Receptor
PDB id Resolution Class Description Source Keywords
5UKL 2.15 Å EC: 2.7.11.15 HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG222886 HOMO SAPIENS KINASE INHIBITOR COMPLEX TRANSFERASE-TRANSFERASE INHIBITOR
Ref.: STRUCTURE-BASED DESIGN OF HIGHLY SELECTIVE AND POTE PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS BASED PAROXETINE. J. MED. CHEM. V. 60 3052 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:701;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
SIX A:702;
Valid;
none;
ic50 = 0.63 uM
480.531 C26 H29 F N4 O4 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5UKL 2.15 Å EC: 2.7.11.15 HUMAN GRK2 IN COMPLEX WITH GBETAGAMMA SUBUNITS AND CCG222886 HOMO SAPIENS KINASE INHIBITOR COMPLEX TRANSFERASE-TRANSFERASE INHIBITOR
Ref.: STRUCTURE-BASED DESIGN OF HIGHLY SELECTIVE AND POTE PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS BASED PAROXETINE. J. MED. CHEM. V. 60 3052 2017
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 4MK0 ic50 = 3.2 uM 29X C20 H19 F N2 O2 c1cc(ccc1[....
2 5UKL ic50 = 0.63 uM SIX C26 H29 F N4 O4 c1cc(c(cc1....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3PVW ic50 = 54 nM QRX C24 H23 F2 N7 O CCCn1c(nnc....
2 3PVU ic50 = 290 nM QRW C24 H21 F3 N6 O Cn1c(nnc1c....
3 3V5W ic50 = 3.16 uM 8PR C19 H20 F N O3 c1cc(ccc1[....
4 4MK0 ic50 = 3.2 uM 29X C20 H19 F N2 O2 c1cc(ccc1[....
5 5UKL ic50 = 0.63 uM SIX C26 H29 F N4 O4 c1cc(c(cc1....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3PVW ic50 = 54 nM QRX C24 H23 F2 N7 O CCCn1c(nnc....
2 3PVU ic50 = 290 nM QRW C24 H21 F3 N6 O Cn1c(nnc1c....
3 3V5W ic50 = 3.16 uM 8PR C19 H20 F N O3 c1cc(ccc1[....
4 4MK0 ic50 = 3.2 uM 29X C20 H19 F N2 O2 c1cc(ccc1[....
5 5UKL ic50 = 0.63 uM SIX C26 H29 F N4 O4 c1cc(c(cc1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SIX; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 SIX 1 1
2 8PR 0.528302 0.764706
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5UKL; Ligand: SIX; Similar sites found: 449
This union binding pocket(no: 1) in the query (biounit: 5ukl.bio1) has 28 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2IO8 ADP 0.00449 0.40734 2.0649
2 4OUC 5ID 0.00001449 0.55029 2.2409
3 4FMS BDP 0.02299 0.41448 2.77078
4 1F8I SIN 0.02485 0.41128 2.94985
5 1UJP CIT 0.004788 0.42266 2.95203
6 3ZGJ RMN 0.02414 0.40781 2.96496
7 5MW8 ATP 0.00002268 0.50684 3.18471
8 4WOE ADP 0.02488 0.41323 3.22581
9 2IF8 ADP 0.003776 0.45442 3.53982
10 3QPB URA 0.005071 0.44847 3.5461
