Receptor
PDB id Resolution Class Description Source Keywords
5FUI 1.4 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF THE C-TERMINAL CBM6 OF LAMC A MARINE LAMINARIANSE FROM ZOBELLIA GALACTANIVORANS ZOBELLIA GALACTANIVORANS HYDROLASE CARBOHYDRATE BINDING MODULE CBM6 POLYSACCHARIDEFIXATION MARINE BACTERIAL LAMINARINASE ZOBELLIA GALACTANI
Ref.: UNRAVELING THE MULTIVALENT BINDING OF A MARINE FAMI CARBOHYDRATE-BINDING MODULE WITH ITS NATIVE LAMINAR LIGAND. FEBS J. V. 283 1863 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL A:131;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
MG A:1386;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
APY A:132;
A:133;
Valid;
Valid;
none;
none;
submit data
108.141 C6 H8 N2 c1ccn...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FUI 1.4 Å EC: 7.-.-.- CRYSTAL STRUCTURE OF THE C-TERMINAL CBM6 OF LAMC A MARINE LAMINARIANSE FROM ZOBELLIA GALACTANIVORANS ZOBELLIA GALACTANIVORANS HYDROLASE CARBOHYDRATE BINDING MODULE CBM6 POLYSACCHARIDEFIXATION MARINE BACTERIAL LAMINARINASE ZOBELLIA GALACTANI
Ref.: UNRAVELING THE MULTIVALENT BINDING OF A MARINE FAMI CARBOHYDRATE-BINDING MODULE WITH ITS NATIVE LAMINAR LIGAND. FEBS J. V. 283 1863 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 250 families.
1 5FUI - APY C6 H8 N2 c1ccnc(c1)....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 217 families.
1 5FUI - APY C6 H8 N2 c1ccnc(c1)....
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 143 families.
1 2V4V Ka = 1700 M^-1 XYP C5 H10 O5 C1[C@H]([C....
2 1UYX - BGC BGC n/a n/a
3 1UZ0 - BGC BGC BGC BGC n/a n/a
4 1UYZ - XYP XYP XYP XYP n/a n/a
5 1UYY - BGC BGC BGC n/a n/a
6 1UY0 - BGC BGC BGC BGC n/a n/a
7 1W9T - XYP XYP n/a n/a
8 1W9W Ka = 290000 M^-1 BGC BGC BGC GLC BGC BGC n/a n/a
9 5FUI - APY C6 H8 N2 c1ccnc(c1)....
10 1UY2 - XYP XYP n/a n/a
11 1UXX - XYP XYP XYP XYP XYP n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: APY; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 APY 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FUI; Ligand: APY; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5fui.bio1) has 5 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5FUI; Ligand: APY; Similar sites found: 293
This union binding pocket(no: 2) in the query (biounit: 5fui.bio1) has 8 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3UW5 MAA CHG PRO 0DQ 0.0001486 0.51149 None
2 2X4Z X4Z 0.0003555 0.5097 None
3 3IWD M2T 0.0001255 0.4799 None
4 3NCQ ATP 0.001424 0.4641 None
5 5F6U 5VK 0.0005515 0.45704 None
6 3MTX PGT 0.002291 0.45632 None
7 4MCC 21X 0.01058 0.45296 None
8 4QAR ADE 0.002759 0.42931 None
9 5UR1 YY9 0.02698 0.41693 None
10 3SAO DBH 0.004683 0.41297 None
11 3I9U DTU 0.01062 0.40734 None
