-->
Receptor
PDB id Resolution Class Description Source Keywords
5O96 2.3 Å EC: 2.1.1.193 STRUCTURE OF THE PUTATIVE METHYLTRANSFERASE LPG2936 FROM LEG PNEUMOPHILA IN COMPLEX WITH THE BOUND COFACTOR SAM LEGIONELLA PNEUMOPHILA RNA METHYLTRANSFERASE RSME-LIKE SAM S-ADENOSYLMETHIONINETRANSFERASE
Ref.: CRYSTAL STRUCTURE OF THE LEGIONELLA PNEUMOPHILA LPG COMPLEX WITH THE COFACTOR S-ADENOSYL-L-METHIONINE R NOVEL INSIGHTS INTO THE MECHANISM OF RSME FAMILY METHYLTRANSFERASES. PROTEIN SCI. V. 26 2381 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM A:501;
E:501;
C:501;
B:501;
G:501;
F:501;
H:501;
D:501;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
Ka = 708000 M^-1
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5O96 2.3 Å EC: 2.1.1.193 STRUCTURE OF THE PUTATIVE METHYLTRANSFERASE LPG2936 FROM LEG PNEUMOPHILA IN COMPLEX WITH THE BOUND COFACTOR SAM LEGIONELLA PNEUMOPHILA RNA METHYLTRANSFERASE RSME-LIKE SAM S-ADENOSYLMETHIONINETRANSFERASE
Ref.: CRYSTAL STRUCTURE OF THE LEGIONELLA PNEUMOPHILA LPG COMPLEX WITH THE COFACTOR S-ADENOSYL-L-METHIONINE R NOVEL INSIGHTS INTO THE MECHANISM OF RSME FAMILY METHYLTRANSFERASES. PROTEIN SCI. V. 26 2381 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5O96 Ka = 708000 M^-1 SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5O96 Ka = 708000 M^-1 SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5O96 Ka = 708000 M^-1 SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 228
This union binding pocket(no: 1) in the query (biounit: 5o96.bio4) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 6MJ7 ARG None
2 1C4Q GLA GAL BGC None
3 1LNX URI None
4 2JAH NDP None
5 5A96 GTP 1.22449
6 1MXI SAH 1.25
7 4QED NAP 1.63265
8 4UX9 ANP 1.63265
9 4LXQ FON 1.63265
10 4LXQ TYD 1.63265
11 1NXJ GLV 1.63934
12 3BP1 GUN 2.04082
13 5FFF 5XC 2.04082
14 1XSE NDP 2.04082
15 5FFF NAP 2.04082
16 2X2M X2M 2.04082
17 2XK9 XK9 2.04082
18 3FSY SCA 2.04082
19 1JA9 NDP 2.04082
20 5BVE 4VG 2.04082
21 4XCZ FON 2.04082
22 4XCZ T3Q 2.04082
23 1U7T TDT 2.04082
24 1TL2 NDG 2.11864
25 4RF2 NAP 2.44898
26 1O97 AMP 2.44898
27 1O97 FAD 2.44898
28 4HXY NDP 2.44898
29 5OVK NDP 2.44898
30 5GT9 NAP 2.44898
31 3OJF IMJ 2.44898
32 1H5Q NAP 2.44898
33 3OJF NDP 2.44898
34 5A5W GUO 2.44898
35 2HK5 1BM 2.44898
36 5OVL NAP 2.44898
37 2BD0 NAP 2.45902
38 6BT4 KPM 2.47525
