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Receptor
PDB id Resolution Class Description Source Keywords
5NMX 1.6 Å EC: 1.-.-.- CRYSTAL STRUCTURE OF THE PYRROLIZIDINE ALKALOID N-OXYGENASE ZONOCERUS VARIEGATUS IN COMPLEX WITH FAD AND NADP+ ZONOCERUS VARIEGATUS PYRROLIZIDINE ALKALOID N-OXYGENASE OXIDOREDUCTASE FLAVIN-CMONOOXYGENASE ROSSMANN FOLD FAD NADP TWO DINUCLEOTIDE BDOMAIN FLAVOPROTEIN SENECIONINE
Ref.: CRYSTAL STRUCTURE OF PYRROLIZIDINE ALKALOID N-OXYGE THE GRASSHOPPER ZONOCERUS VARIEGATUS. ACTA CRYSTALLOGR D STRUCT V. 74 422 2018 BIOL
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FAD C:501;
A:501;
D:501;
B:501;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
MG B:503;
C:503;
D:503;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
NAP A:502;
C:502;
B:502;
D:502;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
743.405 C21 H28 N7 O17 P3 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5NMX 1.6 Å EC: 1.-.-.- CRYSTAL STRUCTURE OF THE PYRROLIZIDINE ALKALOID N-OXYGENASE ZONOCERUS VARIEGATUS IN COMPLEX WITH FAD AND NADP+ ZONOCERUS VARIEGATUS PYRROLIZIDINE ALKALOID N-OXYGENASE OXIDOREDUCTASE FLAVIN-CMONOOXYGENASE ROSSMANN FOLD FAD NADP TWO DINUCLEOTIDE BDOMAIN FLAVOPROTEIN SENECIONINE
Ref.: CRYSTAL STRUCTURE OF PYRROLIZIDINE ALKALOID N-OXYGE THE GRASSHOPPER ZONOCERUS VARIEGATUS. ACTA CRYSTALLOGR D STRUCT V. 74 422 2018 BIOL
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 318 families.
1 5NMW - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5NMX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 280 families.
1 5NMW - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5NMX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 5NMW - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5NMX - NAP C21 H28 N7 O17 P3 c1cc(c[n+]....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Ligand no: 2; Ligand: NAP; Similar ligands found: 123
No: Ligand ECFP6 Tc MDL keys Tc
1 NAP 1 1
2 NA0 0.881356 0.986301
3 TAP 0.872881 0.934211
4 NDO 0.840336 0.972603
5 NAD 0.811966 0.986111
6 N01 0.733871 0.958904
7 A3D 0.712 0.972603
8 NBP 0.707692 0.935065
9 NHD 0.68254 0.958904
10 NJP 0.661417 0.972973
11 NFD 0.658915 0.934211
12 NXX 0.619048 0.959459
13 DND 0.619048 0.959459
14 AMP NAD 0.606061 0.958904
15 ZID 0.605839 0.972603
16 NAQ 0.59854 0.922078
17 ATR 0.59292 0.917808
18 NAE 0.591241 0.946667
19 NDE 0.58042 0.986301
20 A22 0.571429 0.958904
21 NAJ 0.567164 0.986111
22 A2R 0.563025 0.932432
23 NDC 0.561644 0.922078
24 NA7 0.552846 0.907895
25 ODP 0.551471 0.935065
26 A2P 0.539823 0.930556
27 8ID 0.537313 0.910256
28 NPW 0.525547 0.8875
29 NZQ 0.521739 0.910256
30 CNA 0.521739 0.959459
31 NDP 0.514493 0.922078
32 PO4 PO4 A A A A PO4 0.503937 0.930556
33 1DG 0.503401 0.922078
34 DG1 0.503401 0.922078
35 TXP 0.5 0.922078
36 NMN AMP PO4 0.492958 0.921053
37 XNP 0.492958 0.875
38 25L 0.492308 0.958904
39 25A 0.492063 0.972222
40 NMN 0.486726 0.888889
41 NGD 0.485714 0.935065
42 9JJ 0.481707 0.8875
43 2AM 0.477876 0.891892
44 ADP 0.458333 0.945205
45 PAP 0.451613 0.931507
46 A2D 0.445378 0.945205
47 AN2 0.442623 0.932432
48 7L1 0.441558 0.777778
49 ADP PO3 0.44 0.944444