12 2RNF UM3 0.03126 0.40639 None
13 2CM4 RCL 0.009852 0.40638 None
14 5N87 N66 0.00276 0.47214 1.51515
15 1VP5 NAP 0.002576 0.45199 1.51515
16 5TPV TYD 0.004098 0.43284 1.51515
17 1WN3 HXC 0.03333 0.42552 1.51515
18 3R35 4CO 0.04824 0.42169 1.51515
19 5BW4 SAM 0.009259 0.41501 1.51515
20 2CDN ADP 0.0359 0.40683 1.51515
21 3QXV MTX 0.0022 0.43626 1.5873
22 4HIA FMN 0.002499 0.47544 2.27273
23 1C1X HFA 0.002427 0.44503 2.27273
24 1BW9 PPY 0.002837 0.44272 2.27273
25 4Y24 TD2 0.004172 0.42898 2.27273
26 5HWV MBN 0.0004537 0.4216 2.30769
27 2J9D AMP 0.0004769 0.50899 2.52101
28 2J9D ADP 0.0004196 0.48427 2.52101
29 2J9C ATP 0.002041 0.48036 2.52101
30 4F7E 0SH 0.00007332 0.57322 3.0303
31 2NXE SAM 0.0001171 0.54016 3.0303
32 5KVA SAM 0.000589 0.48654 3.0303
33 5E9W SAH 0.006861 0.44664 3.0303
34 2WT2 GAL NAG GAL NAG GAL NAG 0.009678 0.43822 3.0303
35 4NFN 2KC 0.006936 0.42146 3.0303
36 2CWH NDP 0.0226 0.41701 3.0303
37 3CAQ NDP 0.02241 0.41585 3.0303
38 5DEQ ARA 0.01861 0.40403 3.0303
39 4JJF N2I 0.01133 0.40068 3.0303
40 4JJF FE9 0.01032 0.40068 3.0303
41 2Y8L AMP 0.03047 0.40037 3.0303
42 3CM2 X23 0.0001124 0.52482 3.07692
43 1SWG BTN 0.006774 0.40457 3.125
44 5M6M 7H8 0.0001379 0.51976 3.14961
45 4RT1 C2E 0.0001318 0.50994 3.57143
46 1VPV PLM 0.00005738 0.55253 3.78788
47 4M73 SAH 0.0003589 0.55163 3.78788
48 4IGQ THR M3L GLN 0.00004691 0.53959 3.78788
49 4TWP AXI 0.005697 0.49855 3.78788
50 1M5B BN1 0.04337 0.45603 3.78788
51 3IX8 TX3 0.00588 0.45205 3.78788
52 2XXP DSL 0.02007 0.44863 3.78788
53 1RYA GDP 0.003373 0.44188 3.78788
54 4M73 M72 0.01727 0.43904 3.78788
55 3TTZ 07N 0.01356 0.43897 3.78788
56 5JFL NAD 0.004387 0.43582 3.78788
57 3RG9 NDP 0.01584 0.41545 3.78788
58 3RG9 WRA 0.01762 0.41545 3.78788
59 1KPG SAH 0.009715 0.41494 3.78788
60 1KPH SAH 0.01018 0.41213 3.78788
61 3ZLQ 6T9 0.009655 0.4115 3.78788
62 5E72 SAM 0.01338 0.41061 3.78788
63 2HK5 1BM 0.01233 0.41053 3.78788
64 3MJY IJZ 0.01276 0.41017 3.78788
65 3MJY FMN 0.01276 0.41017 3.78788
66 2XMY CDK 0.03467 0.40982 3.78788
67 4YLZ LAT NAG GAL 0.007747 0.40834 3.78788
68 4UIN QI9 0.02112 0.40593 3.78788
69 4G9N NGA 0.001979 0.40418 3.78788
70 3LGS SAH 0.01142 0.40294 3.78788
71 3LGS ADE 0.01142 0.40294 3.78788
72 3T64 DU3 0.03255 0.40192 3.78788
73 1P9P SAH 0.03271 0.40095 3.78788
74 2Z6D FMN 0.005009 0.442 3.84615
75 3Q87 SAM 0.01426 0.42707 4
76 2XCG XCG 0.00004661 0.55077 4.54545
77 2GU8 796 0.0002458 0.54594 4.54545
78 4M38 SAH 0.0002213 0.52936 4.54545
79 1TT8 PHB 0.0003485 0.48814 4.54545
80 2YNE YNE 0.003949 0.48006 4.54545
81 2YNE NHW 0.003949 0.48006 4.54545
82 3NZ1 3NY 0.0004036 0.45551 4.54545
83 2ICK DMA 0.00395 0.4429 4.54545
84 3RHJ NAP 0.003554 0.43661 4.54545
85 5DQ8 FLF 0.004241 0.43631 4.54545
