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Receptor
PDB id Resolution Class Description Source Keywords
5CBL 1.78 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN GALECTIN LACTOSE HOMO SAPIENS GALECTINS BETA-GALACTOSIDES BINDING SUGAR BINDING PROTEIN
Ref.: RECOMBINANT EXPRESSION, PURIFICATION AND PRELIMINAR BIOPHYSICAL AND STRUCTURAL STUDIES OF C-TERMINAL CARBOHYDRATE RECOGNITION DOMAIN FROM HUMAN GALECTIN PROTEIN EXPR.PURIF. V. 118 39 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LAT C:401;
B:401;
A:401;
D:401;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
342.296 C12 H22 O11 C([C@...
GOL C:402;
B:404;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
BME B:402;
Invalid;
none;
submit data
78.133 C2 H6 O S C(CS)...
SO4 B:403;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4YLZ 2.1 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-4 C-TERMINAL CARBOHY RECOGNITION DOMAIN IN COMPLEX WITH LACTO-N-NEOTETRAOSE (LNN HOMO SAPIENS GALECTIN LECTIN SUGAR BINDING PROTEIN CARBOHYDRATE BINDINPROTEIN LACTO-N-NEOTETRAOSE CARBOHYDRATE RECOGNITION BETSANDWICH GLYCOSPHINGOLIPID
Ref.: STRUCTURAL CHARACTERIZATION OF HUMAN GALECTIN-4 C-T DOMAIN: ELUCIDATING THE MOLECULAR BASIS FOR RECOGNI GLYCOSPHINGOLIPIDS, SULFATED SACCHARIDES AND BLOOD ANTIGENS. FEBS J. V. 282 3348 2015
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 4YLZ Kd = 270 uM LAT NAG GAL n/a n/a
2 5CBL - LAT C12 H22 O11 C([C@@H]1[....
3 4YM0 Kd = 510 uM LAT NAG GAL n/a n/a
4 4YM2 Kd = 1400 uM SGA BGC n/a n/a
5 4YM3 Kd = 1900 uM LAT C12 H22 O11 C([C@@H]1[....
6 4YM1 Kd = 580 uM LAT FUC n/a n/a
70% Homology Family (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 4YLZ Kd = 270 uM LAT NAG GAL n/a n/a
2 5CBL - LAT C12 H22 O11 C([C@@H]1[....
3 4YM0 Kd = 510 uM LAT NAG GAL n/a n/a
4 4YM2 Kd = 1400 uM SGA BGC n/a n/a
5 4YM3 Kd = 1900 uM LAT C12 H22 O11 C([C@@H]1[....
6 4YM1 Kd = 580 uM LAT FUC n/a n/a
50% Homology Family (109)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 5NF9 Kd = 4.7 uM 8VW C22 H32 N2 O12 CC(=O)N[C@....
2 5E8A Kd = 0.034 uM 5KS C28 H30 F2 N6 O8 S c1cc(ccc1c....
3 1A3K - GAL NAG n/a n/a
4 3T1M Kd = 0.91 mM DQT C23 H27 N O7 Cc1ccc(cc1....
5 4LBL Kd = 11 uM BGC SIA GAL n/a n/a
6 2NMN Kd = 260 uM GAL BGC n/a n/a
7 4R9B - LAT C12 H22 O11 C([C@@H]1[....
8 2NN8 Kd = 260 uM LAT C12 H22 O11 C([C@@H]1[....
9 4JC1 Kd = 50 uM TDG C12 H22 O10 S C([C@@H]1[....
10 4R9A - LAT C12 H22 O11 C([C@@H]1[....
11 5EXO - 5SY C19 H22 O9 CC(=O)O[C@....
12 5ODY Kd = 7.5 nM 9SK C30 H28 F5 N3 O11 S c1cc(c(c2c....
13 5E88 Kd = 0.065 uM 5KT C24 H28 N6 O8 S3 c1cscc1c2c....
14 4R9D - LAT C12 H22 O11 C([C@@H]1[....
15 1KJL Kd = 67 uM GAL NAG n/a n/a
16 3T1L Kd = 0.55 mM MQT C17 H22 O8 Cc1ccc(cc1....
