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Receptor
PDB id Resolution Class Description Source Keywords
5M51 1.9 Å EC: 2.7.11.1 NEK2 BOUND TO ARYLAMINOPURINE COMPOUND 8 HOMO SAPIENS PROTEIN KINASE INHIBITOR CENTROSOME SEPARATION TRANSFERASINHIBITOR COMPLEX
Ref.: STRUCTURE-GUIDED DESIGN OF PURINE-BASED PROBES FOR NEK2 INHIBITION. ONCOTARGET V. 8 19089 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NU6 A:301;
Valid;
none;
ic50 = 19 uM
366.417 C19 H22 N6 O2 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4A4X 2.4 Å EC: 2.7.11.1 NEK2-EDE BOUND TO CCT248662 HOMO SAPIENS TRANSFERASE PROTEIN KINASE MITOSIS
Ref.: DESIGN OF POTENT AND SELECTIVE HYBRID INHIBITORS OF MITOTIC KINASE NEK2: STRUCTURE-ACTIVITY RELATIONSHI STRUCTURAL BIOLOGY, AND CELLULAR ACTIVITY. J.MED.CHEM. V. 55 3228 2012
Members (22)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 5M51 ic50 = 19 uM NU6 C19 H22 N6 O2 c1cc(cc(c1....
2 2XKD ic50 = 2.3 uM T3M C20 H19 N3 O5 COc1cc(cc(....
3 2XNO ic50 = 6.57 uM ED8 C26 H25 F3 N4 O3 S CN1CCC(CC1....
4 2W5B - SAP C10 H16 N5 O12 P3 S c1nc(c2c(n....
5 5M57 ic50 = 12 uM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
6 4A4X ic50 = 0.059 uM JUP C28 H27 F3 N4 O2 S C[C@H](c1c....
7 2XK4 ic50 = 16.9 uM OL2 C22 H23 N3 O6 CCOc1cc(cc....
8 2XKC ic50 = 2.6 uM 4VQ C21 H21 N3 O5 Cc1cc(ccc1....
9 2XK3 - XK3 C17 H21 N3 O2 S CCc1ccsc1c....
10 2XNP ic50 = 0.66 uM WCX C29 H29 F3 N4 O3 C[C@H](c1c....
11 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
12 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
13 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
14 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
15 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
16 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
17 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
18 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
19 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
20 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
21 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
22 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
70% Homology Family (22)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 5M51 ic50 = 19 uM NU6 C19 H22 N6 O2 c1cc(cc(c1....
2 2XKD ic50 = 2.3 uM T3M C20 H19 N3 O5 COc1cc(cc(....
3 2XNO ic50 = 6.57 uM ED8 C26 H25 F3 N4 O3 S CN1CCC(CC1....
4 2W5B - SAP C10 H16 N5 O12 P3 S c1nc(c2c(n....
5 5M57 ic50 = 12 uM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
6 4A4X ic50 = 0.059 uM JUP C28 H27 F3 N4 O2 S C[C@H](c1c....
7 2XK4 ic50 = 16.9 uM OL2 C22 H23 N3 O6 CCOc1cc(cc....
8 2XKC ic50 = 2.6 uM 4VQ C21 H21 N3 O5 Cc1cc(ccc1....
9 2XK3 - XK3 C17 H21 N3 O2 S CCc1ccsc1c....
10 2XNP ic50 = 0.66 uM WCX C29 H29 F3 N4 O3 C[C@H](c1c....
11 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
12 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
13 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
14 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
15 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
16 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
17 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
18 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
19 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
20 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
21 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
22 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
50% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 5M51 ic50 = 19 uM NU6 C19 H22 N6 O2 c1cc(cc(c1....
2 2XKD ic50 = 2.3 uM T3M C20 H19 N3 O5 COc1cc(cc(....
3 2XNO ic50 = 6.57 uM ED8 C26 H25 F3 N4 O3 S CN1CCC(CC1....
4 2W5B - SAP C10 H16 N5 O12 P3 S c1nc(c2c(n....
5 5M57 ic50 = 12 uM 4SP C18 H22 N6 O3 S c1cc(ccc1N....
6 4A4X ic50 = 0.059 uM JUP C28 H27 F3 N4 O2 S C[C@H](c1c....
7 2XK4 ic50 = 16.9 uM OL2 C22 H23 N3 O6 CCOc1cc(cc....
8 2XKC ic50 = 2.6 uM 4VQ C21 H21 N3 O5 Cc1cc(ccc1....
