Receptor
PDB id Resolution Class Description Source Keywords
5GP7 1.5 Å EC: 2.4.2.30 STRUCTURAL BASIS FOR THE BINDING BETWEEN TANKYRASE-1 AND USP HOMO SAPIENS TANKYRASE USP25 ANKYRIN REPEATS TRANSFERASE
Ref.: USP25 REGULATES WNT SIGNALING BY CONTROLLING THE ST OF TANKYRASES GENES DEV. V. 31 1024 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:1002;
A:1001;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SER LEU SER ARG THR PRO ALA ASP GLY ARG B:1046;
Valid;
Atoms found LESS than expected: % Diff = 0;
submit data
1002.08 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5GP7 1.5 Å EC: 2.4.2.30 STRUCTURAL BASIS FOR THE BINDING BETWEEN TANKYRASE-1 AND USP HOMO SAPIENS TANKYRASE USP25 ANKYRIN REPEATS TRANSFERASE
Ref.: USP25 REGULATES WNT SIGNALING BY CONTROLLING THE ST OF TANKYRASES GENES DEV. V. 31 1024 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 5GP7 - SER LEU SER ARG THR PRO ALA ASP GLY ARG n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 5GP7 - SER LEU SER ARG THR PRO ALA ASP GLY ARG n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 5GP7 - SER LEU SER ARG THR PRO ALA ASP GLY ARG n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER LEU SER ARG THR PRO ALA ASP GLY ARG; Similar ligands found: 117
No: Ligand ECFP6 Tc MDL keys Tc
1 SER LEU SER ARG THR PRO ALA ASP GLY ARG 1 1
2 ALA ARG MLZ SER ALA PRO ALA THR 0.597122 0.913043
3 CYS THR PRO SER ARG 0.581395 0.938462
4 SER ARG ASP HIS SER ARG THR PRO MET 0.563291 0.876712
5 ALA ALA ARG KCR SER ALA PRO ALA 0.544218 0.924242
6 SER ALA PRO ASP THR ARG PRO ALA 0.538462 0.969697
7 ARG VAL ALA SER PRO THR SER GLY VAL 0.538462 0.969231
8 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.526667 0.926471
9 THR PRO ARG VAL THR GLY GLY GLY ALA MET 0.509804 0.887324
10 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.509317 0.969697
11 THR PRO THR ARG ASP VAL ALA THR SER PRO 0.506757 0.969697
12 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.503401 0.909091
13 ARG VAL ALA SEP PRO THR SER GLY VAL 0.5 0.887324
14 MET CYS PRO ARG MET THR ALA VAL MET 0.49359 0.885714
15 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.493333 0.954545
16 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.493243 0.925373
17 GLU PRO GLY GLY SER ARG 0.482014 0.9375
18 ALA ASN SER ARG PHE PRO THR SER ILE ILE 0.47561 0.913043
19 LYS PRO VAL LEU ARG THR ALA 0.473333 0.924242
20 ARG ARG ARG GLU ARG SER PRO THR ARG 0.473333 0.984375
21 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.472393 0.927536
22 ALA PRO ASP THR ARG PRO 0.471831 0.954545
23 ALA PHE ARG ILE PRO LEU THR ARG 0.471698 0.898551
24 ALA MET ALA PRO ARG THR LEU LEU LEU 0.470199 0.859155
25 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.460526 0.838235
26 GLN ARG SER THR SEP THR PRO ASN VAL HIS 0.459119 0.861111
27 ALA PRO ASP THR ARG PRO ALA PRO 0.458904 0.954545
28 LEU PRO PHE ASP ARG THR THR ILE MET 0.458333 0.863014
29 ARG THR PHE SER PRO THR TYR GLY LEU 0.457831 0.863014
30 ALA ASN SER ARG TYR PRO THR SER ILE ILE 0.457317 0.875
31 ALA THR ALY ALA ALA ARG ALY SER ALA PRO 0.456954 0.939394
32 GLU ARG THR ILE PRO ILE THR ARG GLU 0.455782 0.924242
33 ILE SER PRO ARG THR LEU ASP ALA TRP 0.455556 0.876712
34 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.451613 0.849315
35 THR PRO ARG ARG SER MLZ SER ALA 0.451389 0.898551
36 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.451219 0.940298
37 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.450617 0.898551
38 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.450292 0.876712
39 PRO SER ILE ASP ARG SER THR LYS PRO 0.447853 0.955224
40 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.447059 0.9
41 ASN ARG PRO ILE LEU SER LEU 0.446667 0.911765
42 GLY LEU LEU GLY SEP PRO VAL ARG ALA 0.446541 0.833333
43 ARG PRO LYS ARG ILE ALA 0.445946 0.863636
44 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.44586 0.852941
45 LEU PRO PHE GLU ARG ALA THR VAL MET 0.445087 0.861111
46 SER PRO LYS ARG ILE ALA 0.444444 0.923077
47 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.443787 0.887324
48 ALA ASN SER ARG LEU PRO THR SER ILE ILE 0.443709 0.925373
49 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.442529 0.875
