Receptor
PDB id Resolution Class Description Source Keywords
5LXM 2.08 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF AURORA-A BOUND TO A HYDROCARBON-STAPLED PROTEOMIMETIC OF TPX2 HOMO SAPIENS PROTEIN KINASE PROTEOMIMETIC STAPLED HELIX PEPTIDE MITOSITRANSFERASE
Ref.: A TPX2 PROTEOMIMETIC HAS ENHANCED AFFINITY FOR AURO TO HYDROCARBON STAPLING OF A HELIX. ACS CHEM. BIOL. V. 11 3383 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MES A:506;
Invalid;
none;
submit data
195.237 C6 H13 N O4 S C1COC...
MG A:510;
A:509;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
SO4 A:503;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
NH3 D:101;
Invalid;
none;
submit data
17.031 H3 N N
PEG A:504;
A:505;
Invalid;
Invalid;
none;
none;
submit data
106.12 C4 H10 O3 C(COC...
ADP A:501;
Valid;
none;
submit data
427.201 C10 H15 N5 O10 P2 c1nc(...
CL A:508;
Invalid;
none;
submit data
35.453 Cl [Cl-]
P4G A:507;
Invalid;
none;
submit data
162.227 C8 H18 O3 CCOCC...
PG4 A:502;
Invalid;
none;
submit data
194.226 C8 H18 O5 C(COC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LXM 2.08 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF AURORA-A BOUND TO A HYDROCARBON-STAPLED PROTEOMIMETIC OF TPX2 HOMO SAPIENS PROTEIN KINASE PROTEOMIMETIC STAPLED HELIX PEPTIDE MITOSITRANSFERASE
Ref.: A TPX2 PROTEOMIMETIC HAS ENHANCED AFFINITY FOR AURO TO HYDROCARBON STAPLING OF A HELIX. ACS CHEM. BIOL. V. 11 3383 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 5LXM - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 3E5A Ki = 5.9 nM VX6 C23 H28 N8 O S Cc1cc([nH]....
2 1OL5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
3 3HA6 ic50 = 2.1 uM 2JZ C28 H26 F N7 O2 COc1ccc(cc....
4 5LXM - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 3E5A Ki = 5.9 nM VX6 C23 H28 N8 O S Cc1cc([nH]....
2 1OL5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
3 3HA6 ic50 = 2.1 uM 2JZ C28 H26 F N7 O2 COc1ccc(cc....
4 5LXM - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ADP; Similar ligands found: 435
No: Ligand ECFP6 Tc MDL keys Tc
1 ADP 1 1
2 ATP 0.9 1
3 A2D 0.895522 0.971831
4 AQP 0.887324 1
5 5FA 0.887324 1
6 AP5 0.884058 0.971831
7 B4P 0.884058 0.971831
8 BA3 0.869565 0.971831
9 AN2 0.84507 0.985915
10 M33 0.833333 0.958333
11 ACQ 0.826667 0.972222
12 A 0.823529 0.971429
13 AMP 0.823529 0.971429
14 ACP 0.821918 0.972222
15 AR6 0.810811 0.971831
16 APR 0.810811 0.971831
17 ANP 0.802632 0.972222
18 AD9 0.8 0.972222
19 AGS 0.8 0.945946
20 SAP 0.8 0.945946
21 ADX 0.783784 0.873418
22 CA0 0.783784 0.945205
23 TAT 0.779221 0.958904
24 AMP MG 0.774648 0.891892
25 50T 0.773333 0.958333
26 ABM 0.763889 0.917808
27 APC 0.763158 0.958904
28 PRX 0.763158 0.893333
29 ATF 0.759494 0.958904
30 A22 0.753086 0.985915
31 A12 0.743243 0.958904
32 AP2 0.743243 0.958904
33 ADP MG 0.736842 0.905405
34 SRA 0.736111 0.918919
35 ADQ 0.73494 0.945205
36 25L 0.732558 0.985915
37 ADP BEF 0.727273 0.881579
38 BEF ADP 0.727273 0.881579
