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Receptor
PDB id Resolution Class Description Source Keywords
5MZI 1.71 Å EC: 1.14.13.9 PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN WITH 3-(5-CHLORO-6-CYCLOPROPOXY-2-OXO-2,3-DIHYDRO-1,3-BENZOY L)PROPANOIC ACID PSEUDOMONAS FLUORESCENS KMO OXIDOREDUCTASE
Ref.: DEVELOPMENT OF A SERIES OF KYNURENINE 3-MONOOXYGENA INHIBITORS LEADING TO A CLINICAL CANDIDATE FOR THE OF ACUTE PANCREATITIS. J. MED. CHEM. V. 60 3383 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:506;
B:505;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
FYK A:505;
A:504;
B:504;
B:503;
A:503;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
ic50 = 3.162 nM
297.691 C13 H12 Cl N O5 c1c2c...
FAD B:501;
A:501;
Valid;
Valid;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
CL B:502;
A:502;
Invalid;
Invalid;
none;
none;
submit data
35.453 Cl [Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5MZI 1.71 Å EC: 1.14.13.9 PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN WITH 3-(5-CHLORO-6-CYCLOPROPOXY-2-OXO-2,3-DIHYDRO-1,3-BENZOY L)PROPANOIC ACID PSEUDOMONAS FLUORESCENS KMO OXIDOREDUCTASE
Ref.: DEVELOPMENT OF A SERIES OF KYNURENINE 3-MONOOXYGENA INHIBITORS LEADING TO A CLINICAL CANDIDATE FOR THE OF ACUTE PANCREATITIS. J. MED. CHEM. V. 60 3383 2017
Members (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 5Y7A - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5MZI ic50 = 3.162 nM FYK C13 H12 Cl N O5 c1c2c(cc(c....
3 5NA5 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 5NAH - 8RB C17 H16 Cl N3 O4 Cc1ccc(nn1....
5 5N7T ic50 = 6.3 nM JHY C10 H7 Cl2 N O4 c1c2c(cc(c....
6 5Y66 - 7ZR C17 H15 N3 O6 S2 COc1ccc(cc....
7 5NAE - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
8 5NAB - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
9 5NAK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
10 5X6Q - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
11 5MZC ic50 = 5.012 nM 8EQ C12 H12 Cl N O5 CCOc1cc2c(....
12 5NAG - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
13 5MZK ic50 = 251.2 uM OK1 C15 H16 Cl N O5 c1c2c(cc(c....
14 5X6P - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
70% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 5Y7A - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5MZI ic50 = 3.162 nM FYK C13 H12 Cl N O5 c1c2c(cc(c....
3 5NA5 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 5NAH - 8RB C17 H16 Cl N3 O4 Cc1ccc(nn1....
5 5N7T ic50 = 6.3 nM JHY C10 H7 Cl2 N O4 c1c2c(cc(c....
6 5Y66 - 7ZR C17 H15 N3 O6 S2 COc1ccc(cc....
7 5NAE - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
8 5NAB - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
9 5NAK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
10 5X6Q - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
11 5MZC ic50 = 5.012 nM 8EQ C12 H12 Cl N O5 CCOc1cc2c(....
12 5NAG - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
13 5MZK ic50 = 251.2 uM OK1 C15 H16 Cl N O5 c1c2c(cc(c....
14 5X6P - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 5Y7A - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
2 5MZI ic50 = 3.162 nM FYK C13 H12 Cl N O5 c1c2c(cc(c....
3 5NA5 - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 5NAH - 8RB C17 H16 Cl N3 O4 Cc1ccc(nn1....
5 5N7T ic50 = 6.3 nM JHY C10 H7 Cl2 N O4 c1c2c(cc(c....
6 5Y66 - 7ZR C17 H15 N3 O6 S2 COc1ccc(cc....
7 5NAE - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
8 5NAB - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
9 5NAK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
10 5X6Q - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
11 5MZC ic50 = 5.012 nM 8EQ C12 H12 Cl N O5 CCOc1cc2c(....
12 5NAG - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
13 5MZK ic50 = 251.2 uM OK1 C15 H16 Cl N O5 c1c2c(cc(c....