9 2XK3 - XK3 C17 H21 N3 O2 S CCc1ccsc1c....
10 2XNP ic50 = 0.66 uM WCX C29 H29 F3 N4 O3 C[C@H](c1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: NU6; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 NU6 1 1
2 N41 0.738095 1
3 N76 0.727273 0.702703
4 4SP 0.633333 0.702703
5 N20 0.632184 0.927273
6 NU5 0.523364 0.653846
7 CMG 0.505882 0.943396
8 7GJ 0.5 0.822581
9 6CP 0.441176 0.844828
10 2A6 0.4 0.907407
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4A4X; Ligand: JUP; Similar sites found with APoc: 436
This union binding pocket(no: 1) in the query (biounit: 4a4x.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
1 3KIF GDL None
2 6F7X MFU None
3 3FSY SCA 1.43369
4 3PDT ADP 1.45455
5 1RTF BEN 1.5873
6 4PZ6 GMP 1.79211
7 3T1A 5MA 1.79211
8 6GVZ CHO 1.79211
9 4NFE BEN 2.1097
10 4ZS4 ATP 2.15054
11 5MW8 ATP 2.15054
12 2PYW ADP 2.15054
13 3S6X SIA GAL BGC 2.15054
14 2YW2 ATP 2.15054
15 3VOT ADP 2.50896
16 3W0O ADP 2.50896
17 3W0O HY0 2.50896
18 2HGS ADP 2.50896
19 4FE2 ADP 2.7451
20 5V3D FCN 2.75862
21 4GYI ADP 2.86738
22 1IA9 ANP 2.86738
23 2CFM AMP 2.86738
24 4U98 ACP 2.86738
25 3V4S ATP 2.86738
26 5VLQ ANP 2.86738
27 6FL8 ADP 2.86738
28 6FL8 TIY 2.86738
29 3V4S ADP 2.86738
30 5W0N UPU 2.97767
31 6D61 4AA 3.07692
32 3UDZ ADP 3.22581
33 5EQY 5RA 3.22581
34 2QK4 ATP 3.22581
35 5C1P ADP 3.22581
36 3ETH ATP 3.22581
37 1IHU AF3 3.22581
38 2XN3 ID8 3.22581
39 1Z03 OCH 3.22581
40 1IHU ADP 3.22581
41 3PAK MAN 3.37838
42 2F7A BEZ 3.44828
43 3SCH TB6 3.53535
44 3X01 AMP 3.58423
45 3WVR AMP 3.58423
46 1U6R ADP 3.58423
47 1U6R IOM 3.58423
48 5A04 BGC 3.58423
49 3JQ3 ADP 3.58423
50 1S68 AMP 3.61446
51 4B1L FRU 3.63636
52 1WW5 SGA BGC 3.75
53 2D6M LBT 3.77358
54 2GQR ADP 3.79747
55 2GQS ADP 3.79747
56 4CC6 L5Y 3.94265
57 5DZT AMP 3.94265
58 3IAA TYD 3.94265
59 2YRX AMP 3.94265
60 5EXK 5AD 3.94265
61 5OM2 DXT 3.94265
62 4OCJ NDG 3.94265
63 4UWH JXM 3.94265
64 3RSC TYD 3.94265
65 4XGX ADP 3.94265
66 4EN4 GT1 3.94265
67 4EN4 ATP 3.94265
68 4N7C AEF 3.97727
69 2PNZ 5GP 4.01606
70 5LXB 7A9 4.13223
71 4K7O EKZ 4.16667
72 2DT9 THR 4.19162
73 1NBU PH2 4.20168
74 1EHI ADP 4.24403
75 5OCQ CIT 4.30108
76 1I7L ATP 4.30108
77 3ORQ ADP 4.30108
78 3TII ANP 4.30108
79 5IM3 DTP 4.30108
80 2PUZ NIG 4.30108
81 1O68 KIV 4.36364
82 1S9D AFB 4.4335
83 1I06 TZL 4.44444
84 5NC1 NAG 4.64135
85 4IV9 TSR 4.6595
86 5ZCT ANP 4.6595
87 1M0W ANP 4.6595
88 3K5I ADP 4.6595
89 5I35 ANP 4.6595
90 4GLW 0XT 4.6595
91 1Q8A HCS 4.6595
92 4WW7 AMP 4.81283