50 ALA LEU PRO HIS ALA ILE LEU ARG LEU 0.442424 0.788732
51 ARG PRO MET THR PHE LYS GLY ALA LEU 0.440678 0.849315
52 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.43956 0.853333
53 GLY MET PRO ARG GLY ALA 0.438356 0.814286
54 ARG PRO MET THR TYR LYS GLY ALA LEU 0.438202 0.815789
55 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.436464 0.766234
56 SER SER GLY LYS VAL PRO LEU SER 0.435374 0.863636
57 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.435028 0.851351
58 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.433121 0.867647
59 GLN ALA SER TPO PRO ARG NIT 0.431953 0.777778
60 LEU PRO PHE GLU ARG ALA THR ILE MET 0.431818 0.849315
61 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.431579 0.826667
62 ALA ARG M3L SER THR GLY GLY ALY 0.430464 0.777778
63 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.430108 0.831169
64 ACE GLN GLU ARG GLU VAL PRO CYS 0.42953 0.850746
65 SER SER TYR ARG ARG PRO VAL GLY ILE 0.427711 0.875
66 ALA ARG MLY SER THR GLY GLY ALY 0.427632 0.8
67 ALA ARG MLZ SER THR GLY GLY ALY 0.427632 0.768116
68 MET ARG THR GLY ASN ALA XSN 0.425676 0.704225
69 GLU ALA ASP PRO THR GLY HIS SER TYR 0.425287 0.819444
70 ARG PHE PRO LEU THR PHE GLY TRP 0.424581 0.849315
71 ILE GLY PRO GLY ARG ALA PHE TYR THR 0.424419 0.808219
72 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.424051 0.830986
73 VAL PRO LEU THR GLU ASP ALA GLU LEU 0.423841 0.833333
74 ILE GLY PRO GLY ARG ALA PHE TYR THR ILE 0.423729 0.835616
75 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.423729 0.887324
76 DPN PRO DAR DTH NH2 0.423611 0.878788
77 ILE PRO ALA TYR GLY VAL LEU THR ILE 0.423313 0.763889
78 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.422078 0.788732
79 ALA ASN SER ARG HIS PRO THR SER ILE ILE 0.419753 0.9
80 ALA ARG THR M3L GLN THR ALA ARG 0.41958 0.75
81 LEU GLY GLY ALA LYS GLN ARG GLY ASP VAL 0.41958 0.723077
82 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.418848 0.820513
83 ASP ARG VAL GLU LEU ASN ALA PRO ARG GLN 0.41875 0.867647
84 SER SER GLY LYS VAL PRO LEU 0.417808 0.848485
85 ASN LEU VAL PRO SER VAL ALA THR VAL 0.417219 0.850746
86 SAC ARG GLY THR GLN THR GLU 0.416667 0.784615
87 LEU GLU LYS ALA ARG GLY SER THR TYR 0.416667 0.760563
88 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.416216 0.830986
89 GLY VAL VAL ALA SER GLN PRO ALA ARG VAL 0.416107 0.846154
90 ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 0.414773 0.898551
91 ALA GLY SER VAL GLU GLN TPO PRO LYS LYS 0.414201 0.819444
92 TYR PRO LYS ARG ILE ALA 0.4125 0.816901
93 LYS ARG ARG ARG HIS PRO SER GLY 0.4125 0.882353
94 LEU PRO SER PHE GLU THR ALA LEU 0.4125 0.838235
95 ARG ARG ALA SEP ALA PRO LEU PRO 0.4125 0.797297
96 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.412371 0.820513
97 5JP PRO LYS ARG ILE ALA 0.411348 0.880597
98 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.410526 0.851351
99 ARG THR PRO SEP LEU PRO THR 0.410256 0.835616
100 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.409836 0.818182
101 SER PRO HIS ASN PRO ILE SER ASP VAL ASP 0.409722 0.811594
102 ARG TYR PRO LEU THR PHE GLY TRP 0.408602 0.826667
103 VAL ALA ARG SER 0.408 0.692308
104 VAL MET ALA PRO ARG THR LEU PHE LEU 0.406977 0.835616
105 SER HIS PRO ARG PRO ILE ARG VAL 0.406061 0.873239
106 ARG GLY PRO GLY CYS ALA PHE VAL THR ILE 0.404494 0.885714
107 ILE PRO LEU THR GLU GLU ALA GLU LEU 0.403974 0.820895
108 ACE ARG THR PRO SEP LEU PRO THR PIP 0.403727 0.792208
109 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.403509 0.816901
110 HIS HIS ALA SER PRO ARG LYS 0.401198 0.84058
111 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.40107 0.84
112 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.401042 0.828947
113 ILE GLY PRO GLY ARG ALA PHE TYR VAL 0.4 0.783784
114 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.4 0.898551
115 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.4 0.890625
116 ILE SER TYR GLY ASN ASP ALA LEU MET PRO 0.4 0.74026
117 ARG GLU ARG SER PRO THR ARG 0.4 0.9375
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5GP7; Ligand: SER LEU SER ARG THR PRO ALA ASP GLY ARG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5gp7.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback