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Receptor
PDB id Resolution Class Description Source Keywords
5GWX 2.21 Å EC: 2.1.1.156 CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE F METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLMA ND SARCOSINE METHANOHALOPHILUS PORTUCALENSIS FDF-1 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES SAM ADOMCLASS I MONOMETHYLATION GLYCINE SARCOSINE RATE-LIMITING EBETAINE BIOSYNTHESIS BETAINE-MEDIATED FEEDBACK INHIBITION TRANSFERASE
Ref.: STRUCTURAL ANALYSIS OF GLYCINE SARCOSINE N-METHYLTR FROM METHANOHALOPHILUS PORTUCALENSIS REVEALS MECHAN INSIGHTS INTO THE REGULATION OF METHYLTRANSFERASE A SCI REP V. 6 38071 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:304;
A:305;
A:303;
A:306;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
SAR A:302;
Valid;
none;
submit data
89.093 C3 H7 N O2 CNCC(...
SAM A:301;
Valid;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5GWX 2.21 Å EC: 2.1.1.156 CRYSTAL STRUCTURE OF GLYCINE SARCOSINE N-METHYLTRANSFERASE F METHANOHALOPHILUS PORTUCALENSIS IN COMPLEX WITH S-ADENOSYLMA ND SARCOSINE METHANOHALOPHILUS PORTUCALENSIS FDF-1 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASES SAM ADOMCLASS I MONOMETHYLATION GLYCINE SARCOSINE RATE-LIMITING EBETAINE BIOSYNTHESIS BETAINE-MEDIATED FEEDBACK INHIBITION TRANSFERASE
Ref.: STRUCTURAL ANALYSIS OF GLYCINE SARCOSINE N-METHYLTR FROM METHANOHALOPHILUS PORTUCALENSIS REVEALS MECHAN INSIGHTS INTO THE REGULATION OF METHYLTRANSFERASE A SCI REP V. 6 38071 2016
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 5GWX - SAR C3 H7 N O2 CNCC(=O)O
2 5HIM - DMG C4 H9 N O2 CN(C)CC(=O....
3 5HIK - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 5HIL - SAR C3 H7 N O2 CNCC(=O)O
5 5H02 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAR; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 SAR 1 1
2 AAC 0.5 0.633333
3 7UC 0.428571 0.625
Ligand no: 2; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5GWX; Ligand: SAR; Similar sites found with APoc: 444
This union binding pocket(no: 1) in the query (biounit: 5gwx.bio1) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 3S1S SAH 1.40845
2 1L1E SAH 1.76056
3 5MW4 5JU 1.76056
4 1Q19 SSC 1.76056
5 3QOX SAH 1.76056
6 2IVD FAD 1.76056
7 1KNR FAD 1.76056
8 3OFK SAH 1.85185
9 4DE3 DN8 1.90114
10 2BD0 NAP 2.04918
11 5W7R SAH 2.11268
12 1YY5 FAD 2.11268
13 1RSG FAD 2.11268
14 2ZIF SAM 2.11268
15 4ZCC FAD 2.11268
16 4ZCC NAI 2.11268
17 5AHO TLA 2.11268
18 4NTC FAD 2.11268
19 2ZWI C5P 2.11268
20 5X68 FAD 2.11268
21 5BSH PRO 2.16606
22 5O42 NAD 2.18978
23 5O42 9JW 2.18978