17 2XG3 Kd = 18.2 uM UNU GAL NAG n/a n/a
18 4LBJ Kd = 0.39 uM GAL NAG GAL BGC n/a n/a
19 4R9C - LAT C12 H22 O11 C([C@@H]1[....
20 3ZSJ Kd = 231 uM LAT C12 H22 O11 C([C@@H]1[....
21 4LBM Kd = 0.97 uM BGC GAL NAG GAL n/a n/a
22 1KJR Kd = 0.88 uM BEK GAL NAG n/a n/a
23 6EOL Kd = 0.037 uM BKH C20 H16 Cl2 F3 N3 O4 S c1cc(c(cc1....
24 6G0V Kd = 166 uM EGZ C18 H25 N O13 S C1[C@H](NC....
25 3AYE - LAT C12 H22 O11 C([C@@H]1[....
26 6EOG Kd = 1.6 uM BKK C20 H17 Cl F3 N3 O4 S c1cc(cc(c1....
27 5E89 Kd = 0.014 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
28 4LBO Kd = 1.7 uM BGC GAL SIA n/a n/a
29 2NMO Kd = 260 uM GAL BGC n/a n/a
30 3AYC Kd = 57 uM GAL NGA GAL BGC SIA n/a n/a
31 4JCK Kd = 4.3 mM 1LL C12 H22 O10 S C([C@@H]1[....
32 5NFA Kd = 5.6 uM 8VQ C24 H36 N2 O12 CC(=O)N[C@....
33 4LBK Kd = 0.32 uM GAL NAG GAL BGC n/a n/a
34 5OAX Kd = 12 nM 9Q5 C30 H30 F3 N3 O11 S c1cc(cc(c1....
35 4RL7 - LAT C12 H22 O11 C([C@@H]1[....
36 3AYD Kd = 65 uM NPO A2G GAL n/a n/a
37 4LBN Kd = 0.65 uM GLC GAL NAG GAL n/a n/a
38 1G86 - NEQ C6 H7 N O2 CCN1C(=O)C....
39 1QKQ - MAN C6 H12 O6 C([C@@H]1[....
40 1HDK - PMB C6 H5 Hg O3 S c1cc(ccc1S....
41 2D6N - GAL NAG n/a n/a
42 2D6M - LBT C12 H22 O11 C([C@@H]1[....
43 2D6O - NAG GAL GAL NAG n/a n/a
44 4XBN Kd = 93 uM GAL NAG n/a n/a
45 5H9R Kd = 0.84 uM TGZ C20 H26 F N3 O9 S c1cc(cc(c1....
46 5H9P Kd = 0.068 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
47 5DG2 - GAL GLC n/a n/a
48 5EWS - GAL BGC n/a n/a
49 5NM1 - LBT C12 H22 O11 C([C@@H]1[....
50 5NLD - LBT C12 H22 O11 C([C@@H]1[....
51 5NMJ - LBT C12 H22 O11 C([C@@H]1[....
52 5NLH - LBT C12 H22 O11 C([C@@H]1[....
53 5NLE - LBT C12 H22 O11 C([C@@H]1[....
54 4XBL Kd = 340 uM GAL NAG n/a n/a
55 4Y24 Kd = 0.22 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
56 3T2T - MQT C17 H22 O8 Cc1ccc(cc1....
57 3OY8 Kd = 220 uM GAL GCO n/a n/a
58 2EAL - GAL NGA A2G n/a n/a
59 2ZHL Kd = 3 uM NAG GAL GAL NAG n/a n/a
60 2ZHK Kd = 3 uM NAG GAL GAL NAG n/a n/a
61 2ZHN - NAG GAL NAG GAL GAL NAG n/a n/a
62 2ZHM - NAG GAL GAL NAG GAL n/a n/a
63 2EAK - LBT C12 H22 O11 C([C@@H]1[....
64 3WLU - LSE C18 H36 O10 Se Si C[Si](C)(C....
65 5H9S Kd = 87 uM TGZ C20 H26 F N3 O9 S c1cc(cc(c1....
66 5H9Q Kd = 38 uM TD2 C28 H30 F2 N6 O8 S c1cc(cc(c1....