50 SAP 0.44 0.896104
51 AGS 0.44 0.896104
52 M33 0.439024 0.906667
53 AR6 AR6 0.438849 0.945205
54 BA3 0.438017 0.945205
55 OAD 0.43609 0.92
56 ADP BMA 0.43609 0.92
57 DQV 0.435714 0.958904
58 HEJ 0.435484 0.945205
59 ATP 0.435484 0.945205
60 OOB 0.435115 0.958904
61 B4P 0.434426 0.945205
62 AP5 0.434426 0.945205
63 GAP 0.433071 0.92
64 0WD 0.432432 0.922078
65 2A5 0.432 0.87013
66 5FA 0.432 0.945205
67 AQP 0.432 0.945205
68 AT4 0.430894 0.907895
69 00A 0.428571 0.909091
70 DAL AMP 0.427481 0.932432
71 CA0 0.427419 0.92
72 ADP ALF 0.426357 0.871795
73 ALF ADP 0.426357 0.871795
74 9X8 0.425373 0.871795
75 ACP 0.424 0.92
76 NAJ PZO 0.423841 0.897436
77 9SN 0.423358 0.897436
78 ADP VO4 0.423077 0.932432
79 VO4 ADP 0.423077 0.932432
80 WAQ 0.422222 0.884615
81 V3L 0.421875 0.945205
82 ACQ 0.421875 0.92
83 ADQ 0.421053 0.92
84 AR6 0.420635 0.918919
85 APR 0.420635 0.918919
86 ATP A A A 0.42029 0.958333
87 CO7 0.419753 0.786517
88 3OD 0.419118 0.92
89 1ZZ 0.419118 0.841463
90 DLL 0.41791 0.958904
91 AD9 0.417323 0.92
92 NAX 0.416667 0.875
93 OVE 0.416667 0.857143
94 MYR AMP 0.416058 0.841463
95 AV2 0.415385 0.868421
96 A3P 0.414634 0.944444
97 NNR 0.414414 0.72973
98 OMR 0.413793 0.831325
99 6YZ 0.412214 0.92
100 ANP 0.410853 0.92
101 A1R 0.410448 0.860759
102 ABM 0.409836 0.893333
103 A 0.408333 0.944444
104 AMP 0.408333 0.944444
105 SON 0.408 0.933333
106 PPS 0.407692 0.829268
107 5AL 0.407692 0.932432
108 NAI 0.406897 0.909091
109 7D3 0.406504 0.857143
110 ADX 0.404762 0.829268
111 ATF 0.40458 0.907895
112 3UK 0.404412 0.945946
113 TYR AMP 0.404255 0.921053
114 AMP DBH 0.404255 0.894737
115 139 0.402685 0.875
116 50T 0.401575 0.906667
117 SRP 0.401515 0.907895
118 A A 0.40146 0.972222
119 B5V 0.40146 0.933333
120 A3R 0.4 0.860759
121 3AM 0.4 0.90411
122 B5M 0.4 0.921053
123 FA5 0.4 0.933333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5NMX; Ligand: NAP; Similar sites found with APoc: 769
This union binding pocket(no: 1) in the query (biounit: 5nmx.bio2) has 54 residues
No: Leader PDB Ligand Sequence Similarity
1 1ZGS XMM 1.17647
2 4KRI SAH 1.17647
3 3RGG AIR 1.25786
4 2D2I NAP 1.31579
5 5DF1 NAP 1.3587
6 5DF1 58X 1.3587
7 3CIF NAD 1.39276
8 3CIF G3H 1.39276
9 1WVG APR 1.39276
10 3NJ4 NAD 1.41176
11 2YYY NAP 1.45773
12 5MLR GRQ 1.45985
13 3B20 NAD 1.47493
14 3B1J NAD 1.47493
15 1SC6 NAD 1.48515
16 1J0X NAD 1.50602
17 6EL3 NAP 1.5748
18 2O4C NAD 1.57895
19 1Z45 NAD 1.64706
20 4HXY NDP 1.64706
21 3QOX SAH 1.64706
22 5THY SAH 1.7284
23 5THZ SAH 1.7284
24 3X01 AMP 1.78117
25 5C9P FUC 1.83727
26 5ULP KB1 1.86567
27 2IZ1 ATR 1.88235
28 5FJN FAD 1.88235
29 5FJN BE2 1.88235
30 1ELI PYC 1.88235
31 1YQZ FAD 1.88235
32 1SQF SAM 1.88235
33 1UP7 NAD 1.91847
34 5X9D 80F 1.97368
35 3A25 SAM 1.99336
36 1KEV NDP 1.9943
37 1GY8 NAD 2.01511
38 5KOK SAH 2.01511
39 3S1S SAH 2.05011
40 4WZ6 ATP 2.06897
41 1X87 NAD 2.11765
42 6D6Y SAH 2.11765
43 5NUF NAD 2.11765
44 4XZ3 COA 2.11765
45 5NUE NAD 2.11765
46 5UAV TFB 2.17391
47 5UAV NDP 2.17391
48 5M58 SAH 2.17391
49 1LDN NAD 2.21519
50 4R29 SAM 2.23214
51 3DAG FEG 2.23464
52 1HYH NAD 2.26537
53 1FP2 SAH 2.27273
54 3MAG SAH 2.28013
55 1X7D NAD 2.28571