11 3VPC ADP 0.001131 0.4392 3.5461
12 1I7L ATP 0.003104 0.41395 3.55987
13 1SDW IYT 0.0167 0.40814 3.82166
14 2QES ADE 0.02679 0.41721 3.83142
15 1HXD BTN 0.001898 0.43321 4.04984
16 4OCV ANP 0.0002895 0.47341 4.12979
17 1U1J MET 0.01744 0.409 4.12979
18 3BP1 GUN 0.003604 0.46038 4.13793
19 1VKF CIT 0.01426 0.42555 4.25532
20 5GZ9 ANP 0.000002016 0.55098 4.2623
21 3TII ANP 0.02096 0.40701 4.42478
22 4OYA 1VE 0.00276 0.4395 4.46809
23 3MBI HSX 0.0222 0.40969 4.52962
24 2CYC TYR 0.02496 0.41162 4.53333
25 5C1P ADP 0.01158 0.41593 4.57516
26 3AKK ADP 0.0002429 0.47681 4.61538
27 3HQP OXL 0.03844 0.4 4.71976
28 4WCX MET 0.005158 0.43749 4.79167
29 2GQS C2R 0.0006122 0.47296 4.83871
30 2GQS ADP 0.000647 0.46692 4.83871
31 2GQR ADP 0.0008822 0.46065 4.83871
32 3REU ATP 0.002476 0.43572 4.83871
33 2YRX AMP 0.01878 0.41793 4.83871
34 1C1X HFA 0.01282 0.41376 4.83871
35 3S6X SIA GAL BGC 0.02768 0.41032 4.83871
36 3KYG 5GP 5GP 0.005961 0.41481 4.84582
37 1TQP ATP 0.00004236 0.49081 4.96454
38 4ZBY URA 0.0398 0.40499 5.01475
39 5W2I I3P 0.003821 0.41023 5.05837
40 5W2I ADP 0.003821 0.41023 5.05837
41 1OFL NGK GCD 0.001734 0.47056 5.1975
42 3WVR AMP 0.001556 0.45369 5.36913
43 3CM2 X23 0.03506 0.40229 5.38462
44 2UYP PPI 0.006144 0.43773 5.42636
45 3L8G GMB 0.0101 0.43196 5.60472
46 4OUJ LBT 0.02797 0.41145 5.86319
47 3D1R FBP 0.01732 0.40736 5.93472
48 2PHU MAN MAN 0.0283 0.4086 5.95238
49 2PHT MAN MAN MAN 0.0301 0.40758 5.95238
50 1Q8O MAN MMA 0.03269 0.40599 5.95238
51 4P83 U5P 0.02771 0.4009 6.04396
52 4LO2 GAL BGC 0.01484 0.43593 6.12245
53 2Z49 AMG 0.004612 0.45457 6.19469
54 3TDV GDP 0.000003665 0.56453 6.45161
55 2PYW ADP 0.00006598 0.49693 6.45161
56 3SZB I1E 0.008737 0.43763 6.45161
57 3DSK T25 0.009259 0.42482 6.45161
58 2ZL7 FUC GAL NGA 0.01934 0.42254 6.45161
59 1F52 ADP 0.0147 0.41086 6.45161
60 2GK6 ADP 0.03341 0.40626 6.45161
61 4YJK URA 0.00846 0.43119 6.48968
62 3VOT ADP 0.01696 0.41164 6.48968
63 1T36 ADP 0.003446 0.4034 6.48968
64 4FE2 AIR 0.001339 0.46676 6.66667
65 4FE2 ADP 0.002791 0.44609 6.66667
66 4NS0 PIO 0.004024 0.44841 6.76692
67 5XLY C2E 0.004017 0.42614 6.76692
68 1RZ1 NAD 0.02627 0.40916 6.8323
69 3TL1 JRO 0.03877 0.401 6.91824
70 4JNJ BTN 0.01331 0.40924 6.95652
71 4GGZ BTN 0.01611 0.40891 6.95652
72 3X01 AMP 0.002022 0.47117 7.12468
73 5USZ SKE 0.0001437 0.45725 7.26644
74 1CKM GTP 0.03007 0.40287 7.27273
75 2R5V HHH 0.02399 0.4004 7.28291
76 4D4U FUC GAL NAG 0.00327 0.46104 7.30159
