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Receptor
PDB id Resolution Class Description Source Keywords
5LX9 2.4 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION HOMO SAPIENS PROGESTIN AND ADIPOQ RECEPTOR FAMILY INTEGRAL MEMBRANE PROTCERAMIDASE MEMBRANE PROTEIN
Ref.: STRUCTURAL INSIGHTS INTO ADIPONECTIN RECEPTORS SUGG CERAMIDASE ACTIVITY. NATURE V. 6 120 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ZN A:401;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
OLB A:407;
H:302;
A:403;
A:405;
A:411;
A:408;
H:301;
A:404;
A:410;
A:406;
A:409;
A:412;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
356.54 C21 H40 O4 CCCCC...
OLA A:402;
Valid;
none;
submit data
282.461 C18 H34 O2 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LX9 2.4 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE OF HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX C18 FREE FATTY ACID AT 2.4 ANGSTROM RESOLUTION HOMO SAPIENS PROGESTIN AND ADIPOQ RECEPTOR FAMILY INTEGRAL MEMBRANE PROTCERAMIDASE MEMBRANE PROTEIN
Ref.: STRUCTURAL INSIGHTS INTO ADIPONECTIN RECEPTORS SUGG CERAMIDASE ACTIVITY. NATURE V. 6 120 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 5LX9 - OLB C21 H40 O4 CCCCCCCC/C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 5LX9 - OLB C21 H40 O4 CCCCCCCC/C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 5LX9 - OLB C21 H40 O4 CCCCCCCC/C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OLB; Similar ligands found: 71
No: Ligand ECFP6 Tc MDL keys Tc
1 OLC 1 1
2 OLB 1 1
3 MVC 0.958333 1
4 78N 0.9375 1
5 78M 0.9375 1
6 1QW 0.808511 0.969697
7 GYM 0.808511 0.969697
8 NKP 0.683333 0.688889
9 1AG 0.62069 1
10 D3D 0.597222 0.733333
11 PGW 0.597222 0.733333
12 PGV 0.589041 0.733333
13 DR9 0.589041 0.733333
14 P6L 0.581081 0.733333
15 S12 0.577465 0.627451
16 OZ2 0.573333 0.733333
17 PGM 0.571429 0.727273
18 D21 0.558824 0.652174
19 P3A 0.558442 0.733333
20 NKN 0.533333 0.666667
21 NKO 0.533333 0.666667
22 DGA 0.525424 0.828571
23 L2C 0.525424 0.828571
24 DDR 0.525424 0.828571
25 FAW 0.525424 0.828571
26 ELA 0.519231 0.617647
27 NER 0.519231 0.617647
28 OLA 0.519231 0.617647
29 LOP 0.5 0.603774
30 L9Q 0.5 0.603774
31 6OU 0.5 0.603774
32 VCA 0.490566 0.617647
33 PAM 0.490566 0.617647
34 ZPE 0.487179 0.603774
35 MPG 0.483871 0.941176
36 TGL 0.482759 0.722222
37 PGT 0.472222 0.711111
38 LHG 0.472222 0.711111
39 1O2 0.46988 0.711111
40 LBR 0.469697 0.805556
41 B7N 0.469136 0.607843
42 PVC 0.46875 0.815789
43 3TF 0.464286 0.711111
44 RCL 0.453125 0.705882
45 G2A 0.446429 0.882353
46 2JT 0.446429 0.882353
47 GP7 0.435294 0.603774
48 2WA 0.432836 0.885714
49 2WM 0.432836 0.885714
50 3WM 0.432836 0.885714
51 1L2 0.428571 0.711111
52 PGK 0.426829 0.666667
53 LPP 0.426471 0.630435
54 3PH 0.426471 0.630435
55 6PH 0.426471 0.630435
56 F57 0.426471 0.630435
57 7PH 0.426471 0.630435
58 AGA 0.421053 0.711111
59 PX8 0.42029 0.608696
60 PX2 0.42029 0.608696
61 7P9 0.42029 0.630435
62 18C 0.41791 0.608696
63 16C 0.41791 0.608696
64 SPL 0.41791 0.608696
65 PEK 0.411765 0.603774
66 VA 0.40678 0.617647
67 GGD 0.40625 0.680851
68 8ND 0.405797 0.636364
69 CD4 0.405405 0.666667
70 CDL 0.4 0.622222
71 EIC 0.4 0.647059
Ligand no: 2; Ligand: OLA; Similar ligands found: 56
No: Ligand ECFP6 Tc MDL keys Tc
1 OLA 1 1
2 NER 1 1
3 ELA 1 1
4 VCA 0.939394 1
5 PAM 0.939394 1
6 MYZ 0.852941 0.954545
7 EIC 0.725 0.956522
8 DCR 0.71875 0.954545
9 F15 0.71875 0.954545
10 EW8 0.71875 0.954545
11 X90 0.71875 0.954545
12 TDA 0.71875 0.954545
