Receptor
PDB id Resolution Class Description Source Keywords
5URY 2.1 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF FRIZZLED 5 CRD IN COMPLEX WITH PAM HOMO SAPIENS FRIZZLED 5 CRD SIGNALING PROTEIN
Ref.: UNSATURATED FATTY ACYL RECOGNITION BY FRIZZLED RECE MEDIATES DIMERIZATION UPON WNT LIGAND BINDING. PROC. NATL. ACAD. SCI. V. 114 4147 2017 U.S.A.
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NAG FUC FUC FUC A:201;
Invalid;
none;
submit data
n/a n/a
PAM B:201;
A:205;
Valid;
Valid;
none;
none;
submit data
254.408 C16 H30 O2 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5URY 2.1 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF FRIZZLED 5 CRD IN COMPLEX WITH PAM HOMO SAPIENS FRIZZLED 5 CRD SIGNALING PROTEIN
Ref.: UNSATURATED FATTY ACYL RECOGNITION BY FRIZZLED RECE MEDIATES DIMERIZATION UPON WNT LIGAND BINDING. PROC. NATL. ACAD. SCI. V. 114 4147 2017 U.S.A.
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1579 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1312 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1130 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
3 5URV - NER C24 H46 O2 CCCCCCCCC=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PAM; Similar ligands found: 54
No: Ligand ECFP6 Tc MDL keys Tc
1 PAM 1 1
2 VCA 1 1
3 NER 0.939394 1
4 ELA 0.939394 1
5 OLA 0.939394 1
6 MYZ 0.852941 0.954545
7 EIC 0.725 0.956522
8 ODD 0.675 0.956522
9 PLM 0.666667 0.954545
10 TDA 0.666667 0.954545
11 DCR 0.666667 0.954545
12 X90 0.666667 0.954545
13 11A 0.666667 0.954545
14 MYR 0.666667 0.954545
15 KNA 0.666667 0.954545
16 DAO 0.666667 0.954545
17 DKA 0.666667 0.954545
18 STE 0.666667 0.954545
19 EW8 0.666667 0.954545
20 F15 0.666667 0.954545
21 F23 0.666667 0.954545
22 OCA 0.636364 0.954545
23 RCL 0.625 0.88
24 LNL 0.613636 0.869565
25 SHV 0.606061 0.909091
26 KTC 0.564103 0.84
27 ODT 0.555556 0.826087
28 T25 0.54717 0.709677
29 AZ1 0.53125 0.615385
30 10X 0.529412 0.645161
31 10Y 0.529412 0.645161
32 6NA 0.529412 0.863636
33 3X1 0.525 0.863636
34 MVC 0.519231 0.617647
35 243 0.519231 0.846154
36 VA 0.511111 0.692308
37 OLB 0.490566 0.617647
38 OLC 0.490566 0.617647
39 ACD 0.488889 0.956522
40 EOD 0.468085 0.677419
41 78M 0.444444 0.617647
42 78N 0.444444 0.617647
43 3LA 0.44186 0.769231
44 LEA 0.441176 0.772727
45 T24 0.438596 0.769231
46 BRC 0.435897 0.64
47 M12 0.428571 0.833333
48 MPG 0.425926 0.617647
49 9OD 0.422222 0.72
50 14V 0.413043 0.714286
51 BMJ 0.4 0.913043
52 14U 0.4 0.678571
53 D0G 0.4 0.913043
54 BNV 0.4 0.913043
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5URY; Ligand: PAM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5ury.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5URY; Ligand: PAM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5ury.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback