7.78443
204 3TBK ANP 7.78443
205 3T34 GDP 7.78443
206 4H1V GNP 7.78443
207 5LTJ BEF 7.78443
208 5AK0 8V1 7.78443
209 6FAA ADP 7.78443
210 4V03 ADP 7.78443
211 4X8O AP5 7.78443
212 4OKD GLC GLC GLC 7.78443
213 4PJ3 ANP 7.78443
214 1S3G AP5 7.78443
215 5MEX PAP 7.78443
216 5H4S RAM 7.78443
217 3QOX SAH 7.78443
218 1QAN SAH 7.78689
219 2Y7P SAL 7.79817
220 2C78 GNP 7.90123
221 2C77 GNP 7.90123
222 1NJF ADP 8
223 1NJF AGS 8
224 5GVR LMR 8.11966
225 1VHT BA3 8.25688
226 3IHB GLU 8.33333
227 5IRR GSP 8.38323
228 4CVN ADP 8.38323
229 2RCN GDP 8.38323
230 4IDN GNP 8.38323
231 2BIF ANP 8.38323
232 2BIF SIN 8.38323
233 1K6M AGS 8.38323
234 4MKF AP5 8.38323
235 3FYH ADP 8.38323
236 1O8B ABF 8.38323
237 3LRE ADP 8.38323
238 3BP1 GUN 8.38323
239 6M7X JD7 8.38323
240 2JK0 ASP 8.38323
241 4Z7X 3CX 8.40336
242 5EE5 GTP 8.4507
243 2CDN ADP 8.45771
244 1QF5 GDP 8.58469
245 1QF5 RPL 8.58469
246 1ZVX FIN 8.58896
247 1DCP HBI 8.65385
248 4OI4 ATP 8.69565
249 2IL4 COA 8.73786
250 3HCH RSM 8.90411
251 1GPJ CIT 8.91089
252 2GNK ATP 8.92857
253 1V8K ANP 8.98204
254 6AU6 GDP 8.98204
255 1D2E GDP 8.98204
256 4ZG4 VO4 ADP 8.98204
257 1XKV ATP 8.98204
258 2R4V GSH 8.98204
259 3FKQ ATP 8.98204
260 5G3Y ADP 8.98204
261 4MKG AP5 8.98204
262 4LYA ATP 8.98204
263 4IOK ADP 8.98204
264 4IOK XPO 8.98204
265 5G41 AP5 8.98204
266 2VVG ADP 8.98204
267 4QRH 0O2 9.04762
268 3P9Y N7P THR SEP PRO SER TYR SET 9.09091
269 3BFV ADP 9.22509
270 3FB4 AP5 9.25926
271 5TQZ GLC 9.33333
272 2YY8 MTA 9.45274
273 4J0Q GDP 9.58084
274 1KK1 GNP 9.58084
275 4PC3 GDP 9.58084
276 6CS8 F9Y 9.58084
277 3R7F CP 9.58084
278 1AKY AP5 9.58084
279 1ZIN AP5 9.58084
280 2BQP GLC 9.58084
281 4WEI GLC GAL 9.58084
282 2NCD ADP 9.58084
283 3DOE GTP 9.69697
284 2OG2 MLI 9.7493
285 3ZS9 ADP ALF 9.88701
286 2WOJ ADP ALF 9.88701
287 4XVU ATP 9.88701
288 4XTR ATP 9.88701
289 4XTR ADP 9.88701
290 2GMP NAG MAN 9.92064
291 1Q8S MAN MMA 9.92064
292 2GMM MAN MAN 9.92064
293 2QZ4 ADP 9.92366
294 1APZ ASP 9.92908
295 2FAH GDP 9.95851
296 1PTR PRB 10
297 2FMD MAN MAN 10
298 6B8B ADP 10.0402
299 2GWH A3P 10.0671
300 1SKQ GDP 10.1796
301 1BG2 ADP 10.1796
302 4P3Y GDP 10.1796
303 5IFS ADP 10.1796
304 1FNN ADP 10.1796
305 4A4Z ANP 10.1796
306 1D2N ANP 10.1796
307 1NST A3P 10.1796
308 1IN4 ADP 10.1796
309 1F9V ADP 10.1796
310 1P9B GDP 10.1796
311 1KO8 6PG 10.2857
312 3ZQ6 ADP ALF 10.4938
313 2CBZ ATP 10.5485
314 2ODE ALF GDP 10.5714
315 2OFW ADX 10.5769
316 1U3G ADP 10.582
317 1VBO MAN MAN MAN 10.7383
318 1VBO MAN 10.7383
319 3TK1 GDP 10.7784