56 4DMG SAM 2.29008
57 5ZI2 ADP 2.31884
58 5ZI2 NAD 2.31884
59 2VT3 ATP 2.32558
60 5KVS NAP 2.33766
61 5FTW SAH 2.34375
62 5A1T NAI 2.34604
63 5A1T OXM 2.34604
64 3NB0 G6P 2.35294
65 3PT9 SAH 2.35294
66 4FL0 PLP 2.35294
67 1OBB NAD 2.35294
68 3MCT SAH 2.3569
69 2DBZ NAP 2.39521
70 4MDH NAD 2.39521
71 6BII NAP 2.4024
72 2Q1W NAD 2.4024
73 1P0F NAP 2.41287
74 4URF NAD 2.41935
75 1ZQ9 SAM 2.45614
76 3GU3 SAH 2.46479
77 3R51 MMA 2.5
78 2F1K NAP 2.50896
79 5LD5 NAD 2.51397
80 5KVA SAM 2.51799
81 1PL6 NAD 2.52809
82 1PL6 572 2.52809
83 4L8F MTX 2.5641
84 2YY7 NAD 2.5641
85 5H81 NAP 2.57069
86 5UR0 NAD 2.5788
87 3VPH NAD 2.58065
88 3VPH OXM 2.58065
89 6F97 FAD 2.58824
90 1QMG APX 2.58824
91 5YU3 NAD 2.61628
92 5YU3 PRO 2.61628
93 2GDZ NAD 2.62172
94 3NYC FAD 2.62467
95 3NYC IAR 2.62467
96 3SSO SAH 2.6253
97 3AYI FAD 2.63523
98 3AYI HCI 2.63523
99 1O6Z NAD 2.64026
100 5G6U TRP 2.68199
101 1FP1 SAH 2.68817
102 1V6A TRE 2.71084
103 1GAD NAD 2.72727
104 3DXY SAM 2.75229
105 3B1F NAD 2.75862
106 3U31 NAD 2.75862
107 4TM3 FAD 2.82353
108 4KRG SAH 2.82353
109 4N49 SAM 2.82353
110 2VVG ADP 2.85714
111 5CAE COA 2.8754
112 5CAE SIN 2.8754
113 2DFV NAD 2.88184
114 3A4T SFG 2.91971
115 5T9E NAP 2.95203
116 5T9F TYR 2.95203
117 5T9F NAP 2.95203
118 2O07 MTA 2.96053
119 2O07 SPD 2.96053
120 2DC1 NAD 2.9661
121 4GLL NAD 2.96736
122 4GKV NAD 2.97619
123 1FWV SGA MAG FUC 2.98507
124 4NEC SAH 3.0303
125 5Y8L NAD 3.05085
126 5Y8L HUI 3.05085
127 1ZEM NAD 3.05344
128 3S5W NAP 3.05882
129 3S5W FAD 3.05882
130 5DNK SAH 3.05882
131 2ZXI FAD 3.05882
132 2DKH 3HB 3.05882
133 2DKH FAD 3.05882
134 5I39 FAD 3.05882
135 1VKO NAD 3.05882
136 3GDH SAH 3.05882
137 1H2B NAJ 3.06407
138 4DPL NAP 3.06407
139 4XYB NDP 3.06905
140 3BP1 GUN 3.10345
141 5ZW3 SAH 3.11111
142 1GEG NAD 3.125
143 3C6K SPD 3.14961
144 2NXE SAM 3.14961
145 3C6K MTA 3.14961
146 6DUB SAH 3.15315
147 1WG8 SAM 3.15789
148 1J5P NAD 3.16206
149 3K5I AIR 3.22581
150 1D4O NAP 3.26087
151 5FUB SAH 3.2641
152 2XYQ SAH 3.27869
153 1HDR NAD 3.27869
154 1KYZ SAH 3.28767
155 6CEP NAD 3.29341
156 6CEP OXM 3.29341
157 2C7G FAD 3.29412
158 2C7G ODP 3.29412
159 4RSL FAD 3.29412
160 2A8X FAD 3.29412
161 4M52 M52 3.29412
162 4M52 FAD 3.29412
163 4EIP FAD 3.29412
164 2FR1 NDP 3.29412
165 4EIP K2C 3.29412
166 5HJM MTA 3.29412
167 1HDG NAD 3.31325
168 3I53 SAH 3.31325
169 1RRC ADP 3.32226
170 1EJ0 SAM 3.33333
171 1JI0 ATP 3.33333
172 3G2O SAM 3.34448
173 2B5W NAP 3.36134
174 5BW4 SAM 3.37079
175 3EGI ADP 3.39806
176 2RI1 GLP 3.40426
177 1OMO NAD 3.41615
178 5K4W NAI 3.42679
179 1F3L SAH 3.42679
180 1WPQ NAD 3.4384
181 4RQU NAD 3.46667
182 2XVM SAH 3.51759
183 3WLE NAD 3.51906
184 1UJ5 5RP 3.52423
185 3QVP FAD 3.52941
186 2R4J 13P 3.52941
187 2R4J FAD 3.52941
188 4XQC NAD 3.52941
189 4XQC 13D 3.52941
190 1PN0 FAD 3.52941
191 1PN0 IPH 3.52941
192 5IFS ADP 3.52941
193 1CF2 NAP 3.56083
194 3ABI NAD 3.56164
195 1I9G SAM 3.57143
196 2GMM MAN MAN 3.57143
197 2GNB MAN 3.57143
198 5YF1 SFG 3.59116
199 5BSH PRO 3.61011
200 1O5I NAD 3.61446
201 3KLJ FAD 3.63636
202 3NUG NAD 3.64372
203 1SOW NAD 3.65854
204 5NA1 FAD 3.67647
205 5GZ6 NDP 3.68098
206 5GZ6 7C3 3.68098
207 1IM8 SAI 3.68852
