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Receptor
PDB id Resolution Class Description Source Keywords
6BVJ 1.75 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NA C:202;
Part of Protein;
none;
submit data
22.99 Na [Na+]
FMT B:2004;
B:2002;
B:2006;
C:201;
B:2005;
B:2003;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
46.025 C H2 O2 C(=O)...
GNP A:201;
Valid;
none;
submit data
522.196 C10 H17 N6 O13 P3 c1nc2...
MG A:202;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
GOL B:2007;
B:2008;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
EAS B:2001;
Valid;
none;
submit data
484.421 C25 H27 Cl2 N5 O c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6BVJ 1.75 Å EC: 3.-.-.- RAS:SOS:RAS IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR HOMO SAPIENS RAS SOS INHIBITOR ONCOPROTEIN PROTEIN-PROTEIN COMPLEX MSIGNALING PROTEIN
Ref.: DISCOVERY OF AMINOPIPERIDINE INDOLES THAT ACTIVATE GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS1 AND MODULAT SIGNALING. J. MED. CHEM. 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 253 families.
1 6BVJ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 6BVJ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 173 families.
1 6BVJ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GNP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GNP 1 1
2 9GM 1 1
3 GDP 0.839506 0.973684
4 GP3 0.82716 0.948718
5 GTP 0.809524 0.973684
6 GNH 0.807229 0.986842
7 G1R 0.77907 0.961039
8 GCP 0.77907 0.948718
9 GSP 0.770115 0.925
10 5GP 0.756098 0.960526
11 G 0.756098 0.960526
12 G2R 0.747253 0.936709
13 GMV 0.747126 0.948718
14 GAV 0.714286 0.936709
15 GP2 0.712644 0.936709
16 G2P 0.711111 0.936709
17 Y9Z 0.708333 0.880952
18 GDC 0.690722 0.936709
19 GDD 0.690722 0.936709
20 GKE 0.690722 0.936709
21 G5P 0.686869 0.948718
22 GPG 0.684211 0.936709
23 GTG 0.683673 0.91358
24 GDR 0.683673 0.936709
25 GFB 0.683673 0.936709
26 JB2 0.68 0.936709
27 GKD 0.68 0.936709
28 6CK 0.676768 0.91358
29 G3A 0.676768 0.948718
30 GDX 0.673267 0.948718
31 ALF 5GP 0.67033 0.86747
32 YGP 0.663265 0.879518
33 GPD 0.656863 0.902439
34 ALF GDP 0.645833 0.86747
35 GDP AF3 0.645833 0.86747
36 GDP ALF 0.645833 0.86747
37 JB3 0.641509 0.925
38 DBG 0.640351 0.974359
39 G3D 0.638298 0.960526
40 G4P 0.625 0.960526
41 GMP 0.621951 0.857143
42 NGD 0.62037 0.936709
43 GGM 0.618182 0.925926
44 0O2 0.616162 0.960526
45 2MD 0.603604 0.870588
46 CAG 0.60177 0.904762
47 U2G 0.590909 0.91358
48 FEG 0.590909 0.858824
49 GDP 7MG 0.590476 0.888889
50 MGD 0.587719 0.870588
51 G G 0.586538 0.924051
52 ZGP 0.585586 0.848837
53 CG2 0.580357 0.91358
54 ANP 0.568421 0.922078
55 PGD 0.567797 0.902439
56 MD1 0.567797 0.870588
57 3GP 0.56044 0.922078
58 TPG 0.558333 0.822222
59 GH3 0.55 0.948052
60 FE9 0.546219 0.778947
61 GPX 0.539216 0.922078
62 G4M 0.539062 0.860465
63 DGI 0.536082 0.9
64 BGO 0.535088 0.901235
65 IDP 0.53125 0.947368
66 DGT 0.53 0.9
67 2GP 0.526882 0.935065
68 G1R G1R 0.520325 0.901235
69 GCP G 0.518868 0.897436
