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Receptor
PDB id Resolution Class Description Source Keywords
5L9V 1.83 Å NON-ENZYME: OTHER HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1) HOMO SAPIENS OXIDOREDUCTASE NON-HEME DIOXYGENASE IRON 2-OXOGLUTARATE INDUCIBLE FACTOR HIF HIF PROLYL HYDROXYLASE DOMAIN 2 PHDOXYGENASE HYPOXIA DNA-BINDING METAL-BINDING TRANSCRIPTIHELIX-LOOP-HELIX-BETA DSBH FACIAL TRIAD CYTOPLASM TRANSCRIPTION/EPIGENETIC REGULATION SIGNALING DEVELOPMENTSTRUCTURE BETA-HYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIUBL CONJUGATION POLYMORPHISM VITAMIN C ZINC-FINGER FAMIERYTHROCYTOSIS BREAST CANCER TRANSCRIPTION COMPLEX
Ref.: STRUCTURAL BASIS FOR OXYGEN DEGRADATION DOMAIN SELE OF THE HIF PROLYL HYDROXYLASES. NAT COMMUN V. 7 12673 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OGA A:502;
B:502;
Valid;
Valid;
none;
none;
submit data
147.086 C4 H5 N O5 C(C(=...
MN B:501;
A:501;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5L9V 1.83 Å NON-ENZYME: OTHER HIF PROLYL HYDROXYLASE 2 (PHD2-R281C/P317C) CROSS-LINKED TO NODD-L397C/D412C AND N-OXALYLGLYCINE (NOG) (COMPLEX-1) HOMO SAPIENS OXIDOREDUCTASE NON-HEME DIOXYGENASE IRON 2-OXOGLUTARATE INDUCIBLE FACTOR HIF HIF PROLYL HYDROXYLASE DOMAIN 2 PHDOXYGENASE HYPOXIA DNA-BINDING METAL-BINDING TRANSCRIPTIHELIX-LOOP-HELIX-BETA DSBH FACIAL TRIAD CYTOPLASM TRANSCRIPTION/EPIGENETIC REGULATION SIGNALING DEVELOPMENTSTRUCTURE BETA-HYDROXYLATION TRANSCRIPTION ACTIVATOR/INHIUBL CONJUGATION POLYMORPHISM VITAMIN C ZINC-FINGER FAMIERYTHROCYTOSIS BREAST CANCER TRANSCRIPTION COMPLEX
Ref.: STRUCTURAL BASIS FOR OXYGEN DEGRADATION DOMAIN SELE OF THE HIF PROLYL HYDROXYLASES. NAT COMMUN V. 7 12673 2016
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 5LAS - OGA C4 H5 N O5 C(C(=O)O)N....
2 5L9V - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OGA; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OGA 1 1
2 AAC 0.461538 0.827586
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5L9V; Ligand: OGA; Similar sites found with APoc: 144
This union binding pocket(no: 1) in the query (biounit: 5l9v.bio2) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 6BYM HC3 1.47783
2 1DRY AAG 1.5873
3 1DRY AKG 1.5873
4 4RFR RHN 1.97044
5 4BG1 OGA 1.98413
6 4BG1 IVL 1.98413
7 5IVE 6E8 1.98413
8 5EW9 5VC 1.98413
9 5DEP UD1 1.98413
10 1V08 NTZ 1.98413
11 3B6R ADP 1.98413
12 3E2M E2M 2.16216
13 4QM9 CYS 2.31214
14 2A1X AKG 2.38095
15 2CET PGI 2.38095
16 4UF0 MMK 2.38095
17 5XEG AKG 2.5974
18 4XCB HY0 2.77778
19 4XCB AKG 2.77778
20 4LIT AKG 2.77778
21 4PTX BGC 2.77778
22 4O9S 2RY 2.7907
23 3A6T 8OG 3.10078
24 4P7X YCP 3.1746
25 4P7X AKG 3.1746
26 1GP6 QUE 3.1746
27 1GP6 DH2 3.1746
28 1GP6 SIN 3.1746
29 2WA4 069 3.1746
30 5NCJ SIN 3.1746
31 5NCJ HL5 3.1746
32 2WBP SIN 3.1746
