Receptor
PDB id Resolution Class Description Source Keywords
5IH9 1.79 Å EC: 2.7.11.1 MELK IN COMPLEX WITH NVS-MELK8A HOMO SAPIENS KINASE UBA DOMAIN INHIBITOR TRANSFERASE-TRANSFERASE INHIBITCOMPLEX
Ref.: TOWARD THE VALIDATION OF MATERNAL EMBRYONIC LEUCINE KINASE: DISCOVERY, OPTIMIZATION OF HIGHLY POTENT AN SELECTIVE INHIBITORS, AND PRELIMINARY BIOLOGY INSIG J.MED.CHEM. V. 59 4711 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
6BF A:401;
Valid;
none;
ic50 = 0.002 uM
432.561 C25 H32 N6 O CN1CC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5IH9 1.79 Å EC: 2.7.11.1 MELK IN COMPLEX WITH NVS-MELK8A HOMO SAPIENS KINASE UBA DOMAIN INHIBITOR TRANSFERASE-TRANSFERASE INHIBITCOMPLEX
Ref.: TOWARD THE VALIDATION OF MATERNAL EMBRYONIC LEUCINE KINASE: DISCOVERY, OPTIMIZATION OF HIGHLY POTENT AN SELECTIVE INHIBITORS, AND PRELIMINARY BIOLOGY INSIG J.MED.CHEM. V. 59 4711 2016
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 5IH8 ic50 = 0.18 uM 6BJ C21 H17 N5 O c1ccnc(c1)....
2 5IH9 ic50 = 0.002 uM 6BF C25 H32 N6 O CN1CCN(CC1....
3 5IHA ic50 = 0.41 uM 6BE C23 H29 N5 O CC(C)COc1c....
4 4BKZ ic50 = 0.027 uM 1WS C18 H20 F N7 O c1cc(cc(c1....
5 4BKY ic50 = 0.012 uM 82B C26 H30 Br N7 O2 Cn1cc(cc1C....
6 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
7 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
70% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 4BFM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 5IH8 ic50 = 0.18 uM 6BJ C21 H17 N5 O c1ccnc(c1)....
3 5IH9 ic50 = 0.002 uM 6BF C25 H32 N6 O CN1CCN(CC1....
4 5IHA ic50 = 0.41 uM 6BE C23 H29 N5 O CC(C)COc1c....
5 4BKZ ic50 = 0.027 uM 1WS C18 H20 F N7 O c1cc(cc(c1....
6 4BKY ic50 = 0.012 uM 82B C26 H30 Br N7 O2 Cn1cc(cc1C....
7 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
8 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 4BFM - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 5IH8 ic50 = 0.18 uM 6BJ C21 H17 N5 O c1ccnc(c1)....
3 5IH9 ic50 = 0.002 uM 6BF C25 H32 N6 O CN1CCN(CC1....
4 5IHA ic50 = 0.41 uM 6BE C23 H29 N5 O CC(C)COc1c....
5 4BKZ ic50 = 0.027 uM 1WS C18 H20 F N7 O c1cc(cc(c1....
6 4BKY ic50 = 0.012 uM 82B C26 H30 Br N7 O2 Cn1cc(cc1C....