86 1Y0G 8PP 0.006536 0.43305 4.54545
87 1I7M CG 0.00001011 0.42938 4.54545
88 4XV1 904 0.02637 0.42883 4.54545
89 4NON GDP 0.02125 0.42335 4.54545
90 5I0U DCY 0.006694 0.42203 4.54545
91 4CQE CQE 0.008985 0.42077 4.54545
92 2QXL ATP 0.03088 0.4192 4.54545
93 5UL4 SAM 0.0108 0.41056 4.54545
94 3TAO PGH 0.009239 0.41046 4.54545
95 3UWV 2PG 0.01019 0.40706 4.54545
96 1USI PHE 0.005602 0.40467 4.54545
97 3QX9 ATP 0.01277 0.40369 4.54545
98 4GA6 AMP 0.04953 0.403 4.54545
99 4NAE 1GP 0.00288 0.40107 4.54545
100 2WZ5 MET 0.0000004199 0.59704 4.57516
101 5DX0 SFG 0.0005553 0.50162 4.58453
102 5DX1 SFG 0.02935 0.40285 4.58453
103 5F3I 5UJ 0.00034 0.52881 5.30303
104 1V3S ATP 0.001408 0.48336 5.30303
105 1URX AAL GAL AAL GLA 0.001759 0.45772 5.30303
106 4UWJ 7L5 0.005648 0.45418 5.30303
107 4UWJ MYA 0.005648 0.45418 5.30303
108 5EW9 5VC 0.005489 0.45 5.30303
109 3A5Y KAA 0.0016 0.44754 5.30303
110 5C5H 4YB 0.002221 0.4451 5.30303
111 4LXQ FON 0.004185 0.44481 5.30303
112 4LXQ TYD 0.004185 0.44481 5.30303
113 1OFL NGK GCD 0.0006538 0.44234 5.30303
114 3G89 SAM 0.006088 0.44196 5.30303
115 5JCM NAD 0.01053 0.43882 5.30303
116 5A5W GUO 0.008063 0.43716 5.30303
117 5H5J FAD 0.002458 0.43332 5.30303
118 3ILR SGN IXD 0.01282 0.42729 5.30303
119 2Y6O 1N1 0.01654 0.42694 5.30303
120 1JJE BYS 0.008815 0.42636 5.30303
121 3VC1 SAH 0.01044 0.42563 5.30303
122 3VC1 GST 0.01987 0.42563 5.30303
123 1D6S PLP MET 0.01081 0.42321 5.30303
124 2XIQ MLC 0.01331 0.42054 5.30303
125 1D6S MET PLP 0.01205 0.41944 5.30303
126 1NB9 ADP 0.0218 0.4163 5.30303
127 1NB9 RBF 0.0218 0.4163 5.30303
128 2PT9 2MH 0.01706 0.40664 5.30303
129 3GZ8 APR 0.01788 0.40562 5.30303
130 5KF6 NAD 0.02395 0.40493 5.30303
131 3HGM ATP 0.0251 0.40436 5.30303
132 2BGS NDP 0.01852 0.40201 5.30303
133 3DZ6 M8E 0.0000284 0.52524 5.61798
134 4K3H 1OM 0.005409 0.43443 5.9322
135 4B0T ADP 0.00009036 0.57802 6.06061
136 2I7N ACO 0.00004474 0.56541 6.06061
137 5J75 6GQ 0.00003213 0.55995 6.06061
138 3ACL 3F1 0.00001991 0.55768 6.06061
139 3LKJ LKJ 0.0002364 0.55683 6.06061
140 3E9I XAH 0.0004774 0.52228 6.06061
141 2QK4 ATP 0.0001978 0.50008 6.06061
142 5A3T MMK 0.003126 0.46289 6.06061
143 3OV6 MK0 0.00359 0.45431 6.06061
144 5E9X 5LA 0.01603 0.44831 6.06061
145 1NFU RRP 0.006265 0.43478 6.06061
146 5ECP MET 0.01513 0.43401 6.06061
147 5ECP JAA 0.01513 0.43401 6.06061
148 5ECP ATP 0.01565 0.43401 6.06061
149 2OHH FMN 0.006656 0.4163 6.06061
150 5HES 032 0.01988 0.41507 6.06061
151 4X7G NAP 0.01179 0.40906 6.06061
152 2V77 PAY 0.01637 0.40546 6.06061
153 1SDW IYT 0.01353 0.40346 6.06061
154 4LOO SB4 0.008998 0.40319 6.06061
155 4BTI 7R9 0.0188 0.40195 6.06061
156 1PN0 IPH 0.01837 0.40059 6.06061
157 1PN0 FAD 0.01789 0.40059 6.06061
