Receptor
PDB id Resolution Class Description Source Keywords
5L9V 1.83 Å NON-ENZYME: OTHER HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1) HOMO SAPIENS OXIDOREDUCTASE NON-HEME DIOXYGENASE IRON 2-OXOGLUTARATE INDUCIBLE FACTOR HIF HIF PROLYL HYDROXYLASE DOMAIN 2 PHDOXYGENASE HYPOXIA DNA-BINDING METAL-BINDING TRANSCRIPTIHELIX-LOOP-HELIX-BETA DSBH FACIAL TRIAD CYTOPLASM TRANSCRIPTION/EPIGENETIC REGULATION SIGNALING DEVELOPMENTSTRUCTURE BETA-HYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIUBL CONJUGATION POLYMORPHISM VITAMIN C ZINC-FINGER FAMIERYTHROCYTOSIS BREAST CANCER TRANSCRIPTION COMPLEX
Ref.: STRUCTURAL BASIS FOR OXYGEN DEGRADATION DOMAIN SELE OF THE HIF PROLYL HYDROXYLASES. NAT COMMUN V. 7 12673 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OGA A:502;
B:502;
Valid;
Valid;
none;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
MN B:501;
A:501;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5L9V 1.83 Å NON-ENZYME: OTHER HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1) HOMO SAPIENS OXIDOREDUCTASE NON-HEME DIOXYGENASE IRON 2-OXOGLUTARATE INDUCIBLE FACTOR HIF HIF PROLYL HYDROXYLASE DOMAIN 2 PHDOXYGENASE HYPOXIA DNA-BINDING METAL-BINDING TRANSCRIPTIHELIX-LOOP-HELIX-BETA DSBH FACIAL TRIAD CYTOPLASM TRANSCRIPTION/EPIGENETIC REGULATION SIGNALING DEVELOPMENTSTRUCTURE BETA-HYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIUBL CONJUGATION POLYMORPHISM VITAMIN C ZINC-FINGER FAMIERYTHROCYTOSIS BREAST CANCER TRANSCRIPTION COMPLEX
Ref.: STRUCTURAL BASIS FOR OXYGEN DEGRADATION DOMAIN SELE OF THE HIF PROLYL HYDROXYLASES. NAT COMMUN V. 7 12673 2016
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5L9V; Ligand: OGA; Similar sites found: 77
This union binding pocket(no: 1) in the query (biounit: 5l9v.bio2) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1DRY AAG 0.0005099 0.48765 1.5873
2 1DRY AKG 0.0005099 0.48765 1.5873
3 4RFR RHN 0.00003069 0.53304 1.97044
4 1V08 NTZ 0.006969 0.4175 1.98413
5 5IVE 6E8 0.01672 0.41581 1.98413
6 3B6R ADP 0.01196 0.40423 1.98413
7 4QM9 CYS 0.001412 0.42058 2.31214
8 2A1X AKG 0.0000027 0.47478 2.38095
9 4WHZ 3NL 0.009871 0.44291 2.38095
10 2CET PGI 0.009953 0.42463 2.38095
11 4UF0 MMK 0.005852 0.41456 2.38095
12 4XCB AKG 0.000000207 0.5905 2.77778
13 4XCB HY0 0.000004048 0.59018 2.77778
14 4PTX BGC 0.01254 0.40115 2.77778
15 4O9S 2RY 0.008266 0.42279 2.7907
16 4P7X YCP 0.00002586 0.53398 3.1746
17 4P7X AKG 0.00002586 0.53398 3.1746
18 1GP6 QUE 0.0001125 0.51852 3.1746
19 1GP6 SIN 0.0001054 0.51803 3.1746
20 1GP6 DH2 0.0001054 0.51803 3.1746