7 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
8 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: 6BF; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 6BF 1 1
2 6BE 0.677419 0.901639
3 6BB 0.554455 0.825397
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5IH9; Ligand: 6BF; Similar sites found: 373
This union binding pocket(no: 1) in the query (biounit: 5ih9.bio1) has 35 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2Z48 NGA 0.01087 0.45198 1.49254
2 2Z49 AMG 0.01218 0.43132 1.49254
3 4OCV ANP 0.0001771 0.49393 1.79104
4 2VQD AP2 0.0001831 0.48855 1.79104
5 3TII ANP 0.001981 0.46793 1.79104
6 4OCJ NDG 0.001399 0.4122 1.79104
7 2WH8 II2 0.03367 0.40838 1.79104
8 1PK8 ATP 0.001095 0.43922 2.08955
9 1HFU NAG NDG 0.03919 0.41687 2.08955
10 1UH4 GLC GLC GLC GLC GLC 0.03079 0.41508 2.08955
11 5L6G XYP 0.02757 0.40862 2.08955
12 2J5B TYE 0.04831 0.40499 2.08955
13 1IGW PYR 0.0498 0.40367 2.08955
14 1I7E IBS 0.04743 0.40218 2.26415
15 4RDL FUC GAL NDG FUC 0.006246 0.45401 2.27273
16 4XCB AKG 0.03112 0.4142 2.29885
17 1ZP9 ATP 0.00001086 0.5688 2.32558
18 1ZTH ADP 0.000003455 0.41242 2.32558
19 3WDX BGC BGC GLC 0.004164 0.42752 2.34899
20 4PU5 ANP 0.006072 0.41388 2.38806
21 4K55 H6P 0.03868 0.40015 2.41935
22 3TY5 ATP 0.002605 0.46184 2.68657
23 5TT6 ATP 0.002187 0.43653 2.68657
24 3TY5 ADP 0.005856 0.43532 2.68657
25 3WV6 GAL GLC 0.005324 0.43592 2.7027
26 3WV6 GAL BGC 0.01001 0.43233 2.7027
27 4FE2 ADP 0.01007 0.42764 2.7451
28 1KPG 16A 0.02052 0.40857 2.78746
29 3FIU AMP 0.03976 0.40092 2.81124
30 3VPC ADP 0.0002133 0.48112 2.83688
31 2PA7 TYD 0.03266 0.41427 2.83688
32 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.02363 0.41265 2.85714
33 3QX9 ATP 0.03927 0.41177 2.89855
34 3ML5 AZM 0.03834 0.41011 2.97398
35 3I0O ADP 0.0002886 0.51071 2.98507
36 5DZT AMP 0.001413 0.48837 2.98507
37 1A78 TDG 0.01016 0.44789 2.98507
38 3W0O HY0 0.0004652 0.44136 2.98507
39 3W0O ADP 0.0004652 0.44136 2.98507
40 1T36 ADP 0.005199 0.40553 2.98507
41 3DNT ATP 0.008814 0.40405 2.98507
42 1GT4 UNA 0.02272 0.4031 3.14465
43 1J3R 6PG 0.01461 0.42342 3.15789
44 3QRC SCR 0.01664 0.40979 3.18471
45 1IA9 ANP 0.00002404 0.5337 3.21429
46 2PYW ADP 0.00001104 0.54339 3.28358
47 2Q7D ANP 0.001594 0.42927 3.28358
48 3WXL ADP 0.01278 0.42544 3.28358
49 2OVD DAO 0.01758 0.42954 3.2967
50 4LO2 GAL BGC 0.01869 0.42325 3.40136
51 4ZGP ADP 0.008772 0.423 3.41297
52 4X5S AZM 0.00784 0.44747 3.44828
53 2AQX ATP 0.002396 0.43478 3.46021
54 2PUL ACP 0.0000001724 0.64802 3.58209
55 5I35 ANP 0.000008999 0.56593 3.58209