93 2EB5 OXL 4.86891
94 1Q6I FK5 4.91071
95 4QPW XYP XYP XYP 4.92958
96 1A0J BEN 4.93274
97 2IF8 ADP 5.01792
98 5GZ9 ANP 5.01792
99 1IZC PYR 5.01792
100 1KC7 PPR 5.01792
101 3BOF HCS 5.01792
102 5IH1 GDP 5.01792
103 2JKG PRO PRO PRO PRO PRO PRO PRO PRO 5.02793
104 2QX0 PH2 5.03145
105 3PCJ INO 5.04202
106 3AB4 THR 5.05618
107 2DTJ THR 5.05618
108 1KDK DHT 5.08475
109 1IS3 LAT 5.18518
110 2CBT TH2 5.35714
111 3VPD ANP 5.37634
112 4RDL FUC GAL NDG FUC 5.37634
113 1VBH PEP 5.37634
114 5TDF ADP 5.37634
115 3OKP GDD 5.37634
116 2IO8 ADP 5.37634
117 1KJ1 MAN 5.50459
118 1FUT 2GP 5.66038
119 3PN1 IVH 5.73477
120 2VPQ ANP 5.73477
121 2BMB PMM 5.73477
122 1VRP IOM 5.73477
123 4OCV ANP 5.73477
124 5EO8 TFU 5.73477
125 6GW4 CHO 5.73477
126 5LXT ACP 5.73477
127 1VRP ADP 5.73477
128 2XOC ADP 5.74713
129 3ZW0 FUC 5.74713
130 3ZW2 NAG GAL FUC 5.74713
131 3ZW2 GAL FUC 5.74713
132 1J3R 6PG 5.78947
133 1GSA ADP 6.09319
134 1OIJ AKG 6.09319
135 2FB3 MET 6.09319
136 2XZ9 PYR 6.09319
137 3TY5 ATP 6.09319
138 3ZS7 ATP 6.09319
139 4UDK NDG 6.09319
140 5O0J 8BR 6.09319
141 3ZGJ RMN 6.09319
142 2FB3 5AD 6.09319
143 5VZ0 ADP 6.09319
144 3MN5 LAB 6.09319
145 4UDG NDG 6.09319
146 1ZTH ADP 6.20155
147 1ZP9 ATP 6.20155
148 2RIF AMP 6.38298
149 2GC0 PAN 6.38298
150 3VPC ADP 6.45161
151 1OFZ FUL 6.45161
152 1OFZ FUC 6.45161
153 2BKK ADP 6.50888
154 4CPB GAL CN8 6.61157
155 1QXA GLY GLY GLY 6.80851
156 3I0O ADP 6.81004
157 1OBD ATP 6.81004
158 1E4E ADP 6.81004
159 1C1X HFA 6.81004
160 5FCF GLY GLY GLY 6.81004
161 1BW9 PPY 6.81004
162 1T36 ADP 6.81004
163 1C1D PHE 6.81004
164 2YMZ LAT 6.92308
165 2YKL NLD 7.07547
166 3VPB ADP 7.14286
167 3VPB GLU 7.14286
168 5AE9 OKO 7.16846
169 4DFU QUE 7.16846
170 5C4L 4XR 7.16846
171 5C4L SIS 7.16846
172 4M44 SIA GAL NAG GAL 7.16846
173 1DKU AP2 7.16846
174 5XLS URA 7.16846
175 6EZ6 C5Z 7.16846
176 3DGY 2GP 7.2165
177 1TZD ADP 7.27273
178 5K2M ADP 7.32601
179 4LI4 AMP 7.35294
180 1P6O HPY 7.45342
181 1A78 TDG 7.46269
182 2PUL ACP 7.52688
183 4D52 GXL 7.52688
184 4D4U FUC GAL NAG 7.52688
185 3TDV GDP 7.52688
186 1T9D PYD 7.52688
187 1W2D ADP 7.54717
188 1TQP ATP 7.8853
189 1MXG ACR 7.8853
190 3A76 SPD 7.95455
191 6C1S EFV 8.24373
192 5T7I LAT NAG GAL 8.3871
193 4R78 AMP 8.41424
194 5MRH Q9Z 8.60215
195 3NV3 GAL NAG MAN 8.69565
196 5COU ATP 8.96057
197 1CKM GTP 8.96057
198 5KBF CMP 8.96057
199 3CF6 SP1 8.98204
200 4Z4P SAH 9.03614
201 4JOB TLA 9.319
202 1RDS GPC 9.52381
203 4Q5H ANP 9.61539
204 3BP1 GUN 9.67742
