Receptor
PDB id Resolution Class Description Source Keywords
5H7J 2.3 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ELONGATION FACTOR 2 PYROCOCCUS HORIKOSHII OT3 ELONGATION FACTOR PROTEIN BIOSYNTHESIS GTP-BINDING TRANSL
Ref.: THE C-TERMINAL HELIX OF RIBOSOMAL P STALK RECOGNIZE HYDROPHOBIC GROOVE OF ELONGATION FACTOR 2 IN A NOVE NUCLEIC ACIDS RES. V. 46 3232 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GCP B:801;
Valid;
none;
submit data
521.208 C11 H18 N5 O13 P3 c1nc2...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5H7J 2.3 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF ELONGATION FACTOR 2 PYROCOCCUS HORIKOSHII OT3 ELONGATION FACTOR PROTEIN BIOSYNTHESIS GTP-BINDING TRANSL
Ref.: THE C-TERMINAL HELIX OF RIBOSOMAL P STALK RECOGNIZE HYDROPHOBIC GROOVE OF ELONGATION FACTOR 2 IN A NOVE NUCLEIC ACIDS RES. V. 46 3232 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5H7J - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5H7J - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1DAR Kd = 11 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 2BM0 Ki = 440 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 2BV3 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
4 1WDT - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
5 5H7J - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GCP; Similar ligands found: 142
No: Ligand ECFP6 Tc MDL keys Tc
1 GCP 1 1
2 GP3 0.8375 0.948718
3 GDP 0.82716 0.973684
4 GNH 0.817073 0.961039
5 GP2 0.804878 0.987013
6 GTP 0.797619 0.973684
7 G1R 0.788235 0.961039
8 9GM 0.77907 0.948718
9 GNP 0.77907 0.948718
10 GSP 0.77907 0.925
11 G 0.765432 0.960526
12 5GP 0.765432 0.960526
13 G2P 0.758621 0.987013
14 GMV 0.755814 0.948718
15 G2R 0.736264 0.961538
16 Y9Z 0.715789 0.903614
17 GAV 0.703297 0.936709
18 G3A 0.701031 0.948718
19 GKE 0.697917 0.936709
20 GDC 0.697917 0.936709
21 GDD 0.697917 0.936709
22 ALF 5GP 0.696629 0.86747
23 G5P 0.693878 0.948718
24 GPG 0.691489 0.936709
25 GFB 0.690722 0.936709
26 GTG 0.690722 0.91358
27 GDR 0.690722 0.936709
28 GDP AF3 0.688172 0.86747
29 YGP 0.6875 0.879518
30 6CK 0.683673 0.91358
31 JB2 0.67 0.936709
32 GKD 0.67 0.936709
33 GDX 0.663366 0.948718
34 GPD 0.663366 0.925926
35 ALF GDP 0.652632 0.86747
36 GDP ALF 0.652632 0.86747
37 JB3 0.632075 0.925
38 GMP 0.62963 0.857143
39 NGD 0.626168 0.936709
40 G3D 0.610526 0.960526
41 2MD 0.609091 0.870588
42 G G 0.607843 0.924051
43 G4P 0.597938 0.960526
44 U2G 0.59633 0.91358
45 FEG 0.59633 0.880952
46 GDP 7MG 0.596154 0.888889
47 MGD 0.59292 0.870588
48 CAG 0.59292 0.860465
49 ZGP 0.590909 0.870588
50 0O2 0.59 0.960526
51 CG2 0.585586 0.91358
52 MD1 0.57265 0.892857
53 PGD 0.57265 0.902439
54 3GP 0.566667 0.922078
55 TPG 0.563025 0.842697
56 DBG 0.563025 0.925
57 FE9 0.550847 0.760417
58 ACP 0.548387 0.922078
59 GH3 0.54 0.973684
60 GCP G 0.538462 0.922078
61 A G 0.534483 0.911392
62 2GP 0.532609 0.935065
63 G4M 0.53125 0.860465
64 U A G G 0.529915 0.911392
65 GPX 0.529412 0.922078
66 DGI 0.525773 0.924051
67 G A A A 0.521368 0.9
68 IDP 0.520833 0.947368
69 DGT 0.52 0.924051
70 AKW 0.513043 0.869048
71 P1G 0.510417 0.873418
72 G1G 0.504132 0.902439
73 G1R G1R 0.5 0.901235
74 R5I 0.5 0.922078
75 BGO 0.5 0.901235
76 R7I 0.5 0.922078
77 PGD O 0.496 0.831461
78 G U 0.495726 0.878049
79 ACQ 0.494949 0.922078
80 P2G 0.489583 0.860759
