Receptor
PDB id Resolution Class Description Source Keywords
5FA5 2.34 Å EC: 2.1.1.125 CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 HOMO SAPIENS METHYL TRANSFERASE TRANSFERASE-PROTEIN BINDING COMPLEX
Ref.: DISORDERED METHIONINE METABOLISM IN MTAP/CDKN2A-DEL CANCERS LEADS TO DEPENDENCE ON PRMT5. SCIENCE V. 351 1208 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MTA A:701;
Valid;
none;
ic50 = 4.6 uM
297.334 C11 H15 N5 O3 S CSC[C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FA5 2.34 Å EC: 2.1.1.125 CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 HOMO SAPIENS METHYL TRANSFERASE TRANSFERASE-PROTEIN BINDING COMPLEX
Ref.: DISORDERED METHIONINE METABOLISM IN MTAP/CDKN2A-DEL CANCERS LEADS TO DEPENDENCE ON PRMT5. SCIENCE V. 351 1208 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 5FA5 ic50 = 4.6 uM MTA C11 H15 N5 O3 S CSC[C@@H]1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MTA; Similar ligands found: 256
No: Ligand ECFP6 Tc MDL keys Tc
1 MTA 1 1
2 DTA 0.786885 0.867647
3 3DH 0.777778 0.938462
4 RAB 0.758621 0.878788
5 XYA 0.758621 0.878788
6 ADN 0.758621 0.878788
7 DSH 0.705882 0.84507
8 5N5 0.704918 0.878788
9 A4D 0.693548 0.907692
10 5CD 0.693548 0.892308
11 EP4 0.6875 0.939394
12 M2T 0.676923 0.940298
13 A7D 0.657534 0.882353
14 5X8 0.64 0.895522
15 5AD 0.639344 0.857143
16 ZAS 0.628571 0.816901
17 AMP 0.628571 0.794521
18 A 0.628571 0.794521
19 A5D 0.623377 0.867647
20 SAH 0.615385 0.869565
21 ABM 0.60274 0.821918
22 J7C 0.60274 0.794521
23 AAT 0.6 0.797297
24 6RE 0.597222 0.783784
25 SRA 0.597222 0.776316
26 S4M 0.594595 0.84
27 AOC 0.589041 0.880597
28 AMP MG 0.589041 0.773333
29 MAO 0.586667 0.805195
30 S8M 0.583333 0.833333
31 A2D 0.581081 0.773333
32 A3N 0.581081 0.867647
33 5AS 0.578947 0.697674
34 GJV 0.573333 0.773333
35 BA3 0.565789 0.773333
36 A12 0.565789 0.74359
37 AP2 0.565789 0.74359
38 M33 0.564103 0.810811
39 AU1 0.564103 0.753247
40 MHZ 0.564103 0.805195
41 ADX 0.564103 0.719512
42 ADP 0.558442 0.773333
43 AP5 0.558442 0.773333
44 B4P 0.558442 0.773333
45 7D7 0.553846 0.794118
46 Y3J 0.552239 0.80303
47 AN2 0.551282 0.763158
48 SON 0.551282 0.74359
49 SXZ 0.550562 0.849315
50 PRX 0.55 0.8
51 A6D 0.545455 0.766234
52 CA0 0.544304 0.753247
53 ADP MG 0.544304 0.763158
54 SA8 0.54321 0.873239
55 AD9 0.54321 0.753247
56 EEM 0.542169 0.849315
57 BEF ADP 0.5375 0.74359
58 50T 0.5375 0.763158
59 SFG 0.5375 0.826087
60 ACP 0.5375 0.753247
61 ATP 0.5375 0.773333
62 ADP BEF 0.5375 0.74359
63 AR6 0.530864 0.773333
64 APR 0.530864 0.773333
65 5FA 0.530864 0.773333
66 APC 0.530864 0.74359
67 AQP 0.530864 0.773333
68 ANP 0.53012 0.753247
69 SAM 0.53012 0.875
70 SMM 0.529412 0.84
71 3AM 0.527027 0.756757
72 NEC 0.526316 0.823529
73 RBY 0.52439 0.74359
74 SAP 0.52439 0.75641
75 AGS 0.52439 0.75641
76 ADP PO3 0.52439 0.794521
77 ADV 0.52439 0.74359
78 5AL 0.52381 0.786667
79 VMS 0.523256 0.705882
