Receptor
PDB id Resolution Class Description Source Keywords
5LPZ 2.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE BRI1 KINASE DOMAIN (865-1196) IN CO ADP FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA BRASSINOSTEROID RECEPTOR KINASE DOMAIN DUAL-SPECIFICIFY KIMEMBRANE RECEPTOR KINASE PLASMA MEMBRANE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE PHOSPHORYLATED BRI1 KINAS AND IMPLICATIONS FOR BRASSINOSTEROID SIGNAL INITIAT PLANT J. V. 78 31 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ADP A:1200;
Valid;
none;
submit data
427.201 C10 H15 N5 O10 P2 c1nc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LPZ 2.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE BRI1 KINASE DOMAIN (865-1196) IN CO ADP FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA BRASSINOSTEROID RECEPTOR KINASE DOMAIN DUAL-SPECIFICIFY KIMEMBRANE RECEPTOR KINASE PLASMA MEMBRANE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE PHOSPHORYLATED BRI1 KINAS AND IMPLICATIONS FOR BRASSINOSTEROID SIGNAL INITIAT PLANT J. V. 78 31 2014
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 5LPZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 5LPZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
2 5LPB - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 5T1T ic50 = 58 nM 76P C16 H20 N4 O3 CN(C)C1CCC....
2 5T1S ic50 = 84 nM 76Q C27 H29 N3 O Cc1cc(cc(c....
3 2NRU - T12 C22 H24 N4 O6 CC(C)(C)C(....
4 4YO6 - 4GD C17 H14 N6 O Cc1cc(n(n1....
5 2OID - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
6 4ZTN ic50 = 19 nM 4S3 C20 H24 N6 O2 S c1ccc2c(c1....
7 2NRY - STU C28 H26 N4 O3 C[C@@]12[C....
8 4ZTL ic50 = 1.2 uM 4S1 C20 H25 N5 O3 S CCCNc1ncc(....
9 4Y73 ic50 = 0.3 nM XPY C18 H21 F3 N8 O Cn1cc(c(n1....
10 2OIC ic50 = 4 nM STU C28 H26 N4 O3 C[C@@]12[C....
11 5UIS ic50 = 146 nM 8C1 C18 H23 N3 O3 CC(C)Oc1cc....
12 5UIT ic50 = 4.6 nM 8CD C18 H21 N3 O4 CC(C)Oc1cc....
13 5UIU ic50 = 0.2 nM 8CG C18 H20 F N3 O4 CC[C@H]1[C....
14 3UIM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
15 5LPZ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
16 5LPB - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ADP; Similar ligands found: 435
No: Ligand ECFP6 Tc MDL keys Tc
1 ADP 1 1
2 ATP 0.9 1
3 A2D 0.895522 0.971831
4 AQP 0.887324 1
5 5FA 0.887324 1
6 AP5 0.884058 0.971831
7 B4P 0.884058 0.971831
8 BA3 0.869565 0.971831
9 AN2 0.84507 0.985915
10 M33 0.833333 0.958333
11 ACQ 0.826667 0.972222
12 A 0.823529 0.971429
13 AMP 0.823529 0.971429
14 ACP 0.821918 0.972222
15 AR6 0.810811 0.971831
16 APR 0.810811 0.971831
17 ANP 0.802632 0.972222
18 AD9 0.8 0.972222
19 AGS 0.8 0.945946
20 SAP 0.8 0.945946
21 ADX 0.783784 0.873418
22 CA0 0.783784 0.945205
23 TAT 0.779221 0.958904
24 AMP MG 0.774648 0.891892
25 50T 0.773333 0.958333
26 ABM 0.763889 0.917808
27 APC 0.763158 0.958904
28 PRX 0.763158 0.893333
29 ATF 0.759494 0.958904
30 A22 0.753086 0.985915
31 A12 0.743243 0.958904
32 AP2 0.743243 0.958904
33 ADP MG 0.736842 0.905405
34 SRA 0.736111 0.918919
35 ADQ 0.73494 0.945205
36 25L 0.732558 0.985915
37 ADP BEF 0.727273 0.881579
38 BEF ADP 0.727273 0.881579
39 5AL 0.725 0.931507
40 2A5 0.717949 0.918919
41 A1R 0.714286 0.907895
42 AU1 0.714286 0.972222
43 ADP PO3 0.708861 0.943662
44 PAP 0.708861 0.985714
45 ATR 0.708861 0.971429
46 SRP 0.707317 0.906667
47 7D3 0.706667 0.905405
48 25A 0.702381 0.971831
49 ATP MG 0.7 0.905405
50 OAD 0.697674 0.945205
51 RBY 0.6875 0.932432
52 ADV 0.6875 0.932432
53 00A 0.686047 0.883117
54 5SV 0.682353 0.848101
