Receptor
PDB id Resolution Class Description Source Keywords
5VC5 1.93 Å EC: 2.7.10.2 CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WIT 166285 HOMO SAPIENS KINASE DOMAIN CELL CYCLE WEE1 TRANSFERASE INHIBITOR TRATRANSFERASE INHIBITOR COMPLEX
Ref.: STRUCTURAL BASIS OF WEE KINASES FUNCTIONALITY AND INACTIVATION BY DIVERSE SMALL MOLECULE INHIBITORS. J. MED. CHEM. 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PEG A:605;
Invalid;
none;
submit data
106.12 C4 H10 O3 C(COC...
EDO A:602;
Invalid;
none;
submit data
62.068 C2 H6 O2 C(CO)...
96M A:601;
Valid;
none;
Kd = 11 nM
512.431 C26 H27 Cl2 N5 O2 CCN(C...
CL A:603;
A:604;
Invalid;
Invalid;
none;
none;
submit data
35.453 Cl [Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5VC5 1.93 Å EC: 2.7.10.2 CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WIT 166285 HOMO SAPIENS KINASE DOMAIN CELL CYCLE WEE1 TRANSFERASE INHIBITOR TRATRANSFERASE INHIBITOR COMPLEX
Ref.: STRUCTURAL BASIS OF WEE KINASES FUNCTIONALITY AND INACTIVATION BY DIVERSE SMALL MOLECULE INHIBITORS. J. MED. CHEM. 2017
Members (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 35 families.
1 5VC3 Kd = 77.5 nM DB8 C26 H29 Cl2 N5 O3 CN1CCN(CC1....
2 3BI6 ic50 = 15 nM 396 C28 H25 Cl N4 O4 Cn1c2cc(c3....
3 5VD2 - 34W C23 H25 F3 N6 O2 CC(=O)NCC(....
4 1X8B ic50 = 97 nM 824 C20 H12 N2 O3 c1ccc(cc1)....
5 5VC5 Kd = 11 nM 96M C26 H27 Cl2 N5 O2 CCN(CC)CCO....
6 5VC6 Kd = 13.6 nM P48 C25 H32 N8 O CC1(Cc2cnc....
7 5VC4 Kd = 43.7 nM XZN C26 H29 Cl2 N5 O3 CN1CCN(CC1....
8 5V5Y Kd = 13.4 nM 8X7 C27 H32 N8 O2 CC(C)(c1cc....
9 3BIZ ic50 = 58 nM 61E C26 H24 Cl N3 O4 Cn1c2cc(c3....
10 2IN6 ic50 = 0.023 uM 839 C23 H16 N2 O5 c1ccc(cc1)....
11 2IO6 ic50 = 0.03 uM 330 C24 H20 N2 O5 COc1ccccc1....
70% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 5VC3 Kd = 77.5 nM DB8 C26 H29 Cl2 N5 O3 CN1CCN(CC1....
2 3BI6 ic50 = 15 nM 396 C28 H25 Cl N4 O4 Cn1c2cc(c3....
3 5VD2 - 34W C23 H25 F3 N6 O2 CC(=O)NCC(....
4 1X8B ic50 = 97 nM 824 C20 H12 N2 O3 c1ccc(cc1)....
5 5VC5 Kd = 11 nM 96M C26 H27 Cl2 N5 O2 CCN(CC)CCO....
6 5VC6 Kd = 13.6 nM P48 C25 H32 N8 O CC1(Cc2cnc....
7 5VC4 Kd = 43.7 nM XZN C26 H29 Cl2 N5 O3 CN1CCN(CC1....
8 5V5Y Kd = 13.4 nM 8X7 C27 H32 N8 O2 CC(C)(c1cc....
9 3BIZ ic50 = 58 nM 61E C26 H24 Cl N3 O4 Cn1c2cc(c3....
10 2IN6 ic50 = 0.023 uM 839 C23 H16 N2 O5 c1ccc(cc1)....
11 2IO6 ic50 = 0.03 uM 330 C24 H20 N2 O5 COc1ccccc1....
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 5VC3 Kd = 77.5 nM DB8 C26 H29 Cl2 N5 O3 CN1CCN(CC1....
2 3BI6 ic50 = 15 nM 396 C28 H25 Cl N4 O4 Cn1c2cc(c3....
3 5VD2 - 34W C23 H25 F3 N6 O2 CC(=O)NCC(....
4 1X8B ic50 = 97 nM 824 C20 H12 N2 O3 c1ccc(cc1)....