70 A G 0.516949 0.911392
71 U A G G 0.512605 0.911392
72 G A A A 0.504202 0.9
73 AGO 0.504202 0.91358
74 P2G 0.5 0.860759
75 G1G 0.5 0.902439
76 R7I 0.49505 0.922078
77 MGP 0.49505 0.936709
78 R5I 0.49505 0.922078
79 PGD O 0.492063 0.831461
80 6G0 0.490196 0.936709
81 P1G 0.489796 0.85
82 AKW 0.483051 0.869048
83 DG 0.474227 0.8875
84 DGP 0.474227 0.8875
85 G U 0.466667 0.878049
86 IMP 0.463918 0.934211
87 G2Q 0.462963 0.936709
88 GPC 0.459677 0.858824
89 G C 0.459016 0.878049
90 GTA 0.448276 0.91358
91 G7M 0.444444 0.924051
92 MAP 0.439252 0.898734
93 G G G RPC 0.435484 0.853659
94 B4P 0.434343 0.871795
95 AP5 0.434343 0.871795
96 ADP 0.434343 0.896104
97 A2D 0.43299 0.871795
98 AT4 0.43 0.8625
99 G G G C 0.426357 0.890244
100 AU1 0.425743 0.922078
101 SGP 0.425743 0.807229
102 BA3 0.424242 0.871795
103 A G C C 0.423077 0.888889
104 35G 0.423077 0.909091
105 PCG 0.423077 0.909091
106 C2E 0.423077 0.897436
107 APC G U 0.421875 0.864198
108 HEJ 0.421569 0.896104
109 ATP 0.421569 0.896104
110 ACQ 0.419048 0.873418
111 5GP 5GP 0.419048 0.860759
112 5FA 0.417476 0.896104
113 AQP 0.417476 0.896104
114 01G 0.417391 0.880952
115 AN2 0.415842 0.909091
116 UNP 0.415842 0.810127
117 6AD 0.415094 0.821429
118 M33 0.411765 0.860759
119 ITT 0.411765 0.846154
120 G C C C 0.410448 0.901235
121 HFD 0.409524 0.851852
122 G U34 0.408 0.86747
123 ACP 0.407767 0.873418
124 6YZ 0.407407 0.873418
125 AR6 0.403846 0.871795
126 APR 0.403846 0.871795
127 DG DG 0.403509 0.845238
128 A4P 0.403226 0.848837
129 UCG 0.402985 0.888889
130 SAP 0.4 0.851852
131 AGS 0.4 0.851852
132 AD9 0.4 0.873418
Ligand no: 2; Ligand: EAS; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 EAS 1 1
2 EBY 0.884615 0.981818
3 EC4 0.829268 1
4 EAV 0.790698 0.981818
5 EBV 0.494949 0.859649
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6BVJ; Ligand: EAS; Similar sites found with APoc: 340
This union binding pocket(no: 1) in the query (biounit: 6bvj.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 3LLI FAD 1.91571
3 4DR9 BB2 2.08333
4 1SR7 MOF 2.3166
5 4OAR 2S0 2.32558
6 5ZKC 3C0 2.39521
7 4W4S B29 2.66667
8 1OKC CXT 2.6936
9 3GN8 DEX 2.81124
10 5UFS 1TA 2.82258
11 2UYT ADP 2.99401
12 2UYT LRH 2.99401
13 2VZZ SCA 2.99401
14 5N9T 8QQ 2.99401
15 5MDH NAD 2.99401
16 2IMP NAI 3.13152
17 6B2M COA 3.14685
18 3T58 FAD 3.59281
19 3KJD 78P 3.59281
20 6EQS BV8 3.59281
21 4NSQ COA 3.68421
22 4NAT ADP 3.75
23 4NAT 2W5 3.75
24 5SYN 71T 3.8961
25 3LCV SAM 3.91459
26 5JF2 SF7 3.92157
27 1PZG A3D 3.92749
28 2GTE VA 4.03226
29 1Y7I SAL 4.10448
30 2GJ3 FAD 4.16667
31 5X5M 7YU 4.16667
32 4C9G CXT 4.19162
33 3V78 ET 4.19162
34 3ZS7 ATP 4.19162
35 2ISJ FMN 4.19162
36 3EWK FAD 4.19162
37 3D78 NBB 4.20168
38 2OBD PCW 4.20168
39 2OKL BB2 4.32432
40 5CSD ACD 4.40252
41 6F68 GSH 4.47154
42 6F68 4EU 4.47154
43 3RV5 DXC 4.49438
44 1SBR VIB 4.5
45 3SFI 3SF 4.66102
46 2OFV 242 4.69314
47 3KB9 BTM 4.71204
48 1Z8O DEB 4.79042
49 5L92 MLA 4.79042
50 5L92 C0R 4.79042
51 4ORM 2V6 4.79042
52 4ORM ORO 4.79042
53 4ORM FMN 4.79042
