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Receptor
PDB id Resolution Class Description Source Keywords
6BVK 1.8 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NA C:202;
Part of Protein;
none;
submit data
22.99 Na [Na+]
FMT B:2004;
B:2002;
B:2006;
C:201;
B:2005;
B:2003;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
46.025 C H2 O2 C(=O)...
GNP A:201;
Valid;
none;
submit data
522.196 C10 H17 N6 O13 P3 c1nc2...
MG A:202;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
EAV B:2001;
Valid;
none;
submit data
464.002 C26 H30 Cl N5 O Cc1cc...
GOL B:2007;
B:2008;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6BVK 1.8 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 6BVK - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 6BVK - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 6BVK - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GNP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GNP 1 1
2 9GM 1 1
3 GDP 0.839506 0.973684
4 GP3 0.82716 0.948718
5 GTP 0.809524 0.973684
6 GNH 0.807229 0.986842
7 G1R 0.77907 0.961039
8 GCP 0.77907 0.948718
9 GSP 0.770115 0.925
10 5GP 0.756098 0.960526
11 G 0.756098 0.960526
12 G2R 0.747253 0.936709
13 GMV 0.747126 0.948718
14 GAV 0.714286 0.936709
15 GP2 0.712644 0.936709
16 G2P 0.711111 0.936709
17 Y9Z 0.708333 0.880952
18 GDC 0.690722 0.936709
19 GDD 0.690722 0.936709
20 GKE 0.690722 0.936709
21 G5P 0.686869 0.948718
22 GPG 0.684211 0.936709
23 GTG 0.683673 0.91358
24 GDR 0.683673 0.936709
25 GFB 0.683673 0.936709
26 JB2 0.68 0.936709
27 GKD 0.68 0.936709
28 6CK 0.676768 0.91358
29 G3A 0.676768 0.948718
30 GDX 0.673267 0.948718
31 ALF 5GP 0.67033 0.86747
32 YGP 0.663265 0.879518
33 GPD 0.656863 0.902439
34 ALF GDP 0.645833 0.86747
35 GDP AF3 0.645833 0.86747
36 GDP ALF 0.645833 0.86747
37 JB3 0.641509 0.925
38 DBG 0.640351 0.974359
39 G3D 0.638298 0.960526
40 G4P 0.625 0.960526
41 GMP 0.621951 0.857143
42 NGD 0.62037 0.936709
43 GGM 0.618182 0.925926
44 0O2 0.616162 0.960526
45 2MD 0.603604 0.870588
46 CAG 0.60177 0.904762
47 U2G 0.590909 0.91358
48 FEG 0.590909 0.858824
49 GDP 7MG 0.590476 0.888889
50 MGD 0.587719 0.870588
51 G G 0.586538 0.924051
52 ZGP 0.585586 0.848837
53 CG2 0.580357 0.91358
54 ANP 0.568421 0.922078
55 PGD 0.567797 0.902439
56 MD1 0.567797 0.870588
57 3GP 0.56044 0.922078
58 TPG 0.558333 0.822222
59 GH3 0.55 0.948052
60 FE9 0.546219 0.778947
61 GPX 0.539216 0.922078
62 G4M 0.539062 0.860465
63 DGI 0.536082 0.9
64 BGO 0.535088 0.901235
65 IDP 0.53125 0.947368
66 DGT 0.53 0.9
67 2GP 0.526882 0.935065
68 G1R G1R 0.520325 0.901235
69 GCP G 0.518868 0.897436
70 A G 0.516949 0.911392
71 U A G G 0.512605 0.911392
72 G A A A 0.504202 0.9
73 AGO 0.504202 0.91358
74 P2G 0.5 0.860759
75 G1G 0.5 0.902439
76 R7I 0.49505 0.922078
77 MGP 0.49505 0.936709
78 R5I 0.49505 0.922078
79 PGD O 0.492063 0.831461
80 6G0 0.490196 0.936709
81 P1G 0.489796 0.85
82 AKW 0.483051 0.869048
83 DG 0.474227 0.8875
84 DGP 0.474227 0.8875
85 G U 0.466667 0.878049
86 IMP 0.463918 0.934211
87 G2Q 0.462963 0.936709
88 GPC 0.459677 0.858824
89 G C 0.459016 0.878049
90 GTA 0.448276 0.91358
91 G7M 0.444444 0.924051
92 MAP 0.439252 0.898734
93 G G G RPC 0.435484 0.853659
94 B4P 0.434343 0.871795
95 AP5 0.434343 0.871795
96 ADP 0.434343 0.896104
97 A2D 0.43299 0.871795
98 AT4 0.43 0.8625