24 5O42 BGC 2.18978
25 2WSB NAD 2.3622
26 6B92 SAH 2.46479
27 5TS5 FAD 2.46479
28 3HDY FDA 2.46479
29 3HDY GDU 2.46479
30 3HDY FAD 2.46479
31 3O7W SAM 2.46479
32 3AYI FAD 2.46479
33 3AYI HCI 2.46479
34 6C5B SAH 2.46479
35 4DCM SAM 2.46479
36 5BRT FAD 2.46479
37 5BRT CH9 2.46479
38 2DKH 3HB 2.46479
39 2DKH FAD 2.46479
40 5A9A UTP 2.46914
41 3LCV SAM 2.4911
42 3E1T FAD 2.53906
43 1XCL SAH 2.55319
44 5CUQ NSC 2.62172
45 6DUB SAH 2.7027
46 3FRH SAH 2.7668
47 4M73 SAH 2.8169
48 4M73 M72 2.8169
49 3RKR NAP 2.8169
50 5YF1 8V0 2.8169
51 3NDJ SAH 2.8169
52 3NDJ JHZ 2.8169
53 6C8R SAH 2.8169
54 6C8R EQV 2.8169
55 5MBX FAD 2.8169
56 5MBX SP5 2.8169
57 3ICS ADP 2.8169
58 1ZQ9 SAM 2.8169
59 3ICT ADP 2.8169
60 5YF1 SFG 2.8169
61 2NVK NAP 2.8169
62 5HJM MTA 2.8169
63 1QZZ SAM 2.8169
64 1BG2 ADP 2.8169
65 3A4T SFG 2.91971
66 1FWV SGA MAG FUC 2.98507
67 3MB5 SAM 3.13725
68 4KRI SAH 3.16901
69 6ECU SAH 3.16901
70 1GTE FAD 3.16901
71 1REO FAD 3.16901
72 1RJD SAM 3.16901
73 2JHP SAH 3.16901
74 4A6D SAM 3.16901
75 3PT9 SAH 3.16901
76 6GFK SAH 3.18725
77 3ZV6 4HB 3.20285
78 3MQ2 SAH 3.21101
79 4FC7 COA 3.2491
80 4FC7 NAP 3.2491
81 3QDV NDG 3.4965
82 3QDX CBS 3.4965
83 3QDY CBS 3.4965
84 3QDW NDG 3.4965
85 4POO SAM 3.5
86 1P1C SAH 3.51759
87 5KOK S9T 3.52113
88 1FP1 SAH 3.52113
89 5KOK SAH 3.52113
90 5KOK R9T 3.52113
91 3LST SAH 3.52113
92 6FDF SAH 3.52113
93 1KPG SAH 3.52113
94 1XDS SAM 3.52113
95 4ITU 1HS 3.52113
96 2YX1 SFG 3.52113
97 4ITU NAI 3.52113
98 4RVG TYD 3.52113
99 4RVG SAM 3.52113
100 5FWA J7C 3.52113
101 5VN0 NAI 3.52113
102 5VN0 FAD 3.52113
103 5G3U ITW 3.52113
104 5G3U FDA 3.52113
105 5TTJ FAD 3.52113
106 1PR9 NAP 3.52113
107 1FP2 SAH 3.52113
108 1G0N NDP 3.53357
109 1G0N PHH 3.53357
110 5L95 AMP 3.58423
111 4YUW S4M 3.61842
112 4YUW 4JU 3.61842
113 1XXR MAN 3.72671
114 3TL1 JRO 3.77358
115 4FZV SAM 3.87324
116 3P2E SAH 3.87324
117 1YXM ADE 3.87324
118 4DMG SAM 3.87324
119 2ZWA SAH 3.87324
120 3A25 SAM 3.87324
121 1G55 SAH 3.87324
122 4OPC FDA 3.87324
123 4OPC PGT 3.87324
124 5E9W SAH 3.87324
125 2P41 SAH 3.87324
126 1LVL NAD 3.87324
127 2YG3 FAD 3.87324
128 4D7E FAD 3.87324
129 3X0V FAD 3.87324
130 4V3C C 3.87324
131 4FN4 NAD 3.87324
132 3EVG SAH 4
133 4URF 1PS 4.03226
134 4URF NAD 4.03226
135 3D3W NAP 4.09836
136 5BW4 SAM 4.11985
137 2HMT NAI 4.16667
138 6ECT SAM 4.22535
139 6ECW SAH 4.22535
140 6B3A SAM 4.22535
141 5F2K OCA 4.22535
142 5F2K SAH 4.22535
143 5BVA FAD 4.22535
144 5BJX NAD 4.22535
145 1E1M NAP 4.22535
146 1E1M FAD 4.22535
147 5AO7 AH0 NAG 4.22535
148 1YKJ PHB 4.22535
149 1YKJ FAD 4.22535
150 1Y8Q ATP 4.22535
151 5BJX UDP 4.22535