33 2WBP ZZU 3.1746
34 4B7E OGA 3.1746
35 2Y0I AKG 3.1746
36 4D4U FUC GAL NAG 3.1746
37 4D52 GXL 3.1746
38 3AVR OGA 3.1746
39 4D4U FUC 3.1746
40 5FP4 YC8 3.1746
41 2V58 LZJ 3.1746
42 2XUM OGA 3.1746
43 4LHD GLY 3.1746
44 3P3N AKG 3.1746
45 5JWP AKG 3.1746
46 5A0U CHT 3.1746
47 5VC5 96M 3.1746
48 4D52 GIV 3.1746
49 6FUL E7Z 3.1746
50 4NPL AKG 3.2
51 4BXF AKG 3.57143
52 1RJW ETF 3.57143
53 1OFZ FUL 3.57143
54 4OCT AKG 3.6036
55 2YIP YIO 3.62319
56 1LRH NLA 3.68098
57 1WUB OTP 3.93258
58 4IE6 UN9 3.96825
59 5O9W AKG 3.96825
60 1OS7 TAU 3.96825
61 1OS7 AKG 3.96825
62 1T27 PCW 3.96825
63 6EXF LYS 3.96825
64 5N87 N66 3.96825
65 3B1Q NOS 3.96825
66 1U6R ADP 3.96825
67 5FWJ MMK 3.96825
68 3MI3 LYS 3.96825
69 4QXB OGA 4.36508
70 5ZM4 AKG 4.36508
71 5ZM4 9FU 4.36508
72 5HES 032 4.36508
73 1LN1 DLP 4.6729
74 4OJ8 AKG 4.7619
75 4OJ8 2TQ 4.7619
76 1NX4 AKG 4.7619
77 2IUW AKG 5.04202
78 3AGC RCC 5.15873
79 6F6J CUW 5.15873
80 6F6J SIN 5.15873
81 6ALW BNV 5.15873
82 6ALW BMJ 5.15873
83 1UNB AKG 5.55556
84 1UNB PN1 5.55556
85 4CCK OGA 5.55556
86 5G61 FNY 5.55556
87 4CCN OGA 5.55556
88 4CCO OGA 5.55556
89 4Y3O OGA 5.55556
90 1ODM ASV 5.95238
91 5DEY 59T 5.95238
92 5U98 1KX 6.06061
93 4CSD MFU 6.34921
94 5KD6 LBU 6.34921
95 2CER PGI 6.74603
96 5I0U DCY 7
97 5A3T MMK 7.14286
98 5LY2 OGA 7.14286
99 5FWE OGA 7.14286
100 5F3I 5UJ 7.14286
101 2Q8E OGA 7.14286
102 2P5B OGA 7.14286
103 2YBP 2HG 7.14286
104 2OS2 OGA 7.14286
105 6EOZ 58K 7.53968
106 6EOZ AKG 7.53968
107 6F6D AKG 7.93651
108 5FP3 3JI 7.93651
109 6FXR AKG 8.33333
110 1Y0G 8PP 8.37696
111 2JIG PD2 8.48214
112 3VHE 42Q 8.73016
113 4B1M FRU FRU 9.12698
114 4UHL VFV 9.12698
115 3RUG DB6 9.12863
116 4ZSI 4R1 9.35672
117 4ZSI GLP 9.35672
118 2FCU AKG 9.92064
119 2ET1 GLV 9.95025
120 5C5T AKG 10.0877
121 2RDQ AKG 10.3175
122 5JSP DQY 10.4478
123 4M26 AKG 11.1111
124 4M26 ZZU 11.1111
125 4M26 SIN 11.1111
126 5TFZ 7BC 12
127 5L6G XYP 12.6984
128 1H2M OGA 13.4615
129 1QY1 PRZ 13.7931
130 3R1V AZB 14.9606
131 1H2K OGA 17.0732
132 3ZW0 FUC 17.2414
133 5YBL AKG 19.0476
134 1LOJ URI 19.5402
135 5HV0 AKG 23.0415
136 3PUR 2HG 26.3158
137 4NAO AKG 26.3158
138 3N9P OGA 26.3158
139 3N9O OGA 26.3158
140 3N9Q OGA 26.3158
141 2OG7 SIN 26.3158
142 3KV4 OGA 31.5789
143 1ZHX HC3 31.5789
144 6GIN IR2 42.1053
Pocket No.: 2; Query (leader) PDB : 5L9V; Ligand: OGA; Similar sites found with APoc: 13
This union binding pocket(no: 2) in the query (biounit: 5l9v.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 4WHZ 3NL 2.38095
2 1VJY 460 2.38095
3 3RGA LSB 2.4735
4 2WPU KYT 2.51572
5 3DLG GWE 4.7619
6 5A86 D7E 5.15873
7 4D06 NAR 5.95238
8 4F5Z BEZ 6.74603
9 2GJ5 VD3 6.79012
10 2QL9 CIT 7.51445
11 4EK7 BGC 9.52381
12 3VRY B43 10.7143
13 4B1L FRU 13.9394
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