99 G G G C 0.426357 0.890244
100 AU1 0.425743 0.922078
101 SGP 0.425743 0.807229
102 BA3 0.424242 0.871795
103 A G C C 0.423077 0.888889
104 35G 0.423077 0.909091
105 PCG 0.423077 0.909091
106 C2E 0.423077 0.897436
107 APC G U 0.421875 0.864198
108 HEJ 0.421569 0.896104
109 ATP 0.421569 0.896104
110 ACQ 0.419048 0.873418
111 5GP 5GP 0.419048 0.860759
112 5FA 0.417476 0.896104
113 AQP 0.417476 0.896104
114 01G 0.417391 0.880952
115 AN2 0.415842 0.909091
116 UNP 0.415842 0.810127
117 6AD 0.415094 0.821429
118 M33 0.411765 0.860759
119 ITT 0.411765 0.846154
120 G C C C 0.410448 0.901235
121 HFD 0.409524 0.851852
122 G U34 0.408 0.86747
123 ACP 0.407767 0.873418
124 6YZ 0.407407 0.873418
125 AR6 0.403846 0.871795
126 APR 0.403846 0.871795
127 DG DG 0.403509 0.845238
128 A4P 0.403226 0.848837
129 UCG 0.402985 0.888889
130 SAP 0.4 0.851852
131 AGS 0.4 0.851852
132 AD9 0.4 0.873418
Ligand no: 2; Ligand: EAV; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 EAV 1 1
2 EC4 0.822222 0.981818
3 EBY 0.808989 1
4 EAS 0.790698 0.981818
5 EBV 0.459459 0.844828
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6BVK; Ligand: GNP; Similar sites found with APoc: 553
This union binding pocket(no: 1) in the query (biounit: 6bvk.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 2JDU MFU 1.73913
2 2UVO NAG 1.75439
3 2HXW FLC 2.1097
4 2X77 GDP 2.1164
5 1B0U ATP 2.29008
6 2ZFI ADP 2.39521
7 3N5C GDP 2.46914
8 6C90 ADP 2.99401
9 1T3D CYS 2.99401
10 5D9G GLU ASN LEU TYR PHE GLN 2.99401
11 5FTB ANP 3.00231
12 5FHD ADP ALF 3.00231
13 1OSS BEN 3.13901
14 5EXT ADP 3.46154
15 4D81 ADP 3.53357
16 1M7G AV2 3.59281
17 4ZNL BEF ADP 3.59281
18 2FSH ANP 3.59281
19 1M7G ADX 3.59281
20 2FPU HSO 3.59281
21 1M7G ADP 3.59281
22 3QDK QDK 3.59281
23 3H86 AP5 3.64583
24 6A20 ADP 3.73444
25 1FNZ A2G 3.79747
26 1G41 ADP 3.82883
27 3DKP ADP 4.08163
28 1TQ4 GDP 4.11622
29 2IYL GDP 4.19162
30 1YTM ATP 4.19162
31 2J5V PCA 4.19162
32 2Z49 AMG 4.19162
33 1YXM ADE 4.19162
34 2O0J ADP 4.19162
35 1FDJ 13P 4.19162
36 5VHC BEF ADP 4.19162
37 1F0X FAD 4.19162
38 5HR5 ADP 4.19162
39 5ZW3 SAH 4.19162
40 2F5X ASP 4.19162
41 5J6Y BGC 4.25532
42 5J6Y GLC 4.25532
43 1HTW ADP 4.43038
44 2W58 ADP 4.45545
45 5ZB0 ADP 4.54545
46 5ZB0 TYD 4.54545
47 2KIN ADP 4.62185
48 3KC1 2T6 4.74777
49 5M04 GDP 4.79042
50 3DC4 ADP 4.79042
51 1JI0 ATP 4.79042
52 3EZ2 ADP 4.79042
53 4PX9 ADP 4.79042
54 3BOS CDP 4.79042
55 3B7G ANP 4.79042
56 4OHY ANP 4.79042
57 3ITJ CIT 4.79042
58 2OZE AGS 4.79042
59 2Q8M AMP 4.79042
60 5I34 GDP 4.79042
61 6GSG RCO 4.79042
62 5XLS URA 4.79042
63 4MZQ 1VU 4.86111
64 4WOP CTP 4.88889
65 4HE2 AMP 5.02959
66 3PUN FUC GAL NDG FUC 5.06329
67 3AI8 HNQ 5.07812
68 2XCU C5P 5.08021
69 6AR9 3L4 5.14706
70 2Y65 ADP 5.20548
71 2RGX AP5 5.33981
72 1T5C ADP 5.38922
73 5I0H ADP BEF 5.38922
74 1XP8 AGS 5.38922
75 1Z6T ADP 5.38922
76 1G8S MET 5.38922
77 4U60 SIA GAL NGA 5.38922
78 4GOX A3P 5.38922
79 4U60 SIA 5.38922
80 5H68 AGS 5.38922
81 4U60 SIA GAL BGC NGA GAL 5.38922
82 3F4F UMP 5.38922
83 1IWE IMP 5.38922
84 2BO4 FLC 5.38922
85 2Q2Y ADP 5.44959
86 2Q2Y MKR 5.44959
87 3IO3 ADP 5.45977
88 6H5E ANP 5.57769
89 4KAX GTP 5.59006
90 1XXR MAN 5.59006
91 4YDS ATP 5.70175
92 3IUY AMP 5.70175
93 5UIV ADP 5.72687
94 5N69 ADP 5.80913
95 1G6H ADP 5.83658
96 5M7P ADP 5.94714
97 4FRZ ADP 5.95855
98 1VKJ A3P 5.96491
99 4RD0 GDP 5.98802
100 2A5F GTP 5.98802
101 3NHB ADP 5.98802
102 3FWY ADP 5.98802
103 5ZXD ATP 5.98802
104 3Q9L ATP 5.98802
105 2OBM ADP 5.98802
106 1F5N GNP 5.98802
107 5J1J ANP 5.98802
108 5Y6N ADP 5.98802
109 2CE7 ADP 5.98802
110 2C9O ADP 5.98802
111 5MZN ADP 5.98802
112 3FVQ ATP 5.98802
113 5Z69 AGS 5.98802
114 3QKT ANP 5.98802
115 2Z5F A3P 5.98802
116 5Y0T TAT 5.98802
117 1OS1 PYR 6.0166
118 1OS1 ATP 6.0166
119 1I9G SAM 6.07143
120 4TQK NAG 6.15764
121 4GBM A3P 6.19195
122 5TSH ADP 6.22407
123 5TSH ANP 6.22407
124 4JLV ADP 6.3197
125 5BQ5 ADP BEF 6.34921
126 5GOE GDP 6.3981
127 3WY9 GDP 6.45161
128 3WYA GDP 6.45161
129 4OWK NGA 6.52174
130 2HCJ GDP 6.58683
131 3U6B GDP 6.58683
132 2BVN GNP 6.58683
133 1D8T GDP 6.58683
134 5JBQ GDP 6.58683
135 4G5G GDP 6.58683
136 3U6K GDP 6.58683
137 3WXM GTP 6.58683
138 3VMF GTP 6.58683
139 2PZE ATP 6.58683
140 4WZ6 ATP 6.58683
141 5WC2 ADP 6.58683
142 2DPY ADP 6.58683
143 4WZA ACP 6.58683
144 4WZA ADP 6.58683
145 1ION ADP 6.58683
146 4RZ3 ADP 6.58683
147 4R43 GDP 6.58683
148 1EXF GLY 6.58683
149 2ZPA ADP 6.58683
150 4QOS ADP 6.58683
151 2FNA ADP 6.58683
152 1E2K TMC 6.58683
153 3RC3 ANP 6.58683
154 4ZDJ UTP 6.58683
155 5NM7 GLY 6.58683
156 2BEK ATP 6.61479
157 1UPT GTP 6.66667
158 5K5Z ANP 6.6879
159 5L3W GDP 6.86275
160 5OCM 9RH 6.87285
161 4NU0 AP5 6.91244
162 4KJU 1RH 6.97674
163 5XDR ADP 7.05394
164 5VYQ FON 7.05882
165 1DAK DPU 7.14286
166 1DAK ADP 7.14286
167 5W7Q GDP 7.18563
168 3CNL GNP 7.18563
169 5W76 GDP 7.18563
170 5W75 GDP 7.18563
171 3PCR GTP 7.18563
172 1WDT GTP 7.18563
173 1GOJ ADP 7.18563
174 3ZFD ANP 7.18563
175 1FP6 ADP 7.18563
176 1SQ5 ADP 7.18563
177 5IRN ADP 7.18563
178 1U0J ADP 7.18563
179 2GK6 ADP 7.18563
180 2XAU ADP 7.18563
181 2X7I CIT 7.18563
182 1W5T ANP 7.18563
183 1W5T ADP 7.18563
184 3BFX A3P 7.18563
185 4DFU QUE 7.18563
186 2ZJ5 ADP 7.18563
187 5KXE 6Y2 7.18563
188 4E03 ADP 7.28155
189 6EKZ SNP 7.31707
190 4PYA 2X3 7.45342
191 4YFY 1YJ 7.48031
192 5U32 GDP 7.62712
193 5LB3 ADP 7.64045
194 2VB6 ADP BEF 7.67635
195 4PFO ADP 7.67635
196 4YS0 ADP 7.67635
197 2XT3 ADP 7.78443
198 1LVG ADP 7.78443
199 4V03 ADP 7.78443
200 3E70 GDP 7.78443
201 4H1V GNP 7.78443
202 1OXV ANP 7.78443
203 3T34 GDP 7.78443
204 5LTJ ADP 7.78443
205 3TBK ANP 7.78443
206 5LTJ BEF 7.78443
207 5AK0 8V1 7.78443
208 6FAA ADP 7.78443
209 4OKD GLC GLC GLC 7.78443
210 4X8O AP5 7.78443
211 4PJ3 ANP 7.78443
212 1S3G AP5 7.78443
213 5MEX PAP 7.78443
214 5H4S RAM 7.78443
215 3QOX SAH 7.78443
216 1QAN SAH 7.78689
217 2Y7P SAL 7.79817
218 2C77 GNP 7.90123
219 2C78 GNP 7.90123
220 1NJF ADP 8
221 1NJF AGS 8
222 5GVR LMR 8.11966
223 1VHT BA3 8.25688
224 2RCN GDP 8.38323
225 3LRE ADP 8.38323
226 5IRR GSP 8.38323
227 4CVN ADP 8.38323
228 4IDN GNP 8.38323
229 2BIF SIN 8.38323
230 2BIF ANP 8.38323
231 1K6M AGS 8.38323
232 4MKF AP5 8.38323
233 3FYH ADP 8.38323
234 1O8B ABF 8.38323
235 4LZB URA 8.38323
236 6M7X JD7 8.38323
237 3BP1 GUN 8.38323
238 2JK0 ASP 8.38323
239 4Z7X 3CX 8.40336
240 5EE5 GTP 8.4507
241 2CDN ADP 8.45771
242 1QF5 GDP 8.58469
243 1QF5 RPL 8.58469
244 1ZVX FIN 8.58896
245 1DCP HBI 8.65385
246 4OI4 ATP 8.69565
247 3HCH RSM 8.90411
248 1GPJ CIT 8.91089
249 2GNK ATP 8.92857
250 2VVG ADP 8.98204
251 1V8K ANP 8.98204
252 6AU6 GDP 8.98204
253 4ZG4 VO4 ADP 8.98204
254 3FKQ ATP 8.98204
255 4LYA ATP 8.98204
256 1D2E GDP 8.98204
