Receptor
PDB id Resolution Class Description Source Keywords
5KGP 1.8 Å EC: 2.-.-.- X-RAY STRUCTURE OF A GLUCOSAMINE N-ACETYLTRANSFERASE FROM CL ACETOBUTYLICUM IN COMPLEX WITH CHITOSAN CLOSTRIDIUM ACETOBUTYLICUM (STRAIN ATCDSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) N-ACETYLTRANSFERASE ACYLTRANSFERASE GNAT TANDEM-GNAT TRA
Ref.: STRUCTURAL STUDIES ON A GLUCOSAMINE/GLUCOSAMINIDE N-ACETYLTRANSFERASE. BIOCHEMISTRY V. 55 4495 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:404;
A:405;
Invalid;
Invalid;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
COA A:403;
B:402;
A:402;
Valid;
Valid;
Valid;
Atoms found LESS than expected: % Diff = 0.521;
Atoms found LESS than expected: % Diff = 0.521;
Atoms found LESS than expected: % Diff = 0.333;
submit data
767.534 C21 H36 N7 O16 P3 S CC(C)...
MPO B:403;
Invalid;
none;
submit data
209.263 C7 H15 N O4 S C1COC...
ACO B:401;
A:401;
Valid;
Valid;
none;
none;
Ki = 3 uM
809.571 C23 H38 N7 O17 P3 S CC(=O...
PA1 GCS B:404;
A:406;
Valid;
Valid;
none;
none;
submit data
342.345 n/a O(C1O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5KF9 1.49 Å EC: 2.-.-.- X-RAY STRUCTURE OF A GLUCOSAMINE N-ACETYLTRANSFERASE FROM CL ACETOBUTYLICUM IN COMPLEX WITH N-ACETYLGLUCOSAMINE CLOSTRIDIUM ACETOBUTYLICUM (STRAIN ATCDSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) N-ACETYLTRANSFERASE ACYLTRANSFERASE GNAT TANDEM-GNAT TRA
Ref.: STRUCTURAL STUDIES ON A GLUCOSAMINE/GLUCOSAMINIDE N-ACETYLTRANSFERASE. BIOCHEMISTRY V. 55 4495 2016
Members (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 236 families.
1 5KF1 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
2 5KF8 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
3 5KGP Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
4 5KGA Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
5 5KF9 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
6 5KGJ Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
7 5KGH Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
8 5KF2 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
70% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 211 families.
1 5KF1 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
2 5KF8 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
3 5KGP Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
4 5KGA Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
5 5KF9 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
6 5KGJ Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
7 5KGH Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
8 5KF2 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 166 families.
1 5KF1 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
2 5KF8 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
3 5KGP Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
4 5KGA Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
5 5KF9 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
6 5KGJ Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
7 5KGH Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