152 4LHD GLY 4.22535
153 1R18 SAH 4.40529
154 5DM1 5D7 4.49438
155 5DM1 SAH 4.49438
156 2A14 SAH 4.56274
157 1KYZ SAH 4.57746
158 1XF1 CIT 4.57746
159 3CGD COA 4.57746
160 3CGD FAD 4.57746
161 3CGD NAD 4.57746
162 2E5V FAD 4.57746
163 2VVM FAD 4.57746
164 1R6D DAU 4.57746
165 1Q0S SAH 4.6332
166 1JG3 ADN 4.68085
167 3RJ5 NAD 4.72441
168 1WY7 SAH 4.83092
169 4CQM NAP 4.91803
170 4LWP SAH 4.92958
171 3TKY SAH 4.92958
172 4AZW SAM 4.92958
173 5ICE 2H4 4.92958
174 3QJ4 FAD 4.92958
175 2YY7 NAD 4.92958
176 2EFJ SAH 4.92958
177 1NW5 SAM 4.92958
178 5WGR FAD 4.92958
179 4YKG NAD 4.92958
180 5FA8 SAM 4.96894
181 4XUC SAM 5.04587
182 4XUC 43G 5.04587
183 4OBW SAM 5.05837
184 2UYQ SAM 5.28169
185 5JGL SAM 5.28169
186 3VYW SAM 5.28169
187 2DPM SAM 5.28169
188 1UDB NAD 5.28169
189 1UDB UFG 5.28169
190 5NA1 FAD 5.28169
191 4MOP 2H5 5.28169
192 2YVF NAD 5.28169
193 2YVF FAD 5.28169
194 3UCL CYH 5.28169
195 3UCL FAD 5.28169
196 3M6W SAM 5.38793
197 5UFN SAH 5.46218
198 3FUU ADN 5.53506
199 5ULP KB1 5.59701
200 5Y02 MXN 5.60748
201 3X0D SAH 5.6338
202 2IID PHE 5.6338
203 2IID FAD 5.6338
204 5JJR SAH 5.6338
205 1YQZ FAD 5.6338
206 1UWK URO 5.6338
207 1UWK NAD 5.6338
208 5J5Z FAD 5.6338
209 3RNM FAD 5.6338
210 5J60 FAD 5.6338
211 5ERG SAM 5.74413
212 3H2B SAH 5.91133
213 3WV8 ATP 5.9633
214 5FA5 MTA 5.98592
215 2CDU ADP 5.98592
216 4X60 3XV 5.98592
217 4X60 SFG 5.98592
218 4GQB 0XU 5.98592
219 2CDU FAD 5.98592
220 5ZYN FAD 5.98592
221 3CTY FAD 5.98592
222 3FZG SAM 6
223 1I9G SAM 6.07143
224 2WA2 SAM 6.15942
225 4KRG SAH 6.33803
226 1H82 GZZ 6.33803
227 1H82 FAD 6.33803
228 5BUK FAD 6.33803
229 4U8P UDP 6.33803
230 4U8P FDA 6.33803
231 3K7M FAD 6.33803
232 1XHC FAD 6.33803
233 4MO2 FDA 6.33803
234 4IV9 FAD 6.33803
235 4MO2 FAD 6.33803
236 3FPZ AHZ 6.33803
237 3T7S SAM 6.34328
238 5DLY SAH 6.39098
239 5DLY 5D7 6.39098
240 4YAC NAI 6.39731
241 2BZG SAH 6.46552
242 1U2Z SAH 6.46651
243 4Y9D NAI 6.69014
244 6GKV SAH 6.69014
245 2EJU SAH 6.69014
246 3AD8 NAD 6.69014
247 3AXB PRO 6.69014
248 3AXB FAD 6.69014
249 1XTP SAI 6.69291
250 3FPF TNA 6.71141
251 3FPF MTA 6.71141
252 3DUW SAH 6.72646
253 1IM8 SAI 6.96721
254 4KIB SAH 7.04225
255 1JQD SAH 7.04225
256 2EG5 SAH 7.04225
257 1DL5 SAH 7.04225
258 1JQD HSM 7.04225
259 2AOT SAH 7.04225
260 1X87 NAD 7.04225
261 3UOY NAP 7.04225
262 3UOY FAD 7.04225
263 2ZXI FAD 7.04225
264 3C3Y SAH 7.173
265 1EJ0 SAM 7.22222
266 1PS9 FAD 7.30253
267 1G60 SAM 7.30769
268 2CUL FAD 7.32759
269 5WP4 SAH 7.39437
270 5XNC MTA 7.39437
271 2JJQ SAH 7.39437
272 2IZ1 ATR 7.39437
273 4FWE FAD 7.39437
274 4HSU FAD 7.39437
275 4GUS FAD 7.39437