208 1NYT NAP 3.69004
209 5X62 SAH 3.69458
210 4R5M NAP 3.7234
211 4DCM SAM 3.73333
212 3TKA SAM 3.7464
213 3H9E NAD 3.75723
214 5U8U FAD 3.76471
215 2JJQ SAH 3.76471
216 5ZXD ATP 3.76471
217 5KOX RFP 3.76471
218 4J1Q NDP 3.76471
219 5KOX FAD 3.76471
220 1YQT ADP 3.76471
221 5E4R NAP 3.76471
222 1V8B NAD 3.76471
223 1KOL NAD 3.76884
224 4BJZ P3A 3.77358
225 4BJZ FAD 3.77358
226 4JJF FE9 3.77907
227 4JJF N2I 3.77907
228 3TKY SAH 3.80435
229 1GR0 NAD 3.81471
230 5KKA 6V0 3.84615
231 4ZRN NAD 3.84615
232 3V1Y NAD 3.85757
233 4L8V NAP 3.85757
234 5AOV NAP 3.86905
235 1GUZ NAD 3.87097
236 1NV8 SAM 3.87324
237 1NV8 MEQ 3.87324
238 1J49 NAD 3.9039
239 4KOA NDP 3.9039
240 2GLX NDP 3.91566
241 2X6T NAP 3.92157
242 4IWN GEK 3.93013
243 3WBF NAP 3.93443
244 3WBF API 3.93443
245 3H2B SAH 3.94089
246 3FG2 FAD 3.9604
247 1VE3 SAM 3.96476
248 1OXV ANP 3.96601
249 2VHW NAI 3.97878
250 5JCM NAD 3.99113
251 5JCM ISD 3.99113
252 5JCM FAD 3.99113
253 2NVK NAP 4
254 1GET NAP 4
255 1GET FAD 4
256 3OJO NAD 4
257 3LAD FAD 4
258 2JHP SAH 4
259 5EVY FAD 4
260 1GPE FAD 4
261 2NVK FAD 4
262 6F3M NAD 4
263 5BRT FAD 4
264 5BRT CH9 4
265 1KYQ NAD 4.0146
266 6GR0 F8W 4.02299
267 6AIN FAD 4.06699
268 1G55 SAH 4.08163
269 4J36 1HR 4.09639
270 4J36 FAD 4.09639
271 1DL5 SAH 4.10095
272 3T7S SAM 4.10448
273 2CUN 3PG 4.14634
274 2CVZ NDP 4.15225
275 4YMH SAH 4.16667
276 1HKU NAD 4.18994
277 2QA1 FAD 4.2
278 3BAZ NAP 4.2042
279 1UXG NAD 4.20712
280 1UXG FUM 4.20712
281 9LDT NAD 4.21687
282 9LDB NAD 4.21687
283 5JJR SAH 4.23529
284 2ZUX RAM 4.23529
285 3G5S FAD 4.23529
286 4DSG FAD 4.23529
287 4DSG UDP 4.23529
288 4EUE NAI 4.23529
289 2P41 SAH 4.23529
290 3V1U NAD 4.23529
291 2EG5 SAH 4.30108
292 4C2W ANP 4.30108
293 5N2I NAP 4.31034
294 2PT9 S4M 4.36137
295 2PT9 2MH 4.36137
296 2CDC NAP 4.37158
297 2CDC XYP 4.37158
298 2CDC XYS 4.37158
299 1NW5 SAM 4.38871
300 4EMI NAD 4.39024
301 4EMJ FAD 4.39024
302 4EMI FAD 4.39024
303 2YVF NAD 4.41176
304 2YVF FAD 4.41176
305 5A96 GTP 4.41767
306 4YCA NDP 4.42177
307 1IZC PYR 4.42478
308 2EFJ SAH 4.42708
309 1V59 NAD 4.47059
310 3IHG FAD 4.47059
311 3X0V FAD 4.47059
312 1V59 FAD 4.47059
313 1COY FAD 4.47059
314 4HA6 FAD 4.47059
315 3E1T FAD 4.47059
316 5WGR FAD 4.47059
317 3GDN HBX 4.47059
318 1KNR FAD 4.47059
319 3GDN FAD 4.47059
320 1GZ6 NAI 4.47059
321 4KIB SAH 4.48179
322 6C8R SAH 4.48549
323 5CUQ NSC 4.49438
324 1WP4 NDP 4.49827
325 4CQM NAP 4.5082
326 4RDH AMP 4.51389
327 4RDI ATP 4.51389
328 1GV0 NAD 4.51613
329 1EQ2 NAP 4.51613
330 3A06 NDP 4.52128
331 3A06 FOM 4.52128
332 6BQ6 TER 4.53172
333 1D4D FAD 4.54545
334 1D1T NAD 4.55764
335 3GFB NAD 4.57143
336 5MPT SAH 4.58937
337 3L9W AMP 4.60048
338 3L9W GSH 4.60048
339 1KJ8 GAR 4.60358
340 1YJQ NAP 4.62046
341 3OFK SAH 4.62963
342 5TUF FAD 4.64548
343 2PXX SAH 4.65116
344 5MGZ SAH 4.66102
345 4XDZ NDP 4.66472
346 5DN9 NAD 4.67033
347 3C1O NAP 4.6729
348 2PV7 NAD 4.69799
349 4MOP 2H5 4.70588
350 4AT0 FAD 4.70588
351 1FEC FAD 4.70588
352 1E5Q NDP 4.70588
353 1Q1R FAD 4.70588
354 4D79 ATP 4.71014
355 1DLJ NAI 4.72637
356 3GRU AMP 4.74576
357 3O7W SAM 4.7619
358 1BW9 NAD 4.77528
359 1BXG NAD 4.77528
360 1C1X NAD 4.78873
361 3TLJ SAH 4.82574