8 5KF2 Ki = 3 uM ACO C23 H38 N7 O17 P3 S CC(=O)SCCN....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: COA; Similar ligands found: 197
No: Ligand ECFP6 Tc MDL keys Tc
1 COA 1 1
2 0T1 0.894737 0.976744
3 DCA 0.893805 0.954023
4 COS 0.887931 0.977012
5 ETB 0.877193 0.920455
6 CAO 0.871795 0.965909
7 AMX 0.871795 0.988235
8 30N 0.871795 0.913979
9 CMX 0.864407 0.976744
10 SCO 0.864407 0.976744
11 FAM 0.857143 0.954545
12 ACO 0.857143 0.965909
13 FCX 0.857143 0.94382
14 HAX 0.85 0.954545
15 3KK 0.842975 0.977012
16 FYN 0.842975 1
17 CA6 0.836066 0.885417
18 SOP 0.836066 0.977012
19 MCD 0.836066 0.954545
20 COK 0.836066 0.977012
21 OXK 0.836066 0.977012
22 NMX 0.829268 0.903226
23 CO6 0.829268 0.977012
24 CMC 0.829268 0.977012
25 1VU 0.829268 0.965909
26 CAJ 0.822581 0.954545
27 SCD 0.822581 0.976744
28 2MC 0.822581 0.934066
29 2CP 0.81746 0.965909
30 BCO 0.816 0.977012
31 3HC 0.816 0.988372
32 1HE 0.816 0.955056
33 MLC 0.816 0.977012
34 A1S 0.816 0.977012
35 IVC 0.816 0.988372
36 COD 0.810345 0.988235
37 CAA 0.809524 0.988372
38 COO 0.809524 0.977012
39 MCA 0.809524 0.965909
40 YE1 0.809524 0.965517
41 SCA 0.80315 0.977012
42 MC4 0.80315 0.923913
43 IRC 0.796875 0.988372
44 3CP 0.796875 0.977012
45 CA8 0.796875 0.885417
46 BYC 0.796875 0.977012
47 COW 0.796875 0.965909
48 2KQ 0.796875 0.955056
49 COF 0.796875 0.955056
50 HGG 0.796875 0.977012
51 1GZ 0.796875 0.965909
52 4CA 0.790698 0.965909
53 FAQ 0.790698 0.977012
54 BCA 0.790698 0.965909
55 GRA 0.784615 0.977012
56 HXC 0.784615 0.955056
57 1CV 0.781955 0.977012
58 TGC 0.778626 0.965909
59 1CZ 0.772727 0.965909
60 CO8 0.772727 0.955056
61 S0N 0.772727 0.954545
62 2NE 0.772727 0.955056
63 CIC 0.772727 0.977012
64 0FQ 0.766917 0.977012
65 ST9 0.766917 0.955056
66 4CO 0.766917 0.965909
67 UCC 0.766917 0.955056
68 MFK 0.766917 0.955056
69 DCC 0.766917 0.955056
70 MYA 0.766917 0.955056
71 5F9 0.766917 0.955056
72 01A 0.761194 0.934066
73 0ET 0.761194 0.955056
74 CS8 0.755556 0.944444
75 WCA 0.755556 0.955056
76 4KX 0.75 0.944444
77 UOQ 0.75 0.955056
78 NHW 0.75 0.955056
79 HDC 0.75 0.955056
80 NHM 0.75 0.955056
81 HFQ 0.744526 0.955056
82 MRS 0.744526 0.955056
83 MRR 0.744526 0.955056
84 DAK 0.73913 0.944444
85 YNC 0.73913 0.965909
86 8Z2 0.733813 0.944444
87 NHQ 0.723404 0.988372
88 1HA 0.713287 0.955056
89 01K 0.708333 0.977012
90 COT 0.703448 0.977012
91 CCQ 0.695652 0.934066
92 CA3 0.693878 0.977012
93 CA5 0.671053 0.934066
94 UCA 0.666667 0.955056
95 93P 0.666667 0.965909
96 CO7 0.664234 0.977012
97 93M 0.64557 0.965909
98 OXT 0.634146 0.913979
99 5TW 0.607143 0.913979
100 4BN 0.607143 0.913979
101 PAP 0.603604 0.811765
102 JBT 0.598837 0.894737
103 BSJ 0.592814 0.944444
104 HMG 0.581081 0.943182
105 COA MYR 0.573333 0.922222
106 PLM COA 0.573333 0.922222
107 COA PLM 0.573333 0.922222
108 A3P 0.54955 0.8
109 PPS 0.547009 0.752688
110 0WD 0.521739 0.788889
111 RFC 0.490683 0.955056
112 SFC 0.490683 0.955056
113 191 0.490196 0.865979
114 3AM 0.482143 0.788235
115 PTJ 0.48062 0.872093
116 ACE SER ASP ALY THR NH2 COA 0.478261 0.932584