14 5X6P - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FYK; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 FYK 1 1
2 OK1 0.652778 0.918033
3 8EQ 0.647059 0.933333
4 JHY 0.603175 0.947368
5 8RK 0.567164 0.931035
6 8R8 0.535714 0.888889
Ligand no: 2; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5MZI; Ligand: FYK; Similar sites found with APoc: 1005
This union binding pocket(no: 1) in the query (biounit: 5mzi.bio2) has 59 residues
No: Leader PDB Ligand Sequence Similarity
1 1DLJ NAI 1.24378
2 1DLJ UGA 1.24378
3 1EZ4 NAD 1.25786
4 1O0S NAI 1.30152
5 4C3Y FAD 1.30152
6 1YBH P22 1.30152
7 4C3Y ANB 1.30152
8 5CX8 TG6 1.30152
9 3WQQ IB3 1.30152
10 3WQQ NDP 1.30152
11 1VKO NAD 1.30354
12 2JL1 NAP 1.39373
13 5FI3 NAP 1.40056
14 6HL7 CP 1.43678
15 2Z77 HE7 1.43885
16 5ZI2 NAD 1.44928
17 5ZI2 ADP 1.44928
18 5X62 SAH 1.47783
19 4OOE NDP 1.48515
20 1VJT NAD 1.51844
21 4C4A SAH 1.51844
22 2HQM FAD 1.51844
23 1OFL ASG GCD 1.51844
24 5GUD NDP 1.51844
25 5GUD CIT 1.51844
26 3KLJ FAD 1.55844
27 2FCU AKG 1.59744
28 1MV8 NAD 1.6055
29 1MUU NAD 1.6055
30 1D1T NAD 1.60858
31 1WVG APR 1.67131
32 1BW9 NAD 1.68539
33 1BXG NAD 1.68539
34 1C1X NAD 1.69014
35 2ZXI FAD 1.73536
36 4B63 NAP 1.73536
37 4B63 ORN 1.73536
38 4B63 FAD 1.73536
39 4MIG G3F 1.73536
40 5HSA FAS 1.73536
41 3WLE NAD 1.75953
42 1GY8 NAD 1.76322
43 5KVA SAM 1.79856
44 3F8D FAD 1.85759
45 1E3I CXF 1.8617
46 3VV1 GAL FUC 1.875
47 1F06 NDP 1.875
48 1F06 2NP 1.875
49 3OA2 NAD 1.88679
50 4JZ8 CIT 1.89274
51 4LWP SAH 1.90217
52 3SSO SAH 1.90931
53 3LU1 NAD 1.92308
54 5MPT SAH 1.93237
55 1GQ2 NAP 1.95228
56 1GZ4 ATP 1.95228
57 5DNK SAH 1.95228
58 5WP5 SAH 1.95228
59 4JDR FAD 1.95228
60 4ISS TAR 1.95228
61 5AHN IMP 1.95228
62 2VVM FAD 1.95228
63 6E1Q CFA 1.95228
64 1T9D P22 1.95228
65 2VVL FAD 1.95228
66 1FUR MLT 1.95228
67 1ZGA SAH 1.96078
68 2O07 MTA 1.97368
69 2O07 SPD 1.97368
70 1YKD CMP 2.01005
71 3TWO NDP 2.01149
72 6AM8 TRP 2.0202
73 2B4R AES 2.02899
74 2B4R NAD 2.02899
75 6DNT NAD 2.03488
76 2YYY NAP 2.04082
77 1LLU NAD 2.04678
78 3THR C2F 2.04778
79 3U31 NAD 2.06897
80 1WP4 NDP 2.07612
81 2CVZ NDP 2.07612
82 3L4S NAD 2.08333
83 3L4S 3PG 2.08333
84 4XFR CIT 2.10773
85 1J0X NAD 2.10843
86 3C3Y SAH 2.1097
87 2VYN NAD 2.1148
88 1GAD NAD 2.12121
89 1I9G SAM 2.14286
90 3TLJ SAH 2.14477
91 4EUE NAI 2.15311
92 6C4M NAP 2.1692
93 1ZK7 FAD 2.1692
94 2FR1 NDP 2.1692
95 1V8B NAD 2.1692
96 1P31 EPU 2.1692
97 1E7S NAP 2.18069
98 4FK7 P34 2.18341
99 1N1G BCP 2.18579
100 2GZ3 NAP 2.18579
101 1YQD NAP 2.18579
102 5DN9 NAD 2.1978
103 5ULP KB1 2.23881
104 3ULK NDP 2.24033
105 4L8F MTX 2.24359
106 1H5Q NAP 2.26415
107 3H5N ATP 2.26629
108 4OSP NAP 2.28137
109 5HV7 RBL 2.29358
110 5HV0 AKG 2.30415
111 5ZI9 FLC 2.30769
112 1W6U NAP 2.31788
113 5A1T NAI 2.34604
114 5A1T OXM 2.34604
115 5A04 BGC 2.35988
116 5A04 NDP 2.35988
117 3C6K MTA 2.3622
118 3C6K SPD 2.3622
119 4DSG FAD 2.38612
120 4DSG UDP 2.38612
121 1UP7 NAD 2.39808
122 4DCM SAM 2.4
123 2Q1W NAD 2.4024
124 5FEU NAP 2.4055
125 1PJS NAD 2.407
126 3EGI ADP 2.42718