77 4D52 GXL 0.01247 0.43429 7.30159
78 4D4U FUC NDG GAL FUC 0.00999 0.43229 7.30159
79 4D52 GIV 0.02962 0.40176 7.30159
80 3SAO DBH 0.003143 0.46106 7.5
81 3Q60 ATP 0.00002207 0.53515 7.54717
82 4B1L FRU 0.02513 0.40417 7.87879
83 5XQL C2E 0.03988 0.4051 7.90378
84 4OAV ACP 0.00001635 0.54121 8.06452
85 3UDZ ADP 0.000009666 0.53922 8.06452
86 5KJW 53C 0.0001316 0.53828 8.06452
87 3PDT ADP 0.00003328 0.53311 8.06452
88 1IA9 ANP 0.00007464 0.49965 8.06452
89 3PGU OLA 0.007713 0.42879 8.06452
90 3ACL 3F1 0.009426 0.41272 8.06452
91 4UWH JXM 0.01236 0.41078 8.06452
92 5J75 6GQ 0.01256 0.41045 8.06452
93 4NOS H4B 0.03214 0.40656 8.06452
94 1EI6 PPF 0.01933 0.40461 8.06452
95 3JQQ A2P 0.02735 0.40118 8.06452
96 4LRJ ANP 0.00000000887 0.69308 8.28402
97 2YW2 ATP 0.009287 0.40302 8.55457
98 1W1A NDG 0.03888 0.40394 8.56031
99 3CBC DBS 0.003127 0.46242 8.58586
100 4MUQ LY0 0.02727 0.40125 8.62745
101 5KBE IPH 0.02699 0.40939 8.73362
102 5T96 79J 0.03409 0.40241 8.77193
103 2YKL NLD 0.009624 0.41986 8.7963
104 2QX0 PH2 0.02344 0.41764 8.80503
105 5J8O 6GZ 0.006771 0.41943 8.87097
106 3OV6 MK0 0.003104 0.40946 9.14454
107 2IVD ACJ 0.01581 0.40931 9.14454
108 4JLS 3ZE 0.02491 0.412 9.21053
109 5LUN OGA 0.009102 0.42519 9.375
110 5DYO FLU 0.0006089 0.49916 9.43396
111 2AZ5 307 0.008844 0.41049 9.45946
112 2XG5 EC2 0.00263 0.45032 9.63303
113 2XG5 EC5 0.00263 0.45032 9.63303
114 5HV7 RBL 0.000005204 0.62412 9.67742
115 1ZP9 ATP 0.000002283 0.58844 9.67742
116 1ZTH ADP 0.000009005 0.57501 9.67742
117 4WW7 AMP 0.0000346 0.50405 9.67742
118 3I0O ADP 0.0003384 0.49653 9.67742
119 5MRH Q9Z 0.0009271 0.48037 9.67742
120 2QHV OC9 0.002863 0.45534 9.67742
121 3RE4 TO1 0.003132 0.44835 9.67742
122 3NZ1 3NY 0.008101 0.44506 9.67742
123 2QHS OCA 0.003902 0.44358 9.67742
124 4MTI 2DX 0.01833 0.41982 9.67742
125 5JLB SAH 0.007442 0.41752 9.67742
126 2VPQ ANP 0.003377 0.41558 9.67742
127 3WCZ CIT 0.01454 0.41464 9.67742
128 4P25 FUC GAL NAG FUC 0.01944 0.41266 9.67742
129 1IHU AF3 0.006376 0.407 9.67742
130 1J78 OLA 0.04855 0.4061 9.67742
131 4I9B NAD 0.006726 0.40916 9.73451
132 4ZS4 ATP 0.000005616 0.54973 9.77199
133 4RT1 C2E 0.001435 0.45082 9.82143
134 5FUI APY 0.02739 0.40569 9.84848
135 2CJU PHX 0.02536 0.41549 9.91736
136 5HWV MBN 0.003042 0.45935 10
137 2QIE 8CS 0.01328 0.40576 10.3896
138 3WG3 A2G GAL NAG FUC 0.02099 0.41095 10.6742
139 2GOO NDG 0.02282 0.40266 10.7843
140 2H8H H8H 0.00001311 0.53934 10.9145
141 1Y57 MPZ 0.00002169 0.50765 11.0619