117 4PS 0.477477 0.682353
118 A22 0.468254 0.813953
119 A2D 0.465517 0.802326
120 PUA 0.462585 0.820225
121 PAJ 0.460938 0.883721
122 AGS 0.459016 0.806818
123 SAP 0.459016 0.806818
124 ATR 0.459016 0.8
125 3OD 0.458015 0.825581
126 ADP 0.453782 0.823529
127 A2R 0.448819 0.813953
128 BA3 0.445378 0.802326
129 NA7 0.442748 0.858824
130 OAD 0.442748 0.825581
131 ATP 0.442623 0.823529
132 AP5 0.441667 0.802326
133 B4P 0.441667 0.802326
134 APR 0.439024 0.802326
135 5FA 0.439024 0.823529
136 2A5 0.439024 0.847059
137 AQP 0.439024 0.823529
138 AR6 0.439024 0.802326
139 AN2 0.438017 0.813953
140 48N 0.435714 0.808989
141 M33 0.434426 0.813953
142 SRP 0.429688 0.837209
143 ANP 0.428571 0.804598
144 ADQ 0.427481 0.804598
145 YLB 0.426573 0.908046
146 YLP 0.425532 0.886364
147 5AL 0.425197 0.813953
148 7D3 0.425 0.793103
149 AD9 0.424 0.804598
150 APU 0.423611 0.786517
151 7D4 0.422764 0.793103
152 CA0 0.422764 0.804598
153 25L 0.422222 0.813953
154 ATF 0.421875 0.795455
155 NJP 0.421769 0.806818
156 A2P 0.421488 0.788235
157 A A A 0.421053 0.813953
158 8QN 0.419847 0.813953
159 PNS 0.419643 0.682353
160 ACP 0.419355 0.825581
161 NDP 0.417808 0.788889
162 ACQ 0.417323 0.825581
163 A1R 0.416667 0.882353
164 ATP A A A 0.416058 0.770115
165 A 0.415254 0.8
166 AMP 0.415254 0.8
167 FYA 0.414815 0.813953
168 1ZZ 0.414815 0.842697
169 TXA 0.414815 0.816092
170 NB8 0.414815 0.808989
171 AHX 0.413534 0.829545
172 DLL 0.413534 0.793103
173 00A 0.413534 0.758242
174 PAX 0.412903 0.793478
175 OMR 0.409722 0.853933
176 25A 0.409091 0.802326
177 OOB 0.409091 0.793103
178 NPW 0.408163 0.822222
179 WAQ 0.407407 0.860465
180 A A 0.407407 0.781609
181 TAT 0.40625 0.816092
182 4AD 0.406015 0.827586
183 AMO 0.406015 0.837209
184 YAP 0.405797 0.806818
185 FA5 0.405797 0.816092
186 TXP 0.405405 0.829545
187 ABM 0.404959 0.781609
188 PRX 0.404762 0.825581
189 ME8 0.404412 0.842697
190 BIS 0.404412 0.818182
191 AFH 0.404255 0.78022
192 J7V 0.403846 0.778947
193 NAI 0.402778 0.777778
194 ODP 0.402685 0.78022
195 ADX 0.4 0.752688
196 SRA 0.4 0.784091
197 AU1 0.4 0.804598
Ligand no: 2; Ligand: ACO; Similar ligands found: 170
No: Ligand ECFP6 Tc MDL keys Tc
1 ACO 1 1
2 3KK 0.9 0.988636
3 COS 0.898305 0.944444
4 CAO 0.898305 0.934066
5 2MC 0.893443 0.945652
6 OXK 0.892562 0.966292
7 MC4 0.887097 0.935484
8 1VU 0.885246 0.977528
9 CO6 0.885246 0.988636
10 CAA 0.879032 0.977273
11 SOP 0.877049 0.966292
12 IVC 0.870968 0.977273
13 1HE 0.870968 0.966667
14 MLC 0.870968 0.966292
15 BCO 0.870968 0.966292
16 3HC 0.870968 0.977273
17 FYN 0.868852 0.965909
18 COO 0.864 0.966292
19 MCA 0.864 0.977528
20 COK 0.861789 0.944444
21 0T1 0.857143 0.94382
22 SCA 0.857143 0.966292
23 COA 0.857143 0.965909
24 DCA 0.855932 0.94382
25 CMC 0.854839 0.944444
26 30N 0.85124 0.885417
27 HGG 0.850394 0.966292
28 IRC 0.850394 0.977273
29 BYC 0.850394 0.966292
30 COW 0.850394 0.955556
31 1GZ 0.850394 0.955556
32 BCA 0.84375 0.955556
33 FAQ 0.84375 0.966292
34 2CP 0.84252 0.955556
35 A1S 0.84127 0.966292
36 ETB 0.840336 0.932584
37 GRA 0.837209 0.966292
38 HXC 0.837209 0.988764