5 5VC5 Kd = 11 nM 96M C26 H27 Cl2 N5 O2 CCN(CC)CCO....
6 5VC6 Kd = 13.6 nM P48 C25 H32 N8 O CC1(Cc2cnc....
7 5VC4 Kd = 43.7 nM XZN C26 H29 Cl2 N5 O3 CN1CCN(CC1....
8 5V5Y Kd = 13.4 nM 8X7 C27 H32 N8 O2 CC(C)(c1cc....
9 3BIZ ic50 = 58 nM 61E C26 H24 Cl N3 O4 Cn1c2cc(c3....
10 2IN6 ic50 = 0.023 uM 839 C23 H16 N2 O5 c1ccc(cc1)....
11 2IO6 ic50 = 0.03 uM 330 C24 H20 N2 O5 COc1ccccc1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 96M; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 96M 1 1
2 JIN 0.59375 0.732394
3 04K 0.582524 0.917808
4 P16 0.571429 0.756757
5 P17 0.555556 0.702703
6 LHL 0.548077 0.929577
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5VC5; Ligand: 96M; Similar sites found: 446
This union binding pocket(no: 1) in the query (biounit: 5vc5.bio1) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4WVW SLT 0.002096 0.46647 None
2 2BOS GLA GAL GLC 0.01134 0.40881 None
3 2BOS GLA GAL 0.01336 0.40154 None
4 1Y7P RIP 0.008773 0.43513 1.34529
5 2VQD AP2 0.0008231 0.44906 1.38408
6 4AVB CMP 0.004341 0.43674 1.38408
7 5I35 ANP 0.000002322 0.58063 1.7301
8 4DFU QUE 0.001671 0.473 1.7301
9 4D52 GIV 0.00443 0.4576 1.7301
10 5C4L 4XR 0.001524 0.4217 1.7301
11 2Z49 AMG 0.02079 0.4178 1.7301
12 2Z48 NGA 0.02825 0.40945 1.7301
13 5C4L SIS 0.00311 0.40943 1.7301
14 4D52 GXL 0.03155 0.40455 1.7301
15 4RYV ZEA 0.01826 0.41003 1.93548
16 4Y24 TD2 0.00184 0.45987 1.94805
17 3SHR CMP 0.002003 0.45803 2.07612
18 1CKM GTP 0.009873 0.4278 2.07612
19 3K6V CIT 0.01874 0.41421 2.07612
20 2WBV SIA 0.02218 0.41808 2.1164
21 2HK9 SKM 0.03887 0.4027 2.18182
22 3OYW TDG 0.001656 0.47321 2.23881
23 4R78 AMP 0.0001315 0.5237 2.42215
24 4I94 ANP 0.0000003365 0.49922 2.42215
25 4OUJ LBT 0.002804 0.45901 2.42215
26 3JU6 ANP 0.01279 0.42655 2.42215
27 3T1A 5MA 0.004988 0.41827 2.42215
28 3B6R ADP 0.01569 0.40237 2.42215
29 2W58 ADP 0.02957 0.40664 2.47525
30 1TQP ATP 0.0002889 0.45646 2.48227
31 1W2D ADP 0.00314 0.44829 2.64151
32 5V3D FCN 0.01232 0.42864 2.75862
33 5GZ9 ANP 0.0000002377 0.54005 2.76817
34 4RDL FUC GAL NDG FUC 0.0003308 0.51269 2.76817
35 2PYW ADP 0.00009336 0.49034 2.76817
36 4U98 ACP 0.001431 0.45087 2.76817
37 5T96 79J 0.006179 0.44372 2.76817
38 1F52 ADP 0.01019 0.41865 2.76817
39 2Z5Y HRM 0.03372 0.40028 2.76817
40 4O8A 2OP 0.0291 0.40009 2.76817
41 4OFG PCG 0.001727 0.45625 2.77778
42 3VPC ADP 0.001147 0.43895 2.83688
43 2B6N ALA PRO THR 0.0287 0.40537 2.8777
44 4LRJ ANP 0.00004672 0.52 2.95858
45 3T4L ZEA 0.00009459 0.50028 2.96296
46 3NZ1 3NY 0.001843 0.47018 3.06513
47 3KYG 5GP 5GP 0.008388 0.40817 3.0837
48 3H9R TAK 0.00000004863 0.69901 3.11419
49 3VOT ADP 0.0001365 0.51618 3.11419
50 3WV6 GAL GLC 0.0007922 0.47813 3.11419