55 8QN 0.682353 0.931507
56 OOB 0.682353 0.931507
57 3OD 0.681818 0.945205
58 BIS 0.681818 0.933333
59 ADP ALF 0.674699 0.87013
60 ALF ADP 0.674699 0.87013
61 AMO 0.674419 0.932432
62 4AD 0.674419 0.92
63 PAJ 0.674419 0.884615
64 GAP 0.670732 0.893333
65 MAP 0.670588 0.945946
66 DLL 0.666667 0.931507
67 ANP MG 0.666667 0.894737
68 VO4 ADP 0.666667 0.931507
69 AHX 0.666667 0.896104
70 ADP VO4 0.666667 0.931507
71 PTJ 0.662921 0.896104
72 3UK 0.659091 0.918919
73 SON 0.658228 0.932432
74 LAD 0.651685 0.860759
75 WAQ 0.651685 0.883117
76 PR8 0.651685 0.85
77 ITT 0.65 0.943662
78 7D4 0.65 0.905405
79 G5P 0.648936 0.921053
80 RAB 0.647059 0.84507
81 ADN 0.647059 0.84507
82 XYA 0.647059 0.84507
83 TXA 0.644444 0.932432
84 1ZZ 0.644444 0.839506
85 ME8 0.644444 0.839506
86 NB8 0.644444 0.896104
87 FYA 0.644444 0.905405
88 6AD 0.642857 0.909091
89 ADP BMA 0.640449 0.918919
90 G3A 0.638298 0.921053
91 DAL AMP 0.632184 0.905405
92 AFH 0.631579 0.884615
93 9SN 0.630435 0.871795
94 GTA 0.625 0.886076
95 YAP 0.623656 0.894737
96 FA5 0.623656 0.906667
97 UP5 0.622449 0.92
98 XAH 0.617021 0.839506
99 AV2 0.616279 0.917808
100 AOC 0.615385 0.821918
101 48N 0.612245 0.896104
102 4UV 0.610526 0.894737
103 TXD 0.606061 0.907895
104 DND 0.606061 0.932432
105 NAX 0.606061 0.873418
106 NXX 0.606061 0.932432
107 NAI 0.606061 0.907895
108 6V0 0.606061 0.896104
109 5N5 0.605634 0.819444
110 5AS 0.604938 0.77907
111 A4P 0.60396 0.843373
112 DAT 0.60241 0.905405
113 A2R 0.602273 0.985915
114 TXE 0.6 0.907895
115 OMR 0.6 0.851852
116 4UU 0.597938 0.894737
117 A A 0.597826 0.944444
118 A4D 0.597222 0.819444
119 5CD 0.597222 0.805556
120 AP0 0.594059 0.896104
121 4TC 0.594059 0.896104
122 A3P 0.592593 0.971429
123 139 0.592233 0.873418
124 T5A 0.592233 0.841463
125 7D5 0.592105 0.878378
126 ATP A A A 0.589474 0.930556
127 LAQ 0.585859 0.839506
128 MYR AMP 0.585106 0.817073
129 YLP 0.58 0.819277
130 UPA 0.578431 0.907895
131 7DD 0.578313 0.985714
132 ADJ 0.576923 0.851852
133 3AM 0.576923 0.929577
134 COD 0.575472 0.811765
135 NAD 0.575472 0.931507
136 3AT 0.574713 0.971831
137 JB6 0.574468 0.883117
138 4UW 0.574257 0.860759
139 EP4 0.573333 0.753247
140 A2P 0.573171 0.957143
141 CNA 0.571429 0.932432
142 TYM 0.568627 0.906667
143 PPS 0.568182 0.873418
144 TYR AMP 0.56701 0.881579
145 DTA 0.565789 0.786667
146 M2T 0.565789 0.734177
147 AR6 AR6 0.565657 0.917808
148 A3D 0.564815 0.918919
149 3DH 0.564103 0.773333
150 G5A 0.563218 0.77907
151 YLB 0.563107 0.819277
152 YLC 0.563107 0.839506
153 AMP DBH 0.561224 0.893333
154 MTA 0.558442 0.773333
155 DTP 0.556818 0.905405
156 AHZ 0.554455 0.817073
157 NA7 0.553191 0.958904
158 IOT 0.552381 0.831325
159 7MD 0.55 0.8625
160 ZAS 0.55 0.766234
161 IMO 0.548781 0.929577
162 YLA 0.54717 0.819277
163 NAE 0.544643 0.894737
164 TAD 0.544554 0.884615
165 A5A 0.544444 0.807229
166 2AM 0.544304 0.943662
167 TSB 0.543478 0.819277
168 6RE 0.54321 0.759494
169 AYB 0.542056 0.809524
170 NAQ 0.539823 0.871795
171 V3L 0.539326 0.971831
172 ARG AMP 0.539216 0.829268
173 AF3 ADP 3PG 0.538462 0.8375
174 SSA 0.538462 0.8
175 LA8 ALF 3PG 0.538462 0.8375
176 ALF ADP 3PG 0.538462 0.8375
177 ZID 0.535088 0.918919
178 LPA AMP 0.533981 0.817073
179 54H 0.532609 0.788235
180 52H 0.532609 0.77907
181 VMS 0.532609 0.788235
182 BTX 0.53211 0.841463
183 J7C 0.53012 0.769231
184 A3N 0.53012 0.786667
185 5X8 0.528736 0.763158
186 BT5 0.527273 0.831325
187 5CA 0.526882 0.8
188 53H 0.526882 0.77907
189 ARU 0.526316 0.860759
190 EAD 0.525862 0.873418
191 RGT 0.525253 0.958904