276 3VC1 SAH 7.39437
277 3VC1 GST 7.39437
278 4E70 N7I 7.39437
279 4YSX FAD 7.69231
280 2FK8 SAM 7.74648
281 5T67 JHZ 7.74648
282 3SSO SAH 7.74648
283 5EEH SAH 7.74648
284 5EEH P9P 7.74648
285 3GRU AMP 7.74648
286 4C3Y FAD 7.74648
287 2C7G FAD 7.74648
288 3TKA SAM 7.74648
289 4C3Y ANB 7.74648
290 2C7G ODP 7.74648
291 4PIO AVI 7.74648
292 5T67 SAH 7.74648
293 4PIO SAH 7.74648
294 3H8V ATP 7.74648
295 2HQM FAD 7.74648
296 5Z75 NAD 7.74648
297 2FR1 NDP 7.74648
298 4BLW SAH 7.74648
299 1BC5 SAH 7.80669
300 5FTW SAH 7.8125
301 5E1M SAH 7.88382
302 5E1M PRO PRO LYS ARG ILE ALA 7.88382
303 3BGD SAH 8.07692
304 3BGD PM6 8.07692
305 2GAG NAD 8.08081
306 5THZ SAH 8.09859
307 3GWZ SAH 8.09859
308 4M37 SAH 8.09859
309 3GXO SAH 8.09859
310 4M38 SAH 8.09859
311 6ARJ BW4 8.09859
312 6ARJ SAH 8.09859
313 4C4A SAH 8.09859
314 5DX1 SFG 8.09859
315 1N2X SAM 8.09859
316 3A27 SAM 8.09859
317 5DXA SFG 8.09859
318 5DX8 SFG 8.09859
319 5DX0 SFG 8.09859
320 5DWQ SFG 8.09859
321 2XYQ SAH 8.19672
322 3JWH SAH 8.29493
323 2HNK SAH 8.3682
324 5MIT FAD 8.4507
325 5MIT NAP 8.4507
326 4ONQ SFG 8.4507
327 2Z3Y F2N 8.4507
328 4J36 FAD 8.4507
329 2PX8 SAH 8.55019
330 3GDH SAH 8.71369
331 3DMH SAM 8.80282
332 3DMH GMP 8.80282
333 5L2R MLA 8.80282
334 6D6Y SAH 9.15493
335 5F8F SFG 9.15493
336 4RDH AMP 9.15493
337 3DXY SAM 9.17431
338 1ZGA SAH 9.50704
339 1SJD NPG 9.50704
340 1WG8 SAM 9.50704
341 4RPL 3UC 9.50704
342 4RPL FAD 9.50704
343 5FUB SAH 9.50704
344 1I8T FAD 9.50704
345 4II2 ATP 9.50704
346 4YMH SAH 9.58333
347 1I1N SAH 9.73451
348 2OBF F83 9.85915
349 5THY SAH 9.85915
350 5W7M SAH 9.85915
351 1V59 NAD 9.85915
352 5X62 SAH 9.85915
353 2OBF SAH 9.85915
354 1LSS NAD 10
355 3G89 SAM 10.0402
356 3EGI ADP 10.1942
357 3TLJ SAH 10.2113
358 3GF4 UPG 10.2113
359 3GF4 FAD 10.2113
360 2ZFU SAH 10.2326
361 5KVA SAM 10.4317
362 6ER9 FAD 10.5634
363 6ER9 NAP 10.5634
364 2NXE SAM 10.6299
365 1NV8 MEQ 10.9155
366 1NV8 SAM 10.9155
367 2VVL FAD 10.9155
368 6FBZ MGP 11
369 4AP3 NAP 11.2676
370 4AP3 FAD 11.2676
371 3GD4 NAD 11.2676
372 4R84 CSF 11.2676
373 5N5D SAM 11.5044
374 1QAN SAH 11.8852
375 5DNK SAH 11.9718
376 2JB2 FAD 11.9718
377 2VDV SAM 12.1951
378 3VSE SAH 12.3239
379 4Y30 49L 12.5356
380 4Y30 SAH 12.5356
381 1Z3C SA8 12.6761
382 1F3L SAH 12.6761
383 5U19 SAH 12.9032
384 5U19 827 12.9032
385 1L3I SAH 13.0208
386 3GU3 SAH 13.0282
387 6F5Z SAH 13.4199
388 3I53 SAH 13.5542
389 2PXX SAH 13.7324
390 1TH8 ADP 13.7931
391 5XLX SAH 13.8298
392 2PWY SAH 13.9535
393 1E6E FAD 14.0625
394 2F5Z FAD 14.0625
395 5M58 SAH 14.3478
396 3QWI CUE 14.4444
397 6G5J EM8 14.5455
398 4R6W PC 14.7887