51 5DZT AMP 0.003285 0.45749 3.11419
52 3WV6 GAL BGC 0.003615 0.43697 3.11419
53 5DXT 5H5 0.003489 0.4252 3.11419
54 1NY5 ADP 0.005336 0.42051 3.11419
55 5E58 CPZ 0.01645 0.41045 3.11419
56 1SQ5 PAU 0.02614 0.41012 3.11419
57 5L9B AKG 0.02148 0.41043 3.1746
58 5L9V OGA 0.02496 0.40319 3.1746
59 4XMF HSM 0.006991 0.42239 3.26087
60 4LO2 GAL BGC 0.007341 0.42446 3.40136
61 3W0O ADP 0.000884 0.41638 3.4384
62 3W0O HY0 0.000884 0.41638 3.4384
63 1QY1 PRZ 0.008607 0.4014 3.44828
64 2PUL ACP 0.00005555 0.51651 3.46021
65 2CFM AMP 0.0001471 0.51456 3.46021
66 3I0O ADP 0.0002514 0.50296 3.46021
67 2VPN 4CS 0.01933 0.41824 3.46021
68 2VPQ ANP 0.00134 0.40544 3.46021
69 5LUN OGA 0.02344 0.40457 3.46021
70 5TT6 ATP 0.009226 0.40011 3.46021
71 4G9N NGA 0.02247 0.41309 3.4965
72 3AJ6 NGA 0.03867 0.40207 3.4965
73 5A5W GUO 0.007318 0.40487 3.55731
74 3VPB ADP 0.0003879 0.44746 3.57143
75 1H8S AIC 0.0327 0.40097 3.57143
76 4ZGR NGA GAL 0.03182 0.40462 3.64372
77 5IXH OTP 0.005391 0.41232 3.72671
78 3TDV GDP 0.0006517 0.46212 3.80623
79 2YRX AMP 0.009389 0.43685 3.80623
80 1PK8 ATP 0.001226 0.42725 3.80623
81 3LE7 ADE 0.0127 0.42676 3.83142
82 2ZQO NGA 0.03978 0.4017 3.84615
83 2G30 ALA ALA PHE 0.0000435 0.573 3.87597
84 5JSP DQY 0.03757 0.40331 3.9801
85 1UPR 4IP 0.03028 0.40069 4.06504
86 1NC2 DOE 0.01666 0.42088 4.0724
87 5KJW 53C 0.002645 0.46766 4.15225
88 5C1P ADP 0.001064 0.46649 4.15225
89 1I7L ATP 0.001028 0.43374 4.15225
90 4RW3 IPD 0.009674 0.42825 4.15225
91 2YW2 ATP 0.002811 0.42574 4.15225
92 1XL8 152 0.01617 0.42114 4.15225
93 3ZJX BOG 0.02223 0.41632 4.15225
94 2XZ9 PYR 0.03134 0.40633 4.15225
95 4URG C2E 0.01657 0.42285 4.19162
96 5TVM PUT 0.01306 0.42207 4.21053
97 2GQS ADP 0.01703 0.4007 4.21941
98 2OFD NGA 0.02805 0.40419 4.22535
99 2OFE NAG 0.03035 0.40227 4.22535
100 5U98 1KX 0.01894 0.40045 4.33213
101 2D6M LBT 0.005351 0.43618 4.40252
102 4LI4 AMP 0.0007599 0.48478 4.41176
103 4OUC 5ID 0.000002998 0.58282 4.49827
104 5LXC 7AA 0.0000001185 0.5094 4.49827
105 3HQP OXL 0.02566 0.41216 4.49827
106 2AJH MET 0.0214 0.41486 4.59184
107 1J3R 6PG 0.009242 0.42486 4.73684
108 5OO5 UUA 0.01474 0.40363 4.83871
109 4ZS4 ATP 0.00002963 0.51753 4.84429
110 5IQD GNP 0.0004992 0.44789 4.84429
111 5IQD RIO 0.0005368 0.44789 4.84429
112 4OCV ANP 0.001294 0.44442 4.84429
113 5D9G GLU ASN LEU TYR PHE GLN 0.02242 0.40946 4.87805
114 4Z2S NAG 0.02574 0.40688 4.92958
115 4Z2S NDG 0.02574 0.40688 4.92958
116 2AGC DAO 0.01434 0.41946 4.93827
117 2CDO GAL AAL GAL AAL GAL AAL 0.007849 0.43615 5
118 1SU2 ATP 0.01247 0.40367 5.03145
119 3PDT ADP 0.00009099 0.51234 5.09091
120 4GYI ADP 0.000358 0.48951 5.19031
121 3HAV ATP 0.0009499 0.48785 5.19031