54 3HP9 CF1 4.79042
55 2DSA HPX 4.79042
56 6F8A HIS 4.79042
57 5ZM0 FAD 4.79042
58 1FCH TYR GLN SER LYS LEU 4.79042
59 2DSA GSH 4.79042
60 6EYT NDG 4.79042
61 3FRQ ERY 4.79042
62 3EKK GS2 4.79042
63 1MRH FMC 4.79042
64 1JGS SAL 4.79042
65 6G5J EM8 4.84848
66 6ET8 BWH 4.95496
67 3QKD HI0 4.97238
68 5E7V M7E 5
69 3OKI OKI 5.15021
70 2YAY DUP 5.16605
71 3UWB BB2 5.19481
72 1W2Y DUN 5.38922
73 4OKZ 3E9 5.38922
74 3WCA FPS 5.38922
75 3TGE TGE 5.38922
76 5H62 UDP 5.38922
77 4F06 PHB 5.38922
78 2CIX CEJ 5.38922
79 1M13 HYF 5.38922
80 2ZGY GDP 5.38922
81 3A51 VDY 5.38922
82 5UI2 EQ3 5.38922
83 4B74 1LH 5.38922
84 3W5N RAM 5.39419
85 1C3M MAN MAN 5.44218
86 2Q2Y MKR 5.44959
87 2Q2Y ADP 5.44959
88 1E4E ADP 5.53936
89 2FTB OLA 5.6
90 2RH1 CLR 5.60166
91 1JF0 CZH 5.64103
92 5AZC PGT 5.66667
93 4U0I 0LI 5.71429
94 5N8V KZZ 5.7971
95 5DY5 5GR 5.92105
96 3FWY ADP 5.98802
97 4DSG FAD 5.98802
98 4DSG UDP 5.98802
99 4BUY F37 5.98802
100 5K7H IVC 5.98802
101 3IE3 GSH 5.98802
102 3IE3 N11 5.98802
103 4XRZ SI6 5.98802
104 2C9O ADP 5.98802
105 2D4V FLC 5.98802
106 1DB1 VDX 5.98802
107 5IM3 DTP 5.98802
108 3UST FAD 5.99251
109 1BUC CAA 6.00522
110 5L7G 6QE 6.22951
111 4PLT NAI 6.34441
112 4PLT OXM 6.34441
113 2B4D COA 6.43275
114 2B96 ANN 6.50407
115 5OWC AYZ 6.55738
116 6F6E PLM 6.58683
117 1Z3C SA8 6.58683
118 1ION ADP 6.58683
119 4U0S ADP 6.58683
120 2V95 HCY 6.58683
121 3COW 52H 6.58683
122 3PE2 E1B 6.58683
123 2UXI G50 6.58683
124 3RGA ILD 6.58683
125 1W5F G2P 6.58683
126 5NM7 GLY 6.58683
127 4D7M TDC 6.58683
128 4V24 GYR 6.58683
129 5N26 CPT 6.59341
130 4BFW ZVW 6.60377
131 6AD9 KK4 6.62021
132 5EEH P9P 6.64894
133 5EEH SAH 6.64894
134 3V49 PK0 6.76692
135 3G4Q MCH 6.84932
136 4UDB CV7 6.98529
137 6BMS PLM 7.18563
138 4KWD JF2 7.18563
139 3GST GPR 7.18563
140 1ESM COA 7.18563
141 4LY9 1YY 7.18563
142 4LY9 S6P 7.18563
143 3R9V DXC 7.18563
144 5XPL 8C9 7.18563
145 5OLZ T4E 7.18563
146 1YUC EPH 7.18563
147 1YOK P6L 7.18563
148 2O4J VD4 7.18563
149 4RFM 3P6 7.18563
150 3ROE THM 7.18563
151 2VDY HCY 7.18563
152 2IZ1 RES 7.18563
153 4TMC FMN 7.19603
154 1OQC FAD 7.2
155 2Q1H AS4 7.2
156 6A0S NDP 7.22892
157 4UCC ZKW 7.29614
158 3IX9 MTX 7.36842
159 1FK5 OLA 7.52688
160 1DKF OLA 7.65957
161 5OLK DTP 7.67442
162 4DK7 0KS 7.78443
163 4NKW PLO 7.78443
164 3NB0 G6P 7.78443
165 3KFC 61X 7.78443
166 1UHK CZN 7.78443
167 1PFK ADP 7.78443
168 1OPK MYR 7.78443
169 3WBF NAP 7.78443
170 5E4R NAP 7.78443
171 4JGX PLM 7.78443
172 4O4Z N2O 7.79221
173 4RKK GLC GLC GLC GLC GLC GLC 7.83133
174 2C78 PUL 7.90123
175 3V1V GST 8.08314
176 6B8O PSF 8.28402
177 4HBM 0Y7 8.33333
178 5GUE GGS 8.38323
179 2E3N 6CM 8.38323
180 3RDE OYP 8.38323
181 5EIB GTP 8.38323
182 5OSW AE4 8.38323
183 2D37 NAD 8.38323
184 2D37 FMN 8.38323
185 5LX9 OLB 8.38323
186 3IS2 FAD 8.44156
187 5FAH 5VT 8.48214
188 3D72 FAD 8.72483
189 3RLB VIB 8.85417
190 3JQM GTP 8.9172
191 5Z1N PEF 8.92857
192 4RC8 STE 8.98204
193 6CB2 OLC 8.98204
194 1S17 GNR 8.98204
195 3LN0 52B 8.98204
196 1JQ9 PHE LEU SER TYR LYS 9.09091
197 4IS0 1R4 9.12863