399 4R6W SAH 14.7887
400 1KPH SAH 15.1408
401 5JCA NDP 15.493
402 5JCA FAD 15.493
403 2XVM SAH 15.5779
404 4YRY NAD 15.5797
405 4YRY FAD 15.5797
406 5E8J SAH 15.9091
407 5ZW3 SAH 16.4444
408 3OU2 SAH 16.5138
409 5YEC ATP 16.7647
410 1TPY SAH 17.6056
411 3LKZ SFG 17.9577
412 5YJI 8WO 19.0141
413 5YJI SAH 19.0141
414 5YJF 8WO 19.0141
415 5YJF SAH 19.0141
416 3LCC SAH 20
417 5MPT SAH 20.0704
418 5GM1 SAH 20.0704
419 5MGZ SAH 20.339
420 3CBG SAH 20.6897
421 5BSZ SAH 21.2
422 1SQF SAM 22.1831
423 5E72 SAM 22.8873
424 2NPX NAD 23.2394
425 2NPX FAD 23.2394
426 3Q87 SAM 23.5294
427 3PFG TLO 23.5741
428 3PFG SAM 23.5741
429 5WP5 SAH 24.2958
430 5LOG SAH 24.4635
431 3P9C SAH 25
432 5JE0 AZ8 25.1012
433 5JE0 SAH 25.1012
434 5W7K SAH 25.7042
435 4IWN GEK 25.7642
436 1VE3 SAM 26.4317
437 4QTU SAM 26.9231
438 4NEC SAH 28.0303
439 3HVJ 705 28.0543
440 3BXO SAM 30.1255
441 4PNE SAH 30.9859
442 3G2O SAM 30.9859
443 3GCZ SAM 35.9155
444 1XVA SAM 45.4225
Pocket No.: 2; Query (leader) PDB : 5GWX; Ligand: SAM; Similar sites found with APoc: 444
This union binding pocket(no: 2) in the query (biounit: 5gwx.bio1) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 3S1S SAH 1.40845
2 1L1E SAH 1.76056
3 5MW4 5JU 1.76056
4 1Q19 SSC 1.76056
5 3QOX SAH 1.76056
6 2IVD FAD 1.76056
7 1KNR FAD 1.76056
8 3OFK SAH 1.85185
9 4DE3 DN8 1.90114
10 2BD0 NAP 2.04918
11 5W7R SAH 2.11268
12 1YY5 FAD 2.11268
13 1RSG FAD 2.11268
14 2ZIF SAM 2.11268
15 4ZCC FAD 2.11268
16 4ZCC NAI 2.11268
17 5AHO TLA 2.11268
18 4NTC FAD 2.11268
19 2ZWI C5P 2.11268
20 5X68 FAD 2.11268
21 5BSH PRO 2.16606
22 5O42 NAD 2.18978
23 5O42 9JW 2.18978
24 5O42 BGC 2.18978
25 2WSB NAD 2.3622
26 6B92 SAH 2.46479
27 5TS5 FAD 2.46479
28 3HDY FDA 2.46479
29 3HDY GDU 2.46479
30 3HDY FAD 2.46479
31 3O7W SAM 2.46479
32 3AYI FAD 2.46479
33 3AYI HCI 2.46479
34 6C5B SAH 2.46479
35 4DCM SAM 2.46479
36 5BRT FAD 2.46479
37 5BRT CH9 2.46479
38 2DKH 3HB 2.46479
39 2DKH FAD 2.46479
40 5A9A UTP 2.46914
41 3LCV SAM 2.4911
42 3E1T FAD 2.53906
43 1XCL SAH 2.55319
44 5CUQ NSC 2.62172
45 6DUB SAH 2.7027
46 3FRH SAH 2.7668
47 4M73 SAH 2.8169
48 4M73 M72 2.8169
49 3RKR NAP 2.8169
50 5YF1 8V0 2.8169
51 3NDJ SAH 2.8169
52 3NDJ JHZ 2.8169
53 6C8R SAH 2.8169
54 6C8R EQV 2.8169
55 5MBX FAD 2.8169
56 5MBX SP5 2.8169
57 3ICS ADP 2.8169
58 1ZQ9 SAM 2.8169
59 3ICT ADP 2.8169
60 5YF1 SFG 2.8169
61 2NVK NAP 2.8169
62 5HJM MTA 2.8169
63 1QZZ SAM 2.8169
64 1BG2 ADP 2.8169
65 3A4T SFG 2.91971
66 1FWV SGA MAG FUC 2.98507
67 3MB5 SAM 3.13725
68 4KRI SAH 3.16901
69 6ECU SAH 3.16901
70 1GTE FAD 3.16901
71 1REO FAD 3.16901
72 1RJD SAM 3.16901
73 2JHP SAH 3.16901