80 54H 0.523256 0.705882
81 3AD 0.521739 0.863636
82 MTH 0.520548 0.984127
83 SAI 0.518072 0.830986
84 G5A 0.518072 0.678161
85 ATP MG 0.518072 0.763158
86 A5A 0.517647 0.722892
87 ME8 0.516484 0.797468
88 ACQ 0.511905 0.753247
89 GAP 0.511905 0.753247
90 TAT 0.511905 0.766234
91 S7M 0.511628 0.824324
92 8QN 0.511364 0.786667
93 CC5 0.507463 0.876923
94 A3G 0.506494 0.828571
95 A3P 0.506329 0.77027
96 52H 0.505747 0.697674
97 MTP 0.5 0.828571
98 ADP ALF 0.5 0.734177
99 MAP 0.5 0.734177
100 TSB 0.5 0.714286
101 7D5 0.5 0.714286
102 ATF 0.5 0.74359
103 ALF ADP 0.5 0.734177
104 53H 0.5 0.697674
105 DAL AMP 0.5 0.786667
106 5SV 0.494382 0.759494
107 25A 0.494382 0.773333
108 SSA 0.494253 0.678161
109 ANP MG 0.494253 0.734177
110 ADP VO4 0.494253 0.763158
111 SRP 0.494253 0.74359
112 VO4 ADP 0.494253 0.763158
113 2AM 0.493333 0.746667
114 26A 0.492958 0.867647
115 0UM 0.488889 0.810811
116 ADQ 0.488889 0.753247
117 LSS 0.488889 0.701149
118 DSZ 0.488889 0.678161
119 PAJ 0.488889 0.75
120 A1R 0.488889 0.725
121 3OD 0.483871 0.776316
122 62X 0.483516 0.815789
123 NVA LMS 0.483516 0.701149
124 AHX 0.483516 0.716049
125 A22 0.483146 0.763158
126 5CA 0.483146 0.678161
127 A3T 0.481928 0.880597
128 2VA 0.481928 0.855072
129 RP1 0.480519 0.75
130 SP1 0.480519 0.75
131 3L1 0.478873 0.8
132 3D1 0.478873 0.8
133 OAD 0.478261 0.776316
134 K15 0.478261 0.813333
135 LEU LMS 0.478261 0.701149
136 GEK 0.477778 0.833333
137 OOB 0.477778 0.763158
138 A3S 0.47561 0.84058
139 OVE 0.474359 0.74026
140 PR8 0.473118 0.698795
141 P5A 0.473118 0.648352
142 AMO 0.472527 0.74359
143 NSS 0.472527 0.678161
144 4AD 0.472527 0.734177
145 6MD 0.472222 0.893939
146 2FA 0.472222 0.816901
147 NOC 0.471429 0.791045
148 A2P 0.469136 0.756757
149 2BA 0.469136 0.767123
150 CMP 0.469136 0.777778
151 TXA 0.468085 0.766234
152 PTJ 0.468085 0.759494
153 1ZZ 0.468085 0.731707
154 QQX 0.467532 0.714286
155 00A 0.467391 0.725
156 DLL 0.467391 0.763158
157 5F1 0.465753 0.782609
158 MYR AMP 0.463158 0.731707
159 3UK 0.462366 0.753247
160 ADP BMA 0.462366 0.753247
161 ACK 0.461538 0.739726
162 QQY 0.461538 0.723684
163 GSU 0.457447 0.678161
164 A A 0.457447 0.773333
165 WAQ 0.457447 0.725
166 LAD 0.457447 0.707317
167 KAA 0.457447 0.655556
168 PPS 0.454545 0.698795
169 PAP 0.453488 0.76
170 NVA 2AD 0.453488 0.816901
171 NB8 0.452632 0.716049
172 JB6 0.452632 0.746835
173 FYA 0.452632 0.763158
174 BIS 0.452632 0.725
175 1DA 0.452055 0.878788
176 XAH 0.44898 0.690476
177 TYR AMP 0.44898 0.74359
178 VRT 0.448276 0.84507
179 SO8 0.448276 0.869565
180 25L 0.447917 0.763158
181 KB1 0.447917 0.786667
182 4UV 0.444444 0.734177
183 9SN 0.443299 0.716049
184 V3L 0.443182 0.773333
185 LAQ 0.441176 0.710843
186 7D3 0.439024 0.696203
187 ATP A A A 0.438776 0.783784
188 FA5 0.438776 0.74359
189 YAP 0.438776 0.734177
190 J1A 0.4375 0.740741
191 LPA AMP 0.436893 0.710843
192 J1C 0.435897 0.67033
193 AFH 0.435644 0.707317