362 1YKF NAP 4.82955
363 5EZ7 FAD 4.84694
364 2GCG NDP 4.84848
365 5D4V SAH 4.85075
366 5EES NAP 4.8583
367 5X68 FAD 4.85933
368 4JBI NDP 4.86486
369 5N5D SAM 4.86726
370 5DXA SFG 4.87106
371 5DWQ SFG 4.87106
372 5DX8 SFG 4.87106
373 5DX0 SFG 4.87106
374 5DX1 SFG 4.87106
375 4MO2 FAD 4.8913
376 4MO2 FDA 4.8913
377 5TUK FAD 4.90196
378 5KMS FAD 4.93827
379 5KMS NAD 4.93827
380 1PJS NAD 4.94118
381 5J5Z FAD 4.94118
382 3VSE SAH 4.94118
383 5FA5 MTA 4.94118
384 4GQB 0XU 4.94118
385 5MBX FAD 4.94118
386 5MBX SP5 4.94118
387 4C4A SAH 4.94118
388 3X0D SAH 4.94118
389 2E5V FAD 4.94118
390 5ZBC FAD 4.94118
391 4TQG NDP 4.94118
392 2IXB NAD 4.94118
393 1U8X NAD 4.94118
394 2I7C AAT 4.947
395 4B4U NAP 4.9505
396 3RKR NAP 4.96183
397 5G3U ITW 4.96454
398 5G3U FDA 4.96454
399 4RPL FAD 5.01253
400 4RPL 3UC 5.01253
401 1EBF NAD 5.02793
402 3HDY FDA 5.03778
403 3HDY FAD 5.03778
404 3HDY GDU 5.03778
405 3OZ2 FAD 5.03778
406 3WV8 ATP 5.04587
407 2YX1 SFG 5.05952
408 3K7M FAD 5.10441
409 3H8V ATP 5.13699
410 4D3F NAP 5.16129
411 2UYQ SAM 5.16129
412 3QFA FAD 5.17241
413 1QO8 FAD 5.17647
414 2RGH FAD 5.17647
415 2VDV SAM 5.17647
416 4MIG G3F 5.17647
417 5ERG SAM 5.17647
418 5MZI FAD 5.17647
419 5MZI FYK 5.17647
420 4C3Y FAD 5.17647
421 2ZIF SAM 5.17647
422 5Y77 FAD 5.17647
423 4C3Y ANB 5.17647
424 2RGO FAD 5.17647
425 3ZNN FAD 5.18732
426 3ZNN 4WL 5.18732
427 3WGT QSC 5.18732
428 3WGT FAD 5.18732
429 2RGJ FAD 5.22388
430 2XZ9 PYR 5.24691
431 1W8D NAP 5.29801
432 1W73 NAP 5.29801
433 1QAN SAH 5.32787
434 5L95 AMP 5.37634
435 3NKS FAD 5.41176
436 2BRY FAD 5.41176
437 1ZK7 FAD 5.41176
438 1YY5 FAD 5.41176
439 1RSG FAD 5.41176
440 2JB2 FAD 5.41176
441 2JB2 PHE 5.41176
442 1Q9I FAD 5.41176
443 1Q9I TEO 5.41176
444 5BUK FAD 5.41176
445 2GMH FAD 5.41176
446 4TXI FAD 5.41176
447 2WA2 SAM 5.43478
448 2IVD FAD 5.43933
449 4FZV SAM 5.43933
450 1FQK ALF 5.44218
451 5W7K SAH 5.44872
452 4EA7 JB2 5.45455
453 4EA7 COA 5.45455
454 1F8G NAD 5.46875
455 1ORR NAD 5.4755
456 5AYV NAP 5.50162
457 5AYV KPL 5.50162
458 1KJ1 MAN 5.50459
459 1C0I FAD 5.50964
460 1C0I BE2 5.50964
461 3JWH SAH 5.52995
462 4M37 SAH 5.53936
463 4M38 SAH 5.53936
464 3QJ4 FAD 5.55556
465 5LOG SAH 5.5794
466 1YKJ FAD 5.58376
467 1YKJ PHB 5.58376
468 3CBG SAH 5.60345
469 1W6U NAP 5.62914
470 1BXK NAD 5.6338
471 3LRE ADP 5.6338
472 4JDR FAD 5.64706
473 1O0S NAI 5.64706
474 1DJN ADP 5.64706
475 1NAA 6FA 5.64706
476 1NAA ABL 5.64706
477 5N6C NAD 5.66667
478 2NU8 COA 5.6701
479 1O94 ADP 5.68182
480 4Z0H NAD 5.68862
481 1VM6 NAD 5.70175
482 1LSS NAD 5.71429
483 4KQW NAP 5.71429
484 1I8T FAD 5.72207
485 1PZG A3D 5.74018
486 5E9W SAH 5.76923
487 4QTU SAM 5.76923
488 5X20 NAD 5.76923
489 1LDM NAD 5.77508
490 2Y6Q I7T 5.77889
491 2Y6Q FAD 5.77889
492 1Y8Q ATP 5.78035
493 6BWL NAD 5.79268
494 2Q1S NAI 5.83554
495 1K3T BRZ 5.84958
496 1DRV A3D 5.86081
497 2Q7V FAD 5.88235
498 3GF4 UPG 5.89744
499 3GF4 FAD 5.89744
500 1LUA NAP 5.92335
501 5EOW FAD 5.92593
502 3H5N ATP 5.94901
503 6AA8 NAD 5.96026
504 2I3G NAP 5.96591
505 1RJD SAM 5.98802
506 2OOR NAD 5.98958
507 1L7E NAI 5.98958
508 4POO SAM 6
509 5TC4 NAD 6.01266
510 3Q3C NAD 6.02007
511 1RYI GOA 6.02094