56 4IJ6 SEP 0.02473 0.42539 3.58209
57 3V4S ATP 0.006633 0.41524 3.58209
58 3K6V CIT 0.0292 0.41086 3.58209
59 5W0N UPU 0.04342 0.40629 3.58209
60 4D52 GIV 0.03999 0.40629 3.58209
61 1TZD ADP 0.0003681 0.51266 3.63636
62 4RW3 IPD 0.02677 0.41368 3.64238
63 5DG2 GAL GLC 0.003108 0.46448 3.7037
64 2HKA C3S 0.0009726 0.45594 3.84615
65 5H9Q TD2 0.02094 0.41224 3.87097
66 4GYI ADP 0.00001362 0.57103 3.8806
67 3PDT ADP 0.0001212 0.51762 3.8806
68 5DXT 5H5 0.003632 0.43373 3.8806
69 1I06 TZL 0.03645 0.41045 3.88889
70 5F2T PLM 0.02202 0.40376 3.8961
71 4ZS4 ATP 0.00006268 0.51461 3.90879
72 5KBE IPH 0.0203 0.42429 3.93013
73 4LH7 1X8 0.02885 0.40824 4.02477
74 1W2D ADP 0.0001782 0.52141 4.15094
75 1W2D 4IP 0.004912 0.40394 4.15094
76 5VZ0 ADP 0.0004973 0.48266 4.1791
77 4R78 AMP 0.00003663 0.56394 4.20712
78 4R38 RBF 0.01419 0.40348 4.28571
79 5NCY 8TK 0.0005005 0.44012 4.47761
80 1VRP IOM 0.01573 0.42157 4.47761
81 5ENZ UDP 0.01081 0.4152 4.47761
82 1N4K I3P 0.03929 0.41123 4.47761
83 3I7V ATP 0.02473 0.40786 4.47761
84 5CPR 539 0.03755 0.40585 4.47761
85 4XBT FLC 0.009695 0.42459 4.51613
86 4XBT 3ZQ 0.01092 0.41501 4.51613
87 2YMZ LAT 0.003851 0.46205 4.61538
88 2GQS ADP 0.005161 0.43405 4.64135
89 1EB1 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.0004373 0.49578 4.66926
90 5W2I I3P 0.001096 0.44258 4.66926
91 5W2I ADP 0.001096 0.44258 4.66926
92 4ZU4 4TG 0.01203 0.40979 4.72973
93 1U6R IOM 0.01233 0.43083 4.73684
94 4UWH JXM 0.001476 0.46459 4.77612
95 2YW2 ATP 0.002822 0.43512 4.77612
96 4XDA RIB 0.03853 0.40163 4.77612
97 3HQP OXL 0.02113 0.4012 4.77612
98 2GC0 PAN 0.01847 0.40424 4.78723
99 3HPY MCT 0.01721 0.42818 4.85437
100 5KEW 6SB 0.002906 0.47189 4.86111
101 4WVW SLT 0.01206 0.42423 4.86111
102 1OBD ATP 0.002246 0.46027 4.90196
103 2D6M LBT 0.01221 0.42959 5.03145
104 2IO8 ADP 0.000345 0.46391 5.07463
105 3WVR AMP 0.001845 0.45986 5.07463
106 3ITA AIC 0.009986 0.45133 5.07463
107 3B6R CRN 0.01264 0.41687 5.07463
108 4MA6 28E 0.02723 0.41736 5.09554
109 1OPB RET 0.01314 0.41121 5.22388
110 4DFU QUE 0.005249 0.45602 5.2795
111 3SHR CMP 0.004478 0.44979 5.35117
112 4G0P U5P 0.00691 0.46001 5.44218
113 2IF8 ADP 0.0001337 0.54166 5.50964
114 5L9V OGA 0.04013 0.40071 5.55556
115 1X0P FAD 0.02326 0.40588 5.59441
116 3UVD MB3 0.0128 0.4386 5.64516
117 3K5I ADP 0.003189 0.43273 5.67164
118 4BKS X6C 0.04196 0.41009 5.76923
119 4B9K TG0 0.04617 0.40105 5.76923
120 1I7L ATP 0.001109 0.44236 5.82524
121 5AVF TAU 0.03522 0.40734 5.83658
122 3B8Y ADA ADA ADA ADA 0.01401 0.42854 5.97015
123 5KWY C3S 0.009086 0.42227 6.07287