192 OVE 0.52439 0.905405
193 S4M 0.52381 0.666667
194 7DT 0.522727 0.985714
195 GDP 0.522222 0.92
196 DDS 0.522222 0.878378
197 AVV 0.521277 0.896104
198 NDE 0.521008 0.932432
199 7MC 0.518868 0.841463
200 DSH 0.518072 0.725
201 MAO 0.517647 0.759036
202 LSS 0.515789 0.761364
203 DSZ 0.515789 0.8
204 NSS 0.515789 0.8
205 P5A 0.515464 0.744444
206 DZD 0.513514 0.884615
207 NVA LMS 0.510417 0.761364
208 12D 0.509615 0.785714
209 NAD IBO 0.509091 0.87013
210 M24 0.508772 0.85
211 YLY 0.508772 0.809524
212 P1H 0.508333 0.851852
213 5AD 0.506849 0.746479
214 GJV 0.505882 0.75
215 LEU LMS 0.505155 0.761364
216 G A A A 0.504505 0.871795
217 4TA 0.504505 0.807229
218 NAJ PZO 0.504425 0.848101
219 KAA 0.5 0.752809
220 NDC 0.5 0.871795
221 7D7 0.5 0.743243
222 71V 0.5 0.907895
223 A3G 0.5 0.8
224 128 0.5 0.776471
225 GSU 0.5 0.77907
226 N0B 0.495726 0.819277
227 NJP 0.495495 0.945946
228 ODP 0.495495 0.909091
229 2SA 0.494624 0.932432
230 6C6 0.494505 0.881579
231 SFG 0.494382 0.75
232 0WD 0.491071 0.921053
233 YSA 0.490196 0.77907
234 PO4 PO4 A A A A PO4 0.489796 0.902778
235 6IA 0.48913 0.8375
236 SAM 0.48913 0.690476
237 A7D 0.488636 0.776316
238 6FA 0.488 0.841463
239 FB0 0.487805 0.804598
240 NAJ PYZ 0.487179 0.85
241 IDP 0.483516 0.918919
242 A5D 0.483516 0.786667
243 SA8 0.483516 0.707317
244 MHZ 0.483146 0.697674
245 PGS 0.483146 0.883117
246 D5M 0.482353 0.878378
247 DA 0.482353 0.878378
248 NEC 0.482353 0.746667
249 NIA 0.481928 0.822785
250 Y3J 0.480519 0.726027
251 FAD 0.480315 0.851852
252 FAS 0.480315 0.851852
253 FDA 0.48 0.833333
254 N6P 0.479592 0.915493
255 GGZ 0.479167 0.825
256 SAH 0.478261 0.74359
257 SAI 0.478261 0.734177
258 NPW 0.477477 0.886076
259 NDP 0.477477 0.921053
260 AAM 0.476744 0.971429
261 AMZ 0.47561 0.916667
262 C2R 0.47561 0.90411
263 A A A 0.474747 0.905405
264 GTP 0.473684 0.92
265 U A G G 0.473684 0.883117
266 SMM 0.473684 0.686047
267 TXP 0.473214 0.921053
268 NZQ 0.473214 0.909091
269 A3S 0.47191 0.810811
270 AMP NAD 0.470588 0.881579
271 SFD 0.46875 0.734043
272 AIR 0.468354 0.901408
273 AAT 0.468085 0.707317
274 EEM 0.468085 0.690476
275 Z5A 0.466667 0.77907
276 7C5 0.466667 0.818182
277 J7V 0.466667 0.833333
278 62F 0.465649 0.8625
279 FAY 0.462121 0.8625
280 ETB 0.461538 0.833333
281 DCA 0.461538 0.823529
282 A3T 0.461538 0.821918
283 A6D 0.46 0.722892
284 A U 0.459459 0.87013
285 6K6 0.459184 0.930556
286 GEK 0.459184 0.7375
287 RFL 0.458647 0.821429
288 S7M 0.458333 0.690476
289 NAP 0.458333 0.945205
290 4YB 0.457944 0.761364
291 WSA 0.454545 0.788235
292 TAP 0.454545 0.907895
293 FNK 0.454545 0.804598
294 COA 0.453782 0.823529
295 0T1 0.453782 0.823529
296 101 0.453488 0.878378
297 XNP 0.452174 0.873418
298 NA0 0.45082 0.932432
299 7RP 0.448276 0.928571
300 GP3 0.446809 0.921053
301 TM1 0.446602 0.77381
302 APU 0.446429 0.894737
303 PUA 0.445378 0.884615
304 V1N 0.443396 0.917808
305 7RA 0.443182 0.957747
306 30N 0.442623 0.752688
307 CAO 0.442623 0.795455
308 AMX 0.442623 0.833333
309 COS 0.442623 0.804598
310 ACK 0.44186 0.861111
311 QQY 0.44186 0.815789
312 649 0.441441 0.744444
313 0UM 0.44 0.698795
314 NHD 0.439655 0.905405
315 CMX 0.439024 0.823529
316 SCO 0.439024 0.823529
317 GCP 0.438776 0.896104
318 8BR 0.438202 0.906667
319 GNH 0.4375 0.907895
320 3AD 0.4375 0.805556
321 62X 0.435644 0.666667
322 ACO 0.435484 0.795455
323 FCX 0.435484 0.795455
324 FAM 0.435484 0.804598
325 GNP 0.434343 0.896104
326 NMX 0.433071 0.76087
327 MGP 0.43299 0.884615
328 PLP AAD 0.432203 0.741573
329 26A 0.432099 0.763158