67 4XBQ Kd = 270 uM GAL NAG n/a n/a
68 6A62 - LAT C12 H22 O11 C([C@@H]1[....
69 6A64 - LAT C12 H22 O11 C([C@@H]1[....
70 6A63 - LAT C12 H22 O11 C([C@@H]1[....
71 5T7S Kd = 3.1 uM LBT C12 H22 O11 C([C@@H]1[....
72 4BMB Ka = 13000 M^-1 LAT C12 H22 O11 C([C@@H]1[....
73 5T7I Kd = 0.33 uM LAT NAG GAL n/a n/a
74 3VKO - SIA GAL NAG n/a n/a
75 4BME Ka = 13000 M^-1 LBT C12 H22 O11 C([C@@H]1[....
76 5T7T Kd = 2.1 uM GAL NAG n/a n/a
77 3I8T Kd = 600 uM LBT C12 H22 O11 C([C@@H]1[....
78 3WV6 - GAL BGC n/a n/a
79 3NV2 - GAL NDG n/a n/a
80 3NV4 - SIA GAL BGC n/a n/a
81 3NV3 - GAL NAG MAN n/a n/a
82 3WUD Kd = 41 uM GLC GAL n/a n/a
83 3GAL - 1GN C6 H13 N O5 C([C@@H]1[....
84 4UW6 - VV7 C69 H73 N20 O39 [H]1c2c(cc....
85 2GAL - GAL C6 H12 O6 C([C@@H]1[....
86 4GAL - GAL BGC n/a n/a
87 4UW3 - 50G C31 H50 N10 O18 c1c(nnn1[C....
88 4UW4 - 4S0 C49 H80 N10 O33 c1c(nnn1[C....
89 3ZXE Kd = 450 uM PGZ C22 H28 N O8 P S Cc1ccc(cc1....
90 5GAL - NAG GAL n/a n/a
91 4UW5 - 4S0 C49 H80 N10 O33 c1c(nnn1[C....
92 1A78 - TDG C12 H22 O10 S C([C@@H]1[....
93 5DUW Kd = 510 uM 5GO C12 H22 O14 S C([C@@H]1[....
94 5DUV Kd = 1300 uM LAT C12 H22 O11 C([C@@H]1[....
95 5DUX Kd = 380 uM LAT FUC n/a n/a
96 4WVV - LBT C12 H22 O11 C([C@@H]1[....
97 4WVW - SLT C23 H39 N O19 CC(=O)N[C@....
98 4YLZ Kd = 270 uM LAT NAG GAL n/a n/a
99 5CBL - LAT C12 H22 O11 C([C@@H]1[....
100 4YM0 Kd = 510 uM LAT NAG GAL n/a n/a
101 4YM2 Kd = 1400 uM SGA BGC n/a n/a
102 4YM3 Kd = 1900 uM LAT C12 H22 O11 C([C@@H]1[....
103 4YM1 Kd = 580 uM LAT FUC n/a n/a
104 1IS4 - LAT C12 H22 O11 C([C@@H]1[....
105 1WLD - GAL BGC n/a n/a
106 6FOF - LAT C12 H22 O11 C([C@@H]1[....
107 5NFB Kd = 0.77 uM 8VT C30 H40 N2 O13 CC(=O)N[C@....
108 5NF7 Kd = 37.5 uM 8VZ C16 H28 N2 O11 CC(=O)N[C@....