124 3VOT ADP 0.002669 0.4613 6.26866
125 4YVN EBS 0.03499 0.41242 6.26866
126 4CYI ATP 0.00006589 0.40694 6.26866
127 5F1H 5U6 0.04619 0.40104 6.50407
128 4FFG LBS 0.004256 0.45104 6.56716
129 4FFG 0U8 0.0383 0.40927 6.56716
130 2BYC FMN 0.014 0.41675 6.56934
131 5FU3 BGC BGC BGC 0.03889 0.41009 6.60377
132 4NS0 PIO 0.003523 0.46739 6.76692
133 3X01 AMP 0.0006724 0.50707 6.86567
134 1EHI ADP 0.006637 0.4217 6.86567
135 5FQK 6NT 0.03915 0.40972 7.0632
136 4U98 ACP 0.0004837 0.48323 7.16418
137 1Y7P RIP 0.02149 0.41846 7.17489
138 2BKK ADP 0.0002547 0.50751 7.19697
139 3TM0 B31 0.001049 0.41935 7.22433
140 3TM0 ANP 0.001581 0.41528 7.22433
141 4JH6 FCN 0.02273 0.41744 7.24638
142 1YRX FMN 0.01594 0.41053 7.43802
143 4ANW O92 0.00004738 0.47274 7.46269
144 4Q5H ANP 0.0001064 0.50925 7.47126
145 2HZQ STR 0.01105 0.44076 7.47126
146 3TDV GDP 0.000273 0.49008 7.51634
147 2YRX AMP 0.005176 0.45747 7.76119
148 4O1P ANP 0.000001168 0.44612 8.0597
149 3CF6 SP1 0.01816 0.4078 8.38323
150 2E27 AB0 0.02183 0.41073 8.40336
151 1OIJ AKG 0.03008 0.40931 8.63787
152 4IX4 ADP 0.000008884 0.43558 8.65672
153 1NY5 ADP 0.01124 0.41441 8.65672
154 1CBK ROI 0.0332 0.41272 8.75
155 5NBW 8SK 0.006696 0.43653 9.34579
156 4HXY ACA 0.0181 0.4082 9.36073
157 5MW8 ATP 0.0002068 0.40552 9.55224
158 3ORQ ADP 0.003557 0.4306 9.85075
159 4GCZ FMN 0.01048 0.41255 9.85075
160 2AGC DAO 0.02912 0.41173 9.87654
161 5HZX 2GE 0.02428 0.41204 10.2273
162 4Y24 TD2 0.03603 0.40315 10.3896
163 4OFG PCG 0.006283 0.43792 10.4167
164 1W6P NDG GAL 0.007871 0.44652 10.4478
165 5GZ9 ANP 0.0000144 0.44155 10.4918
166 1PVC ILE SER GLU VAL 0.003023 0.48674 10.5042
167 5C1P ADP 0.002826 0.45529 10.7843
168 4O4F ATP 0.001408 0.43466 10.8871
169 4O4F IHP 0.00171 0.42801 10.8871
170 3T50 FMN 0.01082 0.41192 11.0448
171 1BHX ASP PHE GLU GLU ILE 0.000271 0.5121 11.4286
172 1TQP ATP 0.00007224 0.49276 12.2388
173 5H9O GLC 0.04229 0.40932 12.5
174 5CKW ANP 0.00002563 0.56446 12.5373
175 4AZT LY2 0.0004398 0.50135 12.5373
176 4WVO 3UZ 0.006328 0.40208 12.7072
177 4WW7 AMP 0.0000007827 0.46953 13.41
178 3NZ1 3NY 0.008179 0.4541 13.7931
179 3VV1 GAL FUC 0.01036 0.4444 14.375
180 3HAV ATP 0.00312 0.4694 15.0502
181 2XG5 EC5 0.02909 0.41403 15.1376
182 2XG5 EC2 0.02909 0.41403 15.1376
183 4OAV ACP 0.00000122 0.60741 15.5224
184 2CM4 RCL 0.006805 0.41475 16
185 5V3D FCN 0.04474 0.40569 16.5517
186 3KMW ATP 0.0003568 0.48955 16.6052
187 2PR5 FMN 0.01062 0.4123 17.4242
188 3VPB ADP 0.0002277 0.46768 17.8571
189 5MY8 RXZ 0.000005168 0.53628 19.403
190 3VHE 42Q 0.000000003511 0.64091 20.8955