142 4DYG MES 0.02307 0.40062 11.0656
143 2CYB TYR 0.03104 0.40268 11.1455
144 3RF4 FUN 0.007488 0.43879 11.2069
145 5X7Q GLC GLC GLC GLC GLC 0.02296 0.40691 11.2094
146 3VRY B43 0.0002203 0.4574 11.2335
147 2R09 4IP 0.01531 0.42243 11.2392
148 2R0D 4IP 0.02191 0.40998 11.2392
149 1CBK ROI 0.03351 0.40566 11.25
150 4AZW ATP 0.0002792 0.46957 11.2903
151 5VZ0 ADP 0.001262 0.45342 11.2903
152 1OFZ FUC 0.01741 0.4213 11.2903
153 4NZF ARB 0.01751 0.41934 11.2903
154 3TPV ADE 0.004896 0.41863 11.2903
155 4AZT LY2 0.013 0.41743 11.2903
156 3DNT ATP 0.004074 0.40908 11.2903
157 3AVS OGA 0.02298 0.40891 11.2903
158 3ICT ADP 0.01772 0.40687 11.2903
159 3ICS ADP 0.0202 0.40408 11.2903
160 3BJE URA 0.01279 0.42555 11.4613
161 5MY8 RXZ 0.00001723 0.50216 11.4883
162 2WZ5 MET 0.001316 0.486 11.7647
163 2POC UD1 0.02919 0.40354 11.7994
164 3QXV MTX 0.01613 0.40525 11.9048
165 3EFS BTN 0.001374 0.44326 12.0172
166 4RYV ZEA 0.02301 0.40497 12.2581
167 4Q5H ANP 0.000001384 0.58379 12.9032
168 4U98 ACP 0.0006035 0.46832 12.9032
169 1W2D ADP 0.002172 0.45627 12.9032
170 5M6N 7H9 0.02371 0.41368 12.9032
171 4ISS TAR 0.03133 0.40594 12.9032
172 3A23 GAL 0.0341 0.40398 12.9032
173 5C9J STE 0.008303 0.40515 13.1313
174 4NDN PPK 0.03778 0.4016 13.2743
175 3RGA LSB 0.01726 0.40042 13.4276
176 2PZI AXX 0.0003869 0.48787 13.5095
177 2AQX ATP 0.001875 0.4298 13.8408
178 4CYI ATP 0.0001967 0.47621 13.9269
179 3VPB ADP 0.0003085 0.45149 14.2857
180 2QLU ADE 0.0000254 0.56953 14.3312
181 1OBD ATP 0.0007214 0.4747 14.5161
182 3BEO UDP 0.006026 0.4218 14.5161
183 1VBO MAN 0.01537 0.41963 14.5161
184 1F6D UDP 0.02036 0.40764 14.5161
185 5ENZ UDP 0.01071 0.40669 14.5161
186 1YFS ALA 0.02028 0.40436 14.5161
187 2G30 ALA ALA PHE 0.002764 0.40336 14.5161
188 1FWV SGA MAG FUC 0.01081 0.43284 14.9254
189 4IJP 1EH 0.000004421 0.48714 15.0838
190 4R78 AMP 0.001299 0.47289 15.3392
191 4Y93 746 0.000006101 0.52039 15.4709
192 3P9T TCL 0.01449 0.41507 15.5251
193 2PVF ACP 0.00000002286 0.67396 15.5689
194 4O1P ANP 0.00000385 0.56356 16.129
195 5I35 ANP 0.00001122 0.54882 16.129
196 5FYR INS 0.004854 0.44541 16.129
197 4IX4 ADP 0.0001438 0.43243 16.129
198 2VQD AP2 0.003958 0.41924 16.129
199 5JDA AMP 0.02107 0.40781 16.129
200 5CIC 51R 0.02404 0.41067 16.6667
201 2W5P CL8 0.03093 0.40665 16.7785
202 3RI1 3RH 0.0000002303 0.572 17.2524
203 4LOC OXM 0.001694 0.46607 17.7419
204 5DZT AMP 0.01265 0.42729 17.7419
205 2R3A SAM 0.004051 0.42598 17.7419