39 1YOA FMN 2.51572
40 1FUT 2GP 2.83019
41 3NK7 SAM 2.85714
42 2Z3U CRR 2.85714
43 3ZOK GLY 2.85714
44 3A06 NDP 2.85714
45 1JS8 MAN MAN BMA 2.85714
46 1O94 AMP 2.85714
47 1O5I NAD 2.85714
48 2WSI FAD 2.85714
49 3PTG 932 2.85714
50 5DRB 5FJ 2.85714
51 3M2W L8I 2.85714
52 4AT3 LTI 2.85714
53 5MLR GRQ 2.85714
54 5CIC 51R 2.85714
55 2V6G NAP 2.85714
56 3CV3 UDP 2.85714
57 5L4R CPT 2.89855
58 5TVA AMP 2.91667
59 4KWI NAP 3.04183
60 4KWI 1TJ 3.04183
61 5F90 LMR 3.20513
62 1CT9 AMP 3.26531
63 5G6U TRP 3.26531
64 1EFV AMP 3.26531
65 4J7U YTZ 3.26531
66 4J7U NAP 3.26531
67 1EFV FAD 3.26531
68 2VN9 GVD 3.26531
69 4XFR CIT 3.26531
70 3G5D 1N1 3.26531
71 3ZJX BOG 3.26531
72 1G0N PHH 3.26531
73 1G0N NDP 3.26531
74 5Z2L NDP 3.26531
75 1Z6Z NAP 3.26531
76 3U4C NDP 3.26531
77 4CQM NAP 3.27869
78 1KQR MNA 3.35196
79 1FQK ALF 3.40136
80 3B6C SDN 3.4188
81 6EMU SAM 3.5533
82 4JAL SAH 3.59281
83 3DCM SAM 3.64583
84 6CZ3 FLJ 3.67347
85 4K26 NDP 3.67347
86 5H2U 1N1 3.67347
87 5EJ2 NAD 3.67347
88 1Q19 APC 3.67347
89 5WNL STU 3.67347
90 5TTJ FAD 3.67347
91 4XQC NAD 3.67347
92 4XQC 13D 3.67347
93 3D3W NAP 3.68852
94 1PR9 NAP 3.68852
95 2P3I MNA 3.72671
96 3OII SAH 4.08163
97 2AE2 PTO 4.08163
98 2AE2 NAP 4.08163
99 2RH4 EMO 4.08163
100 4AU8 Z3R 4.08163
101 2NU8 COA 4.08163
102 6CI9 NAP 4.08163
103 4WNP 3RJ 4.08163
104 3SJU NDP 4.08163
105 1GPM AMP 4.08163
106 4OSP NAP 4.08163
107 5NKB 8ZT 4.08163
108 2PFY PCA 4.08163
109 1PEA ACM 4.08163
110 2Q37 3AL 4.41989
111 1COY FAD 4.4898
112 3HQ9 OXL 4.4898
113 5CGE 51F 4.4898
114 3ZZH NLG 4.4898
115 2ZV2 609 4.4898
116 1AE1 NAP 4.4898
117 2NGR AF3 4.4898
118 4GN8 ASO 4.89796
119 4U7W NDP 4.89796
120 5MJA 7O3 4.89796
121 5WS9 AMP 4.89796
122 3AY6 BGC 4.89796
123 3O7J 2AL 4.89796
124 2H8H H8H 4.89796
125 1A5V Y3 5.06329
126 1HE1 AF3 5.18518
127 3OID NDP 5.30612
128 1JPA ANP 5.30612
129 1X1T NAD 5.30612
130 1GRN AF3 5.41872
131 5THQ NDP 5.51471
132 4MSG 2C6 5.52995
133 2F6U CIT 5.55556
134 1CBK ROI 5.625
135 4MCC 21X 5.69106
136 5H5F SAM 5.71429
137 3GYQ SAM 5.71429
138 5B4T NAD 5.71429
139 5B4T 3HR 5.71429
140 1JGT CMA 5.71429
141 1JGT APC 5.71429
142 4ZRN NAD 5.71429
143 3GDN MXN 6.12245
144 3OKA GDD 6.12245
145 2Q2V NAD 6.12245
146 5MBX FAD 6.12245
147 5MBX SP5 6.12245
148 1USR SIA WIA 6.12245
149 1XG5 NAP 6.12245
150 1P9P SAH 6.13027
151 5TWJ SAM 6.17284