39 5AL 0.725 0.931507
40 2A5 0.717949 0.918919
41 A1R 0.714286 0.907895
42 AU1 0.714286 0.972222
43 ADP PO3 0.708861 0.943662
44 PAP 0.708861 0.985714
45 ATR 0.708861 0.971429
46 SRP 0.707317 0.906667
47 7D3 0.706667 0.905405
48 25A 0.702381 0.971831
49 ATP MG 0.7 0.905405
50 OAD 0.697674 0.945205
51 RBY 0.6875 0.932432
52 ADV 0.6875 0.932432
53 00A 0.686047 0.883117
54 5SV 0.682353 0.848101
55 8QN 0.682353 0.931507
56 OOB 0.682353 0.931507
57 3OD 0.681818 0.945205
58 BIS 0.681818 0.933333
59 ADP ALF 0.674699 0.87013
60 ALF ADP 0.674699 0.87013
61 AMO 0.674419 0.932432
62 4AD 0.674419 0.92
63 PAJ 0.674419 0.884615
64 GAP 0.670732 0.893333
65 MAP 0.670588 0.945946
66 DLL 0.666667 0.931507
67 ANP MG 0.666667 0.894737
68 VO4 ADP 0.666667 0.931507
69 AHX 0.666667 0.896104
70 ADP VO4 0.666667 0.931507
71 PTJ 0.662921 0.896104
72 3UK 0.659091 0.918919
73 SON 0.658228 0.932432
74 LAD 0.651685 0.860759
75 WAQ 0.651685 0.883117
76 PR8 0.651685 0.85
77 ITT 0.65 0.943662
78 7D4 0.65 0.905405
79 G5P 0.648936 0.921053
80 RAB 0.647059 0.84507
81 ADN 0.647059 0.84507
82 XYA 0.647059 0.84507
83 TXA 0.644444 0.932432
84 1ZZ 0.644444 0.839506
85 ME8 0.644444 0.839506
86 NB8 0.644444 0.896104
87 FYA 0.644444 0.905405
88 6AD 0.642857 0.909091
89 ADP BMA 0.640449 0.918919
90 G3A 0.638298 0.921053
91 DAL AMP 0.632184 0.905405
92 AFH 0.631579 0.884615
93 9SN 0.630435 0.871795
94 GTA 0.625 0.886076
95 YAP 0.623656 0.894737
96 FA5 0.623656 0.906667
97 UP5 0.622449 0.92
98 XAH 0.617021 0.839506
99 AV2 0.616279 0.917808
100 AOC 0.615385 0.821918
101 48N 0.612245 0.896104
102 4UV 0.610526 0.894737
103 TXD 0.606061 0.907895
104 DND 0.606061 0.932432
105 NAX 0.606061 0.873418
106 NXX 0.606061 0.932432
107 NAI 0.606061 0.907895
108 6V0 0.606061 0.896104
109 5N5 0.605634 0.819444
110 5AS 0.604938 0.77907
111 A4P 0.60396 0.843373
112 DAT 0.60241 0.905405
113 A2R 0.602273 0.985915
114 TXE 0.6 0.907895
115 OMR 0.6 0.851852
116 4UU 0.597938 0.894737
117 A A 0.597826 0.944444
118 A4D 0.597222 0.819444
119 5CD 0.597222 0.805556
120 AP0 0.594059 0.896104
121 4TC 0.594059 0.896104
122 A3P 0.592593 0.971429
123 139 0.592233 0.873418
124 T5A 0.592233 0.841463
125 7D5 0.592105 0.878378
126 ATP A A A 0.589474 0.930556
127 LAQ 0.585859 0.839506
128 MYR AMP 0.585106 0.817073
129 YLP 0.58 0.819277
130 UPA 0.578431 0.907895
131 7DD 0.578313 0.985714
132 ADJ 0.576923 0.851852
133 3AM 0.576923 0.929577
134 COD 0.575472 0.811765
135 NAD 0.575472 0.931507
136 3AT 0.574713 0.971831
137 JB6 0.574468 0.883117
138 4UW 0.574257 0.860759
139 EP4 0.573333 0.753247
140 A2P 0.573171 0.957143
141 CNA 0.571429 0.932432
142 TYM 0.568627 0.906667
143 PPS 0.568182 0.873418
144 TYR AMP 0.56701 0.881579
145 DTA 0.565789 0.786667
146 M2T 0.565789 0.734177
147 AR6 AR6 0.565657 0.917808
148 A3D 0.564815 0.918919
149 3DH 0.564103 0.773333
150 G5A 0.563218 0.77907
151 YLB 0.563107 0.819277
152 YLC 0.563107 0.839506
153 AMP DBH 0.561224 0.893333
154 MTA 0.558442 0.773333