205 4QM9 CYS 9.82659
206 5OES ADP 10.0358
207 4CS9 AMP 10.0529
208 2VQD AP2 10.3943
209 3M3E GAL A2G NPO 10.559
210 6E8I PTR 10.6509
211 4XZ3 ACP 10.8696
212 4XYM A12 10.8696
213 1CBK ROI 11.25
214 4NZN 2OU 11.4695
215 4NZN ANP 11.4695
216 4CSD MFU 11.7647
217 2V58 LZJ 11.828
218 3ZJX BOG 11.828
219 4CYI ATP 11.8721
220 5A96 GTP 12.0482
221 2BS5 BGC GAL FUC 12.2222
222 4BQS ADP 12.5
223 5MY8 RXZ 12.5448
224 3EZ2 ADP 12.9032
225 2CSN CKI 13.2616
226 3HAV ATP 13.2616
227 1QKQ MAN 13.3803
228 1RGE 2GP 13.5417
229 1AUX AGS 13.6201
230 1PK8 ATP 13.6201
231 4FFG LBS 13.6201
232 5YK1 ANP 13.9785
233 4LH7 1X8 14.3369
234 4AZW ATP 14.3369
235 5B09 4MX 14.4231
236 4OAV ACP 15.0538
237 4O1P ANP 15.4122
238 2QLU ADE 15.4122
239 5X8I SQZ 15.7706
240 6G33 5ID 15.7706
241 5OKT 9XK 16.129
242 4KBA 1QM 16.129
243 4XMF HSM 16.3043
244 6EOM ALA LYS 16.4875
245 5OLK DTP 18.2796
246 6A1G 9OL 18.638
247 4XH0 ADP 21.5054
248 6CGD GNP 23.6559
249 6CGD AKN 23.6559
250 3PP0 03Q 24.3728
251 3VHE 42Q 25.8065
252 4PNI KQQ 26.1649
253 4L9I 8PR 26.1649
254 5ML3 DL3 26.1745
255 1VJY 460 26.5233
256 6ES0 BW8 26.5233
257 5C03 AGS 26.8817
258 4WOV 3SM 27.2401
259 3H9R TAK 27.2401
260 4IX4 ADP 28.3154
261 4CRL C1I 30.466
262 3KMW ATP 31.7343
263 3GNI ATP 33.3333
264 4E1Z 0MX 33.3333
265 4GJ3 0XP 33.3333
266 3LXN MI1 33.3333
267 5CKW ANP 33.3333
268 6GIN IR2 33.6918
269 5T8O 76Z 33.6918
270 2WU6 DKI 34.0502
271 3UIM ANP 34.0502
272 5Y86 HRM 34.0502
273 4IZY 1J2 34.4086
274 3PLS ANP 34.4086
275 3E7O 35F 34.4086
276 3TTI KBI 34.767
277 4WHZ 3NL 34.767
278 4UX9 ANP 35.1254
279 4Y85 499 35.1254
280 5WNL STU 35.4839
281 5CEO 50D 35.4839
282 3PTG 932 35.4839
283 5AWM ANP 35.4839
284 5QIN J2V 36.2007
285 6GWR FEW 36.2007
286 1XJD STU 36.2007
287 5JKG 6LF 36.2007
288 3GC0 AMP 36.2007
289 4CLI 5P8 36.5591
290 2XVD AS6 36.5591
291 3LXK MI1 36.5591
292 5EKO N17 36.5591
293 1O9U ADZ 36.5591
294 3ZRM ZRM 36.9176
295 3F7Z 34O 36.9176
296 5ZTN CUR 36.9176
297 5EOB 5QQ 36.9906
298 4NM5 ADP 37.276
299 3TXO 07U 37.276
300 5WO4 B7V 37.276
301 2JLD AG1 37.276
302 3BZ3 YAM 37.3188
303 4BCN T9N 37.6344
304 6FYV 3NG 37.6344
305 6C7Y ADP 37.6344
306 1V0O INR 37.6344
307 5LMK 6ZK 37.6344
308 2XMY CDK 37.6344
309 5TO8 7FM 37.6344
310 2BPM 529 37.6344
311 4BCM T7Z 37.9928
312 4CFU 2WC 37.9928
313 4BCQ TJF 37.9928
314 6FYL 3NG 37.9928
315 5DBX ANP 37.9928
316 5LI1 ANP 37.9928
317 1CM8 ANP 37.9928
318 5LI9 ACP 37.9928
319 4DC2 ADE 37.9928
320 5LPZ ADP 38.3513
321 5LPB ADP 38.3513