158 3WGT QSC 0.04189 0.40011 6.06061
159 5L2J 6UL 0.0002031 0.59256 6.81818
160 5L2J 70E 0.0002143 0.59256 6.81818
161 3FYS PLM 0.00005875 0.53728 6.81818
162 3VZ3 NAP 0.000594 0.48508 6.81818
163 3VZ3 SSN 0.0007708 0.48185 6.81818
164 3FIU AMP 0.001569 0.48041 6.81818
165 5BYZ 4WE 0.002548 0.46665 6.81818
166 5IVE 6E8 0.003336 0.46024 6.81818
167 4H6B 10X 0.001544 0.45616 6.81818
168 1U0A BGC BGC BGC BGC 0.009971 0.42656 6.81818
169 1ZMD NAI 0.006311 0.42391 6.81818
170 5F7R GLC GLC 0.01047 0.41834 6.81818
171 5EOB 5QQ 0.03749 0.41511 6.81818
172 2Y6Q I7T 0.02131 0.41295 6.81818
173 2Y6Q FAD 0.01333 0.41295 6.81818
174 4LO2 GAL BGC 0.003622 0.41086 6.81818
175 1J3R 6PG 0.007367 0.40928 6.81818
176 1ZEA DVA DPR GLY DSN DGN DHI DTY DAS DSN 0.001549 0.4412 6.94444
177 4J6W CTP 0.005554 0.44773 7.31707
178 5LRT ADP 0.0003992 0.52422 7.57576
179 5LUN OGA 0.0001735 0.51797 7.57576
180 5LUN ARG 0.0004455 0.50746 7.57576
181 4HWT 1B2 0.0004423 0.48858 7.57576
182 4L3L 5FI 0.0007501 0.45869 7.57576
183 5IXH OTP 0.004074 0.44783 7.57576
184 2JLD AG1 0.003939 0.42971 7.57576
185 1ELI PYC 0.006737 0.42814 7.57576
186 5VC5 96M 0.01072 0.41784 7.57576
187 5HV0 AKG 0.02055 0.40141 7.57576
188 4RYV ZEA 0.00009301 0.5298 8.33333
189 3L9R L9Q 0.0006289 0.52801 8.33333
190 4C4A SAH 0.0002047 0.52055 8.33333
191 5KJW 53C 0.00003289 0.50875 8.33333
192 2QZ3 XYP XYP XYP 0.000324 0.49712 8.33333
193 5H9P TD2 0.0003516 0.48569 8.33333
194 3L9R L9R 0.001871 0.48553 8.33333
195 4OPC FDA 0.003815 0.46787 8.33333
196 4OPC PGT 0.004229 0.46787 8.33333
197 5HR5 FLC 0.001384 0.45668 8.33333
198 2WKQ FMN 0.005674 0.44466 8.33333
199 1J17 ZEN 0.005885 0.44349 8.33333
200 2FK8 SAM 0.005818 0.43371 8.33333
201 2QM9 TDZ 0.01364 0.42839 8.33333
202 5DJT FMN 0.01371 0.41741 8.33333
203 4LH0 GLV 0.007051 0.41726 8.33333
204 4FZV SAM 0.005117 0.41582 8.33333
205 5NJI 8Z2 0.04542 0.40659 8.33333
206 5TVF CGQ 0.00001411 0.40653 8.33333
207 4WN5 MVC 0.005915 0.42562 8.69565
208 5L83 ASP TRP GLU ILE VAL 0.003185 0.42927 8.92857
209 5ALC TIQ 0.00005483 0.57995 9.09091
210 5J8O 6GZ 0.00009036 0.51951 9.09091
211 2RKV ZBA 0.005223 0.45128 9.09091
212 2RKV COA 0.004617 0.45128 9.09091
213 3T1A 5MA 0.003661 0.44415 9.09091
214 3OQJ 3CX 0.005038 0.4206 9.09091
215 4H2W 5GP 0.01682 0.41629 9.09091
216 3WYJ H78 0.02014 0.41597 9.09091
217 3DLG GWE 0.01861 0.40997 9.09091
218 5XDT ZI7 0.003029 0.40885 9.09091
219 4GID 0GH 0.03269 0.40399 9.09091
220 5T0B SIA GAL NAG 0.02572 0.40267 9.09091
221 3FSY SCA 0.006617 0.43639 9.63855
222 5A89 ADP 0.0009512 0.50277 9.84848
223 5A89 FMN 0.0009512 0.50277 9.84848
224 4J4H NAI 0.02613 0.42775 9.84848
225 4J4H 1J1 0.02613 0.42775 9.84848
226 1H8S AIC 0.01012 0.40833 9.84848
