Receptor
PDB id Resolution Class Description Source Keywords
5UF4 2.04 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF VARIABLE LYMPHOCYTE RECEPTOR (VLR) O13 BOUND PETROMYZON MARINUS VARIABLE LYMPHOCYTE RECEPTORS VLR LEUCINE-RICH REPEAT LRRADAPTIVE IMMUNITY IMMUNE SYSTEM SEA LAMPREY JAWLESS FISHRECEPTOR GLYCAN BINDING GLYCAN RECEPTOR
Ref.: STRUCTURAL INSIGHTS INTO VLR FINE SPECIFICITY FOR B GROUP CARBOHYDRATES. STRUCTURE V. 25 1667 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLC GAL NAG GAL E:1;
F:1;
D:1;
 Valid;
Valid;
Valid;
 none;
none;
none;
 Kd = 160 uM
n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5UF1 2.03 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF VARIABLE LYMPHOCYTE RECEPTOR (VLR) O13 WITH H-TRISACCHARIDE PETROMYZON MARINUS VARIABLE LYMPHOCYTE RECEPTORS VLR LEUCINE-RICH REPEAT LRRADAPTIVE IMMUNITY IMMUNE SYSTEM SEA LAMPREY JAWLESS FISHRECEPTOR GLYCAN BINDING GLYCAN RECEPTOR
Ref.: STRUCTURAL INSIGHTS INTO VLR FINE SPECIFICITY FOR B GROUP CARBOHYDRATES. STRUCTURE V. 25 1667 2017
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 5UF1 Kd = 2.6 uM NAG GAL FUC n/a n/a
2 5UF4 Kd = 160 uM GLC GAL NAG GAL n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 5UF1 Kd = 2.6 uM NAG GAL FUC n/a n/a
2 5UF4 Kd = 160 uM GLC GAL NAG GAL n/a n/a
3 3E6J - NAG GAL FUC n/a n/a
4 5UFF Kd = 57.1 uM BGC GAL FUC n/a n/a
5 4K5U Ka = 9600 M^-1 GAL C6 H12 O6 C([C@@H]1[....
6 4K79 Ka = 22100 M^-1 A2G GAL n/a n/a
7 5UFC Kd = 6.9 uM NAG GAL FUC n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 5UF1 Kd = 2.6 uM NAG GAL FUC n/a n/a
2 5UF4 Kd = 160 uM GLC GAL NAG GAL n/a n/a
3 3E6J - NAG GAL FUC n/a n/a
4 5UFF Kd = 57.1 uM BGC GAL FUC n/a n/a
5 4K5U Ka = 9600 M^-1 GAL C6 H12 O6 C([C@@H]1[....
6 4K79 Ka = 22100 M^-1 A2G GAL n/a n/a
7 5UFC Kd = 6.9 uM NAG GAL FUC n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLC GAL NAG GAL; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: GLC GAL NAG GAL; Similar ligands found: 3
No: Ligand Similarity coefficient
1 GLC GAL NAG GAL 1.0000
2 BGC GAL NAG GAL 0.9457
3 NAG GAL NAG GAL 0.8937
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5UF1; Ligand: NAG GAL FUC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5uf1.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
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