21 2WBP ZZU 0.001386 0.4592 3.1746
22 2WBP SIN 0.001386 0.4592 3.1746
23 3AVR OGA 0.0007144 0.43076 3.1746
24 3AVS OGA 0.001882 0.42872 3.1746
25 2V58 LZJ 0.02936 0.41528 3.1746
26 2XUM OGA 0.001091 0.41414 3.1746
27 5VC5 96M 0.02496 0.40319 3.1746
28 4NPL AKG 0.000001551 0.54017 3.2
29 4BXF AKG 0.0002721 0.4501 3.57143
30 4OCT AKG 0.000002254 0.57129 3.6036
31 1LRH NLA 0.004002 0.41981 3.68098
32 1WUB OTP 0.01035 0.43826 3.93258
33 1OS7 AKG 0.001334 0.45617 3.96825
34 1OS7 TAU 0.001334 0.45617 3.96825
35 1T27 PCW 0.009908 0.43925 3.96825
36 5N87 N66 0.01541 0.42224 3.96825
37 4QXB OGA 0.0001356 0.47962 4.36508
38 5HES 032 0.0113 0.41284 4.36508
39 1LN1 DLP 0.01614 0.41897 4.6729
40 2IUW AKG 0.004806 0.44189 5.04202
41 3AGC RCC 0.003464 0.44616 5.15873
42 5G61 FNY 0.006881 0.41973 5.55556
43 5IH9 6BF 0.04013 0.40071 5.55556
44 4Y3O OGA 0.00279 0.40064 5.55556
45 1ODM ASV 0.000007753 0.57402 5.95238
46 5U98 1KX 0.02209 0.43165 6.06061
47 4GJ3 0XP 0.03001 0.40285 6.62252
48 2CER PGI 0.009559 0.42813 6.74603
49 5I0U DCY 0.0001813 0.48249 7
50 5F3I 5UJ 0.00368 0.47067 7.14286
51 5A3T MMK 0.007989 0.43208 7.14286
52 2Q8C AKG 0.009751 0.41216 7.14286
53 5FP3 3JI 0.01109 0.41489 7.93651
54 2JIG PD2 0.0000004356 0.59264 8.48214
55 4GJY OGA 0.0007081 0.42076 8.51064
56 3VHE 42Q 0.02545 0.40531 8.73016
57 3RUG DB6 0.04045 0.40869 9.12863
58 4ZSI 4R1 0.01311 0.40232 9.35672
59 4ZSI GLP 0.0134 0.40187 9.35672
60 2FCU AKG 0.00008493 0.47022 9.92064
61 5C5T AKG 0.00000001145 0.6612 10.0877
62 2RDQ AKG 0.0003902 0.48414 10.3175
63 5JSP DQY 0.003312 0.40339 10.4478
64 4M26 AKG 0.0003507 0.44668 11.1111
65 4M26 ZZU 0.006035 0.43265 11.1111
66 4M26 SIN 0.006035 0.43265 11.1111
67 5TFZ 7BC 0.004283 0.41169 12
68 1QY1 PRZ 0.003075 0.44045 13.7931
69 3R1V AZB 0.0198 0.40548 14.9606
70 5HV0 AKG 0.0000005759 0.60641 23.0415
71 3PUR 2HG 0.0001461 0.50524 26.3158
72 3N9P OGA 0.0001457 0.44294 26.3158
73 3N9O OGA 0.000199 0.43823 26.3158
74 3N9Q OGA 0.000213 0.43715 26.3158
75 2OG7 SIN 0.0002899 0.42154 26.3158
76 3KV4 OGA 0.0004351 0.43768 31.5789
77 1ZHX HC3 0.02162 0.40498 31.5789
Pocket No.: 2; Query (leader) PDB : 5L9V; Ligand: OGA; Similar sites found: 6
This union binding pocket(no: 2) in the query (biounit: 5l9v.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1VJY 460 0.03266 0.40212 2.38095
2 3RGA LSB 0.003053 0.43255 2.4735
3 1EPB REA 0.00389 0.40126 3.04878
4 4OJ8 AKG 0.04919 0.40413 4.7619
5 4UHL VFV 0.03936 0.40011 9.12698
6 4DE9 VTP 0.01596 0.41684 11.5079
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