206 1PK8 ATP 0.002155 0.41733 17.7419
207 4NAE 1GP 0.02879 0.40871 17.7419
208 5IFK HPA 0.03508 0.40379 17.7419
209 3ZCN ATP 0.008198 0.40231 17.7419
210 3GQI ACP 0.0000001242 0.63144 17.7914
211 4K33 ACP 0.000000008508 0.6754 17.8462
212 3LQV ADE 0.01755 0.4066 17.9487
213 3VHE 42Q 0.0001668 0.44376 18.1059
214 5C03 AGS 0.001244 0.44933 18.7134
215 2X2M X2M 0.00000176 0.55943 18.7898
216 2F9W PAU 0.0211 0.41082 18.8192
217 2HK5 1BM 0.000015 0.52502 18.8889
218 5UR1 YY9 0.00003032 0.41663 18.9711
219 4H3Q ANP 0.0000001871 0.59433 19.0608
220 5BVE 4VG 0.00000004483 0.4307 19.1136
221 1Q8Y ADP 0.00000002088 0.64976 19.3029
222 1Q8Y ADE 0.000002082 0.61567 19.3029
223 4UX9 ANP 0.000000008788 0.66617 19.3548
224 4IZY 1J2 0.000007282 0.53873 19.3548
225 3PTG 932 0.0001002 0.52973 19.3548
226 1TZD ADP 0.004817 0.44574 19.3548
227 2PNC CLU 0.02932 0.40951 19.3548
228 2G50 PYR 0.02582 0.40727 19.3548
229 2G50 ALA 0.03522 0.40351 19.3548
230 4QTB 38Z 0.0000003342 0.55184 20
231 4WOV 3SM 0.00263 0.44735 20.1893
232 5K2M ADP 0.001679 0.42496 20.7547
233 2NGR AF3 0.03431 0.40383 20.9677
234 3HZT J60 0.00002014 0.5576 20.985
235 4I94 ANP 0.00000687 0.55873 21.3333
236 4YZC STU 0.0000004149 0.49951 21.4815
237 3GNI ATP 0.000003392 0.55322 21.5938
238 5CEO 50D 0.0001207 0.42896 21.6667
239 4DSU BZI 0.004331 0.45503 21.6931
240 3IGO ANP 0.000001039 0.56923 21.8107
241 2PUL ACP 0.0001448 0.49716 21.9144
242 3SXF BK5 0.000001469 0.49247 22.1074
243 3QDK QDK 0.01714 0.41458 22.5806
244 5KO1 6UY 0.00002726 0.53089 22.6148
245 5JKG 6LF 0.00009354 0.41965 23.1511
246 5CKW ANP 0.0002765 0.5009 23.2816
247 5U6C 7YS 0.0001525 0.47646 23.4921
248 4KAX 4IP 0.02459 0.41153 23.6025
249 5DMZ ADP 0.000000006981 0.68834 23.8356
250 2WU6 DKI 0.0000008672 0.56636 24.147
251 2RIO ADP 0.000000005424 0.70302 24.1935
252 3ZJX BOG 0.02397 0.41439 24.1935
253 3U6W KIV 0.02671 0.40923 24.1935
254 4IP7 FLC 0.03572 0.4029 24.1935
255 5LXC 7AA 0.0000001956 0.50584 24.2647
256 5LXT ACP 0.005141 0.4079 24.4755
257 4Y0X ADP 0.000002221 0.58901 24.5333
258 4E93 GUI 0.000019 0.46833 25.1989
259 1U5R ATP 0.0000004617 0.60548 25.2874
260 3H0L ADP 0.005117 0.4377 25.5319
261 4CRL C1I 0.0003034 0.42121 25.6158
262 3C1X CKK 0.003394 0.41875 25.7373
263 4FL3 ANP 0.00000002509 0.63845 25.8065
264 2BKK ADP 0.001492 0.45934 25.8065
265 5IQD GNP 0.0008542 0.43845 25.8065
266 5IQD RIO 0.0009166 0.43845 25.8065
267 1UI0 URA 0.01709 0.42813 25.8065
268 5FBN 5WF 0.00001499 0.45966 25.8303