320 3EWA ANP 10.7784
321 1OYY AGS 10.7784
322 5VGR GDP 10.7784
323 3COB ADP 10.8401
324 1P4V GLY 10.8475
325 5O96 SAM 11.0204
326 5MVR ADP 11.1111
327 3MB5 SAM 11.3725
328 5ZBR ANP 11.3772
329 2WIC GNP 11.3772
330 4XGU ADP 11.3772
331 4R98 GNH 11.3772
332 1ZUI SKM 11.3772
333 1SVM ATP 11.3772
334 2J0W ASP 11.3772
335 6ACS CIT 11.3772
336 2GUD MAN 11.3772
337 4CTA ATP 11.3772
338 2GUC MAN 11.3772
339 1SVK ALF GDP 11.6147
340 1X6V ADP 11.6183
341 5KUT GDP 11.6402
342 1JJV ATP 11.976
343 2WJG GDP 11.976
344 4IEE AGS 11.976
345 4FCW ADP 11.976
346 4LJ9 ACP 11.976
347 1NY5 ADP 11.976
348 5XKT GNP 12
349 2WJH GDP 12.0482
350 2WJH FLC 12.0482
351 1F2U ATP 12.0805
352 3KTA AP5 12.1387
353 1B7T ADP 12.1795
354 3B9Q MLI 12.2517
355 1L2T ATP 12.3404
356 1Y3A GDP 12.462
357 1KSH GDP 12.5
358 5H67 ATP 12.5
359 4NON GDP 12.5749
360 2WHX ADP 12.5749
361 3P4X ADP 12.5749
362 4YJ1 ADP 12.5749
363 1LVK MNT BEF 12.5749
364 2JLR ANP 12.5749
365 1P72 ADP 12.5749
366 1R0X ATP 12.5874
367 2OM2 GDP 12.6154
368 1XEX ATP 12.7907
369 1BH2 GSP 13.0159
370 1Y63 ADP 13.0435
371 4ZKD GDP 13.1737
372 1JJ7 ADP 13.1737
373 1W7J ADP BEF 13.1737
374 5J1S ATP 13.1737
375 2HF9 GSP 13.2743
376 1KK8 BEF ADP 13.6691
377 4U00 ADP 13.7725
378 4YMU ATP 13.7725
379 3B5J 12D 13.7725
380 4MDB RLT 13.7725
381 1G3Q ADP 13.7725
382 3K5I AIR 13.7725
383 5LWY OLB 14.0187
384 3BER AMP 14.0562
385 4Q1A 2XZ 14.2857
386 4Q1A UDP 14.2857
387 3PQC GDP 14.3713
388 4QM7 GTP 14.3713
389 5L3R GCP 14.3713
390 2PL3 ADP 14.3713
391 1WY7 SAH 14.4928
392 5C2N NAG 14.5833
393 3H4S ADP 14.8148
394 1RRC ADP 14.9701
395 2GKS ADP 14.9701
396 2IS6 ADP 14.9701
397 3UG4 AHR 14.9701
398 4R2I ANP 14.9701
399 1AQU A3P 14.9701
400 4BAS GNP 15.0754
401 3KIF GDL 15.0943
402 3AB4 THR 15.1685
403 6FMC DUE 15.1899
404 2XTZ GSP 15.2542
405 4XDY HIO 15.3846
406 1CS4 GSP 15.566
407 4NCN GTP 15.5689
408 4TMZ GSP 15.5689
409 5HCN GCP 15.5689
410 3L6C MLI 15.5689
411 4UOX PUT 15.5689
412 1G7C 5GP 15.9574
413 3FSY SCA 15.9639
414 3CX8 GSP 16.1677
415 2AWN ADP 16.1677
416 1ZCB GDP 16.1677
417 3AB3 GDP 16.1677
418 1MKY GDP 16.1677
419 6CRK GDP 16.1677
420 2CHG ANP 16.1677
421 3RLF ANP 16.1677
422 1FQJ ALF 16.6667
423 1FQJ GDP 16.6667
424 3IIJ ADP 16.6667
425 1OFH ADP 16.6667
426 1RJ9 GCP 17
427 1PUJ GNP 17.3653
428 4IHQ ADP 17.3653
429 1LOB MMA 17.3653
430 5X40 ACP 17.3653
431 2ZTS ADP 17.3653
432 4G86 BNT 17.9641
433 1KJ8 GAR 17.9641
434 3ZIA ADP 18.0328
435 3ZIA ATP 18.0328
436 5TWJ SAM 18.5185
437 5CK5 GDP 18.5629
438 3TY3 GGG 18.5629
439 6B4K ANP 18.5629
440 4HSE ADP 18.5629
441 1GXU 2HP 18.6813
442 4Y4V DAL 19.1617
443 4P4T GDP 19.1617
444 1TL2 NDG 19.1617
445 2ATJ BHO 19.1617
446 2W83 GTP 19.4805
447 5L3S GNP 19.7605
448 1IHU ADP 19.7605
449 1IHU AF3 19.7605
450 5L3V GDP 19.7605
451 4PPF FLC 20.3593
452 1H65 GDP 20.3593
453 2ZR9 DTP 20.3593
454 6AIC AMP 20.3593
455 5ODQ 9SB 20.3593
456 4BQS K2Q 20.4545
457 4BQS ADP 20.4545
458 1HBK COA 21.3483
459 3UIE ANP 21.5569
460 1UJ2 C5P 22.1557
461 2D7D ADP 22.5
462 4LPS GDP 22.7545
463 5BN3 ADP 22.7545
464 1CR1 TTP 22.7545
465 3A4M ADP 23.3533
466 2FH5 GTP 23.9521
467 1XMV ADP 23.9521
468 3DEF GDP 23.9521
469 5WRI A3P 24.5509
470 2CK3 ADP 25.1497
471 1W0J ADP BEF 25.1497
472 1W0J ADP 25.1497
473 3W5J GDP 25.1497
474 2V7Q ADP 25.1497
475 2V7Q ATP 25.1497
476 2CK3 ANP 25.1497
477 3DZD ADP 26.3473
478 4TL6 ANP 26.3473
479 1XX6 ADP 26.9461
480 4KVA GTP 26.9461
481 4JLS 3ZE 26.9461
482 4TTQ ATP 27.4419
483 4V0K GDP 27.5449
484 1DAR GDP 27.5449
485 4B47 GDP 28.1437
486 3KJI ADP 28.1437
487 4M9Q GNP 28.7425
488 1YRB GDP 29.3413
489 3T12 GDP ALF 29.3413
490 3T1O GDP 29.3413
491 1R4A GNP 29.4118
492 5E50 ALA TYR ASP GLU SEP TPO ASP GLU GLU 29.7297
493 1G7S GDP 29.9401
494 3QF7 ANP 30
495 4B2D FBP 30.5389
496 2PEZ DAT 31.2849
497 2PEZ GGZ 31.2849
498 1J2J GTP 31.7365
499 2J59 GTP 31.7365
500 1O3Y GTP 31.7365
501 5YT0 GDP 31.7365
502 5FG3 GDP 31.7365
503 4DCT GDP 32.3353
504 1ZD9 GDP 32.3353
505 1RE0 GDP 32.3353
506 1S9D GDP 32.3353
507 5H7K GDP 32.9341
508 3AQ4 GDP 32.9341
509 5H7J GCP 32.9341
510 2QN6 GDP 33.3333
511 1NRJ GTP 33.5329
512 1YZG GDP 33.5329
513 4YLG GDP 34.1317
514 1ZJ6 G3D 34.1317
515 5KSP GDP 37.7246
516 5KSZ GCP 37.7246
517 5KDO GDP 39.1892
518 2ZEJ GDP 39.521
519 4GOJ GNP 40.1198
520 1FZQ GDP 40.1198
521 4ZI2 GNP 40.1198
522 2QTV GNP 40.1198
523 1M2O GNP 41.3174
524 5DI3 GNP 41.9162
525 1F6B GDP 41.9162
526 3A1S GDP 43.7126
527 1MR3 G3D 44.3114
528 1M7B GTP 45.509
529 1GWN GTP 45.509
530 3M1I GTP 48.503
531 3GJX GTP 48.503
532 3WYF GTP 48.503
533 3WYG GTP 48.503
534 3GJ4 GDP 48.503
535 3GJ7 GDP 48.503
536 1Z0J GTP 48.503
537 3GJ5 GDP 48.503
538 3GJ8 GDP 48.503
539 4HI0 GDP 48.503
540 1D5C GDP 48.7654
541 4HAT GNP 49.1018
542 5DHF GNP 49.1018
543 5UWP GNP 49.1018
544 5UWQ GNP 49.1018
545 6CIT GNP 49.1018
546 5UWO GNP 49.1018
547 5UWJ GNP 49.1018
548 5UWR GNP 49.1018
549 5UWW GNP 49.1018
550 5UWT GNP 49.1018
551 5UWU GNP 49.1018
552 5UWI GNP 49.1018
553 1WA5 GTP 49.1018
554 5UWS GNP 49.1018
555 5UWH GNP 49.1018
556 5DI9