194 7MD 0.435644 0.690476
195 4UU 0.435644 0.734177
196 J1B 0.434783 0.67033
197 YSA 0.434343 0.678161
198 TXD 0.432692 0.746835
199 4UW 0.432692 0.75
200 ARJ 0.432432 0.776119
201 MCF 0.432099 0.842857
202 KH3 0.431373 0.802632
203 TAD 0.431373 0.728395
204 GTA 0.431373 0.731707
205 4YB 0.431373 0.662921
206 AMP DBH 0.43 0.753247
207 IVH 0.428571 0.813333
208 AHZ 0.427184 0.731707
209 ARG AMP 0.427184 0.682353
210 3NZ 0.427083 0.833333
211 7C5 0.425743 0.773333
212 G3A 0.425743 0.716049
213 2A5 0.425287 0.708861
214 7MC 0.424528 0.694118
215 AP0 0.424528 0.7375
216 TT8 0.423913 0.898551
217 YLP 0.423077 0.694118
218 48N 0.423077 0.7375
219 CNA 0.422018 0.74359
220 AR6 AR6 0.421569 0.773333
221 G5P 0.421569 0.716049
222 ATR 0.420455 0.746667
223 101 0.419753 0.714286
224 D3Y 0.419355 0.816901
225 NXX 0.419048 0.74359
226 NAX 0.419048 0.698795
227 DND 0.419048 0.74359
228 6V0 0.419048 0.716049
229 NAI 0.419048 0.725
230 7D4 0.418605 0.696203
231 A A A 0.416667 0.763158
232 OMR 0.415094 0.722892
233 TXE 0.415094 0.725
234 649 0.415094 0.648352
235 D5M 0.414634 0.714286
236 DA 0.414634 0.714286
237 T5A 0.412844 0.694118
238 139 0.412844 0.698795
239 ADJ 0.412844 0.702381
240 YLB 0.411215 0.714286
241 YLC 0.411215 0.710843
242 J1D 0.410714 0.628866
243 AYB 0.409091 0.705882
244 A2R 0.408602 0.763158
245 A4P 0.407407 0.659091
246 UP5 0.40566 0.734177
247 NAD IBO 0.405405 0.75641
248 IOT 0.40367 0.666667
249 6CR 0.402597 0.805556
250 WSA 0.401869 0.686047
251 TYM 0.401869 0.74359
252 LA8 ALF 3PG 0.401869 0.707317
253 ALF ADP 3PG 0.401869 0.707317
254 AF3 ADP 3PG 0.401869 0.707317
255 4TA 0.401786 0.702381
256 YLA 0.4 0.674419
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found: 415
This union binding pocket(no: 1) in the query (biounit: 5fa5.bio4) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3Q9T FAY 0.01549 0.41427 1.38648
2 1VQW FAD 0.0005222 0.48029 2.18818
3 2GVC FAD 0.0006969 0.47432 2.23714
4 2HQM FAD 0.001561 0.46793 2.29645
5 3SSO SAH 0.002747 0.45388 2.38663
6 4UCI SAM 0.006021 0.41205 2.40964
7 1FP1 SAH 0.009715 0.4241 2.41935
8 3EGI ADP 0.00004393 0.53538 2.42718
9 4RDH AMP 0.0005508 0.45216 2.43056
10 4RDI ATP 0.0007821 0.44997 2.43056
11 4J7U YTZ 0.01148 0.42538 2.43056
12 4J7U NAP 0.01148 0.42538 2.43056
13 3TKY SAH 0.0001584 0.4834 2.45232
14 3AB1 FAD 0.0004852 0.49057 2.5
15 5EZ7 FAD 0.006172 0.43572 2.55102
16 5JAQ NAI 0.004631 0.4418 2.61538
17 3G5S FAD 0.0006675 0.48033 2.7088
18 5X62 SAH 0.0000198 0.50507 2.70936
19 3GWZ SAH 0.0005277 0.44769 2.71003
20 3GXO SAH 0.001221 0.43685 2.71003
21 3TLJ SAH 0.000007486 0.47757 2.7248
22 4FZV SAM 0.0001185 0.49131 2.78552
23 4AZT SAM 0.0001384 0.46069 2.81195
24 2BRY FAD 0.0012 0.46308 2.8169
25 2JJQ SAH 0.0006352 0.44328 2.82353
26 1Z6Z NAP 0.006817 0.42338 2.83688
27 1KYQ NAD 0.001977 0.42168 2.91971
28 2ZIF SAM 0.00007809 0.4611 2.92308
29 4RPL FAD 0.000473 0.51048 2.99728