155 DTP 0.556818 0.905405
156 AHZ 0.554455 0.817073
157 NA7 0.553191 0.958904
158 IOT 0.552381 0.831325
159 7MD 0.55 0.8625
160 ZAS 0.55 0.766234
161 IMO 0.548781 0.929577
162 YLA 0.54717 0.819277
163 NAE 0.544643 0.894737
164 TAD 0.544554 0.884615
165 A5A 0.544444 0.807229
166 2AM 0.544304 0.943662
167 TSB 0.543478 0.819277
168 6RE 0.54321 0.759494
169 AYB 0.542056 0.809524
170 NAQ 0.539823 0.871795
171 V3L 0.539326 0.971831
172 ARG AMP 0.539216 0.829268
173 AF3 ADP 3PG 0.538462 0.8375
174 SSA 0.538462 0.8
175 LA8 ALF 3PG 0.538462 0.8375
176 ALF ADP 3PG 0.538462 0.8375
177 ZID 0.535088 0.918919
178 LPA AMP 0.533981 0.817073
179 54H 0.532609 0.788235
180 52H 0.532609 0.77907
181 VMS 0.532609 0.788235
182 BTX 0.53211 0.841463
183 J7C 0.53012 0.769231
184 A3N 0.53012 0.786667
185 5X8 0.528736 0.763158
186 BT5 0.527273 0.831325
187 5CA 0.526882 0.8
188 53H 0.526882 0.77907
189 ARU 0.526316 0.860759
190 EAD 0.525862 0.873418
191 RGT 0.525253 0.958904
192 OVE 0.52439 0.905405
193 S4M 0.52381 0.666667
194 7DT 0.522727 0.985714
195 GDP 0.522222 0.92
196 DDS 0.522222 0.878378
197 AVV 0.521277 0.896104
198 NDE 0.521008 0.932432
199 7MC 0.518868 0.841463
200 DSH 0.518072 0.725
201 MAO 0.517647 0.759036
202 LSS 0.515789 0.761364
203 DSZ 0.515789 0.8
204 NSS 0.515789 0.8
205 P5A 0.515464 0.744444
206 DZD 0.513514 0.884615
207 NVA LMS 0.510417 0.761364
208 12D 0.509615 0.785714
209 NAD IBO 0.509091 0.87013
210 M24 0.508772 0.85
211 YLY 0.508772 0.809524
212 P1H 0.508333 0.851852
213 5AD 0.506849 0.746479
214 GJV 0.505882 0.75
215 LEU LMS 0.505155 0.761364
216 G A A A 0.504505 0.871795
217 4TA 0.504505 0.807229
218 NAJ PZO 0.504425 0.848101
219 KAA 0.5 0.752809
220 NDC 0.5 0.871795
221 7D7 0.5 0.743243
222 71V 0.5 0.907895
223 A3G 0.5 0.8
224 128 0.5 0.776471
225 GSU 0.5 0.77907
226 N0B 0.495726 0.819277
227 NJP 0.495495 0.945946
228 ODP 0.495495 0.909091
229 2SA 0.494624 0.932432
230 6C6 0.494505 0.881579
231 SFG 0.494382 0.75
232 0WD 0.491071 0.921053
233 YSA 0.490196 0.77907
234 PO4 PO4 A A A A PO4 0.489796 0.902778
235 6IA 0.48913 0.8375
236 SAM 0.48913 0.690476
237 A7D 0.488636 0.776316
238 6FA 0.488 0.841463
239 FB0 0.487805 0.804598
240 NAJ PYZ 0.487179 0.85
241 IDP 0.483516 0.918919
242 A5D 0.483516 0.786667
243 SA8 0.483516 0.707317
244 MHZ 0.483146 0.697674
245 PGS 0.483146 0.883117
246 D5M 0.482353 0.878378
247 DA 0.482353 0.878378
248 NEC 0.482353 0.746667
249 NIA 0.481928 0.822785
250 Y3J 0.480519 0.726027
251 FAD 0.480315 0.851852
252 FAS 0.480315 0.851852
253 FDA 0.48 0.833333
254 N6P 0.479592 0.915493
255 GGZ 0.479167 0.825
256 SAH 0.478261 0.74359
257 SAI 0.478261 0.734177
258 NPW 0.477477 0.886076
259 NDP 0.477477 0.921053
260 AAM 0.476744 0.971429
261 AMZ 0.47561 0.916667
262 C2R 0.47561 0.90411
263 A A A 0.474747 0.905405
264 GTP 0.473684 0.92
265 U A G G 0.473684 0.883117
266 SMM 0.473684 0.686047
267 TXP 0.473214 0.921053
268 NZQ 0.473214 0.909091
269 A3S 0.47191 0.810811