198 1LQY BB2 9.23913
199 5HVA DUP 9.28571
200 1N46 PFA 9.30233
201 4QJR PIZ 9.38776
202 3GYT DL4 9.42623
203 4WT2 3UD 9.52381
204 4ZBR DIF 9.54357
205 4ZBR NPS 9.54357
206 1ZDT PEF 9.54357
207 2QZZ NAP 9.58084
208 2QZZ EMF 9.58084
209 3LDW IPE 9.58084
210 3LDW ZOL 9.58084
211 5UC9 MYR 9.58084
212 4WX0 HXD 9.58084
213 1NTV ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 9.58084
214 5J62 FMN 9.58084
215 2B3D FAD 9.80392
216 1NHZ 486 10
217 5G5W R8C 10
218 1OFU GDP 10.084
219 3RMK BML 10.1796
220 3QCP FAD 10.1796
221 1LBF 137 10.1796
222 2R75 01G 10.1796
223 1XKD ICT 10.1796
224 2AIB ERG 10.2041
225 5G3N X28 10.2362
226 4OHU NAD 10.3806
227 4OHU 2TK 10.3806
228 4H07 IPH 10.3896
229 4OAS 2SW 10.4167
230 5K53 STE 10.7784
231 1JQI CAA 10.7784
232 1YMT DR9 10.7784
233 5IF4 6AK 10.7784
234 4V1T ADP 10.9375
235 4P6X HCY 10.9804
236 2AEL SAZ 11.3772
237 5UC1 486 11.3772
238 4JD3 COA 11.3772
239 4JD3 PLM 11.3772
240 1QZR ANP 11.3772
241 3ND6 ATP 11.3772
242 3ANP DCC 11.3772
243 3KPX CZH 11.6162
244 5DKK FMN 11.7241
245 5Y6Q FAD 11.7284
246 1W2D 4IP 11.976
247 3GKJ HC3 11.976
248 6BMM OLB 11.976
249 3SCM LGN 11.976
250 4MYD 164 11.976
251 4B5P ACO 11.976
252 2YJD YJD 11.976
253 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 12
254 5C9J STE 12.1212
255 3VVY ET 12.3711
256 2PRG BRL 12.5
257 4CRL C1I 12.5749
258 4PGK Y69 12.5749
259 3ET1 ET1 12.5749
260 3D9F N6C 12.5749
261 3SP6 IL2 12.5749
262 4AG8 AXI 12.5749
263 6IIU A8X 12.5749
264 4B7S QLE 12.5749
265 1K7L 544 12.5749
266 2VVT I24 12.5749
267 2VPR TDC 12.5749
268 3S0E EOL 12.605
269 1T0S BML 12.7907
270 2A06 SMA 12.8205
271 1QV1 CZH 12.8205
272 3BEJ MUF 13.0252
273 4YDQ ANP 13.1737
274 4YDQ HFG 13.1737
275 3W54 RNB 13.1737
276 3DCT 064 13.1915
277 1YRX FMN 13.2231
278 3P0K FAD 13.5338
279 3RUU 37G 13.5371
280 5MWE TCE 13.5802
281 6A5Y 9R0 13.5965
282 4OIV XX9 13.7168
283 1G3Q ADP 13.7725
284 2YPO PHE 13.7725
285 4MRP GSH 13.7725
286 3R9C ECL 13.7725
287 3FWN 6PG 13.7725
288 3FZG SAM 14
289 5TVI MYR 14.1304
290 3E3U NVC 14.2132
291 1YKD CMP 14.3713
292 1BWO LPC 14.4444
293 1XVB BHL 14.7059
294 3PVT 3HC 14.9701
295 5B4B LP5 14.9701
296 5MTE BB2 15.3285
297 4LNU GTP 15.3846
298 3IQE H4M 15.5689
299 3IQE F42 15.5689
300 3QQA TCH 16.1677
301 2Z7I 742 16.1677
302 2FP2 TSA 16.2651
303 2W90 6PG 16.7665
304 2HJ3 FAD 16.8
305 3AHQ FAD 17.3653
306 3GWL FAD 17.9245
307 4P4T GDP 19.1617
308 5LOF 70R 19.1617
309 4YV5 SVR 19.6721
310 3KJQ B94 20
311 3CXH SMA 20.4301
312 3CX5 SMA 20.4301
313 5FOI MY8 20.9581
314 1HBK COA 21.3483
315 5LLB 6YZ 21.5569
316 5K52 OCD 22.1557
317 4BNU 9KQ 22.1557
318 1EZV SMA 22.973
319 2IBZ SMA 22.973
320 4MGB XDH 23.3533
321 3UUA 0CZ 23.3533
322 4MGD 27N 23.3533
323 2BJ4 OHT 23.3533
324 4TV1 36M 23.3533
325 4MGA 27L 23.3533
326 5OM2 DXT 25
327 5G57 6M5 25.7485
328 2Y69 CHD 28.5714
329 3EE4 MYR 29.9401
330 5ZCO PSC 33.8983
331 2DYR PSC 33.8983
332 2DYS PSC 33.8983
333 5Z84 PSC 33.8983
334 5Z84 CHD 33.8983
335 5ZCO CHD 33.8983
336 5Z84 TGL 33.8983
337 5W97 CHD 33.8983