30 4RPL 3UC 0.0005715 0.50848 2.99728
31 4J1Q NDP 0.009407 0.41414 2.99728
32 3F8D FAD 0.005515 0.4597 3.09598
33 5KVA SAM 0.006388 0.4144 3.23741
34 1YQZ FAD 0.007138 0.44752 3.26975
35 5BUK FAD 0.004849 0.44566 3.26975
36 4OPC FDA 0.0177 0.44358 3.26975
37 4OPC PGT 0.01999 0.44358 3.26975
38 1YXM ADE 0.0003404 0.47833 3.30033
39 4AZW SAM 0.0001191 0.48897 3.39703
40 5GT9 NAP 0.01388 0.40998 3.42205
41 2AOT SAH 0.0006216 0.44983 3.42466
42 4BV6 FAD 0.0007053 0.48376 3.44828
43 2FK8 SAM 0.0006811 0.45684 3.45912
44 5FJN BE2 0.0007615 0.48629 3.54223
45 5FJN FAD 0.0006589 0.48629 3.54223
46 3CGD COA 0.006475 0.4595 3.54223
47 3CGD NAD 0.006475 0.4595 3.54223
48 3CGD FAD 0.006475 0.4595 3.54223
49 3LCV SAM 0.0001908 0.48602 3.55872
50 4NBU NAI 0.0004108 0.4824 3.6
51 2IID PHE 0.002406 0.46846 3.61446
52 2IID FAD 0.002406 0.46846 3.61446
53 4D79 ATP 0.0013 0.42184 3.62319
54 4ONQ SFG 0.000484 0.43903 3.64146
55 3RIY NAD 0.01073 0.41407 3.663
56 5THQ NDP 0.006664 0.42385 3.67647
57 3JWH SAH 0.00007432 0.4747 3.68664
58 3FUU ADN 0.000006177 0.54696 3.69004
59 4N49 SAM 0.0001597 0.44495 3.73832
60 1NW5 SAM 0.00009326 0.49377 3.76176
61 1DL5 SAH 0.00007624 0.42269 3.78549
62 2A14 SAH 0.0004785 0.4658 3.80228
63 3BMQ NAP 0.01723 0.40431 3.81944
64 5K6A NAP 0.01725 0.40429 3.81944
65 3JQF NAP 0.01985 0.40139 3.81944
66 3JQ9 NAP 0.02003 0.40121 3.81944
67 2O07 MTA 0.00007374 0.5126 3.94737
68 2O07 SPD 0.00008722 0.5126 3.94737
69 3G89 SAM 0.000003882 0.53786 4.01606
70 4YNU LGC 0.000815 0.48771 4.02802
71 4YNU FAD 0.00068 0.48771 4.02802
72 5F2K SAH 0.003903 0.43742 4.07609
73 5F2K OCA 0.003903 0.43742 4.07609
74 1G55 SAH 0.000009315 0.53891 4.08163
75 5KOK SAH 0.00006862 0.49978 4.08719
76 5KOK S9T 0.0002729 0.49512 4.08719
77 1GY8 NAD 0.0003052 0.4885 4.08719
78 1GET FAD 0.001707 0.48338 4.08719
79 1GET NAP 0.001813 0.48338 4.08719
80 5KOK R9T 0.001074 0.46538 4.08719
81 2VZZ SCA 0.005597 0.4261 4.12844
82 3GDH SAH 0.00007758 0.43368 4.14938
83 4CS9 AMP 0.006872 0.43532 4.2328
84 5A3B APR 0.01067 0.4102 4.29043
85 3ZNN 4WL 0.001269 0.48406 4.32277
86 3ZNN FAD 0.001269 0.48406 4.32277
87 5LW0 AR6 0.008943 0.41086 4.329
88 2WA2 SAM 0.0007203 0.44934 4.34783
89 4CNK FAD 0.000283 0.49957 4.35967
90 2EJU SAH 0.0001784 0.45614 4.35967
91 4X7Y SAH 0.002159 0.46001 4.37956
92 5BW4 SAM 0.000005747 0.54286 4.49438
93 3H4V DVP 0.02665 0.40731 4.51389
94 1N5D NDP 0.01978 0.40265 4.51389
95 4NEC SAH 0.00005257 0.49733 4.54545
96 4D42 W0I 0.03524 0.40671 4.60993
97 4D42 NAP 0.03524 0.40671 4.60993
98 4J36 1HR 0.001472 0.4702 4.63215
99 4J36 FAD 0.00107 0.46546 4.63215
100 4USR FAD 0.0009243 0.46848 4.70914
101 1JQ3 AAT 0.000004541 0.57844 4.72973
102 3A4T SFG 0.000005232 0.48868 4.74453
103 2YY7 NAD 0.001124 0.46172 4.80769
104 3NKS FAD 0.002549 0.45223 4.8218
105 4E70 N7I 0.0008812 0.46529 4.89691
106 3NTA FAD 0.004077 0.44344 4.90463