270 AMP NAD 0.470588 0.881579
271 SFD 0.46875 0.734043
272 AIR 0.468354 0.901408
273 AAT 0.468085 0.707317
274 EEM 0.468085 0.690476
275 Z5A 0.466667 0.77907
276 7C5 0.466667 0.818182
277 J7V 0.466667 0.833333
278 62F 0.465649 0.8625
279 FAY 0.462121 0.8625
280 ETB 0.461538 0.833333
281 DCA 0.461538 0.823529
282 A3T 0.461538 0.821918
283 A6D 0.46 0.722892
284 A U 0.459459 0.87013
285 6K6 0.459184 0.930556
286 GEK 0.459184 0.7375
287 RFL 0.458647 0.821429
288 S7M 0.458333 0.690476
289 NAP 0.458333 0.945205
290 4YB 0.457944 0.761364
291 WSA 0.454545 0.788235
292 TAP 0.454545 0.907895
293 FNK 0.454545 0.804598
294 COA 0.453782 0.823529
295 0T1 0.453782 0.823529
296 101 0.453488 0.878378
297 XNP 0.452174 0.873418
298 NA0 0.45082 0.932432
299 7RP 0.448276 0.928571
300 GP3 0.446809 0.921053
301 TM1 0.446602 0.77381
302 APU 0.446429 0.894737
303 PUA 0.445378 0.884615
304 V1N 0.443396 0.917808
305 7RA 0.443182 0.957747
306 30N 0.442623 0.752688
307 CAO 0.442623 0.795455
308 AMX 0.442623 0.833333
309 COS 0.442623 0.804598
310 ACK 0.44186 0.861111
311 QQY 0.44186 0.815789
312 649 0.441441 0.744444
313 0UM 0.44 0.698795
314 NHD 0.439655 0.905405
315 CMX 0.439024 0.823529
316 SCO 0.439024 0.823529
317 GCP 0.438776 0.896104
318 8BR 0.438202 0.906667
319 GNH 0.4375 0.907895
320 3AD 0.4375 0.805556
321 62X 0.435644 0.666667
322 ACO 0.435484 0.795455
323 FCX 0.435484 0.795455
324 FAM 0.435484 0.804598
325 GNP 0.434343 0.896104
326 NMX 0.433071 0.76087
327 MGP 0.43299 0.884615
328 PLP AAD 0.432203 0.741573
329 26A 0.432099 0.763158
330 HAX 0.432 0.804598
331 K15 0.431373 0.682353
332 DG1 0.430894 0.921053
333 1DG 0.430894 0.921053
334 QQX 0.430233 0.805195
335 2VA 0.430108 0.8
336 S8M 0.43 0.759494
337 2MC 0.429688 0.769231
338 3KK 0.428571 0.804598
339 6G0 0.428571 0.884615
340 FYN 0.428571 0.823529
341 P5F 0.428571 0.823529
342 NAD BBN 0.428571 0.841463
343 U G A 0.427481 0.839506
344 AS 0.426966 0.833333
345 FAI 0.426966 0.916667
346 RMB 0.426966 0.873239
347 1RB 0.425287 0.885714
348 MCD 0.425197 0.804598
349 OXK 0.425197 0.804598
350 COK 0.425197 0.804598
351 CA6 0.425197 0.729167
352 SOP 0.425197 0.804598
353 G1R 0.424242 0.907895
354 CC5 0.423077 0.816901
355 SXZ 0.423077 0.710843
356 F2N 0.422535 0.813953
357 NAD CJ3 0.422222 0.811765
358 ANZ 0.422018 0.8
359 CMC 0.421875 0.804598
360 CO6 0.421875 0.804598
361 1VU 0.421875 0.795455
362 ZDA 0.421053 0.864865
363 GDD 0.420561 0.884615
364 GKE 0.420561 0.884615
365 GDC 0.420561 0.884615
366 NFD 0.420168 0.883117
367 GSP 0.42 0.873418
368 D3Y 0.42 0.789474
369 MC4 0.419847 0.76087
370 3L1 0.419753 0.773333
371 3D1 0.419753 0.773333
372 FA9 0.41958 0.864198
373 5GP 0.419355 0.906667
374 G 0.419355 0.906667
375 KB1 0.419048 0.698795
376 SCD 0.418605 0.823529
377 CAJ 0.418605 0.804598
378 2BA 0.417582 0.915493
379 CMP 0.417582 0.901408
380 SO8 0.416667 0.789474
381 N01 0.416667 0.905405
382 VRT 0.416667 0.769231
383 3HC 0.415385 0.813953
384 A1S 0.415385 0.804598
