-->
Receptor
PDB id Resolution Class Description Source Keywords
5V13 1.84 Å NON-ENZYME: BINDING MOSQUITO JUVENILE HORMONE-BINDING PROTEIN AEDES AEGYPTI ODORANT-BINDING PROTEIN AEDES ANOPHELES CULEX D7 HORMONPROTEIN
Ref.: A MOSQUITO HEMOLYMPH ODORANT-BINDING PROTEIN FAMILY SPECIFICALLY BINDS JUVENILE HORMONE. J. BIOL. CHEM. V. 292 15329 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
JH3 B:301;
A:301;
C:301;
Valid;
Valid;
Valid;
none;
none;
none;
Kd = 23.3 nM
266.376 C16 H26 O3 C/C(=...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5V13 1.84 Å NON-ENZYME: BINDING MOSQUITO JUVENILE HORMONE-BINDING PROTEIN AEDES AEGYPTI ODORANT-BINDING PROTEIN AEDES ANOPHELES CULEX D7 HORMONPROTEIN
Ref.: A MOSQUITO HEMOLYMPH ODORANT-BINDING PROTEIN FAMILY SPECIFICALLY BINDS JUVENILE HORMONE. J. BIOL. CHEM. V. 292 15329 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 5V13 Kd = 23.3 nM JH3 C16 H26 O3 C/C(=CCC/C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 5V13 Kd = 23.3 nM JH3 C16 H26 O3 C/C(=CCC/C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 5V13 Kd = 23.3 nM JH3 C16 H26 O3 C/C(=CCC/C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: JH3; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 JH3 1 1
2 2TX 0.553571 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5V13; Ligand: JH3; Similar sites found with APoc: 115
This union binding pocket(no: 1) in the query (biounit: 5v13.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 4TV1 36M None
2 2QLX RM4 None
3 4RJD TFP None
4 2UXI G50 None
5 1UO5 PIH None
6 1UO4 PIH None
7 3AQT RCO 1.22449
8 3B9Z CO2 1.38889
9 4POJ 2VP 1.7316
10 4M8E 29V 1.7316
11 2BIF BOG 1.73611
12 1XQP 8HG 1.95312
13 1J78 OLA 2.08333
14 6CGN DA 2.08333
15 5CX6 CDP 2.08333
16 5M37 9SZ 2.17391
17 3KMZ EQO 2.25564
18 3HP9 CF1 2.28216
19 1R6N 434 2.36967
20 1ZED PNP 2.43056
21 2E9L OLA 2.43056
22 4LH7 NMN 2.43056
23 1DKF BMS 2.55319
24 5DLY 5D7 2.63158
25 3OID TCL 2.71318
26 3O01 DXC 2.77778
27 3G58 988 2.77778
28 2WH8 II2 2.77778
29 5H06 MAL 2.77778
30 4PGK Y69 2.86885
31 6GMN F4E 3.08642
32 2Q8G AZX 3.125
33 3ZQE DXC 3.125
34 2Z9I GLY ALA THR VAL 3.125
35 5KD8 TNR 3.125
36 3BPX SAL 3.37838
37 5AZC PGT 3.47222
38 4ARE FLC 3.47222
39 3UG4 AHR 3.47222
40 2PNC CLU 3.47222
41 2XXP DSL 3.47222
42 6MVU K4V 3.47222
43 5E70 RCD 3.47222
44 5Y02 HBX 3.73832
45 5Y02 MXN 3.73832
46 5OLK DTP 3.81944
47 1YKD CMP 3.81944
48 3PE2 E1B 3.81944
49 4DJA FAD 3.81944
50 4DJA DLZ 3.81944
51 5LX9 OLB 3.81944
52 5ZIC BMA Z4Y NAG 3.81944
53 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 3.91304
54 3KP6 SAL 3.97351
55 4ZGM 32M 4.09836
56 1XMY ROL 4.16667
57 1GNI OLA 4.16667
58 1XM4 PIL 4.16667
59 2Q0D ATP 4.51389
60 5U97 PIT 4.51389
61 4LHD GLY 4.51389
62 3LN0 52B 4.51389
63 4GNC ASO 4.51389
64 5C1M OLC 4.8
65 4MRP GSH 4.86111
66 1ZPD CIT 5.20833
67 4MGA 27L 5.4902
68 6CB2 OLC 5.55556
69 3RMK BML 5.55556
70 4I90 CHT 5.55556
71 3RV5 DXC 5.61798
72 2BCG GER 5.82524
73 5IM3 DTP 5.90278
74 5A8E XTK 5.90278
75 5C9J DAO 6.06061
76 1MT1 AG2 6.19469
77 2QEH SRO 6.2069
78 4WH9 3M8 6.55738
79 2E2R 2OH 6.55738
80 4K10 NI9 6.59722
81 5LWY OLB 6.72269
82 3TL1 JRO 6.91824
83 3KO0 TFP 6.93069
84 2UW1 GVM 7.63889
85 2WOR 2AN 8
86 5W7B MYR 8.51064
87 5KOD IAC 8.68056
88 1T0S BML 9.30233
89 4V1F BQ1 9.30233
90 2YPO PHE 9.375
91 3WQM B29 9.375
92 1RVX NAG 9.375
93 3TDC 0EU 9.72222
94 5M36 9SZ 10.5263
95 4R29 SAM 10.7143
96 5UGW GSH 10.8571
97 4O4Z N2O 11.039
98 3F8C HT1 11.1111
99 1NU4 MLA 11.3402
100 5V4R MGT 11.7284
101 2VWA PTY 11.8812
102 4WGF HX2 12.1951
103 3N7S 3N7 13.0435
104 5TVI MYR 14.1304
105 5MWE TCE 14.8148
106 4OGQ 7PH 21.6216
107 4OGQ 2WD 21.6216
108 5Z84 CHD 23.2143
109 5ZCO CHD 23.2143
110 5W97 CHD 23.2143
111 5NNT DPV 24.3243
112 5XNA SHV 28.2609
113 2Y69 CHD 32.8571
114 3NHT U46 35.0694
115 3DZT EAH 37.5
Pocket No.: 2; Query (leader) PDB : 5V13; Ligand: JH3; Similar sites found with APoc: 11
This union binding pocket(no: 2) in the query (biounit: 5v13.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 3G4G D71 2.77778
2 2VAR AMP 3.47222
3 1XMU ROF 4.16667
4 1SQL GUN 4.79452
5 5C1M CLR 4.8
6 1P0H ACO 4.86111
7 2AK3 AMP 4.86726
8 3MBG FAD 5.03597
9 2Y0I AKG 5.55556
10 2ET1 GLV 6.46766
11 2X5W K2B 7.29167
Pocket No.: 3; Query (leader) PDB : 5V13; Ligand: JH3; Similar sites found with APoc: 7
This union binding pocket(no: 3) in the query (biounit: 5v13.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 5CX8 RP3 2.08333
2 3R9V DXC 4.1958
3 4F06 PHB 4.51389
4 4UBS DIF 7.63889
5 5EW9 5VC 8.11808
6 4MPO AMP 12.4183
7 3O5N BR0 14.2857
APoc FAQ
Feedback