122 4CC6 L5Y 0.002788 0.45593 5.19031
123 3UDZ ADP 0.0001563 0.42525 5.19031
124 5NCY 8TK 0.0009769 0.41666 5.19031
125 1T36 ADP 0.002162 0.41131 5.19031
126 3AB4 THR 0.02694 0.40152 5.19031
127 2YMZ LAT 0.00284 0.42133 5.38462
128 2HKA C3S 0.009615 0.40552 5.38462
129 2ZHL NAG GAL GAL NAG 0.002869 0.44551 5.40541
130 4FE2 ADP 0.01064 0.41772 5.4902
131 2GPT SKM 0.03728 0.40191 5.53633
132 5NBW 8SK 0.01475 0.41078 5.60748
133 3FIU AMP 0.02139 0.40657 5.62249
134 2QX0 PH2 0.003143 0.4654 5.66038
135 1JQY A32 0.0161 0.42127 5.82524
136 4O1P ANP 0.00000003151 0.53883 5.88235
137 4ANW O92 0.0000691 0.44961 5.88235
138 4OCJ NDG 0.003897 0.41289 5.88235
139 4LH7 1X8 0.02994 0.40219 5.88235
140 4NOS ITU 0.03188 0.40155 5.88235
141 3B6O TMP 0.03664 0.40231 6.07287
142 4ZU4 4TG 0.006758 0.41237 6.08108
143 5K8S CMP 0.01327 0.40243 6.08108
144 1UYY BGC BGC 0.01576 0.42176 6.10687
145 4AZT LY2 0.0001124 0.52038 6.22837
146 4AZW ATP 0.0006166 0.41026 6.22837
147 2GCG DGY 0.03139 0.4011 6.22837
148 1CBK ROI 0.0284 0.40955 6.25
149 2IF8 ADP 0.001286 0.47897 6.33609
150 4QPW XYP XYP XYP 0.008639 0.42091 6.33803
151 3ZO7 K6H 0.01692 0.41577 6.38298
152 5H9Q TD2 0.0007982 0.48383 6.45161
153 1TZD ADP 0.001118 0.48677 6.54545
154 3ETH ATP 0.0005308 0.41602 6.57439
155 4YEE 4CQ 0.0222 0.41389 6.66667
156 4CYI ATP 0.00003702 0.44794 6.92042
157 3ORQ ADP 0.00146 0.43819 6.92042
158 2VFT SOR 0.008426 0.42687 6.92042
159 1YRO UDP 0.00762 0.43681 7.34266
160 3KMW ATP 0.000001595 0.58822 7.38007
161 3VV1 GAL FUC 0.006773 0.43403 7.5
162 5K2M ADP 0.001064 0.41358 7.54717
163 2YKL NLD 0.01413 0.41169 7.54717
164 1GT4 UNA 0.01163 0.40845 7.54717
165 5FUI APY 0.01072 0.41784 7.57576
166 1XDN ATP 0.01054 0.41409 7.58123
167 3X01 AMP 0.0008865 0.489 7.61246
168 3AKK ADP 0.001273 0.44473 7.61246
169 4FE9 GLC GLC BGC GLC GLC GLC GLC 0.008417 0.41398 7.61246
170 1FLJ GSH 0.01832 0.4154 7.69231
171 1QKQ MAN 0.001563 0.4077 7.74648
172 3PE2 E1B 0.000001796 0.55895 7.95848
173 4IJP 1EH 0.00000009136 0.5434 7.95848
174 3Q60 ATP 0.00005829 0.51554 7.95848
175 2IO8 ADP 0.0001451 0.46878 7.95848
176 3K5I ADP 0.003242 0.42303 7.95848
177 5COU ATP 0.0002507 0.40649 7.95848
178 4MMP SLB 0.01876 0.40209 7.95848
179 5MY8 RXZ 0.000001899 0.54089 8.3045
180 1EHI ADP 0.003282 0.42639 8.3045
181 4X5S AZM 0.02778 0.41176 8.62069
182 4UWH JXM 0.009481 0.41629 8.65052
183 4K55 H6P 0.0001351 0.53706 8.87097
184 5DG2 GAL GLC 0.001188 0.44996 8.88889
185 3TII ANP 0.001992 0.45816 8.99654
186 5KEW 6SB 0.005187 0.45067 9.02778
187 2GC0 PAN 0.001806 0.44197 9.04255
188 2IDO TMP 0.01073 0.4331 9.13978
189 2PNC CLU 0.0274 0.40858 9.34256
190 4B1L FRU 0.02317 0.41107 9.69697
191 5LXT ACP 0.007162 0.40184 9.79021