338 2DYS TGL 33.8983
339 5ZCO TGL 33.8983
340 4LSJ LSJ 46.1538
Pocket No.: 2; Query (leader) PDB : 6BVJ; Ligand: GNP; Similar sites found with APoc: 555
This union binding pocket(no: 2) in the query (biounit: 6bvj.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 2JDU MFU 1.73913
2 2UVO NAG 1.75439
3 2HXW FLC 2.1097
4 2X77 GDP 2.1164
5 1B0U ATP 2.29008
6 2ZFI ADP 2.39521
7 1XP8 AGS 2.39521
8 3N5C GDP 2.46914
9 6C90 ADP 2.99401
10 1YTM ATP 2.99401
11 1T3D CYS 2.99401
12 5D9G GLU ASN LEU TYR PHE GLN 2.99401
13 5FTB ANP 3.00231
14 5FHD ADP ALF 3.00231
15 1OSS BEN 3.13901
16 2FPU HSO 3.40909
17 5EXT ADP 3.46154
18 4D81 ADP 3.53357
19 1M7G AV2 3.59281
20 3EZ2 ADP 3.59281
21 4ZNL BEF ADP 3.59281
22 1IWE IMP 3.59281
23 2FSH ANP 3.59281
24 1M7G ADX 3.59281
25 1M7G ADP 3.59281
26 4U36 TNR 3.59281
27 3H86 AP5 3.64583
28 6A20 ADP 3.73444
29 1G41 ADP 3.82883
30 3DKP ADP 4.08163
31 1TQ4 GDP 4.11622
32 5M04 GDP 4.19162
33 2IYL GDP 4.19162
34 2J5V PCA 4.19162
35 2Z49 AMG 4.19162
36 1YXM ADE 4.19162
37 2O0J ADP 4.19162
38 4O48 ASP 4.19162
39 5VHC BEF ADP 4.19162
40 5HR5 ADP 4.19162
41 2F5X ASP 4.19162
42 1BO4 COA 4.19162
43 5J6Y GLC 4.25532
44 5J6Y BGC 4.25532
45 3UW4 MAA CHG PRO 0DQ 4.34783
46 1HTW ADP 4.43038
47 2W58 ADP 4.45545
48 5ZB0 TYD 4.54545
49 5ZB0 ADP 4.54545
50 2KIN ADP 4.62185
51 3KC1 2T6 4.74777
52 3DC4 ADP 4.79042
53 1JI0 ATP 4.79042
54 4PX9 ADP 4.79042
55 3BOS CDP 4.79042
56 2OZE AGS 4.79042
57 3B7G ANP 4.79042
58 4OHY ANP 4.79042
59 5Z69 AGS 4.79042
60 3ITJ CIT 4.79042
61 2Q8M AMP 4.79042
62 3AIA SAM 4.79042
63 4GOX A3P 4.79042
64 4G86 BNT 4.79042
65 5I34 GDP 4.79042
66 6GSG RCO 4.79042
67 5XLS URA 4.79042
68 4MZQ 1VU 4.86111
69 4WOP CTP 4.88889
70 4HE2 AMP 5.02959
71 3PUN FUC GAL NDG FUC 5.06329
72 3AI8 HNQ 5.07812
73 2XCU C5P 5.08021
74 6AR9 3L4 5.14706
75 2Y65 ADP 5.20548
76 2RGX AP5 5.33981
77 1T5C ADP 5.38922
78 5I0H ADP BEF 5.38922
79 1Z6T ADP 5.38922
80 1G8S MET 5.38922
81 4U60 SIA GAL NGA 5.38922
82 4U60 SIA 5.38922
83 1FNZ A2G 5.38922
84 5H68 AGS 5.38922
85 3F4F UMP 5.38922
86 4U60 SIA GAL BGC NGA GAL 5.38922
87 2BO4 FLC 5.38922
88 2Q2Y ADP 5.44959
89 2Q2Y MKR 5.44959
90 3IO3 ADP 5.45977
91 3UIE ANP 5.5
92 6H5E ANP 5.57769
93 4KAX GTP 5.59006
94 1XXR MAN 5.59006
95 4YDS ATP 5.70175
96 3IUY AMP 5.70175
97 5UIV ADP 5.72687
98 5N69 ADP 5.80913
99 1G6H ADP 5.83658
100 5M7P ADP 5.94714
101 3H4S ADP 5.95855
102 4FRZ ADP 5.95855
103 1VKJ A3P 5.96491
104 4RD0 GDP 5.98802
105 2A5F GTP 5.98802
106 3NHB ADP 5.98802
107 3FWY ADP 5.98802
108 5ZXD ATP 5.98802
109 3Q9L ATP 5.98802
110 2OBM ADP 5.98802
111 1F5N GNP 5.98802
112 5J1J ANP 5.98802
113 2CE7 ADP 5.98802
114 5Y6N ADP 5.98802
115 2C9O ADP 5.98802
116 5MZN ADP 5.98802
117 3FVQ ATP 5.98802
118 3QKT ANP 5.98802
119 1O8B ABF 5.98802
120 2Z5F A3P 5.98802
121 1OS1 PYR 6.0166
122 1OS1 ATP 6.0166
123 1I9G SAM 6.07143
124 4TQK NAG 6.15764
125 4GBM A3P 6.19195
126 5TSH ADP 6.22407
127 5TSH ANP 6.22407
128 4JLV ADP 6.3197
129 5BQ5 ADP BEF 6.34921
130 5GOE GDP 6.3981
131 3WY9 GDP 6.45161
132 3WYA GDP 6.45161