107 2DPM SAM 0.0004101 0.42471 4.92958
108 5FA8 SAM 0.000001528 0.49568 4.96894
109 3BGD SAH 0.00007142 0.44054 5
110 3BGD PM6 0.00009829 0.41426 5
111 3MQ2 SAH 0.0005057 0.44628 5.04587
112 2VVM FAD 0.002468 0.45614 5.05051
113 2XVE FAD 0.001056 0.49043 5.17711
114 3NTD FAD 0.002315 0.45535 5.17711
115 3LXD FAD 0.002603 0.44948 5.17711
116 4EIP FAD 0.0141 0.4244 5.17711
117 4EIP K2C 0.0141 0.4244 5.17711
118 2CFC NAD 0.003061 0.43841 5.2
119 3E1T FAD 0.001354 0.47197 5.27344
120 5XVK SAH 0.0002396 0.48148 5.28169
121 1NV8 MEQ 0.0001855 0.40316 5.28169
122 1NV8 SAM 0.0002313 0.40015 5.28169
123 3AFN NAP 0.01241 0.41464 5.42636
124 3C3Y SAH 0.006594 0.41026 5.48523
125 1BC5 SAH 0.0003982 0.47137 5.57621
126 5XVQ SAH 0.0002854 0.42286 5.6338
127 5M58 SAH 0.00004881 0.50646 5.65217
128 1RJD SAM 0.0001982 0.48117 5.68862
129 1U2Z SAH 0.00000751 0.55044 5.72207
130 4DCM SAM 0.00007155 0.4914 5.72207
131 3GU3 SAH 0.0001788 0.49124 5.72207
132 3VSE SAH 0.00007513 0.47457 5.72207
133 1PNF NDG NAG 0.009393 0.42114 5.73248
134 1KYZ SAH 0.00165 0.42378 5.75342
135 3O7W SAM 0.00009697 0.49132 5.78231
136 1JQD SAH 0.0016 0.45308 5.82192
137 1JQD HSM 0.003366 0.43358 5.82192
138 5E1M PRO PRO LYS ARG ILE ALA 0.00007447 0.52207 5.84615
139 5E1M SAH 0.00007447 0.52207 5.84615
140 4TQG NDP 0.0001828 0.49585 5.88235
141 3H2B SAH 0.00013 0.45292 5.91133
142 3NDJ JHZ 0.0008344 0.4853 5.99455
143 3NDJ SAH 0.0008344 0.4853 5.99455
144 5F8F SFG 0.00008868 0.48728 6
145 3OFK SAH 0.0001943 0.43476 6.01852
146 1IM8 SAI 0.01806 0.41822 6.14754
147 2AE2 NAP 0.008678 0.42949 6.15385
148 2AE2 PTO 0.008678 0.42949 6.15385
149 2EG5 SAH 0.0001128 0.48834 6.1828
150 2PT9 2MH 0.01252 0.44236 6.23053
151 2PT9 S4M 0.008353 0.44122 6.23053
152 1L1E SAH 0.0004041 0.42927 6.27178
153 1LSS NAD 0.0000402 0.4648 6.42857
154 5LOG SAH 0.003246 0.42418 6.43777
155 4HSU FAD 0.001212 0.47534 6.45161
156 4GUT FAD 0.00183 0.46841 6.45161
157 3FZG SAM 0.001709 0.43037 6.5
158 4A6D SAM 0.009517 0.4303 6.51558
159 1RKX NAD 0.003048 0.44122 6.72269
160 1SQF SAM 0.0003194 0.46742 6.75991
161 3QFA FAD 0.001891 0.46385 6.89655
162 2I7C AAT 0.00001248 0.40672 7.06714
163 5GM1 SAH 0.0001293 0.43732 7.07071
164 5HJM MTA 0.00000529 0.50909 7.10227
165 1S7N COA 0.01138 0.40126 7.14286
166 3Q87 SAM 0.0006062 0.46299 7.2
167 4II2 ATP 0.0003225 0.43349 7.22892
168 2AG5 NAD 0.0005564 0.47469 7.31707
169 1U1I NAD 0.01357 0.41389 7.39796
170 2ZFU SAH 0.0002675 0.47527 7.44186
171 1S7G APR 0.005727 0.43071 7.50988
172 1S7G NAD 0.01438 0.40926 7.50988
173 5E72 SAM 0.0002006 0.48302 7.51445
174 4MO2 FDA 0.0003736 0.4925 7.62943
175 4MO2 FAD 0.0005266 0.48651 7.62943
176 4KRG SAH 0.00005609 0.48554 7.62943
177 5JE0 AZ8 0.0000216 0.54288 7.69231
178 5JE0 SAH 0.0000216 0.54288 7.69231
179 2UYQ SAM 0.00002501 0.55162 7.74194
180 3OID NDP 0.01853 0.40629 7.75194
181 1QO8 FAD 0.001438 0.46968 7.90191
182 1VE3 SAM 0.0001328 0.46234 7.92952