269 2JLD AG1 0.000001442 0.50143 25.9524
270 4XH0 ADP 0.00004456 0.55861 26.3027
271 5AWM ANP 0.00006431 0.53247 26.3959
272 5X8I SQZ 0.00000009547 0.63664 26.8786
273 3GC8 B45 0.0002555 0.46687 27.027
274 3TTI KBI 0.00002366 0.48781 27.4194
275 5C4L 4XR 0.0001948 0.45709 27.4194
276 5C4L SIS 0.0004208 0.44384 27.4194
277 5EKO N17 0.00144 0.43114 27.4933
278 5M06 ADP 0.0000828 0.51428 27.5362
279 3LXN MI1 0.00000009391 0.62125 27.673
280 4P5Z Q7M 0.0001257 0.41754 27.7008
281 3GC0 AMP 0.0002515 0.49698 27.9635
282 3KMW ATP 0.004181 0.4292 28.0443
283 2PVN P63 0.000001942 0.52271 28.125
284 4JR7 GNP 0.000003381 0.56613 28.3422
285 4NM5 ADP 0.000001509 0.55626 28.382
286 5HX8 66P 0.00000344 0.52537 28.4768
287 3H9R TAK 0.00002321 0.56218 28.7879
288 2B9J ADP 0.0000004053 0.61589 28.8952
289 2B9I ADP 0.0000003735 0.60967 28.8952
290 2B9F ADP 0.000001094 0.58843 28.8952
291 2B9H ADP 0.0000005964 0.51201 28.8952
292 4KBA 1QM 0.002957 0.45462 29.003
293 5W4W 9WG 0.0006397 0.41853 29.003
294 3LXK MI1 0.0000003505 0.55916 29.052
295 3KRL KRL 0.0003676 0.46011 29.2537
296 5HCY 60D 0.00000129 0.45568 29.3051
297 4BTK DTQ 0.0003318 0.47547 29.3769
298 3ZRM ZRM 0.00003832 0.51814 29.3801
299 4G17 0VN 0.0006822 0.47073 29.3939
300 4AT3 LTI 0.0001696 0.44369 29.4314
301 4GJ3 0XP 0.00002726 0.46813 29.4702
302 5UIU 8CG 0.0000004083 0.54022 29.7214
303 3FHR P4O 0.000003564 0.55853 29.7619
304 3SXS PP2 0.00003229 0.51048 29.8507
305 1I7M CG 0.004859 0.44358 29.8507
306 3PP0 03Q 0.0001748 0.45763 29.8817
307 4FF8 14S 0.007455 0.42953 30.031
308 4EUU BX7 0.00006835 0.47382 30.094
309 4N70 2HX 0.00002426 0.40841 30.1829
310 1FHX 4IP 0.02143 0.40652 30.2326
311 5EOB 5QQ 0.000001345 0.57326 30.721
312 4U44 3D9 0.0000193 0.5317 30.7229
313 1CM8 ANP 0.00007763 0.50975 30.7902
314 4XMF HSM 0.001293 0.48817 30.9783
315 5HVJ ANP 0.00006563 0.54574 31.1111
316 3F7Z 34O 0.000008612 0.54765 31.1429
317 5LPZ ADP 0.00008069 0.50342 31.3253
318 1VJY 460 0.00002468 0.46433 31.3531
319 3E8N VRA 0.0000009673 0.45687 31.3783
320 3E8N ATP 0.0000009673 0.45687 31.3783
321 3CY2 MB9 0.00002312 0.50649 31.5287
322 3TKI S25 0.0000006983 0.43309 31.5789
323 3EKK GS2 0.000008355 0.46106 31.5961
324 3NW7 LGV 0.000006721 0.429 31.5961
325 2HY0 306 0.000001939 0.59978 31.677
326 4ASE AV9 0.001966 0.41292 31.728
327 4CLI 5P8 0.000009794 0.52567 31.8043
328 4LOO SB4 0.0007182 0.4602 31.856
329 4NST ADP 0.00001459 0.53723 31.9088
330 5TO8 7FM 0.0001628 0.41085 31.9149