330 HAX 0.432 0.804598
331 K15 0.431373 0.682353
332 DG1 0.430894 0.921053
333 1DG 0.430894 0.921053
334 QQX 0.430233 0.805195
335 2VA 0.430108 0.8
336 S8M 0.43 0.759494
337 2MC 0.429688 0.769231
338 3KK 0.428571 0.804598
339 6G0 0.428571 0.884615
340 FYN 0.428571 0.823529
341 P5F 0.428571 0.823529
342 NAD BBN 0.428571 0.841463
343 U G A 0.427481 0.839506
344 AS 0.426966 0.833333
345 FAI 0.426966 0.916667
346 RMB 0.426966 0.873239
347 1RB 0.425287 0.885714
348 MCD 0.425197 0.804598
349 OXK 0.425197 0.804598
350 COK 0.425197 0.804598
351 CA6 0.425197 0.729167
352 SOP 0.425197 0.804598
353 G1R 0.424242 0.907895
354 CC5 0.423077 0.816901
355 SXZ 0.423077 0.710843
356 F2N 0.422535 0.813953
357 NAD CJ3 0.422222 0.811765
358 ANZ 0.422018 0.8
359 CMC 0.421875 0.804598
360 CO6 0.421875 0.804598
361 1VU 0.421875 0.795455
362 ZDA 0.421053 0.864865
363 GDD 0.420561 0.884615
364 GKE 0.420561 0.884615
365 GDC 0.420561 0.884615
366 NFD 0.420168 0.883117
367 GSP 0.42 0.873418
368 D3Y 0.42 0.789474
369 MC4 0.419847 0.76087
370 3L1 0.419753 0.773333
371 3D1 0.419753 0.773333
372 FA9 0.41958 0.864198
373 5GP 0.419355 0.906667
374 G 0.419355 0.906667
375 KB1 0.419048 0.698795
376 SCD 0.418605 0.823529
377 CAJ 0.418605 0.804598
378 2BA 0.417582 0.915493
379 CMP 0.417582 0.901408
380 SO8 0.416667 0.789474
381 N01 0.416667 0.905405
382 VRT 0.416667 0.769231
383 3HC 0.415385 0.813953
384 A1S 0.415385 0.804598
385 BCO 0.415385 0.804598
386 IVC 0.415385 0.813953
387 MLC 0.415385 0.804598
388 1HE 0.415385 0.786517
389 NMN AMP PO4 0.415254 0.87013
390 2FA 0.414634 0.813333
391 MGO 0.414141 0.860759
392 3NZ 0.413462 0.782051
393 MCA 0.412214 0.795455
394 CAA 0.412214 0.813953
395 YE1 0.412214 0.813953
396 COO 0.412214 0.804598
397 GAV 0.411765 0.884615
398 P2P 0.411111 0.902778
399 JLN 0.411111 0.890411
400 ZZB 0.410256 0.77381
401 CNV FAD 0.410072 0.793103
402 SCA 0.409091 0.804598
403 RP1 0.409091 0.842105
404 103 0.409091 0.837838
405 2CP 0.409091 0.795455
406 SP1 0.409091 0.842105
407 PAX 0.408 0.829268
408 FAD NBT 0.407143 0.75
409 NVA 2AD 0.40625 0.74359
410 COW 0.406015 0.795455
411 BYC 0.406015 0.804598
412 2KQ 0.406015 0.786517
413 COF 0.406015 0.786517
414 3CP 0.406015 0.804598
415 IRC 0.406015 0.813953
416 1GZ 0.406015 0.795455
417 HGG 0.406015 0.804598
418 CA8 0.406015 0.729167
419 G2P 0.405941 0.884615
420 SLU 0.404959 0.770115
421 U A C C 0.404959 0.858974
422 RBZ 0.404494 0.849315
423 1CZ 0.404412 0.795455
424 BCA 0.402985 0.795455
425 FAQ 0.402985 0.804598
426 4CA 0.402985 0.795455
427 MTP 0.402439 0.730769
428 8OD 0.402062 0.945205
429 CO7 0.401515 0.804598
430 DAL FAD PER 0.401408 0.809524
431 G2R 0.4 0.884615
432 HXC 0.4 0.786517
433 ENQ 0.4 0.916667
434 GMV 0.4 0.896104
435 GRA 0.4 0.804598
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LPZ; Ligand: ADP; Similar sites found: 356
This union binding pocket(no: 1) in the query (biounit: 5lpz.bio1) has 20 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2IF8 ADP 0.00009707 0.4427 1.20482
2 2VPQ ANP 0.0002537 0.47332 1.50602
3 3ORQ ADP 0.001041 0.44204 1.50602
4 3K5I ADP 0.002131 0.4283 1.50602
5 3K5I AIR 0.006975 0.42056 1.50602
6 5J3Z 6FQ 0.009177 0.4284 1.5625
7 3UDZ ADP 0.00001447 0.52141 1.80723
8 3Q60 ATP 0.00002969 0.51108 1.80723
9 5MW8 ATP 0.00005076 0.5045 1.80723
10 2QK4 ATP 0.001439 0.40394 1.80723
11 4ZGP ADP 0.001596 0.4247 2.38908
12 4CYI ATP 0.000003239 0.55268 2.40964
13 2GQR ADP 0.002398 0.41738 2.53165
14 2GQS ADP 0.007506 0.40391 2.53165
15 5I35 ANP 0.0000004247 0.59328 2.71084