74 4A6D SAM 3.16901
75 3PT9 SAH 3.16901
76 6GFK SAH 3.18725
77 3ZV6 4HB 3.20285
78 3MQ2 SAH 3.21101
79 4FC7 COA 3.2491
80 4FC7 NAP 3.2491
81 3QDV NDG 3.4965
82 3QDX CBS 3.4965
83 3QDY CBS 3.4965
84 3QDW NDG 3.4965
85 4POO SAM 3.5
86 1P1C SAH 3.51759
87 5KOK S9T 3.52113
88 1FP1 SAH 3.52113
89 5KOK SAH 3.52113
90 5KOK R9T 3.52113
91 3LST SAH 3.52113
92 6FDF SAH 3.52113
93 1KPG SAH 3.52113
94 1XDS SAM 3.52113
95 4ITU 1HS 3.52113
96 2YX1 SFG 3.52113
97 4ITU NAI 3.52113
98 4RVG TYD 3.52113
99 4RVG SAM 3.52113
100 5FWA J7C 3.52113
101 5VN0 NAI 3.52113
102 5VN0 FAD 3.52113
103 5G3U ITW 3.52113
104 5G3U FDA 3.52113
105 5TTJ FAD 3.52113
106 1PR9 NAP 3.52113
107 1FP2 SAH 3.52113
108 1G0N NDP 3.53357
109 1G0N PHH 3.53357
110 5L95 AMP 3.58423
111 4YUW S4M 3.61842
112 4YUW 4JU 3.61842
113 1XXR MAN 3.72671
114 3TL1 JRO 3.77358
115 4FZV SAM 3.87324
116 3P2E SAH 3.87324
117 1YXM ADE 3.87324
118 4DMG SAM 3.87324
119 2ZWA SAH 3.87324
120 3A25 SAM 3.87324
121 1G55 SAH 3.87324
122 4OPC FDA 3.87324
123 4OPC PGT 3.87324
124 5E9W SAH 3.87324
125 2P41 SAH 3.87324
126 1LVL NAD 3.87324
127 2YG3 FAD 3.87324
128 4D7E FAD 3.87324
129 3X0V FAD 3.87324
130 4V3C C 3.87324
131 4FN4 NAD 3.87324
132 3EVG SAH 4
133 4URF 1PS 4.03226
134 4URF NAD 4.03226
135 3D3W NAP 4.09836
136 5BW4 SAM 4.11985
137 2HMT NAI 4.16667
138 6ECT SAM 4.22535
139 6ECW SAH 4.22535
140 6B3A SAM 4.22535
141 5F2K OCA 4.22535
142 5F2K SAH 4.22535
143 5BVA FAD 4.22535
144 5BJX NAD 4.22535
145 1E1M NAP 4.22535
146 1E1M FAD 4.22535
147 5AO7 AH0 NAG 4.22535
148 1YKJ PHB 4.22535
149 1YKJ FAD 4.22535
150 1Y8Q ATP 4.22535
151 5BJX UDP 4.22535
152 4LHD GLY 4.22535
153 1R18 SAH 4.40529
154 5DM1 5D7 4.49438
155 5DM1 SAH 4.49438
156 2A14 SAH 4.56274
157 1KYZ SAH 4.57746
158 1XF1 CIT 4.57746
159 3CGD COA 4.57746
160 3CGD FAD 4.57746
161 3CGD NAD 4.57746
162 2E5V FAD 4.57746
163 2VVM FAD 4.57746
164 1R6D DAU 4.57746
165 1Q0S SAH 4.6332
166 1JG3 ADN 4.68085
167 3RJ5 NAD 4.72441
168 1WY7 SAH 4.83092
169 4CQM NAP 4.91803
170 4LWP SAH 4.92958
171 3TKY SAH 4.92958
172 4AZW SAM 4.92958
173 5ICE 2H4 4.92958
174 3QJ4 FAD 4.92958
175 2YY7 NAD 4.92958
176 2EFJ SAH 4.92958
177 1NW5 SAM 4.92958
178 5WGR FAD 4.92958
179 4YKG NAD 4.92958
180 5FA8 SAM 4.96894
181 4XUC SAM 5.04587
182 4XUC 43G 5.04587
183 4OBW SAM 5.05837
184 2UYQ SAM 5.28169
185 5JGL SAM 5.28169
186 3VYW SAM 5.28169
187 2DPM SAM 5.28169
188 1UDB NAD 5.28169
189 1UDB UFG 5.28169
190 5NA1 FAD 5.28169
191 4MOP 2H5 5.28169
192 2YVF NAD 5.28169
193 2YVF FAD 5.28169
194 3UCL CYH 5.28169
195 3UCL FAD 5.28169
196 3M6W SAM 5.38793
197 5UFN SAH 5.46218
198 3FUU ADN 5.53506