127 6C4T NA7 2.44444
128 1GR0 NAD 2.45232
129 5VKT NAP 2.48619
130 1K3T BRZ 2.50696
131 5GWT NAD 2.51799
132 2B5W NAP 2.52101
133 5TC4 NAD 2.53165
134 1IGW PYR 2.53456
135 1YS4 NAP 2.54237
136 1U1I NAD 2.55102
137 1QK3 5GP 2.57511
138 2NU8 COA 2.57732
139 5T9E NAP 2.58303
140 5T9F NAP 2.58303
141 3WGT QSC 2.59366
142 3WGT FAD 2.59366
143 2V6G NAP 2.60304
144 2R4J FAD 2.60304
145 2R4J 13P 2.60304
146 2JB2 PHE 2.60304
147 2JB2 FAD 2.60304
148 1L3I SAH 2.60417
149 5XVH NAP 2.61438
150 5TWB FAD 2.61628
151 3WBF NAP 2.62295
152 3WBF API 2.62295
153 2YG3 FAD 2.64901
154 5N5D SAM 2.65487
155 4MP8 MLI 2.65487
156 4MP8 NAD 2.65487
157 5GT9 NAP 2.6616
158 1CDO NAD 2.6738
159 4GN8 ASO 2.67559
160 6CEP NAD 2.69461
161 6CEP OXM 2.69461
162 1DSS NAD 2.7027
163 4R6W SAH 2.71318
164 1CER NAD 2.71903
165 5FFF NAP 2.72374
166 1LDM NAD 2.73556
167 6BWL NAD 2.7439
168 2HMT NAI 2.77778
169 5YXC CIT 2.77778
170 2RDE C2E 2.78884
171 4D7E FAD 2.7972
172 2PK3 A2R 2.80374
173 1NJR XYL 2.8169
174 2NVK NAP 2.81996
175 2WPF FAD 2.81996
176 2WPF WPF 2.81996
177 3GD4 FAD 2.81996
178 4BV6 FAD 2.81996
179 3GD4 NAD 2.81996
180 3X0D SAH 2.81996
181 3NT6 FAD 2.81996
182 3NTA FAD 2.81996
183 5MBX FAD 2.81996
184 5MBX SP5 2.81996
185 2NVK FAD 2.81996
186 5E4R NAP 2.81996
187 5M67 3D1 2.81996
188 5M67 ADE 2.81996
189 5M67 NAD 2.81996
190 1YKF NAP 2.84091
191 2C7G FAD 2.85088
192 2C7G ODP 2.85088
193 1L7E NAI 2.86458
194 1EDO NAP 2.86885
195 2BGM NAJ 2.8777
196 3ZNN FAD 2.88184
197 3ZNN 4WL 2.88184
198 5KKA 6V0 2.88462
199 5IFK HPA 2.88462
200 1UXG NAD 2.91262
201 1UXG FUM 2.91262
202 1P0F NAP 2.94906
203 1KNR FAD 2.96296
204 5AOV NAP 2.97619
205 1XCL SAH 2.97872
206 2GSD NAD 2.98507
207 5FA5 MTA 2.99728
208 4POO SAM 3
209 3FZG SAM 3
210 5BJX UDP 3.00546
211 5BJX NAD 3.00546
212 4Q9N NAI 3.02013
213 2PZM NAD 3.0303
214 2PZM UDP 3.0303
215 2HK9 ATR 3.03688
216 2IZ1 ATR 3.03688
217 2HK9 NAP 3.03688
218 1MO9 KPC 3.03688
219 1MO9 FAD 3.03688
220 6GAR FAD 3.03688
221 1OBB NAD 3.03688
222 4HA6 FAD 3.03688
223 4YNU LGC 3.03688
224 4YNU FAD 3.03688
225 4W6Z 8ID 3.03688
226 1ZBQ NAD 3.0581
227 1U7T NAD 3.06513
228 5Z21 NAI 3.07263
229 1HKU NAD 3.07263
230 2Q7V FAD 3.07692
231 1G60 SAM 3.07692
232 1F8G NAD 3.125
233 5HJM MTA 3.125
234 1NW5 SAM 3.1348
235 1ZQ9 SAM 3.15789
236 2YVF FAD 3.18627
237 2YVF NAD 3.18627
238 4NPL AKG 3.2
239 3NJ4 NAD 3.21839
240 5U5N NAD 3.22581
241 4Y24 TD2 3.24675
242 5EJ2 NAD 3.24675
243 1BDB NAD 3.2491
244 4Z24 FAD 3.2538
245 3CGB FAD 3.2538
246 4MOP 2H5 3.2538
247 1H82 GZZ 3.2538
248 1H82 FAD 3.2538
249 4DMG SAM 3.2538
250 3X0V FAD 3.2538
251 5UAO FAD 3.2538
252 4AP3 FAD 3.2538
253 4AP3 NAP 3.2538
254 4YKG FAD 3.26296
255 4YKG NAD 3.26296
256 5Z2L NDP 3.26531
257 1PR9 NAP 3.27869
258 3D3W NAP 3.27869
259 1RPN NDP 3.28358
260 9LDT NAD 3.31325
261 9LDB NAD 3.31325
262 2VFT SOR 3.31754
263 4CNK FAD 3.32481
264 5JCM FAD 3.32594
265 5JCM ISD 3.32594
266 5JCM NAD 3.32594
267 3QWI NAP 3.33333
268 3CIF NAD 3.34262
269 3CIF G3H 3.34262
270 4HXY NDP 3.42466
271 4TSK NDP 3.42857
272 5DX8 SFG 3.4384