133 6B4K ANP 6.51163
134 4OWK NGA 6.52174
135 3LEK BCW 6.53595
136 2HCJ GDP 6.58683
137 3U6B GDP 6.58683
138 2BVN GNP 6.58683
139 1D8T GDP 6.58683
140 5JBQ GDP 6.58683
141 4G5G GDP 6.58683
142 3U6K GDP 6.58683
143 3WXM GTP 6.58683
144 3VMF GTP 6.58683
145 2PZE ATP 6.58683
146 4WZ6 ATP 6.58683
147 5WC2 ADP 6.58683
148 2DPY ADP 6.58683
149 1ION ADP 6.58683
150 4RZ3 ADP 6.58683
151 4R43 GDP 6.58683
152 1EXF GLY 6.58683
153 2ZPA ADP 6.58683
154 4QOS ADP 6.58683
155 2FNA ADP 6.58683
156 1E2K TMC 6.58683
157 3RC3 ANP 6.58683
158 4ZDJ UTP 6.58683
159 5NM7 GLY 6.58683
160 5KXE 6Y2 6.58683
161 2BEK ATP 6.61479
162 1UPT GTP 6.66667
163 5K5Z ANP 6.6879
164 5L3W GDP 6.86275
165 5OCM 9RH 6.87285
166 4NU0 AP5 6.91244
167 4KJU 1RH 6.97674
168 5XDR ADP 7.05394
169 5VYQ FON 7.05882
170 1DAK DPU 7.14286
171 1DAK ADP 7.14286
172 5W7Q GDP 7.18563
173 3CNL GNP 7.18563
174 5W76 GDP 7.18563
175 5W75 GDP 7.18563
176 3PCR GTP 7.18563
177 1WDT GTP 7.18563
178 1GOJ ADP 7.18563
179 3ZFD ANP 7.18563
180 1FP6 ADP 7.18563
181 4WZA ACP 7.18563
182 4WZA ADP 7.18563
183 1SQ5 ADP 7.18563
184 5IRN ADP 7.18563
185 1U0J ADP 7.18563
186 2GK6 ADP 7.18563
187 2XAU ADP 7.18563
188 2X7I CIT 7.18563
189 1W5T ANP 7.18563
190 1W5T ADP 7.18563
191 3BFX A3P 7.18563
192 4DFU QUE 7.18563
193 2ZJ5 ADP 7.18563
194 4CTA ATP 7.18563
195 1U2Z SAH 7.18563
196 4E03 ADP 7.28155
197 6EKZ SNP 7.31707
198 4PYA 2X3 7.45342
199 4IHQ ADP 7.46888
200 4YFY 1YJ 7.48031
201 5U32 GDP 7.62712
202 5LB3 ADP 7.64045
203 2VB6 ADP BEF 7.67635
204 4PFO ADP 7.67635
205 4YS0 ADP 7.67635
206 4PVR ASP 7.74194
207 2XT3 ADP 7.78443
208 1LVG ADP 7.78443
209 4V03 ADP 7.78443
210 3E70 GDP 7.78443
211 4H1V GNP 7.78443
212 1OXV ANP 7.78443
213 3T34 GDP 7.78443
214 5LTJ ADP 7.78443
215 3TBK ANP 7.78443
216 5LTJ BEF 7.78443
217 5AK0 8V1 7.78443
218 6FAA ADP 7.78443
219 4X8O AP5 7.78443
220 4OKD GLC GLC GLC 7.78443
221 4PJ3 ANP 7.78443
222 1S3G AP5 7.78443
223 5MEX PAP 7.78443
224 5H4S RAM 7.78443
225 3QOX SAH 7.78443
226 1QAN SAH 7.78689
227 2Y7P SAL 7.79817
228 2C77 GNP 7.90123
229 2C78 GNP 7.90123
230 1NJF ADP 8
231 1NJF AGS 8
232 5GVR LMR 8.11966
233 1VHT BA3 8.25688
234 2RCN GDP 8.38323
235 3LRE ADP 8.38323
236 5IRR GSP 8.38323
237 4CVN ADP 8.38323
238 4IDN GNP 8.38323
239 2BIF SIN 8.38323
240 2BIF ANP 8.38323
241 1K6M AGS 8.38323
242 4MKF AP5 8.38323
243 3FYH ADP 8.38323
244 2GJP MAL 8.38323
245 6M7X JD7 8.38323
246 2JK0 ASP 8.38323
247 4Z7X 3CX 8.40336
248 5HCN GCP 8.42912
249 5EE5 GTP 8.4507
250 2CDN ADP 8.45771
251 1QF5 RPL 8.58469
252 1QF5 GDP 8.58469
253 1ZVX FIN 8.58896
254 1DCP HBI 8.65385
255 4OI4 ATP 8.69565
256 3HCH RSM 8.90411
257 1GPJ CIT 8.91089
258 2GNK ATP 8.92857
259 2VVG ADP 8.98204
260 1V8K ANP 8.98204
261 6AU6 GDP 8.98204
262 4ZG4 VO4 ADP 8.98204
263 4LYA ATP 8.98204
264 1D2E GDP 8.98204
265 1XKV ATP 8.98204
266 2R4V GSH 8.98204
267 5G3Y ADP 8.98204
268 4IOK XPO 8.98204
269 4IOK ADP 8.98204
270 4MKG AP5 8.98204
271 5G41 AP5 8.98204
272 4QRH 0O2 9.04762
273 3P9Y N7P THR SEP PRO SER TYR SET 9.09091
274 3BFV ADP 9.22509