512 1RYI FAD 6.02094
513 1I36 NAP 6.06061
514 3QV1 NAD 6.09756
515 2PZE ATP 6.11354
516 1P31 EPU 6.11765
517 5HSA FAS 6.11765
518 1E3W NAD 6.13027
519 1U7T NAD 6.13027
520 1E6W NAD 6.15385
521 1F8F NAD 6.19946
522 1RM4 NDP 6.23145
523 4LWP SAH 6.25
524 5N0J FAD 6.26781
525 1WY7 SAH 6.28019
526 1UI0 URA 6.34146
527 2VVL FAD 6.35294
528 2VVM FAD 6.35294
529 5ODQ FAD 6.35294
530 1GQ2 NAP 6.35294
531 3GGO NAI 6.36943
532 3GGO ENO 6.36943
533 3LCC SAH 6.38298
534 5Z21 NAI 6.42458
535 3EVG SAH 6.54545
536 5AHO TLA 6.54762
537 5BJX UDP 6.55738
538 5BJX NAD 6.55738
539 4JK3 NAD 6.56371
540 2AHR NAP 6.56371
541 1REO FAD 6.58824
542 1MUU NAD 6.58824
543 2IID FAD 6.58824
544 2IID PHE 6.58824
545 1GTE FAD 6.58824
546 3ULK NDP 6.58824
547 1NVM NAD 6.58824
548 1EZ4 NAD 6.60377
549 1DSS NAD 6.60661
550 1R18 SAH 6.60793
551 1JNR FAD 6.66667
552 5TVA AMP 6.66667
553 1CDO NAD 6.68449
554 5WP5 SAH 6.72098
555 3RFV 15L 6.74157
556 3RFV NAI 6.74157
557 2G5C NAD 6.76157
558 1L3I SAH 6.77083
559 5A04 NDP 6.78466
560 5A04 BGC 6.78466
561 4A6D SAM 6.79887
562 5TS5 FAD 6.82353
563 1MV8 NAD 6.82353
564 4OPC PGT 6.82353
565 1SAY PYR 6.82353
566 4OPC FDA 6.82353
567 1GZ4 ATP 6.82353
568 2EV9 SKM 6.84411
569 2EV9 NAP 6.84411
570 3L4S NAD 6.84524
571 3L4S 3PG 6.84524
572 4TSK NDP 6.85714
573 3LST SAH 6.89655
574 1JJ7 ADP 6.92308
575 1C3V NDP 6.93878
576 1Q0S SAH 6.94981
577 1E6E FAD 6.95652
578 1E1M NAP 6.95652
579 1E1M FAD 6.95652
580 4XFR CIT 7.02576
581 1H82 GZZ 7.05882
582 1H82 FAD 7.05882
583 5OC1 FAD 7.05882
584 2ZWA SAH 7.05882
585 3GCZ SAM 7.0922
586 3VYW SAM 7.14286
587 4ZCC NAI 7.14286
588 4ZCC FAD 7.14286
589 5Z20 NAI 7.24638
590 1BZL FAD 7.29412
591 1BZL GCG 7.29412
592 5A1S FLC 7.29412
593 1R0X ATP 7.34266
594 6GKV SAH 7.40741
595 5EIN NAP 7.40741
596 5NM7 GLY 7.5188
597 2AQJ FAD 7.52941
598 2AQJ TRP 7.52941
599 1JAY NAP 7.54717
600 3OA2 NAD 7.54717
601 6DNT NAD 7.55814
602 2DT5 NAD 7.58294
603 3G89 SAM 7.63052
604 2VOH CIT 7.64331
605 1VI2 NAD 7.66667
606 4MP8 MLI 7.66962
607 4MP8 NAD 7.66962
608 4CNK FAD 7.67263
609 1RP0 AHZ 7.74648
610 5WP4 SAH 7.76471
611 2B4R AES 7.76471
612 2B4R NAD 7.76471
613 1LC3 NAD 7.82313
614 5F8F SFG 7.95756
615 1NPD NAD 7.98611
616 4CJX NAP 8.15047
617 5ZZ6 ADP 8.17308
618 5ZZ6 NAD 8.17308
619 1X14 NAD 8.22943
620 4YNU LGC 8.23529
621 4YNU FAD 8.23529
622 2GJP MAL 8.23529
623 3LKZ SFG 8.47059
624 5OFW 9TW 8.52018
625 1P1C SAH 8.54271
626 5JE8 NAD 8.60927
627 2FWP ICR 8.74317
628 5XNC MTA 8.89488
629 4YKG NAD 8.94118
630 4YKG FAD 8.94118
631 5UAO FAD 8.94118
632 3MB5 SAM 9.01961
633 1E3I CXF 9.04255
634 5BVA FAD 9.04645
635 3LU1 NAD 9.06593
636 3ITJ CIT 9.1716
637 3ITJ FAD 9.1716
638 1MO9 KPC 9.17647
639 1MO9 FAD 9.17647
640 5ZYN FAD 9.17647
641 5YB7 FAD 9.17647
642 5YB7 ORN 9.17647
643 3DMH SAM 9.18635
644 3DMH GMP 9.18635
645 2HNK SAH 9.20502
646 2ZFU SAH 9.30233
647 1VDC FAD 9.30931
648 1A5Z NAD 9.40439
649 1LVL NAD 9.41177
650 2YG3 FAD 9.41177
651 1LVL FAD 9.41177
652 4REP FAD 9.41177
653 1Q19 SSC 9.41177
654 2HK9 ATR 9.45455
655 2HK9 NAP 9.45455
656 4B2H C3F 9.45946
657 2Q46 NAP 9.48617
658 4BVA NDP 9.55224
659 4YSX FAD 9.61539
660 4II2 ATP 9.63855
661 5EB4 FAD 9.64706