273 5DWQ SFG 3.4384
274 5DX0 SFG 3.4384
275 5DX1 SFG 3.4384
276 2OOR NAD 3.44828
277 1GZ6 NAI 3.44828
278 5KMS FAD 3.45679
279 5KMS NAD 3.45679
280 1R37 NAD 3.45821
281 3V1U NAD 3.4632
282 4RQU NAD 3.46667
283 1Z45 NAD 3.47072
284 2Q1S NAI 3.47072
285 5TTJ FAD 3.47072
286 1YP4 ADP 3.47072
287 3S1S SAH 3.47072
288 1NPD NAD 3.47222
289 2AHR NAP 3.4749
290 3OJO NAD 3.48028
291 4PIV NDP 3.48485
292 3OID NDP 3.48837
293 1P1C SAH 3.51759
294 5YEC ATP 3.52941
295 3MB5 SAM 3.52941
296 4L8V NAP 3.56083
297 3VYW SAM 3.57143
298 4NTC FAD 3.58209
299 3MAG SAH 3.58306
300 4Z0H NAD 3.59281
301 4NBU NAI 3.6
302 5BSH PRO 3.61011
303 4TM3 FAD 3.61174
304 3LZW FAD 3.61446
305 5NUF NAD 3.61446
306 3LZW NAP 3.61446
307 5NUE NAD 3.61446
308 1O5I NAD 3.61446
309 5L4L NAP 3.61842
310 1W8D NAP 3.64238
311 1W73 NAP 3.64238
312 1B8U NAD 3.64742
313 5Z75 NAD 3.66972
314 3DMH SAM 3.67454
315 3DMH GMP 3.67454
316 6F9Q NAD 3.67647
317 5I39 FAD 3.67647
318 2BRY FAD 3.68764
319 1V6A TRE 3.68764
320 3CGD FAD 3.68764
321 1PS9 NAP 3.68764
322 3CGD COA 3.68764
323 4TXI FAD 3.68764
324 3CGD NAD 3.68764
325 5J5Z FAD 3.68764
326 5EB4 FAD 3.68764
327 1PS9 FAD 3.68764
328 2WET FAD 3.68764
329 1COY AND 3.68764
330 1COY FAD 3.68764
331 4XYB NDP 3.68764
332 1ON3 DXX 3.68764
333 3MCT SAH 3.7037
334 2AGC MYR 3.7037
335 3GFB NAD 3.71429
336 1X7D NAD 3.71429
337 1X7D ORN 3.71429
338 1JQ3 AAT 3.71622
339 3A06 NDP 3.7234
340 3A06 FOM 3.7234
341 5UAV NDP 3.72671
342 5UAV TFB 3.72671
343 6GNC FAD 3.7415
344 3RFV 15L 3.74532
345 3RFV NAI 3.74532
346 3VSE SAH 3.76884
347 3O03 NAP 3.78007
348 4XDZ NDP 3.79009
349 2DT5 NAD 3.79147
350 4YAG NAI 3.80623
351 1U8X NAD 3.81356
352 6GNA FAD 3.81944
353 3QRC SCR 3.82166
354 4JNA FAD 3.82353
355 2FWP ICR 3.82514
356 2FWP CIT 3.82514
357 5EZ7 FAD 3.82653
358 2IXB NAD 3.82883
359 5ZZ6 ADP 3.84615
360 5ZZ6 NAD 3.84615
361 2YY7 NAD 3.84615
362 4XDY NAI 3.84615
363 1GUZ NAD 3.87097
364 1GV0 NAD 3.87097
365 1RP0 AHZ 3.87324
366 1NV8 MEQ 3.87324
367 1NV8 SAM 3.87324
368 4USR FAD 3.87812
369 3CBG SAH 3.87931
370 1YQZ FAD 3.88128
371 2WW4 ADP 3.88693
372 4USI AKG 3.8961
373 5KVS NAP 3.8961
374 5MQ6 NDP 3.90456
375 2E5V FAD 3.90456
376 6H3O FAD 3.90456
377 3LAD FAD 3.90456
378 4AT0 FAD 3.90456
379 1GPE FAD 3.90456
380 3Q9T FAY 3.90456
381 1GEG NAD 3.90625
382 1EBF NAD 3.91061
383 2GLX NDP 3.91566
384 4Y9D NAI 3.93443
385 3SJU NDP 3.94265
386 1VM6 NAD 3.94737
387 5THY SAH 3.95062
388 5THZ SAH 3.95062
389 5JE8 NAD 3.97351
390 2CDU ADP 3.9823
391 2CDU FAD 3.9823
392 1VI2 NAD 4
393 1E5Q NDP 4
394 6C4N NAP 4.00891
395 1ORR NAD 4.03458
396 1TB4 PEJ 4.04313
397 3H9E NAD 4.04624
398 5K4W NAI 4.04984
399 5K4W THR 4.04984
400 3QH2 3NM 4.0724
401 4YCA NDP 4.08163
402 1KYQ NAD 4.12148
403 2JHP SAH 4.12148
404 5U8U FAD 4.12148
405 4REP FAD 4.12148
406 6ER9 FAD 4.12148
407 6ER9 NAP 4.12148
408 2XVE FAD 4.12148
409 3UCL NAP 4.12148
410 3UCL CYH 4.12148
411 3UCL FAD 4.12148
412 3UOY NAP 4.12148
413 3UOY FAD 4.12148
414 1UWK URO 4.12148
415 1UWK NAD 4.12148
416 2XVF FAD 4.12148