183 5T67 JHZ 0.0008196 0.48471 7.93269
184 5T67 SAH 0.0007091 0.48254 7.93269
185 5JGL SAM 0.002316 0.42672 7.95848
186 1I1N SAH 0.0001183 0.41136 7.9646
187 2WET FAD 0.005741 0.43923 8.21918
188 4POO SAM 0.0001759 0.48957 8.5
189 4R6W SAH 0.00002074 0.40919 8.52713
190 1VL0 NAI 0.01283 0.40507 8.56164
191 1XDS SAM 0.0001154 0.4879 8.71935
192 1QZZ SAM 0.0004126 0.46282 8.71935
193 2YX1 SFG 0.0000005994 0.57291 8.92857
194 1XCL SAH 0.0001455 0.50525 8.93617
195 5FTW SAH 0.0003667 0.43076 8.98438
196 2BZG SAH 0.00006672 0.49792 9.05172
197 3VYW SAM 0.00008559 0.45542 9.09091
198 5EOW FAD 0.01603 0.41041 9.1358
199 4YMH SAH 0.000182 0.43958 9.16667
200 1XG5 NAP 0.01193 0.41311 9.319
201 4OBW SAM 0.0001859 0.45491 9.33852
202 1UAY ADN 0.02438 0.40266 9.50413
203 3DXY SAM 0.00002103 0.52823 9.63303
204 1I9G SAM 0.00003061 0.51799 10
205 2R4J FAD 0.001073 0.48443 10
206 2R4J 13P 0.001073 0.48443 10
207 1Q0S SAH 0.0002909 0.47951 10
208 3KLJ FAD 0.0008895 0.46928 10
209 2E5V FAD 0.002792 0.45653 10
210 1PN0 IPH 0.003563 0.45582 10
211 1PN0 FAD 0.003423 0.45582 10
212 1MO9 FAD 0.01333 0.4436 10
213 1MO9 KPC 0.01588 0.44011 10
214 1V59 NAD 0.0001075 0.49534 10.0817
215 3LCC SAH 0.000007908 0.53668 10.2128
216 4UA3 COA 0.01068 0.40078 10.3093
217 3G2O SAM 0.0002665 0.47095 10.3679
218 1FP2 SAH 0.004546 0.43785 10.5114
219 1P1C SAH 0.0001724 0.48804 10.5528
220 2CDU FAD 0.001306 0.46508 10.6267
221 2PXX SAH 0.00001333 0.49104 10.6977
222 2Q7V FAD 0.0008424 0.47999 10.7692
223 3BXO SAM 0.00007115 0.48367 10.8787
224 5K7U SAM 0.0009243 0.42863 10.8883
225 4FLP JQ1 0.02258 0.40412 10.9244
226 3ITJ FAD 0.01662 0.42319 10.9467
227 1QAN SAH 0.000008586 0.47972 11.0656
228 4QTU SAM 0.00001887 0.48646 11.1111
229 4ITU NAI 0.0002026 0.49988 11.1524
230 4ITU 1HS 0.0003478 0.49988 11.1524
231 1YQC GLV 0.01257 0.40764 11.1765
232 3QOX SAH 0.000004537 0.56048 11.2676
233 3A25 SAM 0.000001514 0.57167 11.2957
234 5DNK SAH 0.000008202 0.50718 11.4441
235 3H8V ATP 0.001288 0.44025 11.6438
236 1KPH SAH 0.000513 0.42166 11.8467
237 5IL1 SAM 0.0005297 0.43737 12
238 5L95 AMP 0.0001945 0.47936 12.1864
239 3P2E SAH 0.0001442 0.48745 12.4444
240 4C4A SAH 0.00000006098 0.63745 12.4615
241 3NUG NAD 0.0002715 0.4909 12.5506
242 3WV8 ATP 0.0008781 0.44982 12.844
243 2YVJ FAD 0.004688 0.43943 12.844
244 2YVJ NAI 0.005239 0.41288 12.844
245 1KPG SAH 0.0005562 0.46281 12.892
246 4I5I NAD 0.009811 0.41329 12.892
247 1ELI PYC 0.0004065 0.49196 13.1105
248 4KXQ APR 0.004725 0.42039 13.3333
249 1XSE NDP 0.01357 0.41998 13.5593
250 1R18 SAH 0.02449 0.4132 13.6564
251 2XYQ SAH 0.001032 0.44458 13.9344
252 1TPY SAH 0.0004316 0.42433 13.9373
253 1Y8Q ATP 0.00001504 0.45686 14.1618
254 2Z3Y F2N 0.0006614 0.48727 14.1689
255 5MW4 5JU 0.00002656 0.55202 14.3713
256 4M73 SAH 0.00006473 0.52786 15
257 4M73 M72 0.00007889 0.5251 15
258 4KIB SAH 0.00001487 0.52446 15
259 3PT9 SAH 0.00001761 0.49497 15