192 1P0Z FLC 0.03174 0.40774 9.92366
193 4WW7 AMP 0.00002201 0.46616 9.96169
194 4XYM A12 0.0009102 0.45123 10
195 1Q8Y ADP 0.000002753 0.49173 10.0346
196 1Q8Y ADE 0.000002762 0.44051 10.0346
197 1OIJ AKG 0.02504 0.40252 10.0346
198 2TPI ILE VAL 0.008863 0.41045 10.3448
199 1A78 TDG 0.0008487 0.48474 10.4478
200 1ZP9 ATP 0.00005012 0.52465 10.4651
201 1ZTH ADP 0.00001451 0.43222 10.4651
202 1IA9 ANP 0.0001896 0.4816 10.7143
203 5MW8 ATP 0.0003327 0.42865 10.7266
204 1S9D AFB 0.007474 0.42947 10.8374
205 3RE4 TO1 0.0000511 0.53744 10.8527
206 4Q5H ANP 0.0005109 0.46693 10.8974
207 2CBZ ATP 0.005439 0.45366 10.9705
208 4CS9 AMP 0.006347 0.43008 11.1111
209 3V4S ATP 0.00178 0.43077 11.4187
210 1RGE 2GP 0.008434 0.43825 11.4583
211 3A6T 8OG 0.009037 0.41358 11.6279
212 3WVR AMP 0.0005804 0.47406 12.4567
213 1Q8A HCS 0.03586 0.40324 12.4567
214 5M6N 7H9 0.01644 0.42351 13.5593
215 4MTI 2DX 0.03308 0.40794 13.913
216 3PNA CMP 0.001135 0.47588 14.2857
217 4DSU BZI 0.006651 0.43998 14.2857
218 4OAV ACP 0.00000005137 0.65761 15.2249
219 2BKK ADP 0.001881 0.45444 16.6667
220 5CKW ANP 0.00007417 0.52938 17.301
221 3OFM 4B0 0.00000134 0.47138 17.7143
222 2PVN P63 0.00000004068 0.58611 18.4659
223 5FPX GLY SER SER HIS HIS HIS HIS HIS 0.01274 0.40005 18.5841
224 4IDT T28 0.0000000716 0.6509 19.7232
225 4WOE ADP 0.001382 0.48111 19.7232
226 4JR7 GNP 0.0000003385 0.61162 19.7861
227 4G17 0VN 0.00007016 0.4268 20.0692
228 4CLI 5P8 0.0000000003564 0.70918 20.4152
229 1PHK ATP 0.0000008192 0.50401 20.4152
230 4IX4 ADP 0.00008139 0.44175 20.4152
231 1U59 STU 0.000000003675 0.70102 20.5575
232 5T8O 76Z 0.00000006665 0.62775 20.7612
233 4IZY 1J2 0.0000001033 0.61944 20.7612
234 4UX9 ANP 0.0000004741 0.59054 20.7612
235 5DMZ ADP 0.000008923 0.54695 20.7612
236 3UIM ANP 0.00000008271 0.63947 21.1073
237 3CY2 MB9 0.0000003475 0.58303 21.1073
238 4EUU BX7 0.0000001717 0.57706 21.1073
239 5W4W 9WG 0.0000003282 0.53799 21.1073
240 4KBA 1QM 0.000003789 0.51884 21.1073
241 4F9C 0SX 0.000001315 0.47298 21.1073
242 4N70 2HX 0.000002946 0.42926 21.1073
243 2XVD AS6 0.0000000005078 0.65841 21.4533
244 4NFN 2KC 0.0000001881 0.6314 21.4533
245 3GC8 B45 0.0000000723 0.61878 21.4533
246 1OUK 084 0.0000007924 0.61869 21.4533
247 2OO8 RAJ 0.00001735 0.51688 21.4533
248 4LOO SB4 0.0000006469 0.49576 21.4533
249 3M2W L8I 0.0000009492 0.48181 21.4533
250 4BTK DTQ 0.00001799 0.45173 21.4533
251 2CSN CKI 0.001024 0.45347 21.7993
252 2WU6 DKI 0.000000001186 0.68661 22.1453
253 3V8S 0HD 0.0000001825 0.63201 22.1453
254 4P5Z Q7M 0.000000001305 0.56739 22.1453
255 5BYZ 4WE 0.0000004162 0.5327 22.1453
256 1V0O INR 0.00000005156 0.64052 22.2222
257 1JPA ANP 0.0000001431 0.70309 22.4914