385 BCO 0.415385 0.804598
386 IVC 0.415385 0.813953
387 MLC 0.415385 0.804598
388 1HE 0.415385 0.786517
389 NMN AMP PO4 0.415254 0.87013
390 2FA 0.414634 0.813333
391 MGO 0.414141 0.860759
392 3NZ 0.413462 0.782051
393 MCA 0.412214 0.795455
394 CAA 0.412214 0.813953
395 YE1 0.412214 0.813953
396 COO 0.412214 0.804598
397 GAV 0.411765 0.884615
398 P2P 0.411111 0.902778
399 JLN 0.411111 0.890411
400 ZZB 0.410256 0.77381
401 CNV FAD 0.410072 0.793103
402 SCA 0.409091 0.804598
403 RP1 0.409091 0.842105
404 103 0.409091 0.837838
405 2CP 0.409091 0.795455
406 SP1 0.409091 0.842105
407 PAX 0.408 0.829268
408 FAD NBT 0.407143 0.75
409 NVA 2AD 0.40625 0.74359
410 COW 0.406015 0.795455
411 BYC 0.406015 0.804598
412 2KQ 0.406015 0.786517
413 COF 0.406015 0.786517
414 3CP 0.406015 0.804598
415 IRC 0.406015 0.813953
416 1GZ 0.406015 0.795455
417 HGG 0.406015 0.804598
418 CA8 0.406015 0.729167
419 G2P 0.405941 0.884615
420 SLU 0.404959 0.770115
421 U A C C 0.404959 0.858974
422 RBZ 0.404494 0.849315
423 1CZ 0.404412 0.795455
424 BCA 0.402985 0.795455
425 FAQ 0.402985 0.804598
426 4CA 0.402985 0.795455
427 MTP 0.402439 0.730769
428 8OD 0.402062 0.945205
429 CO7 0.401515 0.804598
430 DAL FAD PER 0.401408 0.809524
431 G2R 0.4 0.884615
432 HXC 0.4 0.786517
433 ENQ 0.4 0.916667
434 GMV 0.4 0.896104
435 GRA 0.4 0.804598
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LXM; Ligand: ADP; Similar sites found: 255
This union binding pocket(no: 1) in the query (biounit: 5lxm.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3ORQ ADP 0.004709 0.41688 None
2 3KAL ADP 0.004351 0.43517 1.41343
3 4FE2 ADP 0.003734 0.42377 1.96078
4 5EK3 5PK 0.01516 0.40343 2.12014
5 3VPB ADP 0.0002704 0.48097 2.12766
6 3VPC ADP 0.0008903 0.41875 2.12766
7 3W68 4PT 0.01999 0.40615 2.25564
8 1ZP9 ATP 0.00007439 0.49654 2.32558
9 1ZTH ADP 0.00003153 0.48742 2.32558
10 4B1L FRU 0.001852 0.46158 2.42424
11 2VPQ ANP 0.0007425 0.45709 2.4735
12 3ZJX BOG 0.0125 0.4147 2.4735
13 5C1P DAL DAL 0.007762 0.41371 2.4735
14 5C1P ADP 0.00262 0.41316 2.4735
15 2DKN NAI 0.01833 0.4018 2.7451
16 1I7L ATP 0.002109 0.43815 2.82686
17 3K5I ADP 0.001886 0.43484 2.82686
18 3K5I AIR 0.007542 0.42258 2.82686
19 2VQD AP2 0.001036 0.42095 2.82686
20 3ETH ATP 0.004368 0.42019 2.82686
21 3CV2 OXL 0.0281 0.40769 2.82686
22 5W2I ADP 0.002289 0.43652 3.11284
23 5W2I I3P 0.002289 0.43652 3.11284
24 4OCV ANP 0.0001199 0.46669 3.18021
25 4U98 ACP 0.003235 0.41809 3.18021
26 2GQR ADP 0.005106 0.40929 3.79747
27 4ZS4 ATP 0.0000127 0.50486 3.88693
28 3VOT ADP 0.0002933 0.481 3.88693
29 1M0W ANP 0.003434 0.41282 3.88693
30 3PDT ADP 0.00004006 0.49661 4
31 5K2M ADP 0.003228 0.42967 4.0293
32 5MW8 ATP 0.00003884 0.51555 4.24028
33 5FCF GLY GLY GLY 0.01369 0.40491 4.24028
34 1TZD ADP 0.002033 0.45901 4.36364
35 3IT7 TLA 0.02626 0.40039 4.3956
36 1W2D ADP 0.00328 0.43106 4.5283
37 2BKK ADP 0.0003042 0.47437 4.54545
38 4OCJ NDG 0.00004138 0.53721 4.947