191 4B1V LAB 0.03897 0.40137 21.875
192 5LXT ACP 0.002494 0.43064 23.0769
193 4XYM A12 0.002555 0.44075 23.4783
194 2CSN CKI 0.001898 0.42378 23.9057
195 4YZC STU 0.000000002684 0.61759 25.0746
196 5C03 AGS 0.00001286 0.55219 25.9701
197 4FL3 ANP 0.00000003862 0.64614 26.2687
198 4WOV 3SM 0.00009521 0.52885 27.4448
199 3E8N VRA 0.0000003847 0.49458 27.566
200 3E8N ATP 0.0000003847 0.49458 27.566
201 3H9R TAK 0.000001009 0.64563 28.0597
202 3LQV ADE 0.0005072 0.51456 28.2051
203 1JPA ANP 0.0000005129 0.64855 28.5256
204 5EFQ ADP 0.000002261 0.58752 28.9552
205 1VJY 460 0.00000005614 0.58308 29.0429
206 4XH0 ADP 0.000003201 0.63239 29.2537
207 5HCY 60D 0.00000001769 0.53873 29.3051
208 5LXC 7AA 0.0000001082 0.45723 29.5522
209 4KBA 1QM 0.000004338 0.52961 29.6073
210 2QLU ADE 0.00006069 0.54943 29.6178
211 4CLI 5P8 0.0000000004673 0.65758 29.6636
212 3PP0 03Q 0.000009101 0.52125 29.8507
213 4YLL 4E3 0.000000006846 0.53507 30.1493
214 5LPZ ADP 0.0000000136 0.69145 30.4478
215 3C1X CKK 0.0000003648 0.60314 30.4478
216 4Y93 746 0.000004354 0.53938 30.7463
217 4BTK DTQ 0.000003874 0.44215 30.7463
218 4BKJ STI 0.00008847 0.48481 31.1111
219 2XVD AS6 0.000000004953 0.64151 31.1258
220 1U59 STU 0.00000004084 0.66909 31.3589
221 5KO1 6UY 0.00000009782 0.65978 31.4488
222 5MJA 7O3 0.0000000133 0.4815 31.4754
223 5T8O 76Z 0.00000001376 0.67395 31.5186
224 4P5Z Q7M 0.0000000008602 0.61635 31.6418
225 3UIM ANP 0.00004078 0.52873 31.9018
226 5U6C 7YS 0.0000009232 0.58535 32.0635
227 4NM5 ADP 0.00000002248 0.64897 32.5373
228 2JLD AG1 0.0000000206 0.59404 32.5373
229 3F7Z 34O 0.00000001405 0.49823 32.5373
230 3ZRM ZRM 0.0000004491 0.45911 32.5373
231 4AT3 LTI 0.000000002418 0.64721 32.7759
232 4CRL C1I 0.00000000374 0.62154 32.8358
233 4WNK 453 0.00000006197 0.59233 32.8358
234 3VRY B43 0.000001214 0.56253 32.8358
235 3LXN MI1 0.000000731 0.59639 33.0189
236 4IDT T28 0.000000138 0.65264 33.4328
237 1OPK P16 0.00000001652 0.60882 33.7313
238 4EWH T77 0.00000005024 0.60763 33.8182
239 5EOB 5QQ 0.00000004115 0.59921 33.8558
240 3SRV S19 0.0000002876 0.46027 33.935
241 1U5R ATP 0.000001566 0.59498 34.0299
242 3GNI ATP 0.000009953 0.54541 34.0299
243 4E93 GUI 0.000003012 0.51787 34.0299
244 5LPB ADP 0.0000007675 0.64234 34.1216
245 4F4P 0SB 0.000000001525 0.65972 34.4322
246 3KRR DQX 0.000000002194 0.49108 34.5763
247 4GJ3 0XP 0.0000003596 0.55755 34.7682
248 1Y57 MPZ 0.000000292 0.60078 34.9254
249 5USZ SKE 0.00001254 0.51104 34.9481
250 3ALN ANP 0.00004499 0.51596 35.474
251 4ASE AV9 0.00000000514 0.64752 35.5224