662 1CER NAD 9.66767
663 1XCL SAH 9.78723
664 3C3Y SAH 10.5485
665 3TWO NDP 10.6322
666 4XDY NAI 10.6509
667 3KB6 NAD 10.7784
668 5W3K 9TY 10.8824
669 5W3K NDP 10.8824
670 2F5Z FAD 10.9375
671 2HQM FAD 11.0588
672 1JG3 ADN 11.0638
673 3FUU ADN 11.0701
674 2VYN NAD 11.0778
675 1G60 SAM 11.1538
676 2B56 U5P 11.2941
677 1YS4 NAP 11.2994
678 6FP4 FAD 11.5294
679 6FP4 E1T 11.5294
680 3ORF NAD 11.5538
681 1SQL GUN 11.6438
682 1TDF NAP 11.7089
683 1TDF FAD 11.7089
684 3NT6 FAD 11.7647
685 3NTA FAD 11.7647
686 2EJU SAH 11.9048
687 2YVJ NAI 11.9266
688 2YVJ FAD 11.9266
689 4JNA FAD 12.0588
690 1FL2 FAD 12.2581
691 3NTD FAD 12.4706
692 4NTC FAD 12.5373
693 5E5U MLI 12.5628
694 4J56 FAD 13.1579
695 6FDF SAH 13.1737
696 1WDK NAD 13.8462
697 1NVT NAP 13.9373
698 3AD8 NAD 14.1414
699 3AD8 PYC 14.1414
700 3AD8 FAD 14.1414
701 1LTH NAD 14.4201
702 2NPX FAD 14.5882
703 2NPX NAD 14.5882
704 2CC6 LUM 14.7059
705 6F9Q NAD 14.7059
706 6F5Z SAH 14.7541
707 4CS9 AMP 14.8148
708 5O4J PJL 14.9635
709 5O4J SAH 14.9635
710 5O4J 9KH 14.9635
711 2HYR BGC GLC 15.5738
712 2GUC MAN 15.5738
713 2NU5 NAG 15.5738
714 2GUD MAN 15.5738
715 2NUO BGC 15.5738
716 2GUD BMA 15.5738
717 2HYQ MAN MAN 15.5738
718 1RJW ETF 15.9292
719 3FPZ AHZ 15.9509
720 2WPF WPF 16
721 2WPF FAD 16
722 1F06 NDP 16.5625
723 1F06 2NP 16.5625
724 1JQ3 AAT 16.8919
725 4U8P FDA 16.9412
726 4U8P UDP 16.9412
727 3AB1 FAD 17.1765
728 1P77 ATR 17.2794
729 1PS9 FAD 17.4118
730 1PS9 NAP 17.4118
731 5YEC ATP 18.5294
732 2CDU ADP 18.5882
733 2CDU FAD 18.5882
734 5JWC FAD 18.81
735 2PWY SAH 19.3798
736 3SQP FAD 19.8745
737 4AP3 FAD 20.2353
738 4AP3 NAP 20.2353
739 4IV9 FAD 20.2353
740 3UCL NAP 20.4706
741 3UCL FAD 20.4706
742 3UCL CYH 20.4706
743 4D04 FAD 21.1765
744 4D04 NAP 21.1765
745 3F8D FAD 21.3622
746 1NM5 NAD 21.6749
747 5JCA FAD 22.3529
748 5JCA NDP 22.3529
749 3RNM FAD 22.4138
750 2A92 NAI 23.3645
751 6GAR FAD 23.4957
752 3LZW NAP 23.7952
753 3LZW FAD 23.7952
754 5TWB FAD 25
755 6GAS FAD 25.0755
756 5MIT FAD 26.6055
757 5MIT NAP 26.6055
758 2Q0L NAP 27.9743
759 2Q0L FAD 27.9743
760 2HMT NAI 29.8611
761 4UP3 NDP 30.8917
762 4UP3 FAD 30.8917
763 4USR FAD 32.133
764 4USQ FAD 33.241
765 1VQW FAD 40.7059
766 2GV8 FAD 40.7059
767 2GVC FAD 40.7059
768 2GV8 NDP 40.7059
769 2XVF FAD 48.7059
Pocket No.: 2; Query (leader) PDB : 5NMX; Ligand: NAP; Similar sites found with APoc: 62
This union binding pocket(no: 2) in the query (biounit: 5nmx.bio2) has 55 residues
No: Leader PDB Ligand Sequence Similarity
1 5MLR NAP 1.45985
2 5XLX SAH 1.77305
3 2AWN ADP 1.83727
4 2FJK 13P 1.96721
5 3B8I OXL 2.09059
6 3FSY SCA 2.10843
7 2WK1 SAH 2.12766
8 2CVQ NDP 2.14067
9 2XOC ADP 2.29885
10 3SJ7 NDP 2.38095
11 5BSZ SAH 2.4
12 1L7N ALF 2.8436
13 3QWI NAP 2.96296
14 1BGV GLU 3.05882
15 3O03 NAP 3.09278
16 1E7S NAP 3.42679
17 5K4W THR 3.42679
18 1LLU NAD 3.80117
19 2RBK VN4 3.83142
20 1N2X SAM 3.98671
21 1R37 NAD 4
22 5T2Y 753 4.0404
23 1ZH8 NAP 4.11765
24 4FUT ATP 4.37376
25 3A27 SAM 4.41176
26 2AOT SAH 4.45205
27 5E1M SAH 4.56432
28 3OU2 SAH 4.58716
29 3B9Q MLI 4.63576
30 4OBW SAM 4.66926
31 1U1I NAD 4.70588
32 1ZBQ NAD 4.70588
33 2IXB A2G 4.94118
34 1U2Z SAH 4.94118
35 3CYQ AMU 5.07246