152 1T57 FMN 6.31068
153 3H9R TAK 6.42202
154 6EL3 NAP 6.53061
155 5HCY 60D 6.53061
156 2WSB NAD 6.53061
157 2PZM UDP 6.53061
158 2PZM NAD 6.53061
159 4NBI D3Y 6.70732
160 3GD8 GOL 6.72646
161 3RK1 ATP 6.75105
162 3ICC NAP 6.93878
163 2DTX BMA 6.93878
164 1ZX5 LFR 6.93878
165 5ENZ UDP 6.93878
166 2DQA NAG NAG NAG 7.25806
167 2WEL K88 7.33333
168 6EKZ SNP 7.34694
169 5T96 79J 7.34694
170 2BOS GLA GAL GLC 7.35294
171 2BOS GLA GAL GLC NBU 7.35294
172 3HGM ATP 7.48299
173 3AIA SAM 7.58294
174 4TWP AXI 7.7551
175 2Q1W NAD 7.7551
176 1RYD GLC 8.01034
177 5AHW CMP 8.16327
178 5FEU NAP 8.16327
179 1FK8 NAD 8.16327
180 1WMA AB3 8.16327
181 1WMA NDP 8.16327
182 4CNE SAH 8.2397
183 3JQ3 ADP 8.57143
184 5Y80 IRE 8.57143
185 4Y8D 49J 8.57143
186 5APG EEM 8.64865
187 1N13 AG2 8.84956
188 2QQC AG2 8.92857
189 2YY8 SAM 8.95522
190 2YY8 MTA 8.95522
191 2C5S AMP 8.97959
192 5A07 GDP 8.97959
193 5ZDN CDP 9.00474
194 2XVM SAH 9.04523
195 3G6K FAD 9.09091
196 3G6K POP 9.09091
197 1V2X SAM 9.27835
198 5A7Y SAH 9.79592
199 1S4P GDP 9.79592
200 5XWV NDP 9.79592
201 5XWV 8H6 9.79592
202 3O7B SAH 9.83607
203 3DLG GWE 10.2041
204 3KIH GDL 10.3093
205 4JWJ SAH 10.396
206 3QWI CUE 10.6122
207 3QWI NAP 10.6122
208 6GR0 F8W 10.9195
209 4CNG SAH 11.0204
210 1MJH ATP 11.1111
211 4R2M ANP 11.3924
212 4JWH SAH 11.8367
213 6HKE MLT 11.8367
214 6HKE LMR 11.8367
215 3AFN NAP 11.8367
216 1GAR U89 12.7358
217 3BBD SAH 13.1707
218 4JWF SAH 13.3641
219 3BBH SFG 13.6585
220 4GNC ASO 14.6939
221 2UYQ SAM 15.5102
222 3CH6 311 15.5102
223 3CH6 NAP 15.5102
224 4L2I NAD 16.7347
225 4L2I FAD 16.7347
226 1PTR PRB 18
227 5J60 FAD 18.7755
228 5MT9 SRO 26.6667
Pocket No.: 2; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 52
This union binding pocket(no: 2) in the query (biounit: 5o96.bio4) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 5KK4 44E None
2 4Y4V DAL 1.22449
3 1YFZ IMP 1.46341
4 5YW5 ADE 1.67598
5 2UVO NAG 1.75439
6 1DKU AP2 2.44898
7 6EOM ALA LYS 2.44898
8 5UPK GNP 2.44898
9 3BY8 MLT 2.8169
10 5Z5I XYP 2.85714
11 5NC9 8SZ 2.85714
12 1O9U ADZ 2.85714
13 4RPL FAD 3.26531
14 3DDC GNP 3.61446
15 3VSV XYS 3.67347
16 3KCC CMP 3.67347
17 2X1L MET 3.67347
18 1MO9 KPC 3.67347
19 1MO9 FAD 3.67347
20 4ME6 ADP 3.67347
21 4G17 0VN 4.08163
22 2RIF AMP 4.25532
23 4UCI ADN 4.4898
24 3SBZ MLI 4.89796
25 4BCQ TJF 4.89796
26 5THY SAH 5.30612
27 3KIF GDL 5.66038
28 4C2W ANP 5.76923
29 1N5D NDP 6.12245
30 5L4S NAP 6.28931
31 5L4S 6KX 6.28931
32 2HIM ASN 7.34694
33 2HIM ASP 7.34694
34 5O98 NAP 7.34694
35 1BZY IMU 7.37327
36 2ZWS PLM 7.7551
37 4HDO GNP 7.78443
38 3X1Z GNP 7.78443
39 5OCS CIT 8.16327
40 5XG5 A2G 8.96552
41 3THR C2F 10.6122
42 3AB4 LYS 10.6122
43 5TVI O8N 10.8696
44 3WXB NDP 11.0204
45 2ATJ BHO 11.4286
46 6GNF ADP 11.4286
47 3PE2 E1B 11.5727
48 1OAA OAA 12.6531
49 5WQP NAP 14.1026
50 1IV2 CDP 16.4474
51 5MPT SAH 19.1837
52 4HDQ GNP 19.2308
Pocket No.: 3; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 59
This union binding pocket(no: 3) in the query (biounit: 5o96.bio2) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 2FR1 NDP 1.63265
2 2PD4 NAD 2.04082
3 2PD4 DCN 2.04082
4 4HA6 FAD 2.04082
5 3DAK ANP 2.04082
6 5WP4 SAH 2.04082
7 1DQN IMU 2.17391
8 4ZCC FAD 2.44898
9 2GEK GDP 2.44898
10 4ZCC NAI 2.44898
11 5UPK ANP 2.44898
12 1ZK4 AC0 2.44898
13 5O42 NAD 2.85714
14 5O42 9JW 2.85714
15 5O42 BGC 2.85714
16 2Z49 AMG 2.85714
17 4NFE BEN 2.95359
18 1XCL SAH 2.97872
19 4OHU 2TK 3.26531
20 4OHU NAD 3.26531
21 1F6D UDP 3.26531
22 5FPE 3TR 3.26531
23 3ICR FAD 3.26531
24 4JJF N2I 3.67347
25 4K26 SFF 3.67347
26 2RGJ FAD 3.67347
27 5T2U NAP 4.08163
28 2B4Q NAP 4.08163
29 3UG4 AHR 4.08163
30 5TWB FAD 4.08163
31 5JWC FAD 4.4898
32 4FC7 NAP 4.4898
33 4FC7 COA 4.4898
34 5D63 FUC GLA GLA 4.89796
35 4RHS SIA SIA GAL 4.89796
36 3WYF GTP 5.46218
37 5HVJ ANP 5.71429
38 4ZRN UPG 5.71429
39 5YU3 NAD 5.71429
40 5YU3 PRO 5.71429
41 3OKP GDD 6.12245
42 5WKC F50 6.93878
43 1NAA 6FA 7.34694
44 3KMT SAH 7.56302
45 2GKS ADP 8.16327
46 2QX0 PH2 8.1761
47 4NTD FAD 8.57143
48 4M52 FAD 8.57143
49 1WA5 GTP 9.38776
50 6CS9 PIO 9.7561
51 1OBB NAD 9.79592
52 6D5G GNP 11.0204
53 1I8T FAD 11.4286
54 4EMJ FAD 14.0187
55 5LV1 78T 15.102
56 1FQJ ALF 16.6667
57 4JNA FAD 17.1429
58 5KF6 NAD 17.551
59 6GAR FAD 17.9592
Pocket No.: 4; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 53
This union binding pocket(no: 4) in the query (biounit: 5o96.bio2) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 5JKG 6LF 1.63265
2 1E3W NAD 2.04082
3 5K0A FAD 2.04082
4 2QE0 NAP 2.04082
5 5J6Y BGC 2.12766
6 5J6Y GLC 2.12766
7 1GPE FAD 2.44898
8 1ZK4 NAP 2.44898
9 3RJ5 NAD 2.44898
10 4NZ6 DLY 2.44898
11 6GAS FAD 2.44898
12 4ASE AV9 2.44898