258 5EFQ ADP 0.00000002473 0.66334 22.4914
259 5AWM ANP 0.000001176 0.61906 22.4914
260 3TTI KBI 0.00000001889 0.60864 22.4914
261 3PTG 932 0.0000001297 0.47936 22.4914
262 4WHZ 3NL 0.0000001017 0.47016 22.4914
263 2QLU ADE 0.0000008827 0.65257 22.8374
264 4NST ADP 0.00000006885 0.6431 22.8374
265 2B9I ADP 0.0000002455 0.61797 22.8374
266 2B9J ADP 0.0000006926 0.60507 22.8374
267 4L3L 5FI 0.0000003845 0.56205 22.8374
268 2B9H ADP 0.0000001357 0.5318 22.8374
269 2R5T ANP 0.000008288 0.53062 22.8374
270 2B9F ADP 0.0000003805 0.51135 22.8374
271 5LPB ADP 0.000000000542 0.78532 23.1834
272 4OH4 ANP 0.0000000001296 0.76714 23.1834
273 5LPZ ADP 0.0000000005878 0.73725 23.1834
274 2XMY CDK 0.0000000182 0.66434 23.1834
275 4M69 ANP 0.000003208 0.55428 23.1834
276 4BKJ STI 0.00001 0.51171 23.1834
277 3E7O 35F 0.000001783 0.50187 23.1834
278 2BPM 529 0.000000003331 0.49903 23.1834
279 5LMK 6ZK 0.0000003977 0.48601 23.1834
280 3GNI ATP 0.00000002801 0.64419 23.5294
281 4XH0 ADP 0.000005488 0.6071 23.5294
282 3VHE 42Q 0.00000002046 0.58634 23.5294
283 5EKO N17 0.0007565 0.41204 23.5294
284 3DGY 2GP 0.008352 0.43839 23.7113
285 1UNH IXM 0.000000003668 0.73229 23.8754
286 3GC0 AMP 0.00000009375 0.6638 23.8754
287 5X8I SQZ 0.0000001039 0.63497 23.8754
288 4AUA 4AU 0.0000005674 0.60909 23.8754
289 3O0G 3O0 0.00000000472 0.55724 23.8754
290 5MJA 7O3 0.000000009361 0.54191 23.8754
291 1CM8 ANP 0.000004973 0.46417 23.8754
292 4CRL C1I 0.00000262 0.49032 24.1379
293 4H3P ANP 0.000000006849 0.68872 24.2215
294 3PLS ANP 0.00000001152 0.6878 24.2215
295 4NM5 ADP 0.00000003088 0.62718 24.2215
296 5HQ0 LZ9 0.00000007034 0.62673 24.2215
297 5NKB 8ZT 0.00000000008235 0.58053 24.2215
298 3ORK AGS 0.000001045 0.55138 24.2215
299 2JLD AG1 0.00000006565 0.54467 24.2215
300 3F7Z 34O 0.00000005511 0.53424 24.2215
301 5BVE 4VG 0.0000000246 0.4427 24.2215
302 5EOB 5QQ 0.00000002839 0.6444 24.5675
303 4H3Q ANP 0.0000001345 0.54823 24.5675
304 5M06 ADP 0.000003775 0.57806 24.6377
305 4BCM T7Z 0.000000006249 0.75747 24.9135
306 4BCN T9N 0.0000000115 0.70814 24.9135
307 4CFU 2WC 0.000000008078 0.705 24.9135
308 2Y6O 1N1 0.000000001393 0.69221 24.9135
309 3C1X CKK 0.00007613 0.48939 24.9135
310 4BCQ TJF 0.0000004036 0.47947 24.9135
311 5LVP ATP 0.000000552 0.47741 24.9135
312 4QTB 38Z 0.00000003983 0.59847 25.2595
313 4AU8 Z3R 0.000000198 0.65763 25.6055
314 4WNK 453 0.000006131 0.49718 26.6436
315 2YAB AMP 0.000001486 0.57547 27.3356
316 2PZI AXX 0.000018 0.55271 27.6817
317 5UIU 8CG 0.000000006216 0.63264 29.7578
318 4Y0X ADP 0.000002617 0.58562 29.7578
319 4YLL 4E3 0.000003299 0.50316 30.4498
320 1VJY 460 0.0000000005421 0.6252 32.1799
321 2ZV2 609 0.00000008148 0.67684 32.872