417 3WV8 ATP 4.12844
418 5FAG PPI 4.14634
419 4RDH AMP 4.16667
420 4RDI ATP 4.16667
421 5NA1 FAD 4.16667
422 2YX1 SFG 4.16667
423 2D5A COA 4.16667
424 1H2B NAJ 4.17827
425 2VT3 ATP 4.18605
426 2DBZ NAP 4.19162
427 1ZEM NAD 4.19847
428 1GET NAP 4.22222
429 1GET FAD 4.22222
430 2VHW NAI 4.24403
431 1DIG NAP 4.24837
432 2NPX NAD 4.25056
433 2NPX FAD 4.25056
434 4R5M NAP 4.25532
435 4R5M 4NO 4.25532
436 4OBW SAM 4.28016
437 5ZJ5 NAI 4.32099
438 1XTP SAI 4.33071
439 4TQG NDP 4.33437
440 1SC6 NAD 4.33839
441 5ERG SAM 4.33839
442 1GTE FAD 4.33839
443 6F97 FAD 4.33839
444 2V7Y ADP 4.33839
445 4D79 ATP 4.34783
446 4PYA 2X3 4.34783
447 5YU3 PRO 4.36047
448 5YU3 NAD 4.36047
449 1LVL NAD 4.36681
450 1LVL FAD 4.36681
451 4YAC NAI 4.3771
452 3QJ4 FAD 4.38596
453 3WV6 GAL BGC 4.39189
454 1V59 NAD 4.39331
455 1V59 FAD 4.39331
456 2D6M LBT 4.40252
457 3A27 SAM 4.41176
458 5A96 GTP 4.41767
459 2EWM NAD 4.41767
460 4OIT MAN 4.42478
461 4OIT BMA 4.42478
462 4QTU SAM 4.44444
463 4LC1 GDP 4.45104
464 4FZV SAM 4.45682
465 6EL3 NAP 4.46194
466 4XB2 NDP 4.47761
467 4XB2 HSE 4.47761
468 3OYW TDG 4.47761
469 3B1F NAD 4.48276
470 3WG3 A2G GAL NAG FUC 4.49438
471 6DUB SAH 4.5045
472 1Q7B NAP 4.5082
473 5NM7 GLY 4.51128
474 3VPH NAD 4.51613
475 3VPH OXM 4.51613
476 4XZ3 COA 4.52586
477 1UAY ADN 4.54545
478 4IMO PWZ 4.54545
479 3S5W NAP 4.55531
480 4YRY FAD 4.55531
481 4YRY NAD 4.55531
482 5FXD H7Y 4.55531
483 3S5W FAD 4.55531
484 3ETG NDP 4.55531
485 3ETG GLU 4.55531
486 2AG8 NAP 4.56274
487 6F3M NAD 4.56522
488 5TPV TYD 4.57516
489 5X9D 80F 4.60526
490 4J56 FAD 4.62107
491 1ELI PYC 4.62725
492 5L53 NAP 4.62963
493 1I8T FAD 4.63215
494 2AF6 BRU 4.65116
495 3ABI NAD 4.65753
496 1JNR FAD 4.66667
497 4NBW NAD 4.66926
498 4NTD FAD 4.70588
499 3AB1 FAD 4.72222
500 3G5S FAD 4.74041
501 1JA9 NDP 4.74453
502 5Y8L NAD 4.74576
503 5Y8L HUI 4.74576
504 3V1Y NAD 4.74777
505 3SBZ MLI 4.7619
506 4K5S PM0 4.77223
507 4K5S FAD 4.77223
508 4J1Q NDP 4.77223
509 5YB7 ORN 4.77223
510 5YB7 FAD 4.77223
511 4D04 NAP 4.77223
512 4D04 FAD 4.77223
513 5JJR SAH 4.77223
514 4UP3 NDP 4.77707
515 4UP3 FAD 4.77707
516 3ORF NAD 4.78088
517 4IAW LIZ 4.78723
518 3T31 DCQ 4.80549
519 3T31 FAD 4.80549
520 6GAS FAD 4.83384
521 1PZG A3D 4.83384
522 4KRI SAH 4.84988
523 3NUG NAD 4.8583
524 1Q1R FAD 4.87239
525 2HJR APR 4.87805
526 3AXB PRO 4.91071
527 3AXB FAD 4.91071
528 2JJQ SAH 4.94118
529 3HVJ 705 4.97738
530 1E3W NAD 4.98084
531 3C1O NAP 4.98442
532 1F3L SAH 4.98442
533 1OMO NAD 4.98915
534 2AQJ FAD 4.98915
535 2AQJ TRP 4.98915
536 1SAY PYR 4.98915
537 6D6Y SAH 4.98915
538 1U1J MET 4.98915
539 1LSS NAD 5
540 2O4C NAD 5
541 3SAO DBH 5
542 1E6W NAD 5
543 1A5Z NAD 5.01567
544 2HNK SAH 5.02092
545 6AIN FAD 5.02392
546 1KOL NAD 5.02513
547 3WMX NAD 5.02793
548 3ITJ CIT 5.02959
549 3ITJ FAD 5.02959
550 2ZIF SAM 5.05051
551 4GC1 MAN MAN 5.07246
552 3L9W AMP 5.08475
553 3L9W GSH 5.08475
554 2NAD NAD 5.08906
555 6FOF LAT 5.10204
556 4HIA FMN 5.11364
557 4ZRN NAD 5.12821
558 4ZRN UPG 5.12821
559 5UR0 NAD 5.15759
560 1FL2 FAD 5.16129