13 3VHE 42Q 2.44898
14 1GZ6 NAI 2.85714
15 4FL3 ANP 2.85714
16 5F90 GLA GAL 3.20513
17 4RPL 3UC 3.26531
18 1O9J NAD 3.26531
19 5O2T GSP 3.5503
20 4YSX FAD 4.08163
21 3CGB FAD 4.08163
22 1G4U AF3 4.4898
23 1VL8 NAP 4.4898
24 4DQ2 BTX 4.4898
25 5GWT SIN 4.4898
26 5GWT NAD 4.4898
27 5OCG GNP 4.7619
28 3HRD NIO 4.89796
29 4NON GDP 4.89796
30 4NBU NAI 5.30612
31 1ONI BEZ 5.7971
32 2ZXI FAD 6.12245
33 2R4V GSH 6.53061
34 1NAA ABL 7.34694
35 4P5Z Q7M 7.34694
36 2ZAT NAP 7.34694
37 3LXD FAD 8.16327
38 5AHO TLA 8.57143
39 6F97 FAD 8.57143
40 1GUA GNP 8.64198
41 5UWP GNP 9.70464
42 5UWH GNP 9.70464
43 5UWS GNP 9.70464
44 6F9Q NAD 9.79592
45 2CDC XYS 10.2041
46 4HAT GNP 10.6481
47 4Z87 GDP 11.4286
48 2UYN 2KT 11.6279
49 2C5L GTP 12.8205
50 1ZK7 FAD 13.0612
51 5WQP NCA 14.1026
52 1ZEI CRS 15.0943
53 4QTU SAM 18.5185
Pocket No.: 5; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 26
This union binding pocket(no: 5) in the query (biounit: 5o96.bio3) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 1YXM ADE 0.816327
2 2AK3 AMP 0.884956
3 5QIN J2V 2.04082
4 1NF3 GNP 2.05128
5 5UAV TFB 2.44898
6 5UAV NDP 2.44898
7 4AG8 AXI 2.44898
8 2Z48 A2G 2.85714
9 2Y6O 1N1 2.85714
10 5AX9 4KT 3.26531
11 5T63 ALA ALA ALA ALA 3.67347
12 4AP9 1PS 3.9801
13 3BZ3 YAM 4.08163
14 1HSK FAD 4.4898
15 1ME8 RVP 5.30612
16 3M1I GTP 5.30612
17 1Z82 NDP 8.97959
18 5DIF GNP 9.70464
19 5UWQ GNP 9.70464
20 5UWR GNP 9.70464
21 5UWT GNP 9.70464
22 1NVV GNP 11.0204
23 6D5H GNP 11.0204
24 6D59 GNP 11.0204
25 2UYP PPI 11.6279
26 1Z08 GNP 16.4706
Pocket No.: 6; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 71
This union binding pocket(no: 6) in the query (biounit: 5o96.bio3) has 22 residues
No: Leader PDB Ligand Sequence Similarity
1 5C2N NAG None
2 2FKA BEF None
3 4UBS DIF 1.22449
4 2WTX VDO 2.04082
5 2WTX UDP 2.04082
6 2CFI ZZZ 2.44898
7 4JF5 FLC 2.88066
8 5WDR GNP 2.92398
9 1SVK ALF GDP 3.26531
10 6FA4 GNP 3.46821
11 5NGZ 2BG 3.5533
12 2H7C SIA 3.67347
13 1IXE COA 3.67347
14 6AU6 GDP 3.67347
15 3TNF GNP 3.67347
16 1E96 GTP 3.94089
17 1UPR 4IP 4.06504
18 4K81 GTP 4.08163
19 4RDL FUC GAL NDG FUC 4.08163
20 3BC1 GNP 4.10256
21 1VG8 GNP 4.34783
22 5NM7 GLY 4.4898
23 1COY AND 4.4898
24 5MIT NAP 4.4898
25 5MIT FAD 4.4898
26 1QD0 RR6 4.6875
27 4ZTE 4RL 4.73934
28 2Y8E GNP 5.02793
29 2FFQ GSP 5.26316
30 1YZQ GNP 5.29412