36 6APL C5P 5.08021
37 2WSB NAD 5.11811
38 3KO8 NAD 5.12821
39 3EWK FAD 5.28634
40 1N1G BCP 5.46448
41 5EJ2 NAD 5.51948
42 1APZ ASP 5.67376
43 4GKY MAN 5.74713
44 3BGD PM6 5.76923
45 1P3D UMA 6.11765
46 2C29 NAP 6.23145
47 4J4H 1J1 6.56371
48 2FZW NAD 7.23861
49 2BD0 NAP 7.78689
50 2PZM NAD 8.48485
51 2PZM UDP 8.48485
52 6HKE MLT 8.49057
53 4ZNO SUC 9.25373
54 2HK9 SKM 9.45455
55 3JQ7 NAP 10.7639
56 3JQA NAP 10.7639
57 2F5X ASP 11.859
58 1H5Q NAP 13.2075
59 2GJ3 FAD 15
60 3D3W NAP 16.8033
61 1PR9 NAP 16.8033
62 4KXQ APR 30
Pocket No.: 3; Query (leader) PDB : 5NMX; Ligand: FAD; Similar sites found with APoc: 872
This union binding pocket(no: 3) in the query (biounit: 5nmx.bio2) has 35 residues
No: Leader PDB Ligand Sequence Similarity
1 4KRI SAH 1.17647
2 1ZGS XMM 1.17647
3 2WLT ASP 1.20482
4 3RGG AIR 1.25786
5 2D2I NAP 1.31579
6 5DF1 58X 1.3587
7 5DF1 NAP 1.3587
8 3CIF NAD 1.39276
9 3CIF G3H 1.39276
10 1WVG APR 1.39276
11 3NJ4 AFX 1.41176
12 3NJ4 NAD 1.41176
13 2YYY NAP 1.45773
14 5MLR NAP 1.45985
15 5MLR GRQ 1.45985
16 3B20 NAD 1.47493
17 3B1J NAD 1.47493
18 1SC6 NAD 1.48515
19 1J0X NAD 1.50602
20 6EL3 NAP 1.5748
21 2O4C NAD 1.57895
22 3OND ADN 1.64706
23 3OND NAD 1.64706
24 4HXY NDP 1.64706
25 3QOX SAH 1.64706
26 1Z45 NAD 1.64706
27 5THY SAH 1.7284
28 5THZ SAH 1.7284
29 5XLX SAH 1.77305
30 5C9P FUC 1.83727
31 2AWN ADP 1.83727
32 5ULP KB1 1.86567
33 2IZ1 ATR 1.88235
34 1YQZ FAD 1.88235
35 5FJN FAD 1.88235
36 1ELI PYC 1.88235
37 5FJN BE2 1.88235
38 1SQF SAM 1.88235
39 1UP7 NAD 1.91847
40 2FJK 13P 1.96721
41 5O9F 9ON 1.98864
42 5O9F NAD 1.98864
43 3A25 SAM 1.99336
44 1GY8 NAD 2.01511
45 5KOK SAH 2.01511
46 2GN4 UD1 2.03488
47 2GN4 NDP 2.03488
48 3S1S SAH 2.05011
49 4WZ6 ATP 2.06897
50 1R6D NAD 2.07715
51 1R6D DAU 2.07715
52 3B8I OXL 2.09059
53 4ZVV NAD 2.10843
54 4ZVV GN0 2.10843
55 3FSY SCA 2.10843
56 6D6Y SAH 2.11765
57 1X87 NAD 2.11765
58 5NUF NAD 2.11765
59 1RM0 NAI 2.11765
60 1RM0 D6P 2.11765
61 5NUE NAD 2.11765
62 5M58 SAH 2.17391
63 5UAV TFB 2.17391
64 5UAV NDP 2.17391
65 4G5H NAP 2.20386
66 4G5H UD7 2.20386
67 1LDN NAD 2.21519
68 3DAG FEG 2.23464
69 1HYH NAD 2.26537
70 1FP2 SAH 2.27273
71 3MAG SAH 2.28013
72 1X7D NAD 2.28571
73 1X7D ORN 2.28571
74 4DMG SAM 2.29008
75 3FXU TSU 2.29508
76 2XOC ADP 2.29885
77 5ZI2 ADP 2.31884
78 5ZI2 NAD 2.31884
79 2VT3 ATP 2.32558
80 5FTW SAH 2.34375
81 5A1T NAI 2.34604
82 5A1T OXM 2.34604
83 3NB0 G6P 2.35294
84 1UWK URO 2.35294
85 1UWK NAD 2.35294
86 3PT9 SAH 2.35294
87 5ZI9 FLC 2.35294
88 3MCT SAH 2.3569
89 2DBZ NAP 2.39521
90 5BSZ SAH 2.4
91 6BII NAP 2.4024
92 2Q1W NAD 2.4024
93 1P0F NAP 2.41287
94 4URF NAD 2.41935
95 1ZQ9 SAM 2.45614
96 3GU3 SAH 2.46479
97 2F1K NAP 2.50896
98 5LD5 NAD 2.51397
99 5KVA SAM 2.51799
100 1PL6 NAD 2.52809
101 1PL6 572 2.52809
102 2CBZ ATP 2.53165
103 4L8F MTX 2.5641
104 2YY7 NAD 2.5641
105 5H81 NAP 2.57069
106 5UR0 NAD 2.5788
107 3VPH OXM 2.58065
108 3VPH NAD 2.58065
109 6F97 FAD 2.58824
110 1QMG APX 2.58824
111 5F1V 3VN 2.58824
112 3HAD NAD 2.5974
113 5YU3 NAD 2.61628
114 5YU3 PRO 2.61628
115 2GDZ NAD 2.62172
116 3NYC IAR 2.62467
117 3NYC FAD 2.62467
118 3SSO SAH 2.6253
119 3AYI HCI 2.63523
120 3AYI FAD 2.63523
121 1O6Z