260 1N4W FAD 0.0006462 0.48776 15
261 3EGV SAH 0.0001016 0.4748 15
262 4TM3 FAD 0.002663 0.47478 15
263 2NXE SAM 0.000222 0.4745 15
264 2JB2 PHE 0.001295 0.4698 15
265 2JB2 FAD 0.00123 0.4698 15
266 3AYI FAD 0.002104 0.46977 15
267 3AYI HCI 0.002184 0.46977 15
268 1JNR FAD 0.006584 0.45745 15
269 1ZEM NAD 0.00007449 0.42247 15
270 2DX7 CIT 0.003806 0.40955 15
271 5N5D SAM 0.0008959 0.44943 15.0442
272 1ZQ9 SAM 0.000157 0.48126 15.4386
273 4PNE SAH 0.0000651 0.50744 15.894
274 3GRU AMP 0.0001182 0.43316 15.9322
275 1W8D NAP 0.002155 0.43941 16.2252
276 3A27 SAM 0.0000007795 0.5846 16.5441
277 2XVM SAH 0.00002817 0.51565 17.0854
278 1EJ0 SAM 0.00004652 0.50495 18.3333
279 4GLL NAD 0.005455 0.4305 18.3976
280 3X0D SAH 0.0000007908 0.58724 20
281 2VDV SAM 0.000003832 0.55492 20
282 1WG8 SAM 0.000009176 0.54868 20
283 3T7S SAM 0.00005028 0.50343 20
284 1JG3 ADN 0.00005046 0.50337 20
285 4REP FAD 0.0003378 0.49705 20
286 5MGZ SAH 0.00001323 0.4944 20
287 5U8U FAD 0.001292 0.48889 20
288 1ZMD FAD 0.000697 0.48615 20
289 2F5Z FAD 0.0009752 0.47898 20
290 4EMI NAD 0.002782 0.46904 20
291 4EMI FAD 0.001255 0.46824 20
292 5KMS NAD 0.0035 0.46253 20
293 1ZMD NAI 0.001011 0.45626 20
294 3PFG SAM 0.008978 0.45612 20
295 3PFG TLO 0.008978 0.45612 20
296 5KMS FAD 0.002212 0.45405 20
297 4J56 FAD 0.004787 0.44593 20
298 5MPT SAH 0.000557 0.43762 20
299 3OU2 SAH 0.00004478 0.43706 20
300 4M52 FAD 0.007876 0.43344 20
301 3ABI NAD 0.008537 0.41876 20
302 5T2U NAP 0.0111 0.41696 20
303 2DKN NAI 0.009487 0.41531 20
304 3UBM COA 0.0131 0.40167 20
305 1L3I SAH 0.00009035 0.42326 20.3125
306 4Y2H 49K 0.00000006004 0.67917 25
307 4Y2H SAH 0.00000007321 0.67498 25
308 5DXA SFG 0.0000001222 0.53498 25
309 2WSB NAD 0.0001018 0.52361 25
310 1Z3C SA8 0.00007831 0.5148 25
311 1XTP SAI 0.00006729 0.49776 25
312 3GCZ SAM 0.00008632 0.49291 25
313 3S1S SAH 0.0001673 0.48864 25
314 4YAG NAI 0.000971 0.47804 25
315 1G60 SAM 0.0002261 0.47642 25
316 1UWK URO 0.001216 0.47624 25
317 1UWK NAD 0.001216 0.47624 25
318 5E9W SAH 0.00007269 0.47524 25
319 3GDN HBX 0.001628 0.47451 25
320 3GDN FAD 0.001146 0.47451 25
321 4DMG SAM 0.0003055 0.47428 25
322 3FRH SAH 0.0003573 0.47353 25
323 5EB4 FAD 0.001194 0.47153 25
324 5JJR SAH 0.00008231 0.4705 25
325 5THZ SAH 0.0005712 0.46418 25
326 4FC7 COA 0.002116 0.46146 25
327 4FC7 NAP 0.002116 0.46146 25
328 2V3B FAD 0.002277 0.45459 25
329 5G3U FDA 0.003152 0.44886 25
330 1WY7 SAH 0.00008804 0.44387 25
331 3M6W SAM 0.001123 0.43845 25
332 5MBX FAD 0.01108 0.43501 25
333 5MBX SP5 0.01108 0.43501 25
334 3DUW SAH 0.001887 0.43483 25
335 5THY SAH 0.0004614 0.42657 25
336 5G3U ITW 0.01193 0.42632 25
337 2ZWA SAH 0.0003832 0.42348 25
338 1AE1 NAP 0.008358 0.42286 25
339 3O26 NDP 0.01061 0.4143 25
340 5UAO FAD 0.01654 0.41387 25
341 1G8K MGD 0.04866 0.40934 25
342 2CUL FAD 0.02192 0.40491 25
343 3ML1 MGD 0.03749 0.41637 25.9259