199 5ULP KB1 5.59701
200 5Y02 MXN 5.60748
201 3X0D SAH 5.6338
202 2IID PHE 5.6338
203 2IID FAD 5.6338
204 5JJR SAH 5.6338
205 1YQZ FAD 5.6338
206 1UWK URO 5.6338
207 1UWK NAD 5.6338
208 5J5Z FAD 5.6338
209 3RNM FAD 5.6338
210 5J60 FAD 5.6338
211 5ERG SAM 5.74413
212 3H2B SAH 5.91133
213 3WV8 ATP 5.9633
214 5FA5 MTA 5.98592
215 2CDU ADP 5.98592
216 4X60 3XV 5.98592
217 4X60 SFG 5.98592
218 4GQB 0XU 5.98592
219 2CDU FAD 5.98592
220 5ZYN FAD 5.98592
221 3CTY FAD 5.98592
222 3FZG SAM 6
223 1I9G SAM 6.07143
224 2WA2 SAM 6.15942
225 4KRG SAH 6.33803
226 1H82 GZZ 6.33803
227 1H82 FAD 6.33803
228 5BUK FAD 6.33803
229 4U8P UDP 6.33803
230 4U8P FDA 6.33803
231 3K7M FAD 6.33803
232 1XHC FAD 6.33803
233 4MO2 FDA 6.33803
234 4IV9 FAD 6.33803
235 4MO2 FAD 6.33803
236 3FPZ AHZ 6.33803
237 3T7S SAM 6.34328
238 5DLY SAH 6.39098
239 5DLY 5D7 6.39098
240 4YAC NAI 6.39731
241 2BZG SAH 6.46552
242 1U2Z SAH 6.46651
243 4Y9D NAI 6.69014
244 6GKV SAH 6.69014
245 2EJU SAH 6.69014
246 3AD8 NAD 6.69014
247 3AXB PRO 6.69014
248 3AXB FAD 6.69014
249 1XTP SAI 6.69291
250 3FPF TNA 6.71141
251 3FPF MTA 6.71141
252 3DUW SAH 6.72646
253 1IM8 SAI 6.96721
254 4KIB SAH 7.04225
255 1JQD SAH 7.04225
256 2EG5 SAH 7.04225
257 1DL5 SAH 7.04225
258 1JQD HSM 7.04225
259 2AOT SAH 7.04225
260 1X87 NAD 7.04225
261 3UOY NAP 7.04225
262 3UOY FAD 7.04225
263 2ZXI FAD 7.04225
264 3C3Y SAH 7.173
265 1EJ0 SAM 7.22222
266 1PS9 FAD 7.30253
267 1G60 SAM 7.30769
268 2CUL FAD 7.32759
269 5WP4 SAH 7.39437
270 5XNC MTA 7.39437
271 2JJQ SAH 7.39437
272 2IZ1 ATR 7.39437
273 4FWE FAD 7.39437
274 4HSU FAD 7.39437
275 4GUS FAD 7.39437
276 3VC1 SAH 7.39437
277 3VC1 GST 7.39437
278 4E70 N7I 7.39437
279 4YSX FAD 7.69231
280 2FK8 SAM 7.74648
281 5T67 JHZ 7.74648
282 3SSO SAH 7.74648
283 5EEH SAH 7.74648
284 5EEH P9P 7.74648
285 3GRU AMP 7.74648
286 4C3Y FAD 7.74648
287 2C7G FAD 7.74648
288 3TKA SAM 7.74648
289 4C3Y ANB 7.74648
290 2C7G ODP 7.74648
291 4PIO AVI 7.74648
292 5T67 SAH 7.74648
293 4PIO SAH 7.74648
294 3H8V ATP 7.74648
295 2HQM FAD 7.74648
296 5Z75 NAD 7.74648
297 2FR1 NDP 7.74648
298 4BLW SAH 7.74648
299 1BC5 SAH 7.80669
300 5FTW SAH 7.8125
301 5E1M SAH 7.88382
302 5E1M PRO PRO LYS ARG ILE ALA 7.88382
303 3BGD SAH 8.07692
304 3BGD PM6 8.07692
305 2GAG NAD 8.08081
306 5THZ SAH 8.09859
307 3GWZ SAH 8.09859
308 4M37 SAH 8.09859
309 3GXO SAH 8.09859
310 4M38 SAH 8.09859
311 6ARJ BW4 8.09859
312 6ARJ SAH 8.09859
313 4C4A SAH 8.09859
314 5DX1 SFG 8.09859
315 1N2X SAM 8.09859
316 3A27 SAM 8.09859
317 5DXA SFG 8.09859
318 5DX8 SFG 8.09859
319 5DX0 SFG 8.09859
320 5DWQ SFG 8.09859
321 2XYQ SAH 8.19672
322 3JWH SAH 8.29493