331 3BU5 ATP 0.000001261 0.58562 32.0261
332 5NKB 8ZT 0.0001612 0.404 32.0261
333 4NFN 2KC 0.0006695 0.46623 32.0388
334 3C0G 3AM 0.00000936 0.56652 32.1937
335 3E7O 35F 0.0002778 0.42463 32.2222
336 4GYI ADP 0.0001798 0.50407 32.2581
337 3HAV ATP 0.0008293 0.49216 32.2581
338 5EFQ ADP 0.00001186 0.54132 32.2767
339 5JGA 6KC 0.00001529 0.47007 32.381
340 5BYZ 4WE 0.0000001551 0.54793 32.7586
341 1K3A ACP 0.000007195 0.57208 32.7759
342 3DLS ADP 0.000009124 0.45153 32.8358
343 5HES 032 0.000119 0.4385 32.899
344 2Y6O 1N1 0.002456 0.42478 32.9897
345 2A19 ANP 0.0000006638 0.63144 33.0986
346 3ORK AGS 0.00000001704 0.62367 33.119
347 3UIM ANP 0.0001929 0.48619 33.1288
348 3SRV S19 0.000001057 0.59652 33.213
349 4YLL 4E3 0.000000005633 0.6582 33.241
350 5T8O 76Z 0.00004438 0.50445 33.5244
351 4Y8D 49J 0.0001065 0.49794 33.5294
352 4XV1 904 0.0002863 0.42187 33.5616
353 3PLS ANP 0.000000624 0.60717 33.8926
354 4IDT T28 0.0000002008 0.63008 33.9888
355 5TA6 79D 0.00006288 0.47125 34.0782
356 4XLI 1N1 0.0005416 0.47051 34.3284
357 4G31 0WH 0.0009105 0.40275 34.4482
358 3SLS ANP 0.000001393 0.56377 34.5395
359 1FAO 4IP 0.01794 0.41878 34.9206
360 2XVD AS6 0.0000353 0.47518 35.0993
361 5LPB ADP 0.0003393 0.49647 35.1351
362 4M69 ANP 0.00002145 0.51824 35.1438
363 4QMN DB8 0.000008615 0.46397 35.1613
364 4CQE CQE 0.0003198 0.46269 35.2518
365 1JPA ANP 0.0001835 0.52318 35.2564
366 1V0O INR 0.000004189 0.55541 35.4167
367 5HQ0 LZ9 0.000003281 0.55385 35.4305
368 4AG8 AXI 0.0002829 0.41306 35.443
369 4AUA 4AU 0.0001284 0.49958 35.5049
370 5IH9 6BF 0.000004324 0.47134 35.5224
371 4JDI ANP 0.0000003747 0.595 35.5491
372 4BFM ANP 0.000000003309 0.6847 35.6287
373 3HMO STU 0.0000152 0.54269 35.6725
374 3ALN ANP 0.0000023 0.56059 35.7798
375 3PE2 E1B 0.00004118 0.40718 35.905
376 4EWH T77 0.000007606 0.50703 36
377 5MJA 7O3 0.0002616 0.49053 36.0656
378 5DH3 5BS 0.000006767 0.54012 36.1905
379 4X7Q 3YR 0.000001466 0.58265 36.2179
380 4BHN BH9 0.0000005801 0.58671 36.2275
381 4Y85 499 0.00005365 0.51721 36.4458
382 2YAB AMP 0.00000001381 0.66602 36.5651
383 5DBX ANP 0.000001085 0.61206 36.5854
384 5VCV 1N1 0.000003939 0.53331 36.6559
385 2YAK OSV 0.00000009896 0.56303 37.193
386 1U59 STU 0.00000134 0.58442 37.2822
387 1BYG STU 0.0000041 0.57635 37.4101
388 4YMJ 4EJ 0.0006322 0.49725 37.5
389 2V7O DRN 0.0000006189 0.64258 37.7976
390 5H2U 1N1 0.0007468 0.45943 37.8277
391 5DA3 58V 0.00003681 0.54454 38.1132