31 3WYG GTP 5.30612
32 2XTZ GSP 5.71429
33 6GZD LCI 5.71429
34 3DWQ NGC GAL NGA POL AZI 6.34921
35 1ZC3 GNP 7.07965
36 4DFU QUE 7.34694
37 4KVG GTP 7.7381
38 2CB8 MYA 8.04598
39 2ODE ALF GDP 8.16327
40 3E5H GNP 8.42697
41 5DI9 GNP 9.70464
42 5UWI GNP 9.70464
43 5UWO GNP 9.70464
44 5UWW GNP 9.70464
45 6CIT GNP 9.70464
46 5UWU GNP 9.70464
47 5UWJ GNP 9.70464
48 5DHF GNP 9.70464
49 1IBR GNP 10.6481
50 3GJX GTP 10.6481
51 3DCJ THH 10.6977
52 6D5M GNP 11.0204
53 6BVL GNP 11.0204
54 6D5V GNP 11.0204
55 6D56 GNP 11.0204
56 6BVM GNP 11.0204
57 6BVJ GNP 11.0204
58 6D5L GNP 11.0204
59 6BVI GNP 11.0204
60 6BVK GNP 11.0204
61 6D5J GNP 11.0204
62 6D5E GNP 11.0204
63 6D55 GNP 11.0204
64 5SZH GNP 11.33
65 4Z0G 5GP 11.4286
66 3SBD GNP 11.7647
67 2GZ3 NAP 11.8367
68 3NKV GNP 13.1429
69 2UZI GTP 14.0351
70 3QDV NDG 14.6853
71 3RAB GNP 14.7929
Pocket No.: 7; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 18
This union binding pocket(no: 7) in the query (biounit: 5o96.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 3E3U NVC None
2 1MJT ITU 2.44898
3 4DSG FAD 2.85714
4 4W6Z ETF 3.26531
5 4PTN PYR 3.67347
6 4U8P UDP 3.67347
7 4C2C ALA ALA ALA 4.08163
8 3ZV6 4HB 4.08163
9 3ZV6 NAD 4.08163
10 3AY6 NAI 4.89796
11 4DPL NAP 5.30612
12 3W6X HZP 6.9869
13 3RHJ NAP 8.16327
14 3IWJ NAD 8.16327
15 5MUL BDP 8.57143
16 3UYK 0CX 8.97959
17 1RKX NAD 10.2041
18 2GMH FAD 11.0204
Pocket No.: 8; Query (leader) PDB : 5O96; Ligand: SAM; Similar sites found with APoc: 34
This union binding pocket(no: 8) in the query (biounit: 5o96.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 2XOC ADE 1.22449
2 4AML GYU 1.75439
3 2UVO NDG 1.75439
4 3K5I AIR 2.04082
5 3LTW HLZ 2.04082
6 5HXI FAD 2.44898
7 4D79 ATP 2.44898
8 3S6X SIA GAL BGC 2.85714
9 1SBR VIB 3
10 3HQP FDP 3.26531
11 5MST FUM 3.26531
12 5TCI MLI 3.26531
13 6FA4 D1W 3.46821
14 2Z9I GLY ALA THR VAL 3.67347
15 3FJG 3PG 3.67347
16 3X01 AMP 3.81679
17 6F5W KG1 4.4898
18 2YG3 FAD 4.4898
19 4BCN T9N 4.89796
20 2FJK 13P 4.89796
21 5ZI9 FLC 5
22 1LH0 ORO 5.16432
23 2R2N KYN 5.71429
24 2XG5 EC5 7.33945
25 2XG5 EC2 7.33945
26 1M26 GAL A2G 7.5188
27 6AC9 ANP 7.7551
28 2VHL GLP 8.16327
29 4UXL 5P8 8.16327
30 2XYA 7L4 8.24176
31 4CNK MEU 9.79592
32 4CM9 YGL 11.4286
33 3IWD M2T 11.7647
34 3Q3H UDP 22.449
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