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Receptor
PDB id Resolution Class Description Source Keywords
5H2D 1.6 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF OSH1 ORD DOMAIN IN COMPLEX WITH ERGOSTE KLUYVEROMYCES LACTIS OXYSTEROL BINDING LIPID TRANSFER ERGOSTEROL LIPID BINDING
Ref.: STRUCTURE OF YEAST OSBP-RELATED PROTEIN OSH1 REVEAL DETERMINANTS FOR LIPID TRANSPORT AND PROTEIN TARGET THE NUCLEUS-VACUOLE JUNCTION STRUCTURE V. 25 617 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:1304;
A:1303;
A:1302;
A:1305;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
ERG A:1301;
Valid;
none;
submit data
396.648 C28 H44 O CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5H2D 1.6 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF OSH1 ORD DOMAIN IN COMPLEX WITH ERGOSTE KLUYVEROMYCES LACTIS OXYSTEROL BINDING LIPID TRANSFER ERGOSTEROL LIPID BINDING
Ref.: STRUCTURE OF YEAST OSBP-RELATED PROTEIN OSH1 REVEAL DETERMINANTS FOR LIPID TRANSPORT AND PROTEIN TARGET THE NUCLEUS-VACUOLE JUNCTION STRUCTURE V. 25 617 2017
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5WVR - CLR C27 H46 O CC(C)CCC[C....
2 5H2D - ERG C28 H44 O CC(C)[C@@H....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5WVR - CLR C27 H46 O CC(C)CCC[C....
2 5H2D - ERG C28 H44 O CC(C)[C@@H....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 5WVR - CLR C27 H46 O CC(C)CCC[C....
2 5H2D - ERG C28 H44 O CC(C)[C@@H....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ERG; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ERG 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5H2D; Ligand: ERG; Similar sites found with APoc: 99
This union binding pocket(no: 1) in the query (biounit: 5h2d.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 4FFG LBS 1.14943
2 5LXB 7A9 1.65289
3 3RGA LSB 1.76678
4 3AVR OGA 1.83908
5 5FQK 6NT 1.85874
6 4PSB GA3 1.93548
7 1SW0 PGA 2.01613
8 3NV3 GAL NAG MAN 2.17391
9 5O9W AKG 2.17984
10 5X7Q GLC GLC GLC GLC GLC 2.29885
11 5X7Q GLC GLC GLC GLC 2.29885
12 4RF7 ARG 2.52874
13 1H16 DTL 2.52874
14 4NOS ITU 2.57611
15 4L4J NAG NAG BMA MAN NAG 2.71493
16 5XJD 87L 2.72727
17 5NFB 8VT 2.84091
18 5CGE 51F 2.88809
19 4KYS VIB 3.0445
20 1V6A TRE 3.31325
21 5T9C G3P 3.35821
22 1QFT HSM 3.42857
23 6B9T 2HE 3.44828
24 1QKQ MAN 3.52113
25 4OCT AKG 3.6036
26 1C1L GAL BGC 3.64964
27 5EY0 ILE 3.64964
28 2AGC DAO 3.7037
29 1V08 NTZ 3.90805
30 3AB4 THR 3.93258
31 2DTJ THR 3.93258
32 5TFZ 7BC 4
33 3TAO PGH 4.11985
34 4WVW SLT 4.16667
35 4QPW XYP XYP XYP 4.22535
36 2I74 MAN MAN MAN MAN 4.2328
37 3SAO NKN 4.375
38 1QDS PGA 4.38247
39 1RYD GLC 4.39277
40 1N5S ADL 4.46429
41 3ZXE PGZ 4.51128
42 4K90 MLA 4.65116
43 2XMY CDK 4.69799
44 2DT9 THR 4.79042
45 1TRD PGH 4.8
46 3FW9 SLX 4.84848
47 1CKN GTP 4.84848
48 2ET1 GLV 4.97512
49 5O0X FAD 5.15464
50 5T7I LAT NAG GAL 5.16129
51 6BGC BGC 5.16796
52 5GLT BGC GAL NAG GAL 5.28169
53 3OZG SSI 5.6
54 1Y9Q MED 5.72917
55 6A63 LAT 5.7971
56 5DG2 GAL GLC 5.92593
57 3ZO7 K6H 6.38298
58 1BRW URA 6.46651
59 6AYU MLI 6.62824
60 3G08 FEE 6.66667
61 3HDY GDU 6.80101
62 3PIJ FRU 6.89655
63 5XEG AKG 6.92641
64 3UVD MB3 7.25806
65 1OI6 TMP 7.31707
66 3WUD GLC GAL 7.35294
67 2HJ4 PNZ 7.75623
68 1J3R 6PG 7.89474
69 3I8T LBT 7.92683
70 4QM9 CYS 8.09249
71 1W6P NDG GAL 8.20895
72 1W6O LAT 8.20895
73 1GZW GAL BGC 8.20895
74 2QL9 CIT 8.24742
75 5K21 6QF 8.51064
76 1AUA BOG 8.78378
77 1N8V BDD 8.92857
78 1SLT NDG GAL 8.95522
79 2D6M LBT 9.43396
80 2VQ5 HBA 9.45274
81 5AIG VPR 9.6
82 1IS3 LAT 9.62963
83 2IUW AKG 10.084
84 3HQR OGA 10.1626
85 5VNF VAL THR SER VAL VAL 10.1911
86 1Y0G 8PP 10.4712
87 3WV6 GAL BGC 10.473
88 3WV6 GAL GLC 10.473
89 3RUG DB6 11.6183
90 3WUC GLC GAL 11.6788
91 2GC0 PAN 11.7021
92 1A78 TDG 11.9403
93 3WG3 A2G GAL NAG FUC 12.3596
94 2YIP YIO 14.4928
95 1DZK PRZ 14.6497
96 1WUB OTP 20.2247
97 3M3E GAL A2G NPO 26.087
98 1ZHX HC3 29.4253
99 4B2Z P5S 38.6207
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