561 3RNM FAD 5.17241
562 5NMX NAP 5.17647
563 5NMX FAD 5.17647
564 2CFC NAD 5.2
565 3QFA FAD 5.20607
566 1BXK NAD 5.20607
567 1QMG APX 5.20607
568 6FP4 E1T 5.20607
569 6FP4 FAD 5.20607
570 4O0L NDP 5.20607
571 3I7V B4P 5.22388
572 3NYC FAD 5.24934
573 3NYC IAR 5.24934
574 4RPL FAD 5.26316
575 4RPL 3UC 5.26316
576 4USQ FAD 5.26316
577 2JAH NDP 5.26316
578 2JAP NDP 5.26316
579 3K7M FAD 5.33643
580 3RKR NAP 5.34351
581 1DL5 SAH 5.36278
582 5K8S CMP 5.40541
583 4NBT NAD 5.41667
584 3QVP FAD 5.42299
585 1FEC FAD 5.42299
586 4FFG LBS 5.42299
587 6F7L FAD 5.42299
588 1LJ8 NAD 5.42299
589 2PWY SAH 5.42636
590 2CDC XYP 5.46448
591 2CDC XYS 5.46448
592 2CDC NAP 5.46448
593 1AE1 NAP 5.49451
594 5OCM NAP 5.49828
595 1HYH NAD 5.50162
596 4G5H UD7 5.50964
597 5GSN NAP 5.51876
598 5GSN FAD 5.51876
599 5GSN MMZ 5.51876
600 1J5P NAD 5.5336
601 3HDY FDA 5.54156
602 3HDY FAD 5.54156
603 3HDY GDU 5.54156
604 5ZYN FAD 5.63991
605 5OC1 FAD 5.63991
606 4LED XXR 5.63991
607 6BQ6 TER 5.63991
608 3CTY FAD 5.64263
609 4URF NAD 5.64516
610 4ZCC FAD 5.65476
611 4ZCC NAI 5.65476
612 1F8F NAD 5.66038
613 5EES NAP 5.66802
614 3Q3C NAD 5.68562
615 2VDV SAM 5.69106
616 5H9P TD2 5.6962
617 4ZGS NAD 5.69948
618 5FJN FAD 5.70175
619 5FJN BE2 5.70175
620 1VDC FAD 5.70571
621 5ODQ FAD 5.71429
622 6A0S HSE 5.72289
623 6A0S NDP 5.72289
624 2GUD MAN 5.7377
625 2GUC MAN 5.7377
626 2GUD BMA 5.7377
627 4OPC PGT 5.73951
628 4OPC FDA 5.73951
629 4PLT NAI 5.74018
630 4PLT OXM 5.74018
631 1HYE NAP 5.7508
632 2GCG NDP 5.75758
633 2DFV NAD 5.76369
634 1C0I BE2 5.78512
635 1C0I FAD 5.78512
636 4JK3 NAD 5.79151
637 4J4H NAI 5.79151
638 4J4H 1J1 5.79151
639 3AYI HCI 5.82524
640 3AYI FAD 5.82524
641 3FPZ AHZ 5.82822
642 5F2T PLM 5.84416
643 1Y8Q ATP 5.85683
644 1REO FAD 5.85683
645 2DKH 3HB 5.85683
646 2DKH FAD 5.85683
647 1QO8 FAD 5.85683
648 4MDH NAD 5.85683
649 5MDH NAD 5.85683
650 5THQ NDP 5.88235
651 2X6T NAP 5.88235
652 1WDK NAD 5.89744
653 1PL6 NAD 5.89888
654 1PL6 572 5.89888
655 3B12 FAH 5.92105
656 1LUA NAP 5.92335
657 5WUW NAP 5.92335
658 1KPH SAH 5.92335
659 1RM4 NDP 5.93472
660 4B4U NAP 5.94059
661 1YJQ NAP 5.94059
662 1Z82 NDP 5.97015
663 1HGX 5GP 6.01093
664 4II2 ATP 6.0241
665 3G89 SAM 6.0241
666 2XVM SAH 6.03015
667 5K0A FAD 6.06061
668 2IID PHE 6.07375
669 2IID FAD 6.07375
670 1NAA ABL 6.07375
671 5G3U FDA 6.07375
672 5G3U ITW 6.07375
673 1NAA 6FA 6.07375
674 3QV1 NAD 6.09756
675 5U5G NAP 6.1017
676 1AUX AGS 6.10932
677 1J1R ADE 6.13027
678 1HDR NAD 6.14754
679 5AYV NAP 6.14887
680 5AYV KPL 6.14887
681 1ZH8 NAP 6.17647
682 5ZBC FAD 6.20843
683 6AR9 3L4 6.25
684 4EIP FAD 6.29067
685 4EIP K2C 6.29067
686 5VN0 FAD 6.29067
687 5VN0 NAI 6.29067
688 4U8P UDP 6.29067
689 4U8P FDA 6.29067
690 5TS5 FAD 6.29067
691 1KGI T4A 6.29921
692 4KOA NDP 6.30631
693 5JCA NDP 6.33803
694 5JCA FAD 6.33803
695 4EMI NAD 6.34146
696 4EMI FAD 6.34146
697 2DC1 NAD 6.35593
698 1IY8 NAD 6.36704
699 1KJ1 MAN 6.42202
700 3K5I AIR 6.45161
701 2EV9 SKM 6.46388
702 2EV9 NAP 6.46388
703 1X14 NAD 6.48379
704 4MCC 21X 6.50407
705 2AOT SAH 6.50685