323 2HNK SAH 8.3682
324 5MIT FAD 8.4507
325 5MIT NAP 8.4507
326 4ONQ SFG 8.4507
327 2Z3Y F2N 8.4507
328 4J36 FAD 8.4507
329 2PX8 SAH 8.55019
330 3GDH SAH 8.71369
331 3DMH SAM 8.80282
332 3DMH GMP 8.80282
333 5L2R MLA 8.80282
334 6D6Y SAH 9.15493
335 5F8F SFG 9.15493
336 4RDH AMP 9.15493
337 3DXY SAM 9.17431
338 1ZGA SAH 9.50704
339 1SJD NPG 9.50704
340 1WG8 SAM 9.50704
341 4RPL 3UC 9.50704
342 4RPL FAD 9.50704
343 5FUB SAH 9.50704
344 1I8T FAD 9.50704
345 4II2 ATP 9.50704
346 4YMH SAH 9.58333
347 1I1N SAH 9.73451
348 2OBF F83 9.85915
349 5THY SAH 9.85915
350 5W7M SAH 9.85915
351 1V59 NAD 9.85915
352 5X62 SAH 9.85915
353 2OBF SAH 9.85915
354 1LSS NAD 10
355 3G89 SAM 10.0402
356 3EGI ADP 10.1942
357 3TLJ SAH 10.2113
358 3GF4 UPG 10.2113
359 3GF4 FAD 10.2113
360 2ZFU SAH 10.2326
361 5KVA SAM 10.4317
362 6ER9 FAD 10.5634
363 6ER9 NAP 10.5634
364 2NXE SAM 10.6299
365 1NV8 MEQ 10.9155
366 1NV8 SAM 10.9155
367 2VVL FAD 10.9155
368 6FBZ MGP 11
369 4AP3 NAP 11.2676
370 4AP3 FAD 11.2676
371 3GD4 NAD 11.2676
372 4R84 CSF 11.2676
373 5N5D SAM 11.5044
374 1QAN SAH 11.8852
375 5DNK SAH 11.9718
376 2JB2 FAD 11.9718
377 2VDV SAM 12.1951
378 3VSE SAH 12.3239
379 4Y30 49L 12.5356
380 4Y30 SAH 12.5356
381 1Z3C SA8 12.6761
382 1F3L SAH 12.6761
383 5U19 SAH 12.9032
384 5U19 827 12.9032
385 1L3I SAH 13.0208
386 3GU3 SAH 13.0282
387 6F5Z SAH 13.4199
388 3I53 SAH 13.5542
389 2PXX SAH 13.7324
390 1TH8 ADP 13.7931
391 5XLX SAH 13.8298
392 2PWY SAH 13.9535
393 1E6E FAD 14.0625
394 2F5Z FAD 14.0625
395 5M58 SAH 14.3478
396 3QWI CUE 14.4444
397 6G5J EM8 14.5455
398 4R6W PC 14.7887
399 4R6W SAH 14.7887
400 1KPH SAH 15.1408
401 5JCA NDP 15.493
402 5JCA FAD 15.493
403 2XVM SAH 15.5779
404 4YRY NAD 15.5797
405 4YRY FAD 15.5797
406 5E8J SAH 15.9091
407 5ZW3 SAH 16.4444
408 3OU2 SAH 16.5138
409 5YEC ATP 16.7647
410 1TPY SAH 17.6056
411 3LKZ SFG 17.9577
412 5YJI 8WO 19.0141
413 5YJI SAH 19.0141
414 5YJF 8WO 19.0141
415 5YJF SAH 19.0141
416 3LCC SAH 20
417 5MPT SAH 20.0704
418 5GM1 SAH 20.0704
419 5MGZ SAH 20.339
420 3CBG SAH 20.6897
421 5BSZ SAH 21.2
422 1SQF SAM 22.1831
423 5E72 SAM 22.8873
424 2NPX NAD 23.2394
425 2NPX FAD 23.2394
426 3Q87 SAM 23.5294
427 3PFG TLO 23.5741
428 3PFG SAM 23.5741
429 5WP5 SAH 24.2958
430 5LOG SAH 24.4635
431 3P9C SAH 25
432 5JE0 AZ8 25.1012
433 5JE0 SAH 25.1012
434 5W7K SAH 25.7042
435 4IWN GEK 25.7642
436 1VE3 SAM 26.4317
437 4QTU SAM 26.9231
438 4NEC SAH 28.0303
439 3HVJ 705 28.0543
440 3BXO SAM 30.1255
441 4PNE SAH 30.9859
442 3G2O SAM 30.9859
443 3GCZ SAM 35.9155
444 1XVA SAM 45.4225
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