257 1XKV ATP 8.98204
258 2R4V GSH 8.98204
259 5G3Y ADP 8.98204
260 4IOK XPO 8.98204
261 4IOK ADP 8.98204
262 4MKG AP5 8.98204
263 5G41 AP5 8.98204
264 4QRH 0O2 9.04762
265 3P9Y N7P THR SEP PRO SER TYR SET 9.09091
266 3BFV ADP 9.22509
267 3FB4 AP5 9.25926
268 5TQZ GLC 9.33333
269 2YY8 MTA 9.45274
270 4J0Q GDP 9.58084
271 1KK1 GNP 9.58084
272 4PC3 GDP 9.58084
273 6CS8 F9Y 9.58084
274 3R7F CP 9.58084
275 1AKY AP5 9.58084
276 1ZIN AP5 9.58084
277 4WEI GLC GAL 9.58084
278 2BQP GLC 9.58084
279 2NCD ADP 9.58084
280 3DOE GTP 9.69697
281 2OG2 MLI 9.7493
282 4XTR ADP 9.88701
283 3ZS9 ADP ALF 9.88701
284 4XTR ATP 9.88701
285 2WOJ ADP ALF 9.88701
286 4XVU ATP 9.88701
287 2GMP NAG MAN 9.92064
288 2GMM MAN MAN 9.92064
289 2QZ4 ADP 9.92366
290 1APZ ASP 9.92908
291 2FAH GDP 9.95851
292 2FMD MAN MAN 10
293 1PTR PRB 10
294 6B8B ADP 10.0402
295 2GWH A3P 10.0671
296 4P3Y GDP 10.1796
297 1SKQ GDP 10.1796
298 1BG2 ADP 10.1796
299 1F9V ADP 10.1796
300 5IFS ADP 10.1796
301 1FNN ADP 10.1796
302 1IN4 ADP 10.1796
303 1P9B GDP 10.1796
304 4A4Z ANP 10.1796
305 1D2N ANP 10.1796
306 1NST A3P 10.1796
307 1KO8 6PG 10.2857
308 3ZQ6 ADP ALF 10.4938
309 2CBZ ATP 10.5485
310 2ODE ALF GDP 10.5714
311 2OFW ADX 10.5769
312 1U3G ADP 10.582
313 1VBO MAN MAN MAN 10.7383
314 1VBO MAN 10.7383
315 3TK1 GDP 10.7784
316 3EWA ANP 10.7784
317 5VGR GDP 10.7784
318 1OYY AGS 10.7784
319 3COB ADP 10.8401
320 1P4V GLY 10.8475
321 5O96 SAM 11.0204
322 5MVR ADP 11.1111
323 3MB5 SAM 11.3725
324 2WIC GNP 11.3772
325 4R98 GNH 11.3772
326 5ZBR ANP 11.3772
327 4XGU ADP 11.3772
328 1ZUI SKM 11.3772
329 1SVM ATP 11.3772
330 6ACS CIT 11.3772
331 2GUC MAN 11.3772
332 4CTA ATP 11.3772
333 2GUD MAN 11.3772
334 1SVK ALF GDP 11.6147
335 1X6V ADP 11.6183
336 5KUT GDP 11.6402
337 2WJG GDP 11.976
338 1JJV ATP 11.976
339 4IEE AGS 11.976
340 4FCW ADP 11.976
341 4LJ9 ACP 11.976
342 1NY5 ADP 11.976
343 5XKT GNP 12
344 2WJH GDP 12.0482
345 2WJH FLC 12.0482
346 1F2U ATP 12.0805
347 3KTA AP5 12.1387
348 1B7T ADP 12.1795
349 3B9Q MLI 12.2517
350 1L2T ATP 12.3404
351 1Y3A GDP 12.462
352 1KSH GDP 12.5
353 5H67 ATP 12.5
354 2WHX ADP 12.5749
355 4NON GDP 12.5749
356 3P4X ADP 12.5749
357 2JLR ANP 12.5749
358 4YJ1 ADP 12.5749
359 1LVK MNT BEF 12.5749
360 1P72 ADP 12.5749
361 1R0X ATP 12.5874
362 2OM2 GDP 12.6154
363 1XEX ATP 12.7907
364 1BH2 GSP 13.0159
365 1Y63 ADP 13.0435
366 4ZKD GDP 13.1737
367 1JJ7 ADP 13.1737
368 1W7J ADP BEF 13.1737
369 5J1S ATP 13.1737
370 2HF9 GSP 13.2743
371 2O66 FLC 13.3333
372 1KK8 BEF ADP 13.6691
373 4U00 ADP 13.7725
374 4YMU ATP 13.7725
375 3B5J 12D 13.7725
376 1G3Q ADP 13.7725
377 4MDB RLT 13.7725
378 3K5I AIR 13.7725
379 3BER AMP 14.0562
380 4Q1A 2XZ 14.2857
381 4Q1A UDP 14.2857
382 3PQC GDP 14.3713
383 4QM7 GTP 14.3713
384 5L3R GCP 14.3713
385 2PL3 ADP 14.3713
386 1WY7 SAH 14.4928
387 5C2N NAG 14.5833
388 3H4S ADP 14.8148
389 1RRC ADP 14.9701
390 2GKS ADP 14.9701
391 2IS6 ADP 14.9701
392 3UG4 AHR 14.9701
393 4R2I ANP 14.9701
394 1AQU A3P 14.9701
395 4BAS GNP 15.0754
396 3KIF GDL 15.0943
397 3AB4 THR 15.1685
398 6FMC DUE 15.1899
399 2XTZ GSP 15.2542
400 4XDY HIO 15.3846
401 1CS4 GSP 15.566
402 4NCN GTP 15.5689
403 5HCN GCP 15.5689
404 4TMZ GSP 15.5689
405 3L6C MLI 15.5689
406 4UOX PUT 15.5689
407 1G7C 5GP 15.9574
408 3FSY SCA 15.9639
409 1MKY GDP 16.1677
410 2AWN ADP 16.1677
411 3CX8 GSP 16.1677
412 3AB3 GDP 16.1677