344 4XUC 43G 0.0001126 0.51348 27.9817
345 4XUC SAM 0.0001126 0.51348 27.9817
346 5E8J SAH 0.00008971 0.49285 29.5455
347 4IWN GEK 0.00005465 0.51092 30
348 5ITV NAI 0.0001185 0.50792 30
349 2P41 SAH 0.00005977 0.50007 30
350 4KRI SAH 0.000007819 0.49073 30
351 3EVG SAH 0.00004428 0.48085 30
352 1Q9I TEO 0.00166 0.47817 30
353 1Q9I FAD 0.00166 0.47817 30
354 1EFV FAD 0.003064 0.46471 30
355 3VC1 SAH 0.001655 0.46461 30
356 3VC1 GST 0.001655 0.46461 30
357 1EFV AMP 0.003094 0.4645 30
358 3LKZ SFG 0.00006997 0.46406 30
359 4IV9 FAD 0.002828 0.45326 30
360 5JCA NDP 0.007294 0.4484 30
361 5JCA FAD 0.004049 0.44763 30
362 2PWY SAH 0.006066 0.44512 30
363 5ULP KB1 0.00004907 0.44042 30
364 2PX8 SAH 0.00176 0.43416 30
365 4ZA2 NAD 0.005757 0.42552 30
366 3GEG NAD 0.03069 0.41515 30
367 1ZGA SAH 0.01637 0.41104 30
368 4UP3 FAD 0.02229 0.40939 30
369 4LWP SAH 0.0000002148 0.6097 35
370 4HA6 FAD 0.0004521 0.49538 35
371 5JCM NAD 0.001152 0.49143 35
372 5JCM FAD 0.001116 0.49143 35
373 5JCM ISD 0.001152 0.49143 35
374 1D4D FAD 0.0006238 0.48851 35
375 4X9M FAD 0.0005469 0.48804 35
376 4MIG G3F 0.0008146 0.48772 35
377 1E6E FAD 0.0004661 0.48661 35
378 4JDR FAD 0.0007637 0.48207 35
379 1E1M FAD 0.001317 0.4808 35
380 1E1M NAP 0.001317 0.4808 35
381 3I53 SAH 0.0002991 0.47307 35
382 1PR9 NAP 0.001431 0.45944 35
383 3D3W NAP 0.002066 0.45183 35
384 2Y6Q I7T 0.003962 0.45179 35
385 2Y6Q FAD 0.001945 0.45179 35
386 2PZM UDP 0.003578 0.45123 35
387 2PZM NAD 0.003578 0.45123 35
388 2BD0 NAP 0.003846 0.43772 35
389 2JBM SRT 0.02426 0.40845 35
390 2B4Q NAP 0.0159 0.40597 35
391 1F3L SAH 0.00000007949 0.55248 36.1371
392 4FN4 NAD 0.0001765 0.49818 40
393 3QVP FAD 0.0004441 0.49576 40
394 1COY FAD 0.0005443 0.48926 40
395 1IY8 NAD 0.0005099 0.47796 40
396 4D7E FAD 0.001131 0.46809 40
397 3UCL FAD 0.004796 0.4597 40
398 3UCL CYH 0.004796 0.4597 40
399 3UCL NAP 0.005223 0.4597 40
400 5J60 FAD 0.002279 0.45783 40
401 4C3Y ANB 0.003565 0.45406 40
402 4C3Y FAD 0.00287 0.45397 40
403 2WPF FAD 0.01336 0.44926 40
404 2WPF WPF 0.0186 0.44285 40
405 4YSX FAD 0.004951 0.44139 40
406 3DMH GMP 0.000007596 0.5587 45
407 3DMH SAM 0.000004908 0.55406 45
408 3C6K SPD 0.00002302 0.54946 45
409 3C6K MTA 0.00002302 0.54946 45
410 1NFQ NAI 0.004083 0.43648 45
411 1PS9 FAD 0.006949 0.43517 45
412 1N2X SAM 0.0001788 0.43144 45
413 1FEC FAD 0.01428 0.42412 45
414 3CH6 NAP 0.02366 0.42222 45
415 3CH6 311 0.02366 0.42222 45
416 5CUQ NSC 0.00007734 0.51827 50
417 3ICS FAD 0.0006124 0.48334 50
418 3ICR FAD 0.0005939 0.48278 50
Pocket No.: 2; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5fa5.bio3) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 5fa5.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 5FA5; Ligand: MTA; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 5fa5.bio2) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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