706 1NM5 NAD 6.50759
707 5JWC FAD 6.50759
708 5N0J FAD 6.50759
709 4NRT 2NG 6.50759
710 6A3J NAI 6.50759
711 4GLL NAD 6.50759
712 3G5N PB2 6.50759
713 6A3J SOE 6.50759
714 1RYI GOA 6.5445
715 1RYI FAD 6.5445
716 1QAN SAH 6.55738
717 3KB6 NAD 6.58683
718 3H4V NAP 6.59722
719 5BVA FAD 6.60147
720 3KIF GDL 6.60377
721 3BAZ NAP 6.60661
722 4M37 SAH 6.70554
723 4M38 SAH 6.70554
724 1SOW NAD 6.70732
725 5WGR FAD 6.72451
726 1YY5 FAD 6.72451
727 1RSG FAD 6.72451
728 1DCP HBI 6.73077
729 5GZ6 NDP 6.74847
730 5GZ6 7C3 6.74847
731 1EQ2 NAP 6.77419
732 3GRU AMP 6.77966
733 1KEV NDP 6.83761
734 1J49 NAD 6.90691
735 1LDN NAD 6.96203
736 4DPL NAP 6.96379
737 4E5N NAD 6.9697
738 5YRF GLC GLC 7.04225
739 1BZL GCG 7.15835
740 1BZL FAD 7.15835
741 1LC3 NAD 7.15835
742 6FDF SAH 7.18563
743 4RSL FAD 7.19101
744 1I36 NAP 7.19697
745 1EJ0 SAM 7.22222
746 3DAG FEG 7.26257
747 2YVJ NAI 7.33945
748 2YVJ FAD 7.33945
749 1C3V NDP 7.34694
750 2D2I NAP 7.36842
751 1WG8 SAM 7.36842
752 4CS9 AMP 7.40741
753 2ZHL NAG GAL GAL NAG 7.43243
754 1X87 NAD 7.44102
755 3T7S SAM 7.46269
756 4YT4 FE9 7.46667
757 4EMJ FAD 7.47664
758 3LKZ SFG 7.47664
759 3NKS FAD 7.59219
760 1Q9I TEO 7.59219
761 1Q9I FAD 7.59219
762 4MO2 FAD 7.6087
763 4MO2 FDA 7.6087
764 6AA8 NAD 7.61589
765 5JAQ NAI 7.63547
766 1VQW FAD 7.65864
767 5G6U TRP 7.66284
768 2RGJ FAD 7.71144
769 5H81 NAP 7.71208
770 2B9W FAD 7.78302
771 1IM8 SAI 7.78689
772 1OYJ GSH 7.79221
773 5LD5 NAD 7.80911
774 5L2R MLA 7.80911
775 2GV8 NDP 7.82998
776 2GV8 FAD 7.82998
777 2GVC FAD 7.82998
778 4X9M FAD 7.89474
779 1TDF FAD 7.91139
780 1TDF NAP 7.91139
781 2EJU SAH 7.93651
782 3JQA NAP 7.98611
783 5JDI NAP 7.98611
784 3JQF NAP 7.98611
785 3BMQ NAP 7.98611
786 3BMO NAP 7.98611
787 4CMI NAP 7.98611
788 5JCJ NAP 7.98611
789 4CM4 NAP 7.98611
790 3JQ9 NAP 7.98611
791 5JDC NAP 7.98611
792 5K6A NAP 7.98611
793 4CM8 NAP 7.98611
794 4CLR NAP 7.98611
795 3BMN NAP 7.98611
796 3JQG NAP 7.98611
797 4CM9 NAP 7.98611
798 3JQB NAP 7.98611
799 3JQ8 NAP 7.98611
800 3JQ7 NAP 7.98611
801 4CME NAP 7.98611
802 4CLO NAP 7.98611
803 1C1L GAL BGC 8.0292
804 5CAE COA 8.10127
805 5CAE SIN 8.10127
806 5D4V SAH 8.20895
807 1FWV SGA MAG FUC 8.20895
808 4NTO 1PW 8.21256
809 1VL0 NAI 8.21918
810 3B20 NAD 8.25959
811 1NVM NAD 8.33333
812 4WVW SLT 8.33333
813 6FLZ MMA 8.33333
814 1NVT NAP 8.36237
815 2PXX SAH 8.37209
816 3H2B SAH 8.37438
817 5G4L NDP 8.39161
818 6BII NAP 8.40841
819 2A92 NAI 8.41121
820 1DRV A3D 8.42491
821 3P2E SAH 8.44444
822 2IVD FAD 8.45987
823 1JAY NAP 8.49057
824 1Q0S SAH 8.49421
825 4ITU NAI 8.55019
826 2WD7 NAP 8.58209
827 5N2I NAP 8.62069
828 5AHO TLA 8.63095
829 3ICT ADP 8.67679
830 3ICS ADP 8.67679
831 3ICS FAD 8.67679
832 3ICR FAD 8.67679
833 3ICT FAD 8.67679
834 3AD8 NAD 8.67679
835 4XQC NAD 8.67679
836 4XQC 13D 8.67679
837 2JBH 5GP 8.67679
838 3AD8 FAD 8.67679
839 3AD8 PYC 8.67679
840 2Q46 NAP 8.69565
841 3DXY SAM 8.7156
842 5OJL TXP 8.72483
843 1P77 ATR 8.82353
844 1NYT NAP 8.85609
845 5MIT NAP 8.8685
846 5MIT FAD 8.8685
847 5ZW3 SAH 8.88889