16 3I0O ADP 0.00005645 0.51774 2.71084
17 4OCJ NDG 0.0001059 0.51214 2.71084
18 2VQD AP2 0.0002174 0.45296 2.71084
19 3KAL ADP 0.002965 0.4391 2.71084
20 4AVB CMP 0.006629 0.41423 2.71084
21 4OCV ANP 0.00006219 0.4823 3.01205
22 5TDF ADP 0.001114 0.44074 3.01205
23 3RE4 TO1 0.000002639 0.51472 3.10078
24 5W2I I3P 0.0003591 0.46852 3.11284
25 5W2I ADP 0.0003591 0.46852 3.11284
26 3VPC ADP 0.00003991 0.47226 3.19149
27 4R78 AMP 0.00001621 0.55154 3.23625
28 1IOW ADP 0.002649 0.44264 3.26797
29 1IOW PHY 0.002649 0.44264 3.26797
30 5C1P DAL DAL 0.004722 0.41989 3.26797
31 5C1P ADP 0.001175 0.41854 3.26797
32 4GYI ADP 0.00006265 0.50889 3.31325
33 5VZ0 ADP 0.0001067 0.47485 3.31325
34 4MV1 ADP 0.005485 0.42541 3.31325
35 1M0W ANP 0.002808 0.41002 3.31325
36 1GPM AMP 0.02954 0.40321 3.31325
37 3ZJX BOG 0.01135 0.41861 3.46021
38 1ZP9 ATP 0.0000004377 0.60092 3.48837
39 1ZTH ADP 0.0000001562 0.56104 3.48837
40 5TVM PUT 0.01867 0.40221 3.50877
41 4FE2 ADP 0.006664 0.41413 3.52941
42 1TQP ATP 0.0000137 0.47425 3.5461
43 2CFM AMP 0.001116 0.45566 3.61446
44 2YW2 ATP 0.00354 0.40262 3.61446
45 5FI4 5XV 0.01149 0.40089 3.71517
46 3PN1 IVH 0.001553 0.40152 3.77358
47 5AVF TAU 0.009585 0.41523 3.89105
48 3ETH ATP 0.0008435 0.44809 3.91566
49 2YRX AMP 0.005945 0.43304 3.91566
50 3TY5 ATP 0.002386 0.40107 3.91566
51 3VOT ADP 0.000161 0.44814 4.21687
52 2IO8 ADP 0.0002808 0.42491 4.21687
53 1TZD ADP 0.002714 0.44638 4.36364
54 2V58 LZJ 0.001588 0.46331 4.51807
55 1EHI ADP 0.0032 0.41067 4.51807
56 1W2D ADP 0.001456 0.45013 4.5283
57 5IQD RIO 0.0003231 0.48932 4.59016
58 5IQD GNP 0.000303 0.48932 4.59016
59 3AKK ADP 0.0002995 0.46369 4.61538
60 4LH7 1X8 0.002401 0.45193 4.95356
61 4CC6 L5Y 0.001338 0.45734 5.03145
62 4O4F ATP 0.002462 0.43267 5.24194
63 4O4F IHP 0.002672 0.43267 5.24194
64 3HAV ATP 0.00006749 0.43546 5.35117
65 3VPB ADP 0.00007417 0.50127 5.35714
66 4B1L FRU 0.002834 0.44572 5.45455
67 4XYM A12 0.0004353 0.45657 5.65217
68 4OAV ACP 0.00000001749 0.65502 5.72289
69 2PUL ACP 0.0005703 0.47892 5.72289
70 1S9D AFB 0.00925 0.41159 5.91133
71 4OUC 5ID 0.000001815 0.54199 6.0241
72 3V4S ATP 0.001997 0.43147 6.0241
73 3V4S ADP 0.009813 0.41719 6.0241
74 5MY8 RXZ 0.0000004275 0.60224 6.3253
75 3KA2 2NC 0.03075 0.40599 6.40394
76 4LRJ ANP 0.0001847 0.4659 6.50888
77 5IGI ZIT 0.0077 0.42435 6.64452
78 5IGI GMP 0.0073 0.42435 6.64452
79 4ZS4 ATP 0.00001692 0.50638 6.84039
80 2Q7D ANP 0.0005563 0.46356 6.92771
81 4O1P ANP 0.00000001117 0.65432 7.22892
82 3X01 AMP 0.0006263 0.48196 7.22892
83 5ML3 DL3 0.008325 0.42275 7.38255
84 2GJ5 VD3 0.01335 0.41304 7.40741
85 3PDT ADP 0.0001062 0.47044 7.63636
86 2PVN P63 0.00000001485 0.67598 7.83133
87 1T36 ADP 0.002905 0.43256 7.83133
88 1IA9 ANP 0.00002488 0.49884 7.85714
89 3W0O ADP 0.0000458 0.4252 8.13253
90 3W0O HY0 0.0000458 0.4252 8.13253
91 4UWH JXM 0.002982 0.40773 8.13253
92 2PYW ADP 0.000004293 0.54728 8.73494
93 4ZWP M44 0.01433 0.41106 8.73494
94 4AZT LY2 0.001395 0.45102 9.03614
95 2BKK ADP 0.000062 0.47004 9.46746
96 3KDJ A8S 0.008347 0.40024 10.1266
97 4U98 ACP 0.0008248 0.44672 10.241
98 4Q5H ANP 0.00005935 0.49199 10.8974
99 5M06 ADP 0.000001527 0.54277 11.5942
100 4IJP 1EH 0.000000001967 0.69461 11.747
101 2AQX ATP 0.002442 0.40415 12.1107
102 3PE2 E1B 0.00000004182 0.68467 12.6506
103 4JR7 GNP 0.00000001074 0.65506 12.6506
104 3M2W L8I 0.0000001685 0.57272 13.0435
105 1Q8Y ADP 0.0000000104 0.66271 13.253
106 1Q8Y ADE 0.0000001278 0.55756 13.253
107 5IH1 GDP 0.01414 0.42182 13.9073
108 5IH1 6BQ 0.01497 0.42061 13.9073
109 4G17 0VN 0.000002501 0.53411 14.2424
110 4WB6 ATP 0.000000016 0.6693 14.4578
111 5C03 AGS 0.0000001171 0.60986 14.4578
112 4ANW O92 0.0002587 0.40083 14.4578
113 2GU8 796 0.00000004786 0.69352 14.759
114 1RE8 BD2 0.00000005978 0.67721 14.759
115 2QCS ANP 0.00000001425 0.67158 14.759
116 3IDB ANP 0.00000001974 0.58762 14.759
117 4WB7 ATP 0.000000024 0.48839 14.759
118 3FHI ANP 0.00000001121 0.6763 15.0602
119 3FHR P4O 0.000003951 0.53192 15.6627
120 4H3Q ANP 0.00000000006724 0.76681 15.9639
121 4H3P ANP 0.0000000000713 0.74998 15.9639
122 4XBT 3ZQ 0.004352 0.41066 16.129
123 4XBT FLC 0.00579 0.40525 16.129
124 2RIO ADP 0.00000003305 0.62323 16.8675
125 5DMZ ADP 0.000001048 0.56838 17.4699
126 3VHE 42Q 0.000001354 0.46676 18.3735
127 5GZ9 ANP 0.000000009648 0.67056 19.0164
128 3GNI ATP 0.000000001312 0.70237 21.0843
129 5VC5 96M 0.0000000005878 0.73725 23.1834
130 4WOV 3SM 0.0000002393 0.62185 23.7952
131 2WU6 DKI 0.000000000708 0.72118 24.6988
132 3OFM 4B0 0.0000001734 0.57076 25.1429
133 3C0G 3AM 0.0000001199 0.63587 25.3012
134 2ZV2 609 0.00000005428 0.66224 25.5034
135 3TTI KBI 0.0000000198 0.54674 25.9036
136 3PTG 932 0.000002774 0.51369 25.9036
137 4WHZ 3NL 0.0000005904 0.40514 25.9036
138 4IZY 1J2 0.0000005341 0.55415 26.2048
139 2WEL K88 0.000001259 0.49645 26.2997
140 3GC0 AMP 0.00000006241 0.64912 26.4438
141 4UX9 ANP 0.000000005482 0.63583 26.506
142 5X8I SQZ 0.00000009084 0.61466 26.506
143 2V7O DRN 0.00000000822 0.60112 26.506
144 4OTH DRN 0.00000002799 0.59749 26.506
145 3E7O 35F 0.00001915 0.53917 26.506
146 3KN5 ANP 0.0000009267 0.54455 26.7692
147 4YLL 4E3 0.0000001396 0.61878 26.8072
148 5W4W 9WG 0.0000009362 0.59786 27.1903
149 4KBA 1QM 0.000002154 0.47984 27.1903
150 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.000000025 0.70872 27.4096
151 2JDR L20 0.000000025 0.70872 27.4096
152 5AWM ANP 0.00000007827 0.65462 27.4096
153 4IDT T28 0.00000003045 0.62519 27.4096
154 2R5T ANP 0.0000003593 0.54905 27.4096
155 4Y0X ADP 0.000001825 0.54299 27.4096
156 2PZI AXX 0.000093 0.50087 27.4096
157 2VZ6 FEF 0.000003854 0.56546 27.476
158 5VCV 1N1 0.0000000004148 0.6324 27.6527
159 3MVH WFE 0.00000003229 0.66295 27.7108
160 1XJD STU 0.00000004459 0.61361 28.012
161 3IGO ANP 0.000005703 0.50662 28.012
162 5BYZ 4WE 0.0000001213 0.63878 28.3133
163 5T8O 76Z 0.0000000187 0.61337 28.3133
164 4BHN BH9 0.00000002842 0.60722 28.3133
165 4L9I 8PR 0.0003336 0.45531 28.3133
166 1OPK P16 0.00001257 0.43405 28.3133
167 2VN9 GVD 0.0000002061 0.54537 28.5714
168 4YZC STU 0.0000003279 0.62859 28.6145
169 3TXO 07U 0.00000009109 0.59503 28.6145
170 4WNK 453 0.000001212 0.59067 28.6145
171 4CLI 5P8 0.0000000214 0.69533 28.7462
172 3H9R TAK 0.000001103 0.60891 28.7879
173 5BVE 4VG 0.0000000439 0.70179 28.9157
174 4QTB 38Z 0.000000006509 0.69235 28.9157
175 4CRL C1I 0.00000004051 0.66513 28.9157
176 3FC2 IBI 0.000007089 0.59708 28.9157
177 3GC8 B45 0.00000004062 0.58757 28.9157
178 5TA6 79D 0.00000006733 0.53104 28.9157
179 2CSN CKI 0.00006445 0.5419 28.9562
180 2Z7R STU 0.000000002139 0.69645 28.972
181 3ALN ANP 0.00000000311 0.68583 29.052
182 1OUK 084 0.000001878 0.64858 29.2169
183 5LI1 ANP 0.00000009736 0.62286 29.2169
184 3DLS ADP 0.0000003373 0.57126 29.2169
185 5LI9 ACP 0.000005307 0.52716 29.2169
186 4EUU BX7 0.00000037 0.51573 29.5181
187 4Y93 746 0.000001265 0.50389 29.5181
188 4DC2 ADE 0.0000004343 0.49096 29.5181
189 4N70 2HX 0.000000006649 0.72642 29.5732
190 1CM8 ANP 0.00000006521 0.61067 29.8193
191 4LOO SB4 0.00005175 0.49458 29.8193