392 3OFM 4B0 0.00003622 0.53792 38.2857
393 5N87 N66 0.0000000631 0.52892 38.6581
394 5DEY 59T 0.00001951 0.40112 38.7205
395 4E1Z 0MX 0.0000007559 0.56887 38.8316
396 5DRB 5FJ 0.000003053 0.43998 38.8316
397 2WEL K88 0.00001518 0.585 38.8379
398 2VZ6 FEF 0.0000004016 0.63306 38.9776
399 3KN5 ANP 0.00001282 0.44452 39.0769
400 5VC5 96M 0.00003982 0.47899 39.1003
401 3M2W L8I 0.0000000159 0.70129 39.4649
402 4I6H 1C8 0.001015 0.45337 39.6104
403 2F57 23D 0.00001197 0.55423 39.7476
404 4USF 6UI 0.001625 0.42555 40.1316
405 5AX9 4KT 0.0000586 0.50975 40.5844
406 4FG8 ATP 0.0000000003263 0.72864 40.6349
407 3GGF GVD 0.0000004392 0.62248 41.196
408 2WQN ADP 0.000006573 0.57399 41.2903
409 2X4Z X4Z 0.000001012 0.49987 41.5541
410 4H3P ANP 0.000001102 0.58828 41.6667
411 2VN9 GVD 0.0000001815 0.66979 42.1927
412 3AQV TAK 0.001098 0.4518 42.3913
413 1ZY5 ANP 0.0000217 0.53549 42.5743
414 1PHK ATP 0.00000002793 0.65239 42.6175
415 4WNP 3RJ 0.0000009005 0.616 42.8571
416 4D2S DYK 0.00002072 0.54973 42.9577
417 4AU8 Z3R 0.0001461 0.5147 43.2432
418 5JZJ AN2 0.000000000699 0.7444 43.4343
419 5G1X ADP 0.000000003112 0.71424 43.5088
420 5L8L ADP 0.0000003563 0.64491 43.5088
421 4F9C 0SX 0.000000489 0.6121 43.5484
422 2BPM 529 0.000006302 0.42135 43.6893
423 5LXM ADP 0.00000003312 0.66647 43.8163
424 5A6N U7E 0.0000002344 0.52481 43.8163
425 4KS7 X4Z 0.000002288 0.54867 43.8356
426 1UNH IXM 0.00002287 0.54765 43.8356
427 3O0G 3O0 0.00003465 0.43891 43.8356
428 2WEI VGG 0.000006804 0.56589 43.9024
429 4A4X JUP 0.00001606 0.4988 44.086
430 5UOX 8GY 0.000002801 0.55079 44.6494
431 4BCQ TJF 0.0002265 0.50522 44.8505
432 4BCM T7Z 0.0005048 0.50026 44.8505
433 4CFU 2WC 0.00009029 0.5125 44.8845
434 4BCN T9N 0.0002272 0.49912 45
435 3V8S 0HD 0.000000002357 0.71985 45.122
436 4C2V YJA 0.000003784 0.50483 45.2632
437 5LMK 6ZK 0.00229 0.4457 45.4545
438 4WNK 453 0.000000000004068 0.7235 45.485
439 2ZV2 609 0.000001327 0.61645 45.6376
440 2R5T ANP 0.0000005868 0.57985 46.1126
441 4WB7 ATP 0.000000252 0.51216 46.1728
442 3DAK ANP 0.0000001146 0.65022 46.2069
443 4DC2 ADE 0.000003868 0.61343 46.2121
444 4C2W ANP 0.000001366 0.61583 46.2366
445 3E5A VX6 0.00001146 0.50933 46.2687
446 4YZN 4K5 0.0000002705 0.5876 46.3415
447 5EYK 5U5 0.00001088 0.50097 46.7391
448 4OH4 ANP 0.00005541 0.51085 47.619
449 3TXO 07U 0.000008503 0.56129 49.8584
450 4WB6 ATP 0.00000001799 0.61597 50
451 2QCS ANP 0.00000002527 0.61011 50
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