322 6GUE FB8 38.3513
323 4FL3 ANP 38.3513
324 4YZC STU 38.3513
325 3LQV ADE 38.4615
326 1U5R ATP 38.7097
327 2ZV2 609 38.7097
328 6CZ3 FLJ 39.0152
329 4H3P ANP 39.0681
330 3RI1 3RH 39.0681
331 4K33 ACP 39.0681
332 4H3Q ANP 39.0681
333 5BVE 4VG 39.0681
334 3GQI ACP 39.4265
335 4QTB 38Z 39.4265
336 1UNH IXM 39.7849
337 3O0G 3O0 39.7849
338 3GC8 B45 39.7849
339 5NKB 8ZT 39.7849
340 4IDT T28 39.7849
341 3C1X CKK 39.7849
342 6C0T EE4 39.7849
343 5UR1 YY9 39.7849
344 4AU8 Z3R 40.1434
345 4OTH DRN 40.1434
346 4YMJ 4EJ 40.5018
347 4FF8 14S 40.5018
348 1Y57 MPZ 40.8602
349 5U6C 7YS 40.8602
350 2H8H H8H 40.8602
351 5MJA 7O3 40.8602
352 1OUK 084 40.8602
353 2F2U M77 40.8602
354 5HES 032 40.8602
355 3G5D 1N1 40.8602
356 4LOO SB4 40.8602
357 2Y6O 1N1 41.2186
358 5KO1 6UY 41.2186
359 4AUA 4AU 41.2186
360 4E93 GUI 41.2186
361 5JFS 6K0 41.2186
362 1U59 STU 41.2186
363 2B9H ADP 41.5771
364 2B9I ADP 41.5771
365 3SLS ANP 41.5771
366 2B9F ADP 41.5771
367 2B9J ADP 41.5771
368 1JPA ANP 41.9355
369 5EFQ ADP 41.9355
370 4NST ADP 41.9355
371 3VRY B43 41.9355
372 1OPK P16 41.9355
373 4WNK 453 41.9355
374 6E2O S0L 41.9355
375 4RFM 3P6 42.1053
376 4EWH T77 42.1818
377 4BHN BH9 42.2939
378 3E8N ATP 42.2939
379 3E8N VRA 42.2939
380 3KRL KRL 42.6523
381 4AT3 LTI 42.6523
382 4BTK DTQ 42.6523
383 1K3A ACP 43.0108
384 2PVF ACP 43.0108
385 2HK5 1BM 43.3333
386 3BU5 ATP 43.3692
387 1IR3 ANP 43.3692
388 3NW7 LGV 43.3692
389 3EKK GS2 43.7276
390 5HCY 60D 43.7276
391 4TWP AXI 43.9114
392 4CSV STI 44
393 4P5Z Q7M 44.086
394 4UXL 5P8 44.086
395 2X2M X2M 44.086
396 6GQM F8H 44.086
397 5UKL SIX 44.086
398 4U0I 0LI 44.086
399 3PVW QRX 44.086
400 2OO8 RAJ 44.086
401 3SRV S19 44.4043
402 2OFV 242 44.4043
403 1BYG STU 44.4444
404 6GU6 1QK 44.4444
405 5HQ0 LZ9 44.4444
406 5JGA 6KC 44.4444
407 4Y93 746 44.8029
408 4F4P 0SB 45.0549
409 5USZ SKE 45.1613
410 4WB6 ATP 45.1613
411 4WB7 ATP 45.5197
412 5H2U 1N1 45.8781
413 2F57 23D 46.2366
414 6CMJ F6J 46.2366
415 3IDB ANP 46.2366
416 2QCS ANP 46.2366
417 3FHI ANP 46.2366
418 2GU8 796 46.2366
419 1RE8 BD2 46.2366
420 5VC5 96M 46.595
421 4AG8 AXI 46.595
422 4ASE AV9 46.595
423 3ALN ANP 46.595
424 2VZ6 FEF 46.9534
425 5TA6 79D 47.3118
426 3FC2 IBI 47.3118
427 4QMN DB8 47.3118
428 5FBN 5WF 47.6015
429 3HMO STU 47.6702
430 2VN9 GVD 47.6702
431 2WEL K88 47.6702
432 5N87 N66 48.0287
433 2V7O DRN 48.3871
434 3SXS PP2 48.5075
435 4FG8 ATP 49.4624
436 4ONA UW1 49.8208
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