848 5XNC MTA 8.89488
849 2RGO FAD 8.89621
850 1CF2 NAP 8.90208
851 5JSP DQY 8.95522
852 4YSX FAD 8.97436
853 5J7X FAD 9.11063
854 4FWE FAD 9.17085
855 4BVA NDP 9.25373
856 4BVA T3 9.25373
857 2RGH FAD 9.28196
858 1XG5 NAP 9.319
859 1ULE GLA GAL NAG 9.33333
860 1FK8 NAD 9.33852
861 5NBW 8SK 9.34579
862 2F5Z FAD 9.375
863 5OVK NDP 9.375
864 5NII FAD 9.38511
865 4GUT FAD 9.40722
866 4GUS FAD 9.40722
867 4HSU FAD 9.40722
868 3NV3 GAL NAG MAN 9.42029
869 3SJ7 NDP 9.52381
870 6FTB M0E 9.52381
871 3GGO ENO 9.55414
872 3GGO NAI 9.55414
873 5Z20 NAI 9.56522
874 4YMH SAH 9.58333
875 3FG2 FAD 9.65347
876 1TH8 ADP 9.65517
877 4M52 M52 9.65665
878 4M52 FAD 9.65665
879 2A8X FAD 9.69828
880 3SQP FAD 9.76139
881 2CVQ NDP 9.78593
882 1D4D FAD 9.79021
883 3ICC NAP 9.80392
884 3A4T SFG 9.85401
885 5GLT BGC GAL NAG GAL 9.85915
886 4D3F NAP 10
887 2XRH NIO 10
888 1H4H XYP XYS XYP 10.0478
889 3GEG NAD 10.1215
890 3NGL NAP 10.1449
891 3GDN HBX 10.1952
892 4IV9 FAD 10.1952
893 3GDN FAD 10.1952
894 1W55 GPP 10.2426
895 4GKV NAD 10.4167
896 1E1M FAD 10.4348
897 1E1M NAP 10.4348
898 1E6E FAD 10.4348
899 3A25 SAM 10.6312
900 2G5C NAD 10.6762
901 4OM8 NAD 10.6796
902 6D61 4AA 10.7692
903 1RO7 CSF 10.8108
904 3NTD FAD 10.846
905 1XHC FAD 10.8992
906 5H9Q TD2 10.9677
907 3FPF MTA 11.0738
908 3FPF TNA 11.0738
909 5BW4 SAM 11.236
910 5N53 8NB 11.2821
911 2QL9 CIT 11.3402
912 2I3G NAP 11.3636
913 3G2O SAM 11.3712
914 4IF4 BEF 11.5385
915 6BYF CIT 11.7647
916 3GF4 UPG 11.7949
917 3GF4 FAD 11.7949
918 1IS3 LAT 11.8519
919 4XUC SAM 11.9266
920 4XUC 43G 11.9266
921 3LXD FAD 11.9306
922 2RAB NAD 12.1475
923 2RAB FAD 12.1475
924 1MAI I3P 12.2137
925 2Q0L NAP 12.2186
926 2Q0L FAD 12.2186
927 5EVY SAL 12.5571
928 5EVY FAD 12.5571
929 5DG2 GAL GLC 12.5926
930 3ZXE PGZ 12.782
931 1KJ8 GAR 12.7877
932 5BRT CH9 12.7986
933 5BRT FAD 12.7986
934 5J60 FAD 12.8125
935 4FN4 NAD 12.9921
936 2GAG NAD 13.1313
937 2GAG FOA 13.1313
938 2GAG FAD 13.1313
939 2PT9 S4M 13.3956
940 2PT9 2MH 13.3956
941 2C29 NAP 13.6499
942 4E13 NAD 13.7809
943 4CQM NAP 13.7931
944 2XYQ SAH 13.9344
945 4JJF FE9 14.2442
946 4JJF N2I 14.2442
947 5N26 CPT 14.2857
948 4PLG NAI 14.3713
949 4PLG OXM 14.3713
950 4CJX NAP 14.4201
951 5E9W SAH 14.4231
952 5X20 NAD 15.0641
953 2I7C AAT 15.1943
954 2YMZ LAT 15.3846
955 3H8V ATP 15.411
956 1A78 TDG 15.6716
957 1N5S ADL 16.0714
958 5L95 AMP 16.129
959 2F1K NAP 16.129
960 5BUK FAD 16.2222
961 5N6C NAD 16.3333
962 1HDG NAD 16.5663
963 1LTH NAD 16.6144
964 5EIN NAP 16.6667
965 5O4J PJL 16.7883
966 5O4J SAH 16.7883
967 5O4J 9KH 16.7883
968 2CUL FAD 16.8103
969 2QA1 FAD 16.9197
970 2GMH FAD 17.5705
971 1T26 NAI 17.7019
972 1T26 GBD 17.7019
973 3OZ2 FAD 18.3879
974 3FUU ADN 18.8192
975 1O94 ADP 19.9566
976 1DJN ADP 19.9566
977 2PV7 NAD 20.4698
978 2BOS GLA GAL GLC NBU 20.5882
979 2BOS GLA GAL GLC 20.5882
980 1O6Z NAD 20.7921
981 2VOH CIT 23.0769
982 1WPQ NAD 25.2149
983 2Z3Y F2N 26.6811
984 3E1T FAD 27.7657
985 5KOX RFP 31.0195
986 5KOX FAD 31.0195
987 1PN0 IPH 31.4534
988 1PN0 FAD 31.4534
989 3B1J NAD 32