13 DKA 0.71875 0.954545
14 STE 0.71875 0.954545
15 MYR 0.71875 0.954545
16 11A 0.71875 0.954545
17 DAO 0.71875 0.954545
18 KNA 0.71875 0.954545
19 PLM 0.71875 0.954545
20 F23 0.71875 0.954545
21 OCA 0.6875 0.954545
22 ODD 0.675 0.956522
23 RCL 0.625 0.88
24 LNL 0.613636 0.869565
25 SHV 0.606061 0.909091
26 KTC 0.605263 0.84
27 3X1 0.564103 0.863636
28 ODT 0.555556 0.826087
29 T25 0.54717 0.709677
30 AZ1 0.53125 0.615385
31 10X 0.529412 0.645161
32 10Y 0.529412 0.645161
33 6NA 0.529412 0.863636
34 OLB 0.519231 0.617647
35 OLC 0.519231 0.617647
36 243 0.519231 0.846154
37 MVC 0.490566 0.617647
38 ACD 0.488889 0.956522
39 VA 0.478261 0.692308
40 3LA 0.47619 0.769231
41 78M 0.471698 0.617647
42 78N 0.471698 0.617647
43 EOD 0.468085 0.677419
44 MPG 0.45283 0.617647
45 14V 0.444444 0.714286
46 LEA 0.441176 0.772727
47 T24 0.438596 0.769231
48 BRC 0.435897 0.64
49 14U 0.431818 0.678571
50 M12 0.428571 0.833333
51 UNA 0.421053 0.636364
52 OCD 0.421053 0.636364
53 8YP 0.421053 0.636364
54 D0G 0.4 0.913043
55 BNV 0.4 0.913043
56 BMJ 0.4 0.913043
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LX9; Ligand: OLB; Similar sites found with APoc: 598
This union binding pocket(no: 1) in the query (biounit: 5lx9.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 5MWE TCE None
2 6BOC RIM None
3 6BKL RIM None
4 6BKL EU7 None
5 5NNT DPV None
6 3GZ9 D32 1.48699
7 5K7K 6RJ 1.76056
8 5EHR 5OD 1.76056
9 1WS1 BB2 1.92308
10 1NF8 BOG 1.93237
11 5CYV WCA 2.05479
12 1OKC CXT 2.11268
13 1I0B PEL 2.11268
14 2YOO K2B 2.11268
15 4PYW ACE THR THR ALA ILE NH2 2.11268
16 3I51 45C 2.22222
17 3I51 6PL 2.22222
18 1N20 3AG 2.28013
19 1OPK MYR 2.28013
20 4U03 TLL 2.28013
21 5CX6 CDP 2.28013
22 1EE0 CAA 2.28013
23 3W54 RNB 2.28013
24 3TGE TGE 2.28013
25 3QFU ADP 2.28013
26 5N9T 8QQ 2.46479
27 1KGQ SCO 2.55474
28 1KGQ NPI 2.55474
29 1JR8 FAD 2.5641
30 4I6G FAD 2.60586
31 1HV9 COA 2.60586
32 3O01 DXC 2.60586
33 4XRZ SI6 2.60586
34 5AAV GW5 2.77778
35 5B4B LP5 2.82258
36 2QE4 JJ3 2.82258
37 2C3Q GTX 2.83401
38 3LDW ZOL 2.9316
39 3HR1 PF9 2.9316
40 5AM1 I5T 2.9316
41 6F6E PLM 2.9316
42 3HCN CHD 2.9316
43 4ORM ORO 2.9316
44 4ORM FMN 2.9316
45 4ORM 2V6 2.9316
46 2JC9 ADN 2.9316
47 4O1Z MXM 2.9316
48 5UWA 8ND 2.95567
49 3B6C SDN 2.99145
50 1M48 FRG 3.00752
51 2GWH PCI 3.02013
52 5K53 STE 3.05344
53 3I3X U22 3.0888
54 4WOP CTP 3.11111
55 6CB2 OLC 3.16901
56 4ZB6 GDS 3.16901
57 3G4G D71 3.16901
58 5OBU ANP 3.16901
59 1UOU CMU 3.16901
60 1WDK N8E 3.16901
61 6B2M COA 3.16901
62 5NE5 KIF 3.16901
63 6F70 GSH 3.16901
64 4KBS PX2 3.25581
65 4LY9 S6P 3.25733
66 1BUC CAA 3.25733
67 2WSA MYA 3.25733
68 2WSA 646 3.25733
69 5G61 FNY 3.25733
70 2W90 6PG 3.25733
71 1LN1 DLP 3.27103
72 1NQ7 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 3.27869
73 4M4Q 21A 3.3195
74 4UMJ BFQ 3.37838
75 3SFI 3SF 3.38983
76 2X5W K2B 3.40909
77 5DUF G7A 3.42205
78 3U3U EAH 3.43348
79 3HW5 AMP 3.44828
80 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 3.47826
81 3FS1 MYR 3.47826
82 2I0G I0G 3.50195
83 4U82 FPS 3.51562
84 2OBD PCW 3.52113
85 2OBD 2OB 3.52113
86 3CGD FAD 3.52113
87 3CGD NAD 3.52113
88 3CGD COA 3.52113
89 4XVX P33 FDA 3.52113
90 2C78 PUL 3.52113
91 4RXH PRO PRO LYS LYS LYS ARG LYS VAL 3.52113
92 3GXO MQA 3.52113
93 3WYJ H78 3.55731
94 5OHJ 9VE 3.56295
95 4C9G CXT 3.58306
96 3ABA FLI 3.58306
97 2R0N TGC 3.58306
98 5KOK R9T 3.58306
99 5AOV NAP 3.58306
100 3EBL GA4 3.58306
101 3L1N PLM 3.60825
102 2FP2 TSA 3.61446
103 4W4S B29 3.66667
104 4DOL PLM 3.68664
105 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 3.7415
106 5OBY ANP 3.74332
107 1XM4 PIL 3.76884
108 1XMY ROL 3.76884
109 1XMU ROF 3.76884
110 5V13 JH3 3.81944
111 3G5K BB2 3.82514
112 2WZV FMN 3.82979
113 5HCN DAO 3.83142
114 3LLI FAD 3.83142
115 1G27 BB1 3.87324
116 5WX3 COA 3.87324
117 4DXJ 0M9 3.87324
118 3E7O 35F 3.87324
119 5TO8 7FM 3.87324
120 6BLD DXJ 3.87324
121 3HYW DCQ 3.87324
122 4HZD COA 3.90071
123 1OUK 084 3.90879
124 2HKJ RDC 3.90879
125 5OSW DIU 3.90879
126 1ZPD CIT 3.90879
127 5BVE 4VG 3.90879
128 5OSW AE4 3.90879
129 3F5K CE5 3.9501
130 6AYH C3G 3.9801
131 6AYI C3G 4.0201
132 5W7U GY8 4.06091
133 6GL8 F3Q 4.06977
134 2A1L PCW 4.07407
135 4NB5 2JT 4.09357
136 2E2R 2OH 4.09836
137 2QHD DAO 4.09836
138 3GYT DL4 4.09836
139 3ET3 ET1 4.10959
140 2Y31 SMQ 4.11985
141 1GUX ASP LEU TYR CYS TYR GLU GLN LEU ASN 4.12844
142 4RFM 3P6 4.13534
143 3GST GPR 4.14747
144 5F1R 42O 4.21941
145 5MZI FAD 4.22535
146 5MZI FYK 4.22535
147 1MGP PLM 4.22535
148 4YDQ HFG 4.22535
149 4YDQ ANP 4.22535
150 5Y79 3PG 4.22535
151 2E9L OLA 4.22535
152 2E9L BGC 4.22535
153 2E9L PLM 4.22535
154 2VAT COA 4.22535
155 1LBT T80 4.22535
156 4IA6 EIC 4.22535
157 3ETG GWD 4.22535
158 2IZ1 RES 4.22535
159 1P1M MET 4.23453
160 3G58 988 4.23453
161 4M52 M52 4.23453
162 4C2X NHW 4.23453
163 1OWB NAD 4.23453
164 3ICS COA 4.23453
165 3B1M KRC 4.24028
166 3GWT 066 4.24929
167 1XON PIL 4.29799
168 1HG4 LPP 4.30108
169 5V4R MGT 4.32099
170 2P4Y C03 4.33213
171 5TVI O8N 4.34783
172 1UVC STE 4.3956
173 3QKD HI0 4.41989
174 3G9E RO7 4.42804
175 1TMX HGX 4.43686
176 1ATL 0QI 4.45545
177 4Q9M FPP 4.47154
178 3RWP ABQ 4.50161
179 6BMS PLM 4.56026
180 6C7D EOJ 4.56026
181 2YNC YNC 4.56026
182 4Q86 AMP 4.57746
183 1EM6 CP4 4.57746
184 3V66 D3A 4.57746
185 2RH1 CLR 4.57746
186 2WH8 II2 4.57746
187 5UV1 0FV 4.57746
188 1YQZ FAD 4.57746
189 2RH1 CAU 4.57746
190 3WHB DCC 4.63918
191 5DEP UD1 4.65116
192 5AZC PGT 4.66667
193 5HCV 60R 4.66926
194 2E3N 6CM 4.70588
195 4INB 1F6 4.79452
196 3WH1 NAG NAG NAG NAG 4.85437
197 1KPH 10A 4.87805
198 1KPG 16A 4.87805
199 4NKW PLO 4.88599
200 2JBZ COA 4.8951
201 3EE4 MYR 4.92958
202 1D6H COA 4.92958
203 2VL8 CTS 4.92958
204 2VL8 UDP 4.92958
205 5LOF 70R 4.92958
206 1HK8 DGT 4.92958
207 4CDN FO1 4.92958
208 4CDN FAD 4.92958
209 2EIX FAD 4.92958
210 3GQT UFO 4.92958
211 5NWI TYR PHE SER SEP ASN 4.96183
212 3COW 52H 4.98339
213 3WQM B29 4.98339
214 3E8T UQ8 5
215 3KYQ DPV 5.02513
216 5CSD ACD 5.03145
217 1XW6 GSH 5.04587
218 3KPX CZH 5.05051
219 6CC0 EWM 5.06329
220 1YOK P6L 5.07812
221 4RHP PEF 5.10638
222 2A3I C0R 5.13834
223 1T27 PCW 5.16605
224 4H07 IPH 5.19481
225 5N5U 7N8 5.21173
226 5C2H 4PX 5.21173
227 4IGH 1EA 5.21173
228 4IGH ORO 5.21173
229 4IGH FMN 5.21173
230 5C2H 4XU 5.21173
231 5N5U AMP 5.21173
232 5B25 4QJ 5.21173
233 2RDT 2RD 5.21173
234 2RDT FMN 5.21173
235 2EVL GAL SPH EIC 5.26316
236 3T6E UQ9 5.28169
237 4G31 0WH 5.28169
238 4COL DTP 5.28169
239 6CIB ADP 5.28169
240 3T6E MQ9 5.28169
241 1S17 GNR 5.28169
242 4EI7 GDP 5.28169
243 6CI7 ACP 5.28169
244 3B9Z CO2 5.28169
245 1N6B DMZ 5.28541
246 5UNJ RJW 5.30612
247 3AQT RCO 5.30612
248 1FK5 OLA 5.37634
249 2OZ5 7XY 5.40541
250 3KRO DST 5.47445
251 3KRO IPE 5.47445
252 5DRB 5FJ 5.49828
253 2XXP DSL 5.52764
254 4D7M TDC 5.52995
255 4UHL VFV 5.53746
256 4M0R 644 5.5409
257 3E3U NVC 5.58376
258 2HJ3 FAD 5.6
259 3N7H DE3 5.6
260 2BHW LUX 5.60345
261 1RQJ RIS 5.6338
262 5G57 6M5 5.6338
263 4GU5 FAD 5.6338
264 4KCF AKM 5.6338
265 4JZX 476 5.6338
266 2H7C COA 5.6338
267 6BQC LOP 5.6338
268 3OGN 3OG 5.64516
269 4B7P 9UN 5.65217
270 3D04 SAK 5.66038
271 3E85 BSU 5.6962
272 4PGK Y69 5.7377
273 4YV5 SVR 5.7377
274 4OIV XX9 5.75221
275 5UC9 MYR 5.75221
276 4WQ2 3SU 5.78035
277 5BQI 4UL 5.84416
278 5BQI GSH 5.84416
279 2EV1 OLA 5.85586
280 2Q6B HR2 5.86319
281 5J6A P46 5.86319
282 3WCA FPS 5.86319
283 1T57 FMN 5.86319
284 3L9W AMP 5.86319
285 5NI5 8YB 5.90278
286 2EI4 22B 5.92885
287 1GSU GTX 5.93607
288 3OZV ECN 5.95534
289 5ICE 2H4 5.96591
290 2OKL BB2 5.98592
291 3NHT U46 5.98592
292 4B5P ACO 6
293 3OKI OKI 6.00858
294 1DKF OLA 6.00858
295 4E1M TQ2 6.0241
296 4E1N TQX 6.0241
297 3GKJ HC3 6.03448
298 4POJ 2VP 6.06061
299 4M8E 29V 6.06061
300 1ZDU P3A 6.12245
301 3H0A D30 6.14035
302 1R6N 434 6.16114
303 1IID NHM 6.16114
304 1OW4 2AN 6.20155
305 4DR9 BB2 6.25
306 5IJJ I6P 6.25
307 1YUC EPH 6.27451
308 3TL1 JRO 6.28931
309 3ZLR X0B 6.32911
310 2ZFZ ARG 6.32911
311 4L1F COS 6.33803
312 4M73 M72 6.33803
313 4M73 SAH 6.33803
314 4KIB SAH 6.33803
315 2BIF BOG 6.33803
316 4LPG 1MV 6.33803
317 3F8C HT1 6.34921
318 3O55 FAD 6.4
319 2C4J GSO 6.42202
320 4XRQ 1B0 6.49351
321 3GX0 GDS 6.51163
322 3UMV FAD 6.51466
323 5UQK U2F 6.51466
324 5MBC FMN 6.51466
325 6EQ8 BQZ 6.51466
326 2J1P GRG 6.51466
327 3RMK BML 6.53595
328 5T2Y 753 6.56566
329 2XCG XCG 6.69014
330 4ONC 40B 6.69014
331 5OLK DTP 6.69014
332 5FUS DAO 6.69014
333 5W8Q BU4 6.69014
334 3VVY ET 6.70103
335 1CMC SAM 6.73077
336 4RC8 STE 6.75676
337 2ZCQ B65 6.82594
338 5HGR 45D 6.84039
339 3Q8G PEE 6.84039
340 2BCG GER 6.84039
341 4P42 PEE 6.84039
342 5JF2 SF7 6.86275
343 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 6.86275
344 2VZZ SCA 6.88073
345 6BYM HC3 6.89655
346 5IF4 6AK 6.91824
347 3KCC CMP 6.92308
348 3RET SAL 6.93069
349 3RET PYR 6.93069
350 2WOR 2AN 7
351 4TMK T5A 7.04225
352 5W7B MYR 7.04225
353 4ZBR NPS 7.04225
354 4ZBR DIF 7.04225
355 5V3Y 5V8 7.04225
356 1XVB BHL 7.05882
357 1SSQ CYS 7.11611
358 4J7Q B7N 7.16612
359 3PE2 E1B 7.16612
360 3FWN 6PG 7.16612
361 4FDV 0UK 7.17703
362 3KXC PLM 7.2165
363 3KDU NKS 7.22022
364 3VHZ SOG 7.25191
365 3VHZ L2P GLC MAN SGA 7.25191
366 5LGD PLM 7.26257
367 3IIS PID 7.28477
368 5CHR 4NC 7.29927
369 4GFD 0YB 7.31707
370 1VPV PLM 7.33333
371 1FO3 KIF 7.39437
372 2BHZ MAL 7.39437
373 3T58 FAD 7.39437
374 1POC GEL 7.46269
375 3FEI CTM 7.49064
376 1W96 S1A 7.49186
377 4RKK GLC GLC GLC GLC GLC GLC 7.49186
378 5GUE GGS 7.49186
379 4W97 UCA 7.5
380 5YWX 93C 7.57576
381 5YWX GSH 7.57576
382 1JJE BYS 7.65766
383 2FV5 541 7.66284
384 3ZS7 ATP 7.66667
385 2EW5 Y12 7.73481
386 5KKB BMA NAG MAN MAN MAN MAN MAN MAN MAN 7.74648
387 4ZW3 4S9 7.74648
388 4QO5 NAG 7.74648
389 2C9E DGD 7.74648
390 5TVJ 7LF 7.74648
391 5TVJ COA 7.74648
392 2C9E PID 7.74648
393 1GNI OLA 7.81759
394 5G3N X28 7.87402
395 3GWN FAD 7.89474
396 6C7R EO4 8
397 1N8V BDD 8.03571
398 6BR9 PGV 8.07799
399 6BR9 6OU 8.07799
400 1F6B GDP 8.08081
401 2UXI G50 8.09524
402 1M13 HYF 8.09859
403 4JE7 BB2 8.12183
404 2Z7I 742 8.14332
405 1UUO BRF 8.14332
406 4KVL PLM 8.14332
407 6FP4 FAD 8.14332
408 1JF0 CZH 8.20513
409 1QV1 CZH 8.20513
410 2VG1 FPP 8.33333
411 1PZO CBT 8.36502
412 1Q1Y BB2 8.37696
413 3BQD DAY 8.4507
414 4GBD MCF 8.4507
415 1EE4 PRO ALA ALA LYS ARG VAL LYS LEU ASP 8.4507
416 2AMV BIN 8.46906
417 5EEH SAH 8.46906
418 5EEH P9P 8.46906
419 6B3A SAM 8.46906
420 2WCJ M21 8.51064
421 4IBF 1D5 8.52713
422 4ZB8 GDS 8.55856
423 4UCC ZKW 8.58369
424 6CHP F0Y 8.69565
425 4K4D HFQ 8.75912
426 2GMH UQ5 8.79479
427 2QJY SMA 8.79479
428 1N1G BCP 8.80282
429 1X9D SMD 8.80282
430 4BXK 1IU 8.80282
431 4RLT FSE 8.84354
432 4EOX 0S5 8.86699
433 2J8C U10 8.8968
434 2J8C SPO 8.8968
435 5Z1N PEF 8.92857
436 3QQA TCH 9.25926
437 4WGF HX2 9.26829
438 5B0W 22B 9.27835
439 3QMK SGN IDS SGN IDS 9.34579
440 3JRX S1A 9.44625
441 3BAZ NAP 9.44625
442 6CAY ERG 9.46746
443 5EY0 GTP 9.48905
444 4UMX VVS 9.50704
445 5VRH OLB 9.50704
446 4OKZ 3E9 9.58904
447 1Q0S SAH 9.65251
448 4BNU 9KQ 9.66543
449 4RYV ZEA 9.67742
450 5FH7 5XL 9.67742
451 2VBQ BSJ 9.69697
452 4CL6 7SB 9.94152
453 1BWO LPC 10
454 1BII ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 10.084
455 5K52 OCD 10.0977
456 4V1T ADP 10.0977
457 1EWF PC1 10.0977
458 1TV5 N8E 10.0977
459 1YRE COA 10.1523
460 4DW4 U5P 10.1796
461 3S5W FAD 10.2113
462 1UBY DMA 10.2113
463 3BKR PLM 10.3175
464 3OV6 MK0 10.3275
465 4I67 G G G RPC 10.3448
466 2BVL UDP 10.4235
467 2BVL GLC 10.4235
468 1UHK CZN 10.4712
469 3OTH CLJ 10.5634
470 3LN0 52B 10.5634
471 2BUP ADP 10.5634
472 2BUP ATP 10.5634
473 4IXH IMP 10.5634
474 3ZJ0 ACO 10.6796
475 4TWP AXI 10.7011
476 5YZC 95C 10.9155
477 5XJ8 NKO 10.9453
478 5XJ7 87O 10.9453
479 4V2O CLQ 10.9756
480 4ZE0 VOR 11.0749
481 4QWT ACD 11.0749
482 6BR8 6OU 11.1111
483 6BR8 PGV 11.1111
484 3PMD 11A 11.1111
485 3L9R L9R 11.2245
486 5FPE 3TR 11.2676
487 1RX0 2MC 11.2676
488 3ZCB ATP 11.2903
489 5X4Q 7Z6 11.3475
490 1YMT DR9 11.3821
491 1LQY BB2 11.413
492 4OAS 2SW 11.4583
493 1JQ9 PHE LEU SER TYR LYS 11.5702
494 3SE5 ANP 11.5854
495 4F0B GDS 11.6071
496 5LXT GDP 11.6197
497 5LXT 7AK 11.6197
498 3SQP 3J8 11.6197
499 5XK9 GST 11.6379
500 5XK9 DMA 11.6379
501 6B21 C9V 11.7264
502 4F4S EFO 11.8421
503 3ET1 ET1 12.0275
504 3G08 FEE 12.1212
505 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 12.1212
506 1LEK GLU GLN TYR LYS PHE TYR SER VAL 12.1212
507 6G3R ADP 12.3239
508 4K49 HFQ 12.5
509 2XSU PIE 12.8205
510 1RV1 IMZ 12.9412
511 4R57 ACO 13.0682
512 5MTE BB2 13.1387
513 2HW2 RFP 13.2867
514 4HBM 0Y7 13.3333
515 3UR0 SVR 13.355
516 2A06 SMA 13.3803
517 5KOR GDP 13.7324
518 4QVX 3CQ 13.7725
519 3KP6 SAL 13.9073
520 3PVT 3HC 14.0845
521 4F7E 0SH 14.1343
522 5H94 LYS MET ASN THR GLN PHE THR ALA VAL 14.2857
523 4X9X OLA 14.3813
524 2D5Z L35 14.3836
525 1U1B PAX 14.5161
526 5KAU RHQ 14.5455
527 3SDV 911 14.9837
528 5FPN KYD 14.9837
529 3F8K COA 15
530 4LWU 20U 15.2941
531 1CZA ADP 15.3094
532 4YSX E23 15.4255
533 4XIZ LPP 15.7143
534 5GPG RAP 16.2393
535 5Y02 HBX 16.8224
536 4X6F 3XU 17.1429
537 2ZXG S23 17.2638
538 3U5S FAD 17.4603
539 3WUR O4B 17.5439
540 2F99 AKV 17.6471
541 6GH1 ARG LEU PRO ALA LYS ALA PRO LEU LEU 18
542 5WL1 D3D 18.1818
543 5WL1 CUY 18.1818
544 5C9J DAO 18.1818
545 5C9J STE 18.1818
546 5U98 1KX 18.1818
547 5T70 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 18.1818
548 2RFX LEU SER SER PRO VAL THR LYS SER PHE 18.1818
549 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 18.3673
550 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 18.3673
551 2FKW RG1 19.5122
552 6CS9 PIO 19.5122
553 2ALG HP6 20.6522
554 2ALG DAO 20.6522
555 1FO0 ILE ASN PHE ASP PHE ASN THR ILE 21.5517
556 1OQC FAD 21.6
557 3QUZ QUV 22.9665
558 3SCM LGN 23.1884
559 3MBG FAD 23.741
560 3BEJ MUF 24
561 1FM9 9CR 24
562 1FM9 570 24
563 4HEE 14R 24
564 1NRL SRL 24
565 5IVX ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 24.7423
566 4NAT ADP 25
567 4WO4 JLS 25.1208
568 3TJH SER PRO LEU ASP SER LEU TRP TRP ILE 25.2212
569 2QZT PLM 25.2252
570 3HUJ AGH 25.8373
571 3RUG DB6 25.9804
572 6BJ3 ILE PRO LEU THR GLU GLU ALA GLU LEU 25.9804
573 5LJ0 6XX 27.6923
574 1B4B ARG 28.169
575 1K7L 544 28.5714
576 2HFP NSI 28.5714
577 4OGQ 1O2 29.7297
578 4DRI RAP 30.6122
579 4DRJ RAP 30.6122
580 3FAP ARD 31.9149
581 5OCA 9QZ 35.2941
582 6FS0 E4W 38.9908
583 2DYS TGL 39.2857
584 5ZCO PEK 39.2857
585 5ZCO PGV 39.2857
586 2DYS PGV 39.2857
587 2DYS PEK 39.2857
588 2DYR PEK 39.2857
589 5Z84 PGV 39.2857
590 5Z84 TGL 39.2857
591 5ZCO TGL 39.2857
592 2DYR TGL 39.2857
593 5Z84 PEK 39.2857
594 2DYR PGV 39.2857
595 5ZCO CHD 39.2857
596 5W97 CHD 39.2857
597 5Z84 CHD 39.2857
598 1PZL MYR 42.8571
Pocket No.: 2; Query (leader) PDB : 5LX9; Ligand: OLB; Similar sites found with APoc: 190
This union binding pocket(no: 2) in the query (biounit: 5lx9.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 3KPE TM3 None
2 4WG0 CHD None
3 5IKR ID8 2.28013
4 3KU0 ADE 2.39044
5 5O42 9JW 2.55474
6 5O42 BGC 2.55474
7 5O42 NAD 2.55474
8 3D9F N6C 2.60586
9 3D9F FAD 2.60586
10 2ART LPA AMP 2.67176
11 3GWL FAD 2.83019
12 3JRS A8S 2.88462
13 3LDW IPE 2.9316
14 3M31 FAD 2.9316
15 1F0X FAD 2.9316
16 3LXI CAM 2.9316
17 5IUY BOG 3.09051
18 2QZO KN1 3.10078
19 4V3I ASP LEU THR ARG PRO 3.11284
20 3X01 AMP 3.16901
21 6DIO CIT 3.16901
22 5F2T PLM 3.16901
23 2Q2Y ADP 3.25733
24 2Q2Y MKR 3.25733
25 4LY9 1YY 3.25733
26 2UW1 GVM 3.25733
27 1YYE 196 3.35821
28 2LBD REA 3.37079
29 4ARE FLC 3.58306
30 5K0A FAD 3.58306
31 1ECM TSA 3.66972
32 1U3R 338 3.73444
33 1U72 MTX 3.76344
34 1U72 NDP 3.76344
35 1FCZ 156 3.82979
36 2QES ADE 3.83142
37 4DXJ IPE 3.87324
38 2QA8 GEN 3.87597
39 3TDC 0EU 3.93701
40 1N83 CLR 4.07407
41 1NU4 MLA 4.12371
42 6AD9 KK4 4.18118
43 3QCP FAD 4.22535
44 5IM3 DTP 4.23453
45 5TVI MYR 4.34783
46 5EW9 5VC 4.42804
47 6B5Q PPI CZS 2KY MLY 1XY 4.44444
48 2HHP FLC 4.56026
49 6BMS POV 4.56026
50 4MDH NAD 4.56026
51 3X0V FAD 4.56026
52 1OLM VTQ 4.71464
53 5X3R 7Y3 4.87805
54 1YC4 43P 4.92424
55 4Y9J UCC 4.92958
56 4EKQ NPO 4.92958
57 5EK3 5PK 5.21173
58 3NB0 G6P 5.21173
59 1E4I NFG 5.21173
60 4IDT T28 5.21173
61 1ZED PNP 5.28169
62 4DO1 ANN 5.28169
63 3AHQ FAD 5.28169
64 1FX8 BOG 5.33808
65 5URY PAM 5.47945
66 3DCT 064 5.53191
67 2BHW NEX 5.60345
68 1H82 GZZ 5.6338
69 4G86 BNT 5.6338
70 5B0I BOG 5.6338
71 5M37 9SZ 5.65217
72 4MNS 2AX 5.66038
73 5A4W QCT 5.66038
74 3RUU 37G 5.67686
75 2YI0 YI0 5.67686
76 5ICK FEZ 5.67686
77 5UGW GSH 5.71429
78 3WDM ADN 5.74713
79 3G5N PB2 5.86319
80 5UC4 83S 5.90909
81 3KO0 TFP 5.94059
82 3G5D 1N1 5.94406
83 1BGQ RDC 5.98592
84 4DV8 0LX 5.98592
85 1DKF BMS 6.00858
86 3P0K FAD 6.01504
87 4MRP GSH 6.18893
88 1W55 GPP 6.18893
89 1XRO LEU 6.48464
90 3IS2 FAD 6.49351
91 4USI ATP 6.49351
92 4WH9 3M8 6.55738
93 1DB1 VDX 6.56371
94 4ELG 52I 6.62651
95 4ELG 52J 6.62651
96 3D72 FAD 6.71141
97 2J9C ATP 6.72269
98 2GJ5 VD3 6.79012
99 1DTL BEP 6.8323
100 4OMJ 2TX 6.83453
101 2V57 PRL 6.84211
102 2NNQ T4B 6.87023
103 1XZ3 ICF 6.89655
104 2VWA PTY 6.93069
105 4URX FK1 7.02703
106 2IID FAD 7.04225
107 2IID PHE 7.04225
108 2O1V ADP 7.04225
109 1T0S BML 7.04225
110 3RLF MAL 7.04225
111 3NRR D16 7.04225
112 4OHU 2TK 7.04225
113 4OHU NAD 7.04225
114 3NRR NAP 7.04225
115 5CQG 55C 7.04225
116 3LF0 ATP 7.04225
117 4OIC A8S 7.04225
118 1XVB 3BR 7.05882
119 4O4Z N2O 7.14286
120 1Y7P RIP 7.17489
121 4WPF 3SN 7.19697
122 4NTO 1PW 7.24638
123 6D28 NEC 7.32601
124 5X13 HC4 7.44681
125 2P54 735 7.49064
126 2GMV UN8 7.81759
127 3KDJ A8S 8.09859
128 2VHW NAI 8.09859
129 5W7D PX8 8.09859
130 4IV9 FAD 8.14332
131 4LAE 1VM 8.38323
132 4LAE NAP 8.38323