39 AMX 0.836066 0.954545
40 TGC 0.830769 0.955556
41 SCO 0.829268 0.94382
42 CMX 0.829268 0.94382
43 1CZ 0.824427 0.955556
44 CO8 0.824427 0.988764
45 2NE 0.824427 0.945055
46 FAM 0.822581 0.923077
47 FCX 0.822581 0.913043
48 2KQ 0.821705 0.988764
49 COF 0.821705 0.923913
50 3CP 0.821705 0.944444
51 UCC 0.818182 0.988764
52 ST9 0.818182 0.988764
53 DCC 0.818182 0.988764
54 MFK 0.818182 0.988764
55 5F9 0.818182 0.988764
56 MYA 0.818182 0.988764
57 HAX 0.816 0.923077
58 4CA 0.815385 0.934066
59 WCA 0.80597 0.945055
60 CS8 0.80597 0.977778
61 SCD 0.804688 0.94382
62 CA6 0.80315 0.896907
63 MCD 0.80315 0.966292
64 4KX 0.8 0.934783
65 HDC 0.8 0.988764
66 CIC 0.796992 0.944444
67 NMX 0.796875 0.875
68 MRS 0.794118 0.988764
69 MRR 0.794118 0.988764
70 4CO 0.791045 0.934066
71 0FQ 0.791045 0.944444
72 CAJ 0.790698 0.944444
73 YNC 0.788321 0.955556
74 DAK 0.788321 0.934783
75 01A 0.785185 0.904255
76 0ET 0.785185 0.966667
77 8Z2 0.782609 0.977778
78 HFQ 0.781022 0.923913
79 1CV 0.779412 0.966292
80 YE1 0.778626 0.933333
81 NHM 0.773723 0.966667
82 NHW 0.773723 0.966667
83 UOQ 0.773723 0.966667
84 CA8 0.766917 0.877551
85 1HA 0.760563 0.945055
86 NHQ 0.746479 0.955056
87 S0N 0.744526 0.923077
88 CCQ 0.744526 0.945652
89 01K 0.743056 0.966292
90 COT 0.737931 0.944444
91 CA3 0.727891 0.944444
92 UCA 0.721854 0.988764
93 CO7 0.713235 0.966292
94 CA5 0.703947 0.904255
95 93P 0.699346 0.934066
96 COD 0.692913 0.954545
97 93M 0.666667 0.934066
98 4BN 0.656627 0.946237
99 5TW 0.656627 0.946237
100 OXT 0.634731 0.946237
101 HMG 0.62585 0.933333
102 PLM COA 0.61745 0.955556
103 COA MYR 0.61745 0.955556
104 COA PLM 0.61745 0.955556
105 JBT 0.609195 0.926316
106 BSJ 0.594118 0.913979
107 PAP 0.577586 0.784091
108 PPS 0.53719 0.729167
109 191 0.532895 0.877551
110 RFC 0.53125 0.966667
111 SFC 0.53125 0.966667
112 A3P 0.525862 0.772727
113 ACE SER ASP ALY THR NH2 COA 0.505435 0.923077
114 0WD 0.503497 0.763441
115 PTJ 0.462687 0.842697
116 3AM 0.461538 0.761364
117 3OD 0.451852 0.797753
118 A22 0.450382 0.786517
119 PUA 0.447368 0.793478
120 A2D 0.446281 0.775281
121 PAJ 0.443609 0.853933
122 ATR 0.440945 0.772727
123 AGS 0.440945 0.8
124 SAP 0.440945 0.8
125 OAD 0.437037 0.797753
126 ADP 0.435484 0.795455
127 A2R 0.431818 0.786517
128 BA3 0.427419 0.775281
129 NA7 0.426471 0.829545
130 ATP 0.425197 0.795455
131 AP5 0.424 0.775281
132 B4P 0.424 0.775281
133 ADQ 0.422222 0.777778
134 5FA 0.421875 0.795455
135 AR6 0.421875 0.775281
136 APR 0.421875 0.775281
137 AQP 0.421875 0.795455
138 2A5 0.421875 0.818182
139 48N 0.42069 0.802198
140 AN2 0.420635 0.786517
141 FYA 0.42029 0.786517
142 M33 0.417323 0.786517
143 SRP 0.413534 0.808989
144 ANP 0.412214 0.777778
145 YLB 0.412162 0.877778
146 FA5 0.411348 0.788889
147 YLP 0.410959 0.877778
148 ME8 0.410072 0.835165
149 APU 0.409396 0.76087
150 5AL 0.409091 0.786517
151 7D3 0.408 0.766667
152 NJP 0.407895 0.78022
153 AD9 0.407692 0.777778
154 25L 0.407143 0.786517
155 7D4 0.40625 0.766667
156 CA0 0.40625 0.777778
157 ATF 0.406015 0.769231
158 A A A 0.405797 0.786517