109 1SLA - NAG MAN GAL BMA NAG MAN NAG GAL n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LAT; Similar ligands found: 333
No: Ligand ECFP6 Tc MDL keys Tc
1 GLA GLA 1 1
2 GAL BGC 1 1
3 GLC GAL 1 1
4 BMA GAL 1 1
5 LBT 1 1
6 BGC GAL 1 1
7 CBI 1 1
8 MAL 1 1
9 CBK 1 1
10 BGC BMA 1 1
11 N9S 1 1
12 MAB 1 1
13 LAT 1 1
14 GLA GAL 1 1
15 B2G 1 1
16 BMA BMA BMA 0.909091 1
17 GLA GAL GLC 0.909091 1
18 GLC BGC BGC 0.909091 1
19 GLC BGC BGC BGC 0.909091 1
20 GLC GLC GLC GLC GLC 0.909091 1
21 CT3 0.909091 1
22 BGC GLC GLC GLC 0.909091 1
23 BGC BGC BGC BGC 0.909091 1
24 CTT 0.909091 1
25 CTR 0.909091 1
26 GLC GAL GAL 0.909091 1
27 MAN BMA BMA BMA BMA BMA 0.909091 1
28 BGC BGC BGC GLC 0.909091 1
29 CEY 0.909091 1
30 B4G 0.909091 1
31 BGC BGC BGC 0.909091 1
32 GLC GLC BGC 0.909091 1
33 CE5 0.909091 1
34 BGC BGC BGC BGC BGC BGC 0.909091 1
35 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.909091 1
36 BMA BMA BMA BMA BMA BMA 0.909091 1
37 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.909091 1
38 GLA GAL BGC 0.909091 1
39 MLR 0.909091 1
40 MAN BMA BMA 0.909091 1
41 BGC GLC GLC GLC GLC GLC GLC 0.909091 1
42 BMA BMA BMA BMA BMA 0.909091 1
43 BGC BGC GLC 0.909091 1
44 MAN MAN BMA BMA BMA BMA 0.909091 1
45 BGC GLC GLC 0.909091 1
46 BGC BGC BGC BGC BGC 0.909091 1
47 MT7 0.909091 1
48 GLC BGC BGC BGC BGC 0.909091 1
49 CE6 0.909091 1
50 MTT 0.909091 1
51 CE8 0.909091 1
52 MAN BMA BMA BMA BMA 0.909091 1
53 GLC BGC GLC 0.909091 1
54 DXI 0.909091 1
55 GLC BGC BGC BGC BGC BGC 0.909091 1
56 CEX 0.909091 1
57 GAL GAL GAL 0.909091 1
58 BMA MAN BMA 0.909091 1
59 BGC GLC GLC GLC GLC 0.909091 1
60 GLA GAL GAL 0.816327 1
61 BGC BGC BGC BGC BGC BGC BGC BGC 0.754717 1
62 BMA BMA GLA BMA BMA 0.689655 1
63 XYT 0.685185 0.767442
64 LAT GLA 0.680851 1
65 GLC GLC GLC BGC 0.672414 1
66 U63 0.647059 0.891892
67 MMA MAN 0.64 0.942857
68 DR5 0.64 0.942857
69 GLA EGA 0.634615 0.942857
70 GAL FUC 0.615385 0.941176
71 2M4 0.612245 1
72 BGC GAL FUC 0.610169 0.970588
73 FUC GAL GLC 0.610169 0.970588
74 8B7 0.610169 0.970588
75 GLC GAL FUC 0.610169 0.970588
76 LAT FUC 0.610169 0.970588
77 BGC GLA GAL FUC 0.609375 0.970588
78 BQZ 0.608696 0.909091
79 BGC GAL NAG GAL 0.606061 0.733333
80 GAL NAG GAL GLC 0.606061 0.733333
81 BMA BMA BMA BMA 0.603448 0.941176
82 M3M 0.6 1
83 LB2 0.6 1
84 NGR 0.6 1
85 MAN GLC 0.6 1
86 MAL EDO 0.592593 0.942857
87 BGC BGC BGC XYS GAL 0.588235 0.942857
88 XYS BGC BGC BGC BGC XYS BGC BGC BGC 0.588235 0.942857
89 XYS BGC BGC XYS BGC XYS BGC BGC BGC 0.588235 0.942857
90 BGC BGC BGC XYS BGC BGC 0.588235 0.942857
91 LAT NAG GAL 0.588235 0.733333
92 GLC GAL NAG GAL 0.588235 0.733333
93 NGA GAL BGC 0.587302 0.733333
94 TRE 0.581395 1
95 ABD 0.57971 0.75