133 6BVJ EAS 8.38323
134 1H9G COA MYR 8.4507
135 4Z87 GDP 8.46906
136 1MID LAP 8.79121
137 5ZYN FMN 8.79479
138 5UI2 EQ3 8.80282
139 6BVK EAV 8.98204
140 6BVM EBV 8.98204
141 6BVL EBY 8.98204
142 2CIX CEJ 9.15493
143 1JQI CAA 9.15493
144 3IX9 MTX 9.47368
145 6C0B PAM 9.61539
146 5JO1 6LM 9.85915
147 4LA7 A1O 9.85915
148 4DS8 A8S 9.85915
149 5U3B 7TD 10.0334
150 3D78 NBB 10.084
151 5N8V KZZ 10.1449
152 2GFD RDA 10.1695
153 5CKS GAL 10.5413
154 4RJD TFP 10.6061
155 4K90 MLA 10.7492
156 2YLD CMO 11.0236
157 3L9R L9Q 11.2245
158 2DRC MTX 11.3208
159 1OYF MHN 11.5702
160 5LXT GTP 11.6197
161 3EYK EYK 11.6279
162 2GJ3 FAD 11.6667
163 2ZFU SAH 12.093
164 6GMN F4E 12.5
165 5G3U ITW 12.6761
166 2P1C GG3 12.7036
167 5M36 9SZ 13.1579
168 3HSS MLA 13.3803
169 3EWK FAD 14.978
170 4WT2 3UD 15.2381
171 5U97 PIT 17.2535
172 5TUX ECH 17.2535
173 1HBK MYR 17.9775
174 2D5X L35 19.1781
175 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 21.3389
176 4V1F BQ1 22.093
177 2GBB CIT 22.4359
178 5ISZ GLY ILE LEU GLY PHE VAL PHE THR LEU 23.5
179 3IPQ 965 24
180 4DM8 REA 24
181 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 24.6512
182 3QFJ LEU LEU PHE GLY PHE PRO VAL TYR VAL 25
183 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 25.8216
184 2Y69 CHD 27.5
185 4OGQ UMQ 29.7297
186 4OGQ 7PH 29.7297
187 5O3Q CMP 30
188 4XB4 45D 33.5526
189 3UUD EST 46.1538
190 3KMR EQN 46.1538
Pocket No.: 3; Query (leader) PDB : 5LX9; Ligand: OLB; Similar sites found with APoc: 183
This union binding pocket(no: 3) in the query (biounit: 5lx9.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 4R6W PC 1.93798
2 1YKJ FAD 2.11268
3 1YKJ PHB 2.11268
4 2ZPA ACO 2.28013
5 2JFN UMA 2.45614
6 1LAF ARG 2.52101
7 6AP6 TLF 2.60223
8 5A3B APR 2.8169
9 1DMH LIO 2.8169
10 1X6V ADP 2.8169
11 4ZRN UPG 2.9316
12 1V0C ACO 2.9703
13 1V0C KNC 2.9703
14 4RW3 SHV 2.98013
15 2JJK R15 3.16901
16 1QM5 PLP 3.16901
17 5M1Z 6LW AHR 3.16901
18 3NC9 TR3 3.25733
19 3VGL ANP 3.25733
20 5KF9 ACO 3.25733
21 1M7G ADX 3.31754
22 1M7G AV2 3.31754
23 3P3G 3P3 3.33333
24 3P3G UKW 3.33333
25 4DHY S41 3.52113
26 2WW4 ADP 3.53357
27 4I4B 1CV 3.58306
28 4I4B NAD 3.58306
29 4NE2 ADP 3.58306
30 4NE2 SH2 3.58306
31 4V24 GYR 3.58306
32 3QCJ NX4 3.58306
33 2JLB UDM 3.58306
34 4OR7 NAP 3.63636
35 4OPC FDA 3.87324
36 5K7H IVC 3.87324
37 4X60 3XV 3.87324
38 4X60 SFG 3.87324
39 5YJF SAH 3.87324
40 5YJF 8WO 3.87324
41 5IGI ZIT 3.87324
42 5IGI GMP 3.87324
43 2IGA XX3 3.87324
44 5KDS A2G THR ALA PRO GLY GLY NAG SIA 3.90879
45 2GSQ GBI 4.22535
46 1P0H ACO 4.22535
47 1P0H COA 4.22535
48 4QJL COA 4.23453
49 3V2U ATP 4.23453
50 2YQS UD1 4.23453
51 3AJH BL3 4.43548
52 5CJH 522 4.45026
53 4KVX ACO 4.48718
54 1USF FMN 4.49438
55 2X24 X24 4.56026
56 1EM6 NBG 4.57746
57 6ECU SAH 4.57746
58 6DNT EPZ 4.65116
59 4Y30 SAH 4.88599
60 4Y30 49L 4.88599
61 1E8G FCR 4.88599
62 1E8G FAD 4.88599
63 3RGA ILD 4.88599
64 5LUN OGA 4.92958
65 4QVH COA 4.92958
66 5LUN ARG 4.92958
67 5YJI SAH 4.92958
68 5YJI 8WO 4.92958
69 4RPO T6C 4.93274
70 3LSJ COA PLM 5
71 3LSJ PLM COA 5
72 6AP8 BNY 5.20446
73 5DM1 SAH 5.24345
74 4JDR FAD 5.28169
75 6EJI UD2 5.28169
76 5J60 FAD 5.28169
77 3ZKK XYP XYP XYP XYP 5.28169
78 6BTN E8M 5.44554
79 5XDT ZI7 5.51948
80 4XSU UDP 5.53746
81 4XSU GLC 5.53746
82 2V2V V12 5.6338
83 4CS4 AXZ 5.6338
84 2J07 HDF 5.86319
85 2J07 FAD 5.86319
86 3AAQ ARU 5.94901
87 4WRI OKA 5.98592
88 4XPL ACO 6.13497
89 5ECP ATP 6.27803
90 5ECP JAA 6.27803
91 5ECP MET 6.27803
92 2WPW ACO 6.33803
93 2WPX ACO 6.33803