192 4FL3 ANP 0.00000000174 0.70043 30.1205
193 4JDI ANP 0.00000003562 0.63911 30.1205
194 3V8S 0HD 0.000001271 0.57206 30.1205
195 3VRY B43 0.00000001489 0.56831 30.1205
196 5EKO N17 0.0001399 0.48486 30.1205
197 3LXK MI1 0.00000002696 0.66163 30.2752
198 1Y57 MPZ 0.0000000004032 0.65084 30.4217
199 2H8H H8H 0.0000000169 0.64649 30.4217
200 4BFM ANP 0.00000001329 0.62102 30.4217
201 3SXF BK5 0.000002657 0.44072 30.4217
202 2XK9 XK9 0.0009912 0.49506 30.4348
203 5IH9 6BF 0.0000000136 0.69145 30.4478
204 4X7Q 3YR 0.00000007621 0.61798 30.4487
205 4BKJ STI 0.0001365 0.48933 30.4762
206 2PVF ACP 0.000000003137 0.68828 30.7229
207 4Y85 499 0.000001197 0.55835 30.7229
208 3PP0 03Q 0.0000002423 0.51729 30.7229
209 4AU8 Z3R 0.0000005165 0.54479 30.7432
210 4L3L 5FI 0.0000005951 0.60485 30.9211
211 3TKI S25 0.0000002852 0.65292 30.9598
212 1U5R ATP 0.0000000009116 0.70175 31.0241
213 2HY0 306 0.00000136 0.5866 31.0559
214 4F9C 0SX 0.000001377 0.55575 31.3253
215 5UKL SIX 0.00008069 0.50342 31.3253
216 3PVW QRX 0.0001099 0.43614 31.3253
217 4G31 0WH 0.00002052 0.4143 31.4381
218 5HQ0 LZ9 0.000000003662 0.6827 31.457
219 5HX8 66P 0.000000007617 0.57038 31.457
220 4I6H 1C8 0.0000008704 0.57189 31.4935
221 2B9H ADP 0.000000003911 0.6779 31.6265
222 2B9F ADP 0.000000003294 0.67743 31.6265
223 2B9I ADP 0.00000001296 0.65152 31.6265
224 2B9J ADP 0.00000000919 0.64724 31.6265
225 4E93 GUI 0.0000000008662 0.5474 31.6265
226 3E8N ATP 0.0000000002826 0.4872 31.6265
227 3E8N VRA 0.0000000002826 0.4872 31.6265
228 5KO1 6UY 0.000000002997 0.68917 31.8021
229 5JKG 6LF 0.00006198 0.52311 31.8328
230 1UNH IXM 0.000000002592 0.64303 31.8493
231 3O0G 3O0 0.00000003086 0.62465 31.8493
232 2F57 23D 0.0000004102 0.6022 31.8612
233 4FF8 14S 0.000004254 0.50536 31.8885
234 3GQI ACP 0.00000003746 0.63143 31.9018
235 5EFQ ADP 0.00000000104 0.69925 31.9277
236 4NST ADP 0.000000002356 0.68378 31.9277
237 5JZJ AN2 0.000000007993 0.6487 31.9865
238 3F7Z 34O 0.000000001824 0.68862 32.2289
239 3EKK GS2 0.000000003382 0.50747 32.2476
240 4M69 ANP 0.000000007857 0.66807 32.2684
241 4K33 ACP 0.00000001266 0.65553 32.3077
242 3BU5 ATP 0.000000003272 0.67756 32.3529
243 5DH3 5BS 0.0000003466 0.5644 32.381
244 2WEI VGG 0.00004499 0.50914 32.4042
245 3CY2 MB9 0.000000008956 0.603 32.4841
246 2QLU ADE 0.0000001919 0.46452 32.4841
247 3ZRM ZRM 0.0000000932 0.61418 32.5301
248 3RI1 3RH 0.00000002054 0.66439 32.5879
249 4NW6 2NS 0.000000005455 0.52872 32.8173
250 2YAB AMP 0.000002111 0.55807 32.8313
251 3HZT J60 0.0000116 0.55066 32.8313
252 3GGF GVD 0.00000002719 0.61704 32.8904
253 5G1X ADP 0.00000008255 0.62499 32.9825
254 5L8L ADP 0.0000002395 0.55902 32.9825
255 2BPM 529 0.000000001683 0.45504 33.0097
256 4EWH T77 0.000000185 0.51546 33.0909
257 2JLD AG1 0.00000000477 0.70829 33.1325
258 4NM5 ADP 0.0003218 0.50184 33.1325
259 5LXM ADP 0.00000005074 0.61546 33.2155
260 3NW7 LGV 0.00000203 0.60354 33.2248
261 5U6C 7YS 0.0000000003979 0.72887 33.3333
262 5EYK 5U5 0.000001006 0.59008 33.3333
263 2X2M X2M 0.0000001394 0.61594 33.4395
264 5UR1 YY9 0.000001862 0.60107 33.4405
265 3ORK AGS 0.0000005452 0.52225 33.4405
266 4AUA 4AU 0.000006181 0.52876 33.5505
267 5DRB 5FJ 0.000003161 0.40239 33.677
268 1V0O INR 0.00000003333 0.61926 33.6806
269 2OO8 RAJ 0.000267 0.43828 33.7539
270 5JFS 6K0 0.000000003508 0.72725 33.7662
271 5HCY 60D 0.000000002881 0.737 33.8369
272 4USF 6UI 0.0000006196 0.59248 33.8816
273 1VJY 460 0.000000000353 0.75829 33.9934
274 4CFU 2WC 0.0000000002007 0.75321 33.9934