275 3FB4 AP5 9.25926
276 5TQZ GLC 9.33333
277 4J0Q GDP 9.58084
278 1KK1 GNP 9.58084
279 4PC3 GDP 9.58084
280 6CS8 F9Y 9.58084
281 3R7F CP 9.58084
282 1AKY AP5 9.58084
283 1ZIN AP5 9.58084
284 2BQP GLC 9.58084
285 4WEI GLC GAL 9.58084
286 2NCD ADP 9.58084
287 3DOE GTP 9.69697
288 2OG2 MLI 9.7493
289 4XTR ADP 9.88701
290 3ZS9 ADP ALF 9.88701
291 4XVU ATP 9.88701
292 4XTR ATP 9.88701
293 2WOJ ADP ALF 9.88701
294 2GMP NAG MAN 9.92064
295 1Q8S MAN MMA 9.92064
296 2GMM MAN MAN 9.92064
297 2QZ4 ADP 9.92366
298 1APZ ASP 9.92908
299 2FAH GDP 9.95851
300 1PTR PRB 10
301 2FMD MAN MAN 10
302 6B8B ADP 10.0402
303 2GWH A3P 10.0671
304 4P3Y GDP 10.1796
305 1SKQ GDP 10.1796
306 1BG2 ADP 10.1796
307 1F9V ADP 10.1796
308 5IFS ADP 10.1796
309 1FNN ADP 10.1796
310 1IN4 ADP 10.1796
311 1P9B GDP 10.1796
312 4A4Z ANP 10.1796
313 1D2N ANP 10.1796
314 1NST A3P 10.1796
315 1KO8 6PG 10.2857
316 3ZQ6 ADP ALF 10.4938
317 2CBZ ATP 10.5485
318 2ODE ALF GDP 10.5714
319 2OFW ADX 10.5769
320 1U3G ADP 10.582
321 1VBO MAN MAN MAN 10.7383
322 1VBO MAN 10.7383
323 3TK1 GDP 10.7784
324 3EWA ANP 10.7784
325 5VGR GDP 10.7784
326 1OYY AGS 10.7784
327 3COB ADP 10.8401
328 1P4V GLY 10.8475
329 5O96 SAM 11.0204
330 5MVR ADP 11.1111
331 3MB5 SAM 11.3725
332 2WIC GNP 11.3772
333 4R98 GNH 11.3772
334 5ZBR ANP 11.3772
335 4XGU ADP 11.3772
336 4IEE AGS 11.3772
337 1ZUI SKM 11.3772
338 1SVM ATP 11.3772
339 2GUC MAN 11.3772
340 2GUD MAN 11.3772
341 1SVK ALF GDP 11.6147
342 1X6V ADP 11.6183
343 5KUT GDP 11.6402
344 2WJG GDP 11.976
345 1JJV ATP 11.976
346 4FCW ADP 11.976
347 4LJ9 ACP 11.976
348 1NY5 ADP 11.976
349 5XKT GNP 12
350 2WJH GDP 12.0482
351 2WJH FLC 12.0482
352 1F2U ATP 12.0805
353 3KTA AP5 12.1387
354 1B7T ADP 12.1795
355 3B9Q MLI 12.2517
356 1L2T ATP 12.3404
357 1Y3A GDP 12.462
358 1KSH GDP 12.5
359 5H67 ATP 12.5
360 2WHX ADP 12.5749
361 4NON GDP 12.5749
362 2JLR ANP 12.5749
363 4YJ1 ADP 12.5749
364 1LVK MNT BEF 12.5749
365 1P72 ADP 12.5749
366 3P4X ADP 12.5749
367 1R0X ATP 12.5874
368 2OM2 GDP 12.6154
369 1BH2 GSP 13.0159
370 1Y63 ADP 13.0435
371 5LWY OLB 13.0841
372 4ZKD GDP 13.1737
373 1JJ7 ADP 13.1737
374 1W7J ADP BEF 13.1737
375 5J1S ATP 13.1737
376 2HF9 GSP 13.2743
377 2O66 FLC 13.3333
378 1KK8 BEF ADP 13.6691
379 4U00 ADP 13.7725
380 4YMU ATP 13.7725
381 3B5J 12D 13.7725
382 1G3Q ADP 13.7725
383 1XX6 ADP 13.7725
384 4MDB RLT 13.7725
385 3K5I AIR 13.7725
386 3BER AMP 14.0562
387 4Q1A UDP 14.2857
388 4Q1A 2XZ 14.2857
389 3PQC GDP 14.3713
390 4QM7 GTP 14.3713
391 5L3R GCP 14.3713
392 2PL3 ADP 14.3713
393 1WY7 SAH 14.4928
394 5C2N NAG 14.5833
395 1RRC ADP 14.9701
396 2GKS ADP 14.9701
397 2IS6 ADP 14.9701
398 3UG4 AHR 14.9701
399 4R2I ANP 14.9701
400 1AQU A3P 14.9701
401 4BAS GNP 15.0754
402 3KIF GDL 15.0943
403 3AB4 THR 15.1685
404 6FMC DUE 15.1899
405 2XTZ GSP 15.2542
406 4XDY HIO 15.3846
407 1CS4 GSP 15.566
408 1MKY GDP 15.5689
409 4NCN GTP 15.5689
410 4TMZ GSP 15.5689
411 3L6C MLI 15.5689
412 4UOX PUT 15.5689
413 1G7C 5GP 15.9574
414 3FSY SCA 15.9639
415 2AWN ADP 16.1677