39 4RDL FUC GAL NDG FUC 0.008346 0.42335 5.26316
40 4MV1 ADP 0.01439 0.40924 5.30035
41 4R78 AMP 0.00002655 0.53824 5.65371
42 3X01 AMP 0.004162 0.4374 5.65371
43 1TQP ATP 0.00006573 0.4469 5.67376
44 1IOW ADP 0.005239 0.43255 6.00707
45 1IOW PHY 0.005239 0.43255 6.00707
46 3HCN CHD 0.0401 0.40165 6.00707
47 2GQS ADP 0.002129 0.42615 6.32911
48 2GQS C2R 0.004949 0.41388 6.32911
49 3TII ANP 0.005786 0.4193 7.06714
50 1UPR 4IP 0.02193 0.41505 7.31707
51 3TDV GDP 0.000001683 0.55202 7.77385
52 3UDZ ADP 0.00004985 0.5036 7.77385
53 2CI5 HCS 0.009823 0.42125 7.77385
54 2PUL ACP 0.01276 0.41836 7.89474
55 3P7G MAN 0.01385 0.41079 7.89474
56 1EHI ADP 0.003432 0.40686 8.48057
57 2QK4 ATP 0.002118 0.40676 9.54064
58 5IQD GNP 0.0004577 0.4857 10.2473
59 5IQD RIO 0.0004868 0.4857 10.2473
60 4Q5H ANP 0.000009078 0.53401 10.2564
61 2PYW ADP 0.00001828 0.5257 10.5263
62 3HAV ATP 0.005049 0.43455 10.5263
63 4PU5 ANP 0.0008656 0.41635 10.5263
64 2V58 LZJ 0.001035 0.47667 10.9541
65 1OBD ATP 0.003402 0.40975 11.6608
66 4WW7 AMP 0.00005497 0.50645 11.8774
67 4XYM A12 0.0005393 0.45722 13.0435
68 4AZW ATP 0.000435 0.46359 13.0742
69 4AZT LY2 0.005509 0.42032 13.0742
70 2IO8 ADP 0.0002563 0.42692 13.1579
71 4FFG LBS 0.00901 0.41987 13.1579
72 2H92 C5P 0.009995 0.40386 13.1579
73 2IF8 ADP 0.001786 0.40237 13.1579
74 1OX5 1PR 0.01716 0.40187 13.1579
75 5TDF ADP 0.002707 0.42775 13.4276
76 5LN8 GAL 0.006373 0.4028 13.7405
77 4OUJ LBT 0.003803 0.42494 15.7895
78 2CFM AMP 0.01036 0.40722 15.7895
79 1IA9 ANP 0.000166 0.46015 16.4286
80 5GZ9 ANP 0.000000004197 0.69649 18.3746
81 4GYI ADP 0.000103 0.49619 18.4211
82 3V4S ATP 0.004485 0.41967 18.4211
83 2Z49 AMG 0.01985 0.41021 18.4211
84 3DNT ATP 0.001276 0.40611 18.4211
85 4YNM SAM 0.00809 0.40246 18.4211
86 3V4S ADP 0.02502 0.40108 18.4211
87 4OAV ACP 0.000000005936 0.67209 19.0813
88 5CKW ANP 0.000023 0.49253 19.4346
89 5I35 ANP 0.000002891 0.5531 21.0526
90 3I0O ADP 0.001139 0.45295 21.0526
91 3VSV XYS 0.004442 0.43812 21.9081
92 5C4L 4XR 0.00005392 0.52243 23.6842
93 4CYI ATP 0.00003827 0.51122 23.6842
94 5C4L SIS 0.0001745 0.49842 23.6842
95 3WVR AMP 0.0006336 0.45437 23.6842
96 2QX0 PH2 0.005921 0.43629 23.6842
97 1T36 ADP 0.01217 0.40754 23.6842
98 3VHE 42Q 0.000000547 0.47469 25.0883
99 5C03 AGS 0.0000003776 0.59556 26.1484
100 4WOV 3SM 0.00001382 0.5367 26.1484
101 4RIF 3R2 0.008257 0.41541 28.9474
102 4BTK DTQ 0.00002502 0.51438 30.7421
103 5VZ0 ADP 0.001166 0.43773 31.5789
104 4E1Z 0MX 0.00000004737 0.56925 31.8021
105 3LXN MI1 0.0000000002039 0.68243 32.1555
106 4XH0 ADP 0.00001321 0.56585 32.1555
107 4GJ3 0XP 0.000000007013 0.5274 32.1555
108 3GNI ATP 0.000000006879 0.68021 32.8622
109 5LPZ ADP 0.00000005074 0.61546 33.2155
110 5LPB ADP 0.00000006465 0.5916 33.2155
111 5NKB 8ZT 0.000005227 0.40149 33.5689
112 4IDT T28 0.000000001406 0.69978 33.9223
113 2XVD AS6 0.000001775 0.4768 33.9223
114 4O1P ANP 0.0000000008169 0.71433 34.2105
115 5HX8 66P 0.000000001162 0.5882 34.2756