94 3RDE OYP 6.33803
95 1YSL COA 6.33803
96 1J3I NDP 6.33803
97 1J3I WRA 6.33803
98 3WR7 COA 6.47059
99 3LOO B4P 6.51466
100 1QSM ACO 6.57895
101 1S8G DAO 6.61157
102 5FVJ ACO 6.62651
103 1TIQ COA 6.66667
104 4MIB 28M 6.69014
105 3KV8 FAH 6.69014
106 2WUF KEM 6.87285
107 3X1M COA 6.91824
108 3E2M E2M 7.02703
109 2FXU BID 7.04225
110 1SAZ ACP 7.16612
111 4UA3 COA 7.2165
112 4C5N ACP 7.24638
113 4C5N PXL 7.24638
114 2JFZ DGL 7.45098
115 2JFZ 003 7.45098
116 4WZ8 3W7 7.49186
117 4OYA 1VE 7.49186
118 4QJK COA 7.65957
119 2XMY CDK 7.71812
120 2YPO PHE 7.74648
121 3HKW IX6 7.74648
122 4QC6 30N 7.82123
123 4KOT CE3 8.02469
124 2BL9 NDP 8.09859
125 4EIL FOL 8.09859
126 3K9U ACO 8.1761
127 6C8R EQV 8.17942
128 2WPF WPF 8.46906
129 1GHE ACO 8.47458
130 5MOB A8S 8.62069
131 4U9W COA 8.69565
132 1S7G NAD 8.69565
133 1D5Z ACE ALC ARG ALA ODA SER LEU NH2 8.78661
134 2D3M COA 8.79479
135 3PXP MYR 8.80282
136 1WWZ ACO 8.80503
137 3NIP 16D 8.89571
138 5FS0 5JC 9.00474
139 6MPT C30 9.09091
140 6C28 WCA 9.15493
141 1YBU APC 9.23913
142 3F3E LEU 9.44625
143 5HGZ ACO 9.46502
144 5IOR FAD 9.48276
145 5IOR DUS 9.48276
146 5IOR RBF 9.48276
147 4WVO 3UZ 9.85915
148 4CR6 MAN 9.85915
149 1ME8 RVP 9.94036
150 3C8Z 5CA 10.2113
151 4AG9 COA 10.303
152 2JEV NHQ 10.3448
153 4XU6 TDA 10.4762
154 6BWL UDP 10.5634
155 2AMT 1AA 10.6918
156 3EM0 CHD 10.8696
157 2CNT COA 11.25
158 5DXV NAP 11.5385
159 2FT0 ACO 12.3404
160 1YKI FMN 12.9032
161 1YKI NFZ 12.9032
162 3RYC GTP 13.2867
163 4XF6 LIP 13.5531
164 4XF6 INS 13.5531
165 1I1D 16G 13.6646
166 1I1D COA 13.6646
167 2WG9 OCA 13.8462
168 4KM2 TOP 13.9665
169 4KM2 ATR 13.9665
170 1RV0 NDG 15
171 4OBW SAM 15.1751
172 4OGN 2U5 15.2381
173 5K04 COA 15.2941
174 5O0B 9FE 15.4321
175 3ER9 3AT 15.8249
176 4C8E C5P 17.033
177 2PRG BRL 17.0455
178 2Q4V ACO 17.0588
179 6GD6 EVB 18.5185
180 2F5Z FAD 20.3125
181 4IHL 1F5 22.2222
182 1YRX FMN 23.1405
183 3R1V AZB 23.622
Pocket No.: 4; Query (leader) PDB : 5LX9; Ligand: OLB; Similar sites found with APoc: 423
This union binding pocket(no: 4) in the query (biounit: 5lx9.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 5DJT FMN None
2 2V0U FMN None
3 1UO5 PIH None
4 1AL8 DHP 1.9544
5 5UCD NAP 1.9544
6 4PJT 2YQ 2.11268
7 5EOB 5QQ 2.28013
8 1OPK P16 2.28013
9 2G86 UMP 2.28013
10 3SHZ 5CO 2.28013
11 1U8V FAD 2.28013
12 3HB5 E2B 2.46479
13 3HB5 NAP 2.46479
14 3B99 U51 2.46479
15 4PA0 2OW 2.46479
16 3ZUY TCH 2.46479
17 4BJZ FAD 2.59434
18 4BJZ P3A 2.59434
19 1ZGA HMK 2.60586
20 3VEH 0GA 2.60586
21 1H16 COA 2.60586
22 5MLR GRQ 2.60586
23 5HIP 61O 2.64026
24 2PGJ N1C 2.67176
25 4KWD JF2 2.8169
26 4WAS COO 2.8169
27 5AHS COA 2.8169
28 4INW 1EY 2.85714
29 1WXI AMP 2.90909
30 5J47 6JJ 2.9316
31 2WKQ FMN 2.9316
32 3W5N RAM 2.9316
33 4DE3 DN8 3.04183
34 1W2Y DUN 3.05677
35 3GB5 FMN 3.0888
36 4NSQ COA 3.15789
37 8CAT NDP 3.16206
38 5AEI LYS ARG LYS ARG LYS ARG LYS ARG LYS ARG 3.16901
39 3MPI GRA 3.16901
40 5OKL PAM 3.16901
41 6FK6 DOK 3.16901
42 6DIO NAD 3.16901
43 5EKO N17 3.16901
44 4BFW ZVW 3.16901
45 5OPM DTP 3.16901
46 5F5N 5VD 3.16901
47 4I90 CHT 3.16901
48 4UWJ MYA 3.25733
49 4UWJ 7L5 3.25733
50 4U0S ADP 3.25733
51 5IBE 69M 3.25733
52 4QJR PIZ 3.26531
53 1NQ7 ARL 3.27869
54 1QZR CDX 3.34928
55 1QZR ANP 3.34928
56 1XAP TTB 3.37079
57 1KUK PCA LYS TRP 3.52113
58 4PXZ 6AD 3.52113
59 1GPE FAD 3.52113
60 1QNF FAD 3.52113
61 1QNF HDF 3.52113
62 5G3Y ADP 3.52113
63 3Q9T FAY 3.52113
64 1YKD CMP 3.52113
65 1UUY PPI 3.52113
66 4DJA FAD 3.58306
67 4DJA DLZ 3.58306
68 2ZKJ ADP 3.58306