252 3PVW QRX 0.000003922 0.53624 35.5224
253 5UKL SIX 0.000004324 0.47134 35.5224
254 5KMJ 6UF 0.0007478 0.44964 35.5623
255 4E1Z 0MX 0.000002472 0.56064 35.7388
256 3LXK MI1 0.000001531 0.54784 36.0856
257 2Y6O 1N1 0.00000002137 0.65747 36.4261
258 5HES 032 0.00000007694 0.4983 36.4821
259 2OO8 RAJ 0.00000153 0.57568 36.5931
260 3BU5 ATP 0.0000001136 0.47275 36.6013
261 2WU6 DKI 0.0000002172 0.60635 36.7164
262 3NW7 LGV 0.00000009673 0.575 36.8078
263 5L9B AKG 0.0399 0.40084 36.8421
264 2H8H H8H 0.0000006987 0.61138 37.0149
265 3KRL KRL 0.0000003489 0.60399 37.0149
266 1K3A ACP 0.0000004921 0.64305 37.1237
267 3EKK GS2 0.00000008398 0.55454 37.1335
268 2X2M X2M 0.00000002048 0.51582 37.5796
269 5NKB 8ZT 0.0000000002444 0.61208 37.5817
270 3PLS ANP 0.0000001184 0.65582 37.5839
271 5FBN 5WF 0.000001235 0.5157 37.6384
272 4Y85 499 0.000005356 0.57671 37.6506
273 4AG8 AXI 0.00000001852 0.58524 37.6582
274 5JFS 6K0 0.00000001785 0.59365 37.987
275 3GC0 AMP 0.0000006564 0.6368 37.9939
276 4BHN BH9 0.0000005417 0.60224 38.024
277 5CEO 50D 0.000003899 0.43481 38.3333
278 2A19 ANP 0.0000001631 0.67672 38.3803
279 4U0I 0LI 0.00000002963 0.59909 38.4127
280 3GC8 B45 0.00000001533 0.66383 38.5075
281 4L9I 8PR 0.000001715 0.60035 38.5075
282 2OFV 242 0.00000007598 0.56319 38.9892
283 3SLS ANP 0.000001046 0.58295 39.1447
284 3SLS 77D 0.005521 0.42892 39.1447
285 5JGA 6KC 0.0000000001094 0.68528 39.3651
286 5X8I SQZ 0.0000000644 0.65984 39.403
287 1CM8 ANP 0.000008792 0.56642 39.403
288 3GQI ACP 0.000000549 0.61629 39.5706
289 4QMN DB8 0.00000001356 0.59012 39.6774
290 4H3P ANP 0.00000006164 0.66073 39.7015
291 5TA6 79D 0.00000004533 0.60942 39.7015
292 4NST ADP 0.000004692 0.57268 39.7015
293 4H3Q ANP 0.0000001194 0.49777 39.7015
294 5BVE 4VG 0.0000001062 0.45032 39.7015
295 4NST AF3 0.002344 0.4083 39.7015
296 2PVF ACP 0.00000005282 0.67257 39.8204
297 5TO8 7FM 0.00000002422 0.56083 40.0709
298 5JKG 6LF 0.00000002198 0.58656 40.1929
299 4OTH DRN 0.000000001643 0.7066 40.597
300 2HK5 1BM 0.0000000006116 0.55 40.7407
301 1XJD STU 0.00000001607 0.67929 40.8955
302 3G5D 1N1 0.0000000009148 0.52234 40.9091
303 4K33 ACP 0.00000008716 0.47918 40.9231
304 5HQ0 LZ9 0.0000003648 0.60996 41.0596
305 4YMJ 4EJ 0.00000204 0.64318 41.1184
306 5BYZ 4WE 0.0000002882 0.56123 41.194
307 4LOO SB4 0.00001228 0.55312 41.194
308 5EKO N17 0.000006171 0.45277 41.194
309 1OUK 084 0.000000003317 0.40459 41.194
310 3HMO STU 0.00000003668 0.68014 41.2281
311 4UX9 ANP 0.00000008314 0.63883 41.4925
312 5AWM ANP 0.000005549 0.59842 41.4925
313 4IZY 1J2 0.000001695 0.57997 41.4925