227 5UKL SIX 0.02739 0.40569 9.84848
228 5L2R MLA 0.002872 0.40504 9.84848
229 5DYO FLU 0.002235 0.4069 10.6061
230 2CJU PHX 0.0001709 0.43717 10.6195
231 2GJ3 FAD 0.008272 0.40546 10.8333
232 5CPR 539 0.000171 0.51033 11.3636
233 4BPZ GLC BGC BGC 0.002059 0.47343 11.3636
234 3UYK 0CX 0.008908 0.44849 11.3636
235 1T90 NAD 0.00245 0.44762 11.3636
236 5VNF VAL THR SER VAL VAL 0.004162 0.44696 11.3636
237 1UTJ ABN 0.008139 0.44468 11.3636
238 2VBU CDP 0.03935 0.40902 11.3636
239 3TTC ADP 0.01402 0.40582 11.3636
240 3R5Y F42 0.01557 0.40483 11.3636
241 2P1O IHP 0.001262 0.47018 12.1212
242 2P1O NLA 0.001262 0.47018 12.1212
243 4YWV SSN 0.001318 0.4664 12.1212
244 2P1M IHP 0.0006554 0.4553 12.1212
245 1GQG DCD 0.002477 0.42857 12.1212
246 1I1Q TRP 0.01319 0.40634 12.1212
247 5FLJ QUE 0.000008121 0.58431 12.8788
248 3NKS ACJ 0.00001655 0.5606 12.8788
249 3TKY SAH 0.0008093 0.49592 12.8788
250 4DSU BZI 0.00005764 0.43908 12.8788
251 5X8G S0N 0.04081 0.41961 12.8788
252 2RCU BUJ 0.00001151 0.63108 13.6364
253 3E85 BSU 0.00008776 0.56149 13.6364
254 1LSH PLD 0.0001846 0.50655 13.6364
255 5U98 1KX 0.001551 0.481 13.6364
256 5MW4 5JU 0.001465 0.47983 13.6364
257 5IXG OTP 0.03549 0.43583 13.6364
258 4M1U MBG A2G 0.004375 0.43304 13.6364
259 4USF 6UI 0.01252 0.42904 13.6364
260 1QY1 PRZ 0.01976 0.41752 13.6364
261 4LGY ADP 0.005186 0.41637 13.6364
262 5U98 VAL THR THR ASP ILE GLN VAL LYS VAL 0.04037 0.4126 13.6364
263 1ZB6 DIN 0.02019 0.4218 14.3939
264 4USI ATP 0.0003056 0.50155 15.1515
265 1BC5 ACE ASN TRP GLU THR PHE 0.0008544 0.45287 15.1515
266 3DMH GMP 0.01888 0.42488 15.1515
267 3WG3 A2G GAL NAG FUC 0.005105 0.41579 15.1515
268 3KJD 78P 0.01945 0.41379 15.1515
269 2AG4 LP3 0.0006254 0.53165 15.9091
270 2AG4 OLA 0.0005741 0.53165 15.9091
271 3KH5 AMP 0.00204 0.48514 15.9091
272 3KH5 ADP 0.002813 0.48514 15.9091
273 3UW4 MAA CHG PRO 0DQ 0.0002266 0.49272 16.3043
274 1NV8 SAM 0.0004943 0.52291 16.6667
275 2RDE C2E 0.00003984 0.51615 16.6667
276 4RLT FSE 0.003296 0.45926 16.6667
277 1NV8 MEQ 0.01596 0.42842 16.6667
278 5U3F 7TS 0.006287 0.40835 16.6667
279 3K56 IS3 0.001699 0.40171 16.6667
280 5IXJ THR 0.02592 0.40606 18.1818
281 2B9W FAD 0.009879 0.43022 18.9394
282 3T4L ZEA 0.0005883 0.49109 19.697
283 1QO8 FAD 0.005411 0.44464 19.697
284 3H0L ADP 0.0001997 0.45318 20.4545
285 4FJU NAI 0.01146 0.43424 21.2121
286 3IWJ NAD 0.001343 0.43325 21.2121
287 5M6N 7H9 0.0002188 0.411 22.0339
288 3A7R LAQ 0.000564 0.51682 22.7273
289 2P5B OGA 0.003416 0.45899 22.7273
290 4A0M NAD 0.001484 0.45617 25
291 4OUJ LBT 0.00234 0.4063 25
292 3HVJ 705 0.0008372 0.50624 29.5455
293 5X7Q GLC GLC GLC BGC 0.01703 0.40731 35.6061
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