413 1ZCB GDP 16.1677
414 6CRK GDP 16.1677
415 2CHG ANP 16.1677
416 3RLF ANP 16.1677
417 1FQJ ALF 16.6667
418 1FQJ GDP 16.6667
419 3IIJ ADP 16.6667
420 1OFH ADP 16.6667
421 1RJ9 GCP 17
422 1PUJ GNP 17.3653
423 4IHQ ADP 17.3653
424 2ZTS ADP 17.3653
425 5X40 ACP 17.3653
426 1LOB MMA 17.3653
427 4G86 BNT 17.9641
428 1KJ8 GAR 17.9641
429 3ZIA ADP 18.0328
430 3ZIA ATP 18.0328
431 5TWJ SAM 18.5185
432 5CK5 GDP 18.5629
433 4HSE ADP 18.5629
434 6B4K ANP 18.5629
435 3TY3 GGG 18.5629
436 1GXU 2HP 18.6813
437 4P4T GDP 19.1617
438 1TL2 NDG 19.1617
439 2ATJ BHO 19.1617
440 2W83 GTP 19.4805
441 5L3V GDP 19.7605
442 5L3S GNP 19.7605
443 1IHU AF3 19.7605
444 1IHU ADP 19.7605
445 4PPF FLC 20.3593
446 1H65 GDP 20.3593
447 2ZR9 DTP 20.3593
448 6AIC AMP 20.3593
449 5ODQ 9SB 20.3593
450 4BQS ADP 20.4545
451 4BQS K2Q 20.4545
452 1HBK COA 21.3483
453 3UIE ANP 21.5569
454 1UJ2 C5P 22.1557
455 2D7D ADP 22.5
456 4LPS GDP 22.7545
457 5BN3 ADP 22.7545
458 1CR1 TTP 22.7545
459 3A4M ADP 23.3533
460 2FH5 GTP 23.9521
461 3DEF GDP 23.9521
462 1XMV ADP 23.9521
463 5WRI A3P 24.5509
464 3W5J GDP 25.1497
465 1W0J ADP 25.1497
466 2CK3 ANP 25.1497
467 1W0J ADP BEF 25.1497
468 2CK3 ADP 25.1497
469 2V7Q ADP 25.1497
470 2V7Q ATP 25.1497
471 3DZD ADP 26.3473
472 4TL6 ANP 26.3473
473 4KVA GTP 26.9461
474 1XX6 ADP 26.9461
475 4JLS 3ZE 26.9461
476 4TTQ ATP 27.4419
477 4V0K GDP 27.5449
478 1DAR GDP 27.5449
479 4B47 GDP 28.1437
480 3KJI ADP 28.1437
481 4M9Q GNP 28.7425
482 1YRB GDP 29.3413
483 3T12 GDP ALF 29.3413
484 3T1O GDP 29.3413
485 1R4A GNP 29.4118
486 1G7S GDP 29.9401
487 3QF7 ANP 30
488 4B2D FBP 30.5389
489 2PEZ DAT 31.2849
490 2PEZ GGZ 31.2849
491 5YT0 GDP 31.7365
492 5FG3 GDP 31.7365
493 1J2J GTP 31.7365
494 2J59 GTP 31.7365
495 1O3Y GTP 31.7365
496 4DCT GDP 32.3353
497 1ZD9 GDP 32.3353
498 1RE0 GDP 32.3353
499 1S9D GDP 32.3353
500 3AQ4 GDP 32.9341
501 5H7K GDP 32.9341
502 5H7J GCP 32.9341
503 2QN6 GDP 33.3333
504 1YZG GDP 33.5329
505 1NRJ GTP 33.5329
506 1ZJ6 G3D 34.1317
507 4YLG GDP 34.1317
508 5KSP GDP 37.7246
509 5KSZ GCP 37.7246
510 5KDO GDP 39.1892
511 2ZEJ GDP 39.521
512 4ZI2 GNP 40.1198
513 4GOJ GNP 40.1198
514 1FZQ GDP 40.1198
515 2QTV GNP 40.1198
516 1M2O GNP 41.3174
517 5DI3 GNP 41.9162
518 1F6B GDP 41.9162
519 3A1S GDP 43.7126
520 1MR3 G3D 44.3114
521 1GWN GTP 45.509
522 1M7B GTP 45.509
523 3M1I GTP 48.503
524 3GJX GTP 48.503
525 3WYF GTP 48.503
526 3GJ4 GDP 48.503
527 3GJ7 GDP 48.503
528 1Z0J GTP 48.503
529 3WYG GTP 48.503
530 3GJ8 GDP 48.503
531 3GJ5 GDP 48.503
532 4HI0 GDP 48.503
533 1D5C GDP 48.7654
534 4HAT GNP 49.1018
535 5DHF GNP 49.1018
536 6CIT GNP 49.1018
537 5UWQ GNP 49.1018
538 5UWO GNP 49.1018
539 5UWJ GNP 49.1018
540 5UWR GNP 49.1018
541 5UWW GNP 49.1018
542 5UWT GNP 49.1018
543 5UWU GNP 49.1018
544 5UWI GNP 49.1018
545 5UWH GNP 49.1018
546 5UWP GNP 49.1018
547 5DI9 GNP 49.1018
548 5UWS GNP 49.1018
549 3GJ3 GDP 49.1018
550 3CH5 GDP 49.1018
551 1WA5 GTP 49.1018
552 5OEC GDP 49.1018
553 1YVD GNP 49.1124
Pocket No.: 2; Query (leader) PDB : 6BVK; Ligand: EAV; Similar sites found with APoc: 479
This union binding pocket(no: 2) in the query (biounit: 6bvk.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 2GSU AMP 1.79641
2 4Q6R 30J 1.86722
3 3LLI FAD 1.91571
4 4DR9 BB2 2.08333
5 2C43 COA 2.16718
6 4OAR 2S0 2.32558
7 2XSU PIE 2.39521
8 5ZKC 3C0 2.39521
9 5EUD 5S6 2.39521
10 3P9T TCL 2.39521
11 3GN8 DEX 2.81124
12 5UFS 1TA 2.82258
13 5N9T 8QQ 2.99401
14 2UYT LRH 2.99401
15 2UYT ADP 2.99401
16 6EQ8 BQZ 2.99401
17 3ZLR X0B 3.16456
18 2X5W K2B 3.18182
19 5JFS 6K0 3.24675
20 1MID LAP 3.2967
21 6F70 GSH 3.57143
22 3JZB 4HY 3.59281
23 3KJD 78P 3.59281
24 3RY9 1CA 3.59281
25 3T58 FAD 3.59281
26 4ZZE GLC GLC GLC 3.59281
27 3E7O 35F 3.61111
28 4NSQ COA 3.68421
29 5EK3 5PK 3.72208
30 4NAT ADP 3.75
31 4NAT 2W5 3.75
32 5SYN 71T 3.8961
33 5JF2 SF7 3.92157
34 2HW1 ANP 4.02685
35 2GTE VA 4.03226
36 2G3F IZC 4.038
37 1Y7I SAL 4.10448
38 2GJ3 FAD 4.16667
39 5X5M 7YU 4.16667
40 3V78 ET 4.19162
41 3ZS7 ATP 4.19162
42 3EWK FAD 4.19162
43 5NJI 8Z2 4.19162
44 1XMY ROL 4.19162
45 2OBD PCW 4.20168
46 3WYJ H78 4.34783
47 4EHU ANP 4.34783
48 5CSD ACD 4.40252
49 6F68 GSH 4.47154
50 6F68 4EU 4.47154
51 3RV5 DXC 4.49438
52 1SBR VIB 4.5
53 3FAL REA 4.54545
54 5HGR 45D 4.61538
55 2OFV 242 4.69314
56 3KB9 BTM 4.71204
57 2JJK R15 4.73373
58 1Z8O DEB 4.79042
59 5L92 MLA 4.79042
60 5L92 C0R 4.79042
61 3HP9 CF1 4.79042
62 2DSA HPX 4.79042
63 4F4S EFO 4.79042
64 6F8A HIS 4.79042
65 1FCH TYR GLN SER LYS LEU 4.79042
66 2DSA GSH 4.79042
67 3FRQ ERY 4.79042
68 6BR8 6OU 4.79042
69 5KLP IHP 4.79042
70 1G27 BB1 4.79042
71 2OWZ CIT 4.79042
72 3OJI PYV 4.79042
73 1JGS SAL 4.79042
74 6G5J EM8 4.84848
75 6ET8 BWH 4.95496
76 6H0B UDP 4.97925
77 5E7V M7E 5
78 3OKI OKI 5.15021
79 3UWB BB2 5.19481
80 4DXJ IPE 5.24862
81 1W2Y DUN 5.38922
82 4OKZ 3E9 5.38922
83 3WCA FPS 5.38922
84 3TGE TGE 5.38922
85 5UR1 YY9 5.38922
86 4L1F COS 5.38922
87 1M13 HYF 5.38922
88 2CIX CEJ 5.38922
89 4F06 PHB 5.38922
90 3A51 VDY 5.38922
91 5UI2 EQ3 5.38922
92 5TUX ECH 5.38922
93 4B74 1LH 5.38922
94 2QJY SMA 5.38922
95 3W5N RAM 5.39419
96 2Q2Y MKR 5.44959
97 2Q2Y ADP 5.44959
98 2FTB OLA 5.6
99 2RH1 CLR 5.60166
100 1JF0 CZH 5.64103
101 4U0I 0LI 5.71429
102 5N8V KZZ 5.7971
103 5DY5 5GR 5.92105
104 4C2V YJA 5.96491
105 3FWY ADP 5.98802
106 6BMS PLM 5.98802
107 5K7H IVC 5.98802
108 4DSG FAD 5.98802
109 4DSG UDP 5.98802
110 2D4V FLC 5.98802
111 2C9O ADP 5.98802
112 1NVM NAD 5.98802
113 1DB1 VDX 5.98802
114 5F5N 5VD 5.98802
115 1DMH LIO 5.98802
116 5J1J ANP 5.98802
117 3ICT COA 5.98802
118 6FX0 E9T 5.98802
119 5IM3 DTP 5.98802
120 3UST FAD 5.99251
121 5B0I BOG 6.12245
122 5TZ1 VT1 6.43154
123 6BTN E8M 6.43564
124 2B96 ANN 6.50407
125 3ET3 ET1 6.50685
126 2ALG HP6 6.52174
127 2ALG DAO 6.52174
128 6AYI C3G 6.53266
129 5OWC AYZ 6.55738
130 1Z3C SA8 6.58683
131 3PE2 E1B 6.58683
132 4U0S ADP 6.58683
133 2V95 HCY 6.58683
134 6F6E PLM 6.58683
135 1W5F G2P 6.58683
136 3COW 52H 6.58683
137 4V24 GYR 6.58683
138 1ION ADP 6.58683
139 4XRZ SI6 6.58683
140 2UXI G50 6.58683
141 4D7M TDC 6.58683
142 4KVL PLM 6.58683
143 1U8V FAD 6.58683
144 5NM7 GLY 6.58683
145 2FV5 541 6.58683
146 5X3R 7Y3 6.58683
147 3NJQ NJQ 6.58683
148 5N26 CPT 6.59341
149 4BFW ZVW 6.60377
150 6ES0 BW8 6.62461
151 2EW5 Y12 6.62983
152 5EEH P9P 6.64894
153 5EEH SAH 6.64894
154 1RDT 570 6.69014
155 3V49 PK0 6.76692
156 3KMR EQN 6.76692
157 3G4Q MCH 6.84932
158 1FM9 570 6.98529
159 1FM9 9CR 6.98529
160 2QV6 GTP 7.08955
161 2VDY HCY 7.18563
162 4KWD JF2 7.18563
163 3GST GPR 7.18563
164 1ESM COA 7.18563
165 4LY9 1YY 7.18563
166 5OLZ T4E 7.18563
167 3VRV YSD 7.18563
168 4NE2 SH2 7.18563
169 3RGA ILD 7.18563
170 5XPL 8C9 7.18563
171 3ROE THM 7.18563
172 3RO7 TDR 7.18563
173 2O4J VD4 7.18563
174 2IZ1 ATR 7.18563
175 2IZ1 RES 7.18563
176 2R40 EPH 7.18563
177 4O1Z MXM 7.18563
178 1FP6 ADP 7.18563
179 1OQC FAD 7.2
180 2Q1H AS4 7.2
181 6A0S NDP 7.22892
182 4UCC ZKW 7.29614
183 3CEV ARG 7.35786
184 5HCV 60R 7.393
185 2A3I C0R 7.50988
186 1FK5 OLA 7.52688
187 1DKF OLA 7.65957
188 5OLK DTP 7.67442
189 1UVC STE 7.69231
190 4NKW PLO 7.78443
191 3NB0 G6P 7.78443
192 1UHK CZN 7.78443
193 5NWI TYR PHE SER SEP ASN 7.78443
194 3F10 8HG 7.78443
195 5E4R NAP 7.78443
196 4JGX PLM 7.78443
197 1OPK MYR 7.78443
198 5IQT 6CU 7.78443
199 5IQT AKG 7.78443
200 2P4Q FLC 7.78443
201 2VAP GDP 7.78443
202 4B7H NDP 7.78443
203 3WBF NAP 7.78443
204 3KFC 61X 7.78443
205 4O4Z N2O 7.79221
206 3T50 FMN 7.8125
207 4RKK GLC GLC GLC GLC GLC GLC 7.83133
208 4R38 RBF 7.85714
209 2LBD REA 7.86517
210 1XAP TTB 7.86517
211 4DM8 REA 7.86517
212 4B2G V1N 7.88382
213 3RET PYR 7.92079
214 3RET SAL 7.92079
215 3O55 FAD 8
216 3V1V GST 8.08314
217 1BZL GCG 8.09129
218 6B8O PSF 8.28402
219 5GUE GGS 8.38323
220 5LIA 6XN 8.38323
221 3RDE OYP 8.38323
222 2D37 FMN 8.38323
223 5OSW AE4 8.38323
224 2YOO K2B 8.38323
225 5EIB GTP 8.38323
226 5X20 AOT 8.38323
227 5OSW DIU 8.38323
228 5XDT GDP 8.38323
229 3IS2 FAD 8.44156
230 1JR8 FAD 8.54701
231 3JRS A8S 8.65385
232 3D72 FAD 8.72483
233 3RLB VIB 8.85417
234 3KDJ A8S 8.91089
235 5Z1N PEF 8.92857
236 1FCZ 156 8.93617
237 1YOK P6L 8.98204
238 1S17 GNR 8.98204
239 3LN0 52B 8.98204
240 1YUC EPH 8.98204
241 4RC8 STE 8.98204
242 6CB2 OLC 8.98204
243 5LX9 OLB 8.98204
244 5UNJ RJW 8.98204
245 4LH7 NMN 8.98204
246 3P5P A3C 8.98204
247 2RHO GDP 8.98204
248 2RHO GSP 8.98204
249 1JQ9 PHE LEU SER TYR LYS 9.09091
250 4IS0 1R4 9.12863
251 1LQY BB2 9.23913
252 1N46 PFA 9.30233
253 4QJR PIZ 9.38776
254 3GYT DL4 9.42623
255 4WT2 3UD 9.52381
256 4ZBR DIF 9.54357
257 4ZBR NPS 9.54357
258 1ZDT PEF 9.54357
259 3LDW ZOL 9.58084
260 3LDW IPE 9.58084
261 4QWT ACD 9.58084
262 2QZZ NAP 9.58084
263 2QZZ EMF 9.58084
264 5UC9 MYR 9.58084
265 5J62 FMN 9.58084
266 1NTV ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 9.58084
267 2XCG XCG 9.58084
268 4WX0 HXD 9.58084
269 5KAU RHQ 9.69697
270 2B3D FAD 9.80392
271 1N8V BDD 9.82143
272 3RUG DB6 9.93377
273 1NHZ 486 10
274 5G5W R8C 10
275 1OFU GDP 10.084
276 1XKD ICT 10.1796
277 2R75 01G 10.1796
278 5NTP 98E 10.1796
279 3RMK BML 10.1796
280 4B98 PXG 10.1796
281 2AIB ERG 10.2041
282 4HIA FMN 10.2273
283 1JAY F42 10.3774
284 4H07 IPH 10.3896
285 4OAS 2SW 10.4167
286 5XJ8 NKO 10.4478
287 5K53 STE 10.7784
288 1YMT DR9 10.7784
289 4IVG ANP 10.7784
290 1JQI CAA 10.7784
291 4WRI OKA 10.7784
292 5IF4 6AK 10.7784
293 5U5G 7VD 10.7784
294 4ZM4 P3B 10.7784
295 1M2Z DEX 10.8949
296 4V1T ADP 10.9375
297 3BQD DAY 10.9804
298 4P6X HCY 10.9804
299 5UC1 486 11.3772
300 2AEL SAZ 11.3772
301 3ND6 ATP 11.3772
302 3ANP DCC 11.3772
303 1QZR CDX 11.3772
304 1QZR ANP 11.3772
305 2AE2 PTO 11.3772
306 5CXI 5TW 11.3772
307 2F59 INI 11.465
308 2Z6D FMN 11.5385
309 3KPX CZH 11.6162
310 5DKK FMN 11.7241
311 5DUF G7A 11.7871
312 3GKJ HC3 11.976
313 6BMM OLB 11.976
314 3SCM LGN 11.976
315 4J24 EST 11.976
316 3OLL EST 11.976
317 4J26 EST 11.976
318 4MYD 164 11.976
319 2YJD YJD 11.976
320 2NVA PL2 11.976
321 3R9V DXC 11.976
322 1U3R 338 11.976
323 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 12
324 3QDJ ALA ALA GLY ILE GLY ILE LEU THR VAL 12
325 3OGN 3OG 12.0968
326 5C9J STE 12.1212
327 3HUJ AGH 12.1212
328 5C9J DAO 12.1212
329 3VVY ET 12.3711
330 2PRG BRL 12.5
331 4CRL C1I 12.5749
332 3ET1 ET1 12.5749
333 1ITU CIL 12.5749
334 3D9F N6C 12.5749
335 3D9F FAD 12.5749
336 4AG8 AXI 12.5749
337 3SP6 IL2 12.5749
338 6IIU A8X 12.5749
339 1IYK MYA 12.5749
340 2VPR TDC 12.5749
341 1X8J A3P 12.5749
342 1K7L 544 12.5749
343 2UW1 GVM 12.5749
344 3KDU NKS 12.5749
345 2F5T MAL 12.5749
346 3S0E EOL 12.605
347 1T0S BML 12.7907
348 2A06 SMA 12.8205
349 1QV1 CZH 12.8205
350 2IYG FMN 12.9032
351 3BEJ MUF 13.0252
352 5BYK OAQ 13.1274
353 5BYK A3P 13.1274
354 3W54 RNB 13.1737
355 4XT8 TMQ 13.1737
356 3DCT 064 13.1915
357 1YRX FMN 13.2231
358 3P0K FAD 13.5338
359 3RUU 37G 13.5371
360 5MWE TCE 13.5802
361 6A5Y 9R0 13.5965
362 4OIV XX9 13.7168
363 1G3Q ADP 13.7725
364 3QUZ QUV 13.7725
365 3R9C ECL 13.7725
366 2YPO PHE 13.7725
367 3FWN 6PG 13.7725
368 3FWN ATR 13.7725
369 4MRP GSH 13.7725
370 4MRV HGD 13.7725
371 2VHW NAI 13.7725
372 4MRS GDS 13.7725
373 1GUX ASP LEU TYR CYS TYR GLU GLN LEU ASN 13.8158
374 5LWY OLB 14.0187
375 5TVI MYR 14.1304
376 3E3U NVC 14.2132
377 1YKD CMP 14.3713
378 5EW9 5VC 14.3713
379 1RX0 2MC 14.3713
380 4M4Q 21A 14.3713
381 3OA2 NAD 14.3713
382 1BWO LPC 14.4444
383 1XVB BHL 14.7059
384 5DJT FMN 14.7541
385 4EES FMN 14.7826
386 2BTO GTP 14.8148
387 5UR6 8KM 14.9171
388 5B4B LP5 14.9701
389 5C2H 4PX 14.9701
390 5C2H 4XU 14.9701
391 3N7H DE3 15.2
392 5MTE BB2 15.3285
393 4LNU GTP 15.3846
394 1CS4 FOK 15.566
395 1CS4 101 15.566
396 3IQE H4M 15.5689
397 3IQE F42 15.5689
398 5B25 4QJ 15.5689
399 4UOX PLP PUT 15.5689
400 4XU6 TDA 15.5689
401 5IUY BOG 15.5689
402 4UOX PLP 15.5689
403 3KP6 SAL 15.894
404 2IFB PLM 16.0305
405 3QQA TCH 16.1677
406 2Z7I 742 16.1677
407 4EPL JAI 16.1677
408 2FP2 TSA 16.2651
409 5X13 HC4 16.4894
410 2W90 6PG 16.7665
411 4TMC FMN 16.7665
412 3IL6 B83 16.7665
413 2HJ3 FAD 16.8
414 3AHQ FAD 17.3653
415 4ELG 52J 17.4699
416 4ELG 52I 17.4699
417 3GWL FAD 17.9245
418 1L0I PSR 17.9487
419 3BJC WAN 17.9641
420 3SHZ 5CO 17.9641
421 3GWN FAD 18.4211
422 3DST GRG 18.5629
423 5D9J 0N8 18.5629
424 2E1A MSE 18.6667
425 4P4T GDP 19.1617
426 5LOF 70R 19.1617
427 4YV5 SVR 19.6721
428 1ZXM ANP 19.7605
429 4ZW3 4S9 19.7605
430 3RYC GTP 20.2797
431 5U3B 7TD 20.3593
432 3CXH SMA 20.4301
433 3CX5 SMA 20.4301
434 5FOI MY8 20.9581
435 1XRO LEU 21.1604
436 1HBK COA 21.3483
437 4X7Q 3YR 21.5569
438 4BNU 9KQ 22.1557
439 1EZV SMA 22.973
440 2IBZ SMA 22.973
441 1Q1Y BB2 23.3533
442 5K52 OCD 23.9521
443 4MGB XDH 24.5509
444 3UUA 0CZ 24.5509
445 2QE4 JJ3 24.5509
446 4MGD 27N 24.5509
447 5WGD EST 24.5509
448 5WGQ EST 24.5509
449 4TV1 36M 24.5509
450 3UUD EST 24.5509
451 4MG9 27K 24.5509
452 2BJ4 OHT 24.5509
453 2QA8 GEN 24.5509
454 5DXG EST 24.5509
455 5DXE EST 24.5509
456 4MG7 27H 24.5509
457 5HYR EST 24.5509
458 4MGA 27L 24.5509
459 2QZO KN1 24.5509
460 5OM2 DXT 25
461 5DX3 EST 25.1497
462 5G57 6M5 25.7485
463 2PR5 FMN 26.5152
464 3CR4 PNT 27.1739
465 2Y69 CHD 28.5714
466 3EE4 MYR 30.5389
467 2DYR PSC 33.8983
468 2DYS PSC 33.8983
469 5ZCO PSC 33.8983
470 5Z84 PSC 33.8983
471 5Z84 CHD 33.8983
472 5ZCO CHD 33.8983
473 2DYS TGL 33.8983
474 5ZCO TGL 33.8983
475 5Z84 TGL 33.8983
476 5ZCO PEK 33.8983
477 5W97 CHD 33.8983
478 5Z84 PEK 33.8983
479 4LSJ LSJ 46.1538
APoc FAQ