314 2B9F ADP 0.0000006101 0.45614 41.4925
315 4TWP AXI 0.0000000008319 0.57486 41.6974
316 2B9I ADP 0.00000005037 0.66483 41.791
317 2B9J ADP 0.0000003141 0.63557 41.791
318 2B9H ADP 0.00000007876 0.48442 41.791
319 3TXO 07U 0.00000009229 0.46163 41.791
320 2BPM 529 0.00000001575 0.51769 42.0712
321 3E7O 35F 0.00000001114 0.60956 42.0896
322 5UR1 YY9 0.000000002339 0.62982 42.1222
323 5H2U 1N1 0.000003212 0.58038 42.3221
324 3TTI KBI 0.0000003407 0.57413 42.3881
325 4WHZ 3NL 0.000001461 0.46426 42.3881
326 3PTG 932 0.0000002682 0.42638 42.3881
327 1BYG STU 0.0000004544 0.63611 42.446
328 4XLI 1N1 0.00000001168 0.7039 42.5373
329 2F57 23D 0.0000000462 0.68459 42.5868
330 5DA3 58V 0.000006478 0.59499 42.6415
331 3BZ3 YAM 0.00000007115 0.47722 42.7536
332 4CFU 2WC 0.0000001036 0.66747 42.9043
333 4QTB 38Z 0.0000005212 0.56141 42.9851
334 4AUA 4AU 0.00001078 0.56219 42.9967
335 3RI1 3RH 0.00000001133 0.64033 43.131
336 4BCQ TJF 0.0000002027 0.6719 43.1894
337 4BCM T7Z 0.000003323 0.62783 43.1894
338 4RFM 3P6 0.0000001199 0.49497 43.2331
339 3SXS PP2 0.0000002377 0.61832 43.2836
340 2QCS ANP 0.0000006923 0.49217 43.2836
341 3FHI ANP 0.0000008193 0.48941 43.2836
342 2V7O DRN 0.00000005301 0.43832 43.2836
343 4BCN T9N 0.0000001613 0.66724 43.3333
344 4AU8 Z3R 0.000002305 0.61792 43.5811
345 3IDB ANP 0.0000002775 0.60174 43.5821
346 1RE8 BD2 0.0000003809 0.5528 43.5821
347 2GU8 796 0.000000003888 0.5036 43.5821
348 4WB7 ATP 0.000005656 0.49585 43.5821
349 5VC5 96M 0.00000004186 0.61082 43.5986
350 2XMY CDK 0.00000002351 0.62012 43.6242
351 4CSV STI 0.0000006717 0.58513 43.6364
352 5LMK 6ZK 0.00002716 0.54935 43.771
353 4WB6 ATP 0.0000008326 0.56383 43.8806
354 1ZY5 ANP 0.0000124 0.41203 43.8944
355 5LI1 ANP 0.0000001864 0.616 44.4776
356 5LI9 ACP 0.0000005181 0.61011 44.4776
357 3IGO ANP 0.000001934 0.57119 44.4776
358 3SXF BK5 0.000001596 0.51971 44.7761
359 1UNH IXM 0.00000006209 0.68795 44.863
360 3O0G 3O0 0.0000001354 0.47027 44.863
361 5N87 N66 0.00000005972 0.56695 45.0479
362 3HZT J60 0.00005545 0.54733 45.6716
363 2WEL K88 0.0000009209 0.4011 45.8716
364 5HX8 66P 0.000001625 0.55193 46.0265
365 4I6H 1C8 0.000008646 0.56026 46.4286
366 5UOX 8GY 0.0000002387 0.61126 46.8635
367 2ZV2 609 0.0000003571 0.65932 46.9799
368 1V0O INR 0.0000002291 0.62637 47.2222
369 2VZ6 FEF 0.0000006318 0.63763 47.2843
370 1PHK ATP 0.0000001013 0.47978 47.3154
371 4D2S DYK 0.0000002647 0.6565 47.8873
372 4FG8 ATP 0.0000002477 0.61752 48.254
373 2VN9 GVD 0.0000001125 0.42748 49.8339
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