416 3CX8 GSP 16.1677
417 3AB3 GDP 16.1677
418 6CRK GDP 16.1677
419 1ZCB GDP 16.1677
420 2CHG ANP 16.1677
421 3RLF ANP 16.1677
422 1FQJ ALF 16.6667
423 1FQJ GDP 16.6667
424 3IIJ ADP 16.6667
425 1OFH ADP 16.6667
426 1RJ9 GCP 17
427 1PUJ GNP 17.3653
428 2ZTS ADP 17.3653
429 5X40 ACP 17.3653
430 1LOB MMA 17.3653
431 3KIH GDL 17.5258
432 3FKQ ATP 17.9641
433 1KJ8 GAR 17.9641
434 3ZIA ADP 18.0328
435 3ZIA ATP 18.0328
436 5TWJ SAM 18.5185
437 5CK5 GDP 18.5629
438 4HSE ADP 18.5629
439 3TY3 GGG 18.5629
440 1GXU 2HP 18.6813
441 4Y4V DAL 19.1617
442 4P4T GDP 19.1617
443 1TL2 NDG 19.1617
444 2W83 GTP 19.4805
445 4PPF FLC 19.7605
446 4HI0 GDP 19.7605
447 5L3V GDP 19.7605
448 5L3S GNP 19.7605
449 2ZR9 DTP 19.7605
450 1IHU AF3 19.7605
451 1IHU ADP 19.7605
452 1H65 GDP 20.3593
453 6AIC AMP 20.3593
454 5ODQ 9SB 20.3593
455 4BQS K2Q 20.4545
456 4BQS ADP 20.4545
457 4LPS GDP 20.9581
458 1HBK COA 21.3483
459 1UJ2 C5P 21.5569
460 2D7D ADP 22.5
461 5BN3 ADP 22.7545
462 1CR1 TTP 22.7545
463 2FH5 GTP 23.3533
464 3DEF GDP 23.3533
465 3A4M ADP 23.3533
466 1XMV ADP 23.3533
467 5WRI A3P 24.5509
468 3W5J GDP 25.1497
469 1W0J ADP 25.1497
470 2CK3 ANP 25.1497
471 1W0J ADP BEF 25.1497
472 2CK3 ADP 25.1497
473 2V7Q ADP 25.1497
474 2V7Q ATP 25.1497
475 3DZD ADP 25.7485
476 4TL6 ANP 26.3473
477 4JLS 3ZE 26.3473
478 4KVA GTP 26.9461
479 4TTQ ATP 27.4419
480 4V0K GDP 27.5449
481 1DAR GDP 27.5449
482 4B47 GDP 28.1437
483 3KJI ADP 28.1437
484 4M9Q GNP 28.7425
485 1YRB GDP 29.3413
486 3T12 GDP ALF 29.3413
487 3T1O GDP 29.3413
488 1R4A GNP 29.4118
489 5E50 ALA TYR ASP GLU SEP TPO ASP GLU GLU 29.7297
490 1G7S GDP 29.9401
491 3QF7 ANP 30
492 2PEZ DAT 31.2849
493 2PEZ GGZ 31.2849
494 5YT0 GDP 31.7365
495 5FG3 GDP 31.7365
496 1J2J GTP 31.7365
497 2J59 GTP 31.7365
498 1O3Y GTP 31.7365
499 4DCT GDP 32.3353
500 1ZD9 GDP 32.3353
501 1RE0 GDP 32.3353
502 1S9D GDP 32.3353
503 3AQ4 GDP 32.9341
504 5H7K GDP 32.9341
505 5H7J GCP 32.9341
506 2QN6 GDP 33.3333
507 1YZG GDP 33.5329
508 1NRJ GTP 33.5329
509 1ZJ6 G3D 34.1317
510 4YLG GDP 34.1317
511 5KSP GDP 37.7246
512 5KSZ GCP 37.7246
513 5KDO GDP 39.1892
514 2QTV GNP 39.521
515 2ZEJ GDP 39.521
516 4ZI2 GNP 40.1198
517 4GOJ GNP 40.1198
518 1FZQ GDP 40.1198
519 1M2O GNP 40.7186
520 5DI3 GNP 41.3174
521 1F6B GDP 41.3174
522 3A1S GDP 43.7126
523 1MR3 G3D 44.3114
524 1M7B GTP 45.509
525 1GWN GTP 45.509
526 3M1I GTP 48.503
527 3GJX GTP 48.503
528 3WYF GTP 48.503
529 3GJ4 GDP 48.503
530 3GJ7 GDP 48.503
531 1Z0J GTP 48.503
532 3GJ8 GDP 48.503
533 3WYG GTP 48.503
534 3GJ5 GDP 48.503
535 1D5C GDP 48.7654
536 5DHF GNP 49.1018
537 6CIT GNP 49.1018
538 5UWQ GNP 49.1018
539 5UWJ GNP 49.1018
540 5UWO GNP 49.1018
541 5UWR GNP 49.1018
542 5UWW GNP 49.1018
543 5UWT GNP 49.1018
544 5UWU GNP 49.1018
545 5UWI GNP 49.1018
546 5UWH GNP 49.1018
547 4HAT GNP 49.1018
548 5UWP GNP 49.1018
549 5DI9 GNP 49.1018
550 5UWS GNP 49.1018
551 3GJ3 GDP 49.1018
552 3CH5 GDP 49.1018
553 1WA5 GTP 49.1018
554 5OEC GDP 49.1018
555 1YVD GNP 49.1124
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