81 GGM 0.487395 0.879518
82 MGP 0.485149 0.936709
83 6G0 0.480392 0.936709
84 6YZ 0.480392 0.922078
85 DGP 0.479167 0.911392
86 DG 0.479167 0.911392
87 GPC 0.47541 0.858824
88 G C 0.475 0.878049
89 4TC 0.470085 0.876543
90 IMP 0.46875 0.934211
91 GTA 0.464912 0.91358
92 G2Q 0.453704 0.961538
93 A2D 0.452632 0.871795
94 G G G C 0.452381 0.890244
95 G7M 0.44898 0.924051
96 AT4 0.44898 0.8625
97 APC G U 0.448 0.8875
98 SGP 0.444444 0.807229
99 BA3 0.443299 0.871795
100 G G G RPC 0.439024 0.853659
101 B4P 0.438776 0.871795
102 AP5 0.438776 0.871795
103 ADP 0.438776 0.896104
104 A G C C 0.4375 0.888889
105 ANP 0.436893 0.873418
106 G C C C 0.435115 0.901235
107 AN2 0.434343 0.884615
108 M33 0.43 0.860759
109 A12 0.428571 0.910256
110 AP2 0.428571 0.910256
111 A G U 0.427536 0.86747
112 35G 0.427184 0.909091
113 C2E 0.427184 0.897436
114 PCG 0.427184 0.909091
115 HEJ 0.425743 0.896104
116 ATP 0.425743 0.896104
117 5GP 5GP 0.423077 0.860759
118 G U34 0.422764 0.86747
119 AR6 0.421569 0.871795
120 AQP 0.421569 0.896104
121 5FA 0.421569 0.896104
122 APR 0.421569 0.871795
123 AGS 0.417476 0.851852
124 AD9 0.417476 0.873418
125 SAP 0.417476 0.851852
126 UP5 0.416667 0.851852
127 CA0 0.415842 0.873418
128 ATF 0.415094 0.8625
129 HFD 0.413462 0.851852
130 A G U U 0.412587 0.86747
131 A1R 0.409091 0.841463
132 01G 0.408696 0.880952
133 PRT 0.408696 0.934211
134 APC 0.407767 0.910256
135 DG DG 0.40708 0.86747
136 A4P 0.406504 0.848837
137 UCG 0.406015 0.888889
138 7DD 0.405941 0.883117
139 93A 0.405941 0.813953
140 6AD 0.40566 0.821429
141 ADX 0.401961 0.790698
142 AGO 0.401575 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5H7J; Ligand: GCP; Similar sites found with APoc: 73
This union binding pocket(no: 1) in the query (biounit: 5h7j.bio2) has 15 residues
No: Leader PDB Ligand Sequence Similarity
1 6AU6 GDP 2.91777
2 5M04 GDP 3.05556
3 1Y3A GDP 3.64742
4 1TAD GDP 3.7037
5 1TAD ALF 3.7037
6 1BH2 GSP 3.80952
7 1FZQ GDP 3.8674
8 3CX8 GSP 4.14201
9 1O3Y GTP 4.21687
10 1CS4 GSP 4.24528
11 1ZD9 GDP 4.25532
12 1ZJ6 G3D 4.27807
13 2RCN GDP 4.46927
14 2A5F GTP 4.66321
15 1RE0 GDP 4.97738
16 2XTZ GSP 5.36723
17 5KDO GDP 5.40541
18 1Z2A GDP 5.95238
19 2G77 GDP 6.06061
20 3MD0 GDP 6.19718
21 3RWO GDP 6.48649
22 2FFQ GSP 7.01754
23 3AB3 GDP 7.31707
24 1S9D GDP 7.38916
25 3Q85 GNP 7.69231
26 3T1O GDP 8.08081
27 6CRK GDP 8.4507
28 1GP2 GDP 8.4507
29 5Z2M GTP 8.52273
30 2GJ8 ALF GDP 8.72093
31 1MR3 G3D 8.83978
32 1VG0 GDP 9.17874
33 5FG3 GDP 9.79133
34 3GJ8 GDP 9.95475
35 3CH5 GDP 10.1852
36 6G14 G4P 10.2041
37 1KSH GDP 10.2151
38 1VG9 GDP 10.2703
39 2ODE ALF GDP 10.2857
40 1PUJ GNP 10.6383
41 2WIC GNP 11.236
42 1UPT GTP 11.6667
43 1MKY GDP 12.0729
44 1G7S GDP 12.4579
45 3T12 GDP ALF 12.5
46 1YZG GDP 13.4078
47 4V0K GDP 13.6095
48 1R4A GNP 13.7255
49 2OM2 GDP 13.8889
50 1F6B GDP 15.1515
51 1FQK GDP 15.6463
52 4M9Q GNP 16.7401
53 1G7C 5GP 17.4672
54 4RD0 GDP 17.8313
55 1KK1 GNP 18.0488
56 2QN6 GDP 18.1159
57 1D2E GDP 18.3879
58 2WJG GDP 18.617
59 3WXM GTP 19.6809
60 1SKQ GDP 20.2299
61 1D8T GDP 20.8651
62 4BAS GNP 21.1055
63 1WF3 GNP 21.2625
64 1GOT GDP 21.9178
65 2WJH GDP 22.8916
66 1J2J GTP 26.6667
67 2CJW GDP 28.6458
68 2HT6 GDP 31.6092
69 2C77 GNP 34.0741
70 2C78 GNP 34.321
71 2HCJ GDP 35.1351
72 5YT0 GDP 38.0952
73 4B47 GDP 40.4959
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