322 3HMO STU 0.0000000003865 0.75637 33.0409
323 3LQV ADE 0.01311 0.41373 33.3333
324 2HY0 306 0.0000000009894 0.75998 33.564
325 4KS7 X4Z 0.00000007644 0.61065 33.564
326 3TKI S25 0.00000000642 0.67033 33.91
327 5UR1 YY9 0.000000016 0.63913 34.2561
328 3GQI ACP 0.0000003727 0.60972 34.2561
329 4XV1 904 0.000000006002 0.64039 35.2941
330 5JFS 6K0 0.00000005442 0.61375 35.2941
331 5LI1 ANP 0.000000458 0.58445 35.6401
332 5LI9 ACP 0.000001447 0.57598 35.6401
333 3BU5 ATP 0.000000003723 0.57034 35.6401
334 3E8N ATP 0.000000009347 0.50375 35.6401
335 3E8N VRA 0.000000009347 0.50375 35.6401
336 5DRB 5FJ 0.0000002041 0.46241 35.6401
337 4DC2 ADE 0.0000005468 0.42063 35.6401
338 2YAK OSV 0.0000001398 0.55696 35.7895
339 5H4I 7HQ 0.01214 0.40961 35.8491
340 5N87 N66 0.000000004695 0.56735 36.1022
341 1XJD STU 0.00000007179 0.63412 36.6782
342 3EKK GS2 0.000000001497 0.57528 36.6782
343 4CQE CQE 0.00000004722 0.6267 36.6906
344 5HVJ ANP 0.00000004367 0.72415 37.0242
345 5JGA 6KC 0.000000001295 0.61042 37.0242
346 5CEO 50D 0.000001214 0.48975 37.0242
347 1BYG STU 0.00000001938 0.68693 37.0504
348 4X7Q 3YR 0.0000000854 0.63884 37.3702
349 4YZC STU 0.0000003206 0.57703 37.3702
350 3TXO 07U 0.0000006105 0.49125 37.3702
351 5KO1 6UY 0.00000002733 0.67036 37.4558
352 4YMJ 4EJ 0.000000002274 0.79157 37.7163
353 4FF8 14S 0.0000006001 0.46307 37.7163
354 1K3A ACP 0.00000003586 0.68411 38.0623
355 5JKG 6LF 0.00000003219 0.61935 38.0623
356 4Y85 499 0.0000005976 0.60805 38.4083
357 4ASE AV9 0.0000001053 0.57953 38.4083
358 4AG8 AXI 0.000000005555 0.56164 38.4083
359 4L9I 8PR 0.00004549 0.52055 38.4083
360 4ITH RCM 0.001529 0.43359 38.4083
361 4U44 3D9 0.00000006562 0.53131 38.5542
362 3KRL KRL 0.00000001959 0.64305 38.7543
363 4K33 ACP 0.0000001495 0.52512 38.7543
364 4WB6 ATP 0.000009805 0.4981 38.7543
365 4OTH DRN 0.00000001497 0.64805 39.1003
366 3NW7 LGV 0.0000002487 0.59468 39.1003
367 1RE8 BD2 0.000002108 0.55605 39.1003
368 3IDB ANP 0.000002245 0.54902 39.1003
369 2QCS ANP 0.000009421 0.49818 39.1003
370 3FHI ANP 0.00001171 0.49512 39.1003
371 3PVW QRX 0.00002729 0.48966 39.1003
372 5UKL SIX 0.00003982 0.47899 39.1003
373 3KN5 ANP 0.000002942 0.44813 39.1003
374 4WB7 ATP 0.00002329 0.4479 39.1003
375 2PVF ACP 0.00000004011 0.6626 39.4464
376 5U6C 7YS 0.00000000956 0.65639 39.4464
377 5TA6 79D 0.00000000184 0.64809 39.4464
378 3RI1 3RH 0.0000001365 0.56882 39.4464
379 5HCY 60D 0.000000000887 0.54184 39.4464
380 4U0I 0LI 0.0000002308 0.53841 39.4464
381 4D2S DYK 0.00000001155 0.70805 39.7887
382 2GU8 796 0.0000000166 0.46449 39.7924
383 4C2V YJA 0.000000007204 0.6044 40
384 3MVH WFE 0.0000004522 0.53711 40.1384
385 2X2M X2M 0.0000000003957 0.63155 40.4844