159 A2P 0.404762 0.761364
160 8QN 0.404412 0.786517
161 LAQ 0.40411 0.815217
162 NDP 0.403974 0.763441
163 ACP 0.403101 0.797753
164 ACQ 0.401515 0.797753
165 YAP 0.401408 0.78022
166 ATP A A A 0.401408 0.744444
167 1ZZ 0.4 0.855556
168 PAX 0.4 0.768421
169 TXA 0.4 0.788889
170 NB8 0.4 0.782609
Ligand no: 3; Ligand: PA1 GCS; Similar ligands found: 65
No: Ligand ECFP6 Tc MDL keys Tc
1 PA1 GCS 1 1
2 GCS GCS 1 1
3 GCS GCS GCS GCS GCS 0.916667 1
4 GCS GCS GCS GCS GCS GCS 0.916667 1
5 GCS GCS GCS 0.916667 1
6 LAT 0.448276 0.804878
7 GLC GAL 0.448276 0.804878
8 BGC GAL 0.448276 0.804878
9 GLC BGC 0.448276 0.804878
10 CBI 0.448276 0.804878
11 MAL MAL 0.448276 0.785714
12 BMA GAL 0.448276 0.804878
13 GAL BGC 0.448276 0.804878
14 GLA GLA 0.448276 0.804878
15 CBK 0.448276 0.804878
16 GAL GLC 0.448276 0.804878
17 MAB 0.448276 0.804878
18 GLA GAL 0.448276 0.804878
19 BMA BMA 0.448276 0.804878
20 B2G 0.448276 0.804878
21 BGC GLC 0.448276 0.804878
22 LBT 0.448276 0.804878
23 N9S 0.448276 0.804878
24 MAL 0.448276 0.804878
25 BGC BMA 0.448276 0.804878
26 MAN MAN BMA BMA BMA BMA 0.419355 0.804878
27 BGC GLC GLC GLC GLC 0.419355 0.804878
28 BGC BGC BGC GLC 0.419355 0.804878
29 BGC GLC GLC 0.419355 0.804878
30 BMA BMA BMA 0.419355 0.804878
31 CTT 0.419355 0.804878
32 BGC BGC BGC BGC BGC BGC 0.419355 0.804878
33 MAN BMA BMA BMA BMA 0.419355 0.804878
34 CTR 0.419355 0.804878
35 CE6 0.419355 0.804878
36 GLC GAL GAL 0.419355 0.804878
37 CE5 0.419355 0.804878
38 GLA GAL GLC 0.419355 0.804878
39 DXI 0.419355 0.804878
40 GLC BGC BGC BGC BGC BGC 0.419355 0.804878
41 GLC GLC GLC GLC GLC 0.419355 0.804878
42 GLC BGC GLC 0.419355 0.804878
43 BMA BMA BMA BMA BMA BMA 0.419355 0.804878
44 GLC GLC BGC 0.419355 0.804878
45 MTT 0.419355 0.804878
46 BMA BMA BMA BMA BMA 0.419355 0.804878
47 CEX 0.419355 0.804878
48 BMA MAN BMA 0.419355 0.804878
49 BGC GLC GLC GLC GLC GLC GLC 0.419355 0.804878
50 B4G 0.419355 0.804878
51 GAL GAL GAL 0.419355 0.804878
52 GLC GLC GLC GLC GLC GLC GLC 0.419355 0.804878
53 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.419355 0.804878
54 GLC BGC BGC BGC BGC 0.419355 0.804878
55 BGC GLC GLC GLC 0.419355 0.804878
56 MLR 0.419355 0.804878
57 CE8 0.419355 0.804878
58 MAN BMA BMA 0.419355 0.804878
59 CEY 0.419355 0.804878
60 GLC BGC BGC 0.419355 0.804878
61 GLC GLC BGC GLC GLC GLC GLC 0.419355 0.804878
62 GLC GLC GLC GLC GLC GLC GLC GLC 0.419355 0.804878
63 CT3 0.419355 0.804878
64 MT7 0.419355 0.804878
65 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.419355 0.804878
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5KF9; Ligand: NAG; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5kf9.bio1) has 31 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5KF9; Ligand: COA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5kf9.bio1) has 31 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 5KF9; Ligand: ACO; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 5kf9.bio1) has 29 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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