116 3KMW ATP 0.00005447 0.49665 34.3173
117 5LXC 7AA 0.000000001412 0.68638 34.9823
118 3UIM ANP 0.00000003352 0.6244 34.9823
119 2Y6O 1N1 0.00003752 0.51397 34.9823
120 2QLU ADE 0.000001303 0.45375 35.689
121 5T8O 76Z 0.00000006724 0.5815 36.0424
122 5KO1 6UY 0.000001292 0.56859 36.0424
123 1VJY 460 0.00000001746 0.68906 36.3958
124 2H8H H8H 0.00000006628 0.60999 36.7491
125 1Y57 MPZ 0.00000114 0.5166 36.7491
126 3GC8 B45 0.00001084 0.4881 36.7491
127 3E8N VRA 0.00000001095 0.44606 36.7491
128 3E8N ATP 0.00000001095 0.44606 36.7491
129 4KBA 1QM 0.0001626 0.41598 36.7491
130 1JPA ANP 0.00000183 0.6225 36.8421
131 1PHK ATP 0.0000000000517 0.77199 37.1025
132 4FL3 ANP 0.000000001324 0.71599 37.1025
133 2CSN CKI 0.002854 0.46473 37.1025
134 3G5D 1N1 0.000001739 0.62414 37.4558
135 4CRL C1I 0.000004141 0.57859 37.4558
136 4AT3 LTI 0.000001272 0.46576 37.4558
137 5USZ SKE 0.00000001712 0.53955 37.8092
138 4EWH T77 0.000000008136 0.5507 38.1818
139 4CLI 5P8 0.0000004063 0.64199 38.5159
140 5MY8 RXZ 0.000001944 0.57974 38.5159
141 3PP0 03Q 0.000001116 0.49203 38.5159
142 3C1X CKK 0.0001016 0.45004 38.5159
143 5EOB 5QQ 0.0000009567 0.63593 38.8693
144 4BKJ STI 0.003759 0.42826 39.2226
145 5MJA 7O3 0.00003409 0.49852 39.4737
146 5EKO N17 0.001024 0.45071 39.576
147 3SRV S19 0.000000002231 0.69091 39.7112
148 4YLL 4E3 0.000001983 0.57449 39.9293
149 3PLS ANP 0.000000006355 0.67078 40.2827
150 1K3A ACP 0.0000001008 0.59736 40.2827
151 4IX4 ADP 0.00002702 0.51804 40.2827
152 4E93 GUI 0.0000000948 0.48938 40.2827
153 2OO8 RAJ 0.0008143 0.41639 40.2827
154 4F4P 0SB 0.000001251 0.63477 40.293
155 3BU5 ATP 0.000000007114 0.67244 40.636
156 3NW7 LGV 0.0000009033 0.62795 40.636
157 3H9R TAK 0.00002255 0.5417 40.636
158 2OFV 242 0.000009199 0.4194 40.7942
159 3EKK GS2 0.000000262 0.45064 40.9894
160 4U0I 0LI 0.00004146 0.41196 40.9894
161 5TO8 7FM 0.000004798 0.58378 41.1348
162 1OUK 084 0.000419 0.53074 41.3428
163 4LOO SB4 0.0003089 0.46574 41.3428
164 5DA3 58V 0.0000006995 0.60583 41.5094
165 5H2U 1N1 0.0001151 0.47318 41.573
166 4YZC STU 0.0000000001884 0.79191 41.6961
167 4WNK 453 0.0000000004508 0.75888 41.6961
168 5CEO 50D 0.00000406 0.54958 41.6961
169 1CM8 ANP 0.00001154 0.52649 42.0495
170 3KRR DQX 0.00000001333 0.73928 42.4028
171 3LXK MI1 0.000000009534 0.69162 42.4028
172 1OPK P16 0.00001885 0.42414 42.4028
173 4FF8 14S 0.001014 0.42327 42.4028
174 1U59 STU 0.000000002873 0.66799 42.7562
175 5HCY 60D 0.0000008308 0.62682 42.7562
176 5DBX ANP 0.0000004835 0.56821 42.7562
177 4YMJ 4EJ 0.0000006007 0.63411 43.1095
178 5U6C 7YS 0.0000007205 0.59187 43.1095
179 5BVE 4VG 0.00000001582 0.733 43.4629
180 5N87 N66 0.00000006019 0.66986 43.4629
181 5HES 032 0.0000003513 0.60602 43.4629
182 4Y85 499 0.000001082 0.57199 43.4629
183 3KRL KRL 0.000000862 0.527 43.4629
184 3VRY B43 0.000006689 0.47274 43.4629
185 5UKL SIX 0.00000003312 0.66647 43.8163
186 3F7Z 34O 0.00000007488 0.62687 43.8163