386 5HES 032 0.000000002233 0.60309 40.4844
387 4JDI ANP 0.0000006235 0.58534 40.4844
388 2X4Z X4Z 0.000000009462 0.56585 40.4844
389 3ZRM ZRM 0.0000002774 0.51273 40.625
390 3DAK ANP 0.00000001294 0.69527 40.8304
391 3FHR P4O 0.0000006133 0.59259 40.8304
392 2RIO ADP 0.0000001252 0.51133 40.8304
393 3DLS ADP 0.000006557 0.4588 40.8304
394 4C2W ANP 0.00000001885 0.50305 40.8602
395 2F57 23D 0.000000007926 0.70539 41.1765
396 3C0G 3AM 0.0000000206 0.69583 41.1765
397 4I6H 1C8 0.00000001624 0.67166 41.1765
398 3HZT J60 0.000004467 0.59018 41.1765
399 3IGO ANP 0.0000005045 0.58266 41.1765
400 4FG8 ATP 0.000001731 0.56598 41.1765
401 3AQV TAK 0.000009694 0.45978 41.3043
402 2WEI VGG 0.00000009395 0.65433 41.4634
403 4Y8D 49J 0.00000005561 0.64732 41.5225
404 2VN9 GVD 0.00000001149 0.50229 41.5225
405 2WEL K88 0.00000006724 0.45774 41.5225
406 3PP0 03Q 0.00000008122 0.58998 41.8685
407 4BFM ANP 0.00000004037 0.63726 42.2145
408 5JZJ AN2 0.0000001495 0.63603 42.2145
409 2V7O DRN 0.000000006146 0.51176 42.2145
410 3SLS ANP 0.00000000562 0.66627 42.5606
411 4AT3 LTI 0.00000007705 0.56498 42.5606
412 5DEY 59T 0.0000000009276 0.49601 42.5606
413 3SLS 77D 0.0121 0.40427 42.5606
414 4NW6 2NS 0.0000001204 0.54314 42.9066
415 2JDR L20 0.000001211 0.41035 42.9066
416 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.000001211 0.41035 42.9066
417 2VZ6 FEF 0.0000002142 0.64634 43.2526
418 5DBX ANP 0.000002901 0.44576 43.2526
419 4WNP 3RJ 0.00000000004484 0.82536 43.554
420 4BHN BH9 0.00000001342 0.65815 43.5986
421 5IH9 6BF 0.00000004186 0.61082 43.5986
422 5EYK 5U5 0.000000003473 0.63733 43.8406
423 1U5R ATP 0.00000000477 0.69587 43.9446
424 3ALN ANP 0.00000007751 0.62488 43.9446
425 3SXF BK5 0.0000006609 0.50343 43.9446
426 3E5A VX6 0.000000008085 0.63676 44.0299
427 5L8L ADP 0.0000000259 0.70164 44.2105
428 5G1X ADP 0.00000001671 0.68029 44.2105
429 2XK9 XK9 0.000144 0.50286 44.2907
430 5LXM ADP 0.00000001704 0.6799 44.523
431 4YZN 4K5 0.000000001924 0.67779 44.5993
432 5AX9 4KT 0.00000003367 0.65724 44.6367
433 4USF 6UI 0.0000000905 0.56343 44.6367
434 5UOX 8GY 0.000000009051 0.65741 44.6494
435 2WQN ADP 0.00000131 0.60808 44.9827
436 2Z7R STU 0.00000001136 0.65318 45.3287
437 1ZY5 ANP 0.000001073 0.4781 45.3287
438 5A6N U7E 0.0000005941 0.5067 45.583
439 2J7T 274 0.003941 0.43278 46.0208
440 4A4X JUP 0.0000000003107 0.68597 46.595
441 3GGF GVD 0.0000000006596 0.75674 47.0588
442 2A19 ANP 0.000000002348 0.75359 47.8873
443 5DH3 5BS 0.000000003297 0.68477 48.0969
444 4QMN DB8 0.0000000009369 0.59029 48.4429
445 5VCV 1N1 0.000000000008962 0.76579 49.1349
446 4G31 0WH 0.0000006211 0.50816 49.481
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