96 NLC 0.578947 0.733333
97 NDG GAL 0.578947 0.733333
98 GAL NDG 0.578947 0.733333
99 5GO 0.578947 0.66
100 DEL 0.574074 0.970588
101 MVP 0.571429 0.733333
102 GAL NGA GLA BGC GAL 0.571429 0.733333
103 GAL BGC BGC XYS 0.569231 0.942857
104 SGA BGC 0.568965 0.66
105 BGC BGC 0.566038 0.914286
106 BMA BMA 0.566038 0.914286
107 GLC GLC XYP 0.557377 1
108 BGC BGC XYS BGC 0.552239 0.942857
109 NAG GAL BGC 0.552239 0.733333
110 GLA GAL BGC 5VQ 0.551724 0.891892
111 G2F BGC BGC BGC BGC BGC 0.55 0.868421
112 GLA MBG 0.54902 0.942857
113 GLC ACI G6D BGC 0.547945 0.733333
114 GLC G6D ACI GLC 0.547945 0.733333
115 GLC ACI GLD GLC 0.547945 0.733333
116 GLC G6D ADH GLC 0.547945 0.733333
117 GLC BGC BGC BGC BGC BGC BGC 0.545455 1
118 BGC BGC BGC GLC BGC BGC 0.545455 1
119 BMA BMA MAN 0.535714 1
120 MAN MAN BMA 0.535714 1
121 NGA GLA GAL BGC 0.535211 0.733333
122 GAL BGC BGC BGC XYS BGC XYS 0.533333 0.942857
123 BGC BGC BGC XYS BGC XYS GAL 0.533333 0.942857
124 BGC BGC BGC XYS BGC XYS XYS 0.528571 0.942857
125 BGC BGC XYS BGC XYS BGC XYS 0.528571 0.942857
126 GLC BGC BGC XYS BGC XYS XYS 0.528571 0.942857
127 BMA MAN MAN MAN 0.525424 1
128 GLA GAL GLC NBU 0.52459 0.846154
129 FUC BGC GAL 0.52459 0.970588
130 GLC GLC G6D ACI GLC GLC GLC 0.519481 0.733333
131 GLC ACI GLD GAL 0.519481 0.702128
132 GLC ACI G6D GLC 0.519481 0.702128
133 BGC BGC BGC FRU 0.516129 0.868421
134 DOM 0.509091 0.942857
135 G3I 0.507937 0.767442
136 LMU 0.507937 0.785714
137 DMU 0.507937 0.785714
138 UMQ 0.507937 0.785714
139 OXZ BGC BGC 0.507937 0.6875
140 G2I 0.507937 0.767442
141 LMT 0.507937 0.785714
142 GAL XYS XYS BGC BGC BGC XYS GAL BGC 0.506329 0.942857
143 BGC BGC XYS BGC GAL XYS BGC XYS GAL 0.506329 0.942857
144 GAL BGC BGC BGC XYS XYS 0.506329 0.942857
145 GLC BGC BGC XYS BGC XYS XYS GAL GAL 0.506329 0.942857
146 GLC BGC BGC XYS BGC XYS XYS GAL 0.506329 0.942857
147 FMO 0.5 0.868421
148 MAN BMA NAG 0.5 0.733333
149 SOR GLC GLC 0.5 0.970588
150 GLA GAL NAG 0.5 0.733333
151 8VZ 0.5 0.673469
152 ACR GLC GLC GLC 0.493827 0.702128
153 GLC GLC DAF BGC 0.493827 0.702128
154 GLC GLC ACI G6D GLC GLC 0.493827 0.702128
155 ARE 0.493827 0.733333
156 GLC GLC AGL HMC GLC 0.493827 0.702128
157 AAO 0.493827 0.733333
158 GLC GLC XYS 0.492308 0.970588
159 MAN BMA MAN 0.491803 1
160 CGC 0.491525 0.941176
161 5QP 0.491228 0.885714
162 GAL MBG 0.490909 0.942857
163 MDM 0.490909 0.942857
164 RZM 0.490909 0.688889
165 M13 0.490909 0.942857
166 GAL NAG MAN 0.485294 0.733333
167 SOR GLC GLC GLC 0.484848 0.970588
168 GLO GLC GLC GLC 0.484848 0.970588
169 6UZ 0.484848 0.846154
170 LAG 0.484848 0.6
171 GAL BGC NAG GAL 0.478873 0.733333
172 GTM BGC BGC 0.477612 0.868421
173 10M 0.477612