187 4L9I 8PR 0.0000001567 0.60915 43.8163
188 5JFS 6K0 0.000001609 0.60828 43.8163
189 3PVW QRX 0.0000000005472 0.59443 43.8163
190 3HMO STU 0.0000004873 0.58734 43.8163
191 4NM5 ADP 0.0004078 0.50169 43.8163
192 1BYG STU 0.000000003019 0.69557 43.8849
193 2JLD AG1 0.00000002283 0.68576 44.1696
194 2A19 ANP 0.00000005068 0.66009 44.1696
195 2B9F ADP 0.00000002765 0.64616 44.1696
196 3ZRM ZRM 0.000009765 0.5326 44.1696
197 4TWP AXI 0.0000003732 0.64531 44.2804
198 4CSV STI 0.0003347 0.4263 44.3636
199 5VC5 96M 0.00000001704 0.6799 44.523
200 2B9H ADP 0.00000002542 0.65127 44.523
201 2B9J ADP 0.00000002553 0.64404 44.523
202 2B9I ADP 0.0000000261 0.62813 44.523
203 4Y93 746 0.000000715 0.50642 44.523
204 3SXS PP2 0.000003777 0.5566 44.7761
205 3GQI ACP 0.0000000001514 0.72115 44.8763
206 4OTH DRN 0.000000001492 0.6339 44.8763
207 5UR1 YY9 0.000001488 0.61297 44.8763
208 4P5Z Q7M 0.000001137 0.61231 44.8763
209 5BYZ 4WE 0.000001162 0.60091 44.8763
210 1U5R ATP 0.000009137 0.40181 44.8763
211 4D2S DYK 0.0000008919 0.55438 45.0704
212 2HK5 1BM 0.000005391 0.54963 45.1852
213 2WU6 DKI 0.00000001172 0.67615 45.2297
214 5X8I SQZ 0.000000001888 0.67581 45.2297
215 4QTB 38Z 0.00000002716 0.67298 45.2297
216 5JKG 6LF 0.0000004721 0.63068 45.2297
217 4XLI 1N1 0.00001425 0.52243 45.5224
218 5JGA 6KC 0.00000002054 0.50065 45.583
219 4H3Q ANP 0.00000004715 0.64857 45.9364
220 5AWM ANP 0.000000268 0.62566 45.9364
221 4H3P ANP 0.00000006903 0.61079 45.9364
222 4DC2 ADE 0.0000003062 0.50804 45.9364
223 4AG8 AXI 0.0000008188 0.43969 45.9364
224 4ASE AV9 0.00002553 0.43675 45.9364
225 5FBN 5WF 0.0000005604 0.62171 46.1255
226 5LI1 ANP 0.0000000001517 0.75869 46.2898
227 2PVF ACP 0.00000000008993 0.75265 46.2898
228 2X2M X2M 0.000000003788 0.69528 46.2898
229 3RI1 3RH 0.00000001197 0.68437 46.2898
230 5LI9 ACP 0.00000004565 0.60448 46.2898
231 4K33 ACP 0.00000000007841 0.76388 46.6431
232 3SLS ANP 0.000000002057 0.70731 46.6431
233 4UX9 ANP 0.0000000001418 0.68596 46.6431
234 2F57 23D 0.0000006789 0.58898 46.6431
235 4IZY 1J2 0.00000763 0.50633 46.6431
236 5UOX 8GY 0.000000001273 0.63413 46.8635
237 5EFQ ADP 0.000000007863 0.6705 46.9965
238 3TXO 07U 0.00000007931 0.61209 46.9965
239 3E7O 35F 0.00001116 0.55642 47.3498
240 3FC2 IBI 0.0001098 0.54288 47.3498
241 3TTI KBI 0.0000001602 0.51423 47.3498
242 3PTG 932 0.000004603 0.51264 47.3498
243 5TA6 79D 0.0000004458 0.49364 47.3498
244 1XJD STU 0.000000003862 0.64754 47.7032
245 2ZV2 609 0.0000001181 0.6426 47.7032
246 4I6H 1C8 0.00000262 0.55806 47.7032
247 1ZY5 ANP 0.000003883 0.54743 47.7032
248 4NST ADP 0.00000001893 0.65349 48.0565
249 4BHN BH9 0.000000001485 0.64772 48.0565
250 3ALN ANP 0.00000002278 0.65675 48.4099
251 4QMN DB8 0.0000002822 0.46127 48.4099
252 5HQ0 LZ9 0.000000003162 0.69544 49.1166
253 3GC0 AMP 0.00000006946 0.64342 49.1166
254 4AUA 4AU 0.000001201 0.57 49.1166
255 4AU8 Z3R 0.000001014 0.54513 49.47
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