275 4U44 3D9 0.0000007113 0.57571 34.0361
276 1K3A ACP 0.00000000846 0.62502 34.1137
277 2X4Z X4Z 0.0000001983 0.63506 34.1216
278 3SLS ANP 0.0000000003443 0.73166 34.2105
279 4BCQ TJF 0.000000005924 0.61828 34.2193
280 4BCM T7Z 0.00000001261 0.5739 34.2193
281 2XMY CDK 0.0000003719 0.65908 34.2282
282 4BCN T9N 0.000000000316 0.75638 34.3333
283 5DEY 59T 0.000000208 0.65961 34.3434
284 4C2V YJA 0.000006752 0.45666 34.386
285 5TO8 7FM 0.0000001852 0.64384 34.3972
286 5AX9 4KT 0.00000003673 0.6318 34.4156
287 5JGA 6KC 0.00000004418 0.5038 34.6032
288 3HMO STU 0.0000001276 0.59775 34.6386
289 4ASE AV9 0.0000007907 0.48823 34.6386
290 5LMK 6ZK 0.0000004319 0.56671 34.6801
291 5EW9 5VC 0.000004775 0.62741 34.6863
292 4XLI 1N1 0.0000003876 0.59505 34.7015
293 3E5A VX6 0.000000306 0.52751 34.7015
294 3AQV TAK 0.0002359 0.46587 34.7826
295 3KRL KRL 0.000002188 0.52295 34.9398
296 5USZ SKE 0.000000004032 0.56943 34.9481
297 3G5D 1N1 0.000000009421 0.72816 34.965
298 4TWP AXI 0.00000005644 0.67681 35.0554
299 5UOX 8GY 0.00000001598 0.60319 35.0554
300 4C2W ANP 0.0000006074 0.54321 35.1254
301 3DAK ANP 0.00000007561 0.59799 35.1724
302 4WNP 3RJ 0.000000001029 0.73242 35.1916
303 4YMJ 4EJ 0.0000000001892 0.82096 35.1974
304 5CEO 50D 0.0000003246 0.59056 35.3333
305 4AT3 LTI 0.00000003699 0.51349 35.4515
306 4P5Z Q7M 0.000000003665 0.72233 35.5422
307 4BTK DTQ 0.000003115 0.54776 35.5422
308 1PHK ATP 0.00000000125 0.69962 35.5705
309 3KMW ATP 0.0000001075 0.60175 35.7934
310 3PLS ANP 0.0000000004463 0.72603 35.906
311 3KRR DQX 0.0000000119 0.73244 36.2712
312 1ZY5 ANP 0.000001062 0.55964 36.3036
313 4AG8 AXI 0.000002127 0.43318 36.3924
314 5NKB 8ZT 0.00000001089 0.46563 36.6013
315 2A19 ANP 0.000000004979 0.71192 36.6197
316 5N87 N66 0.0000002531 0.63202 36.7412
317 4KS7 X4Z 0.0000001287 0.56125 36.9863
318 2HK5 1BM 0.00000004939 0.63284 37.037
319 3SRV S19 0.0000000008421 0.69011 37.1841
320 4CSV STI 0.000009747 0.48593 37.4545
321 2Y6O 1N1 0.00000006018 0.63213 37.457
322 4RFM 3P6 0.0000002507 0.41197 37.594
323 4F4P 0SB 0.0000000244 0.71189 37.7289
324 4QMN DB8 0.00000005072 0.48028 38.0645
325 4NFN 2KC 0.00001455 0.51049 38.1877
326 2YAK OSV 0.0000001782 0.50366 38.2456
327 4A4X JUP 0.000000002595 0.70509 38.3513
328 2OFV 242 0.00000005269 0.66392 38.9892
329 4I94 ANP 0.0000005272 0.57199 39
330 1JPA ANP 0.00000000363 0.76802 39.1026
331 4Y8D 49J 0.0000004371 0.58493 39.4578
332 5A6N U7E 0.0000004706 0.58666 39.9293
333 2WQN ADP 0.000005532 0.55813 40
334 5LVP ATP 0.000001337 0.5395 40
335 3C1X CKK 0.00002601 0.47961 40.3614
336 2XVD AS6 0.00000001839 0.53743 40.3974
337 1U59 STU 0.00000008109 0.61681 40.4181
338 5H2U 1N1 0.00000005402 0.6245 40.4494
339 5MJA 7O3 0.0000003161 0.57004 40.6557
340 5DA3 58V 0.00000001144 0.69462 40.7547
341 4D2S DYK 0.0000007454 0.54628 40.8451
342 3LXN MI1 0.000000002565 0.6495 41.195
343 5HES 032 0.0000002119 0.60788 41.3681
344 4YZN 4K5 0.000000001947 0.70158 41.8118
345 4FG8 ATP 0.0000007339 0.58113 41.9048
346 5EOB 5QQ 0.0000001689 0.66535 42.3197
347 4E1Z 0MX 0.0000002244 0.55097 42.6117
348 5FBN 5WF 0.00000006728 0.65695 42.8044
349 2J7T 274 0.01882 0.42412 43.0464
350 5HVJ ANP 0.00000008364 0.68459 43.1746
351 4U0I 0LI 0.0000119 0.43095 43.4921
352 4GJ3 0XP 0.000000002422 0.54552 43.7086
353 4XV1 904 0.00000001681 0.68287 43.8356
354 1BYG STU 0.000000008422 0.67918 45.6835
355 4CQE CQE 0.0000002877 0.60198 46.0432
356 3SXS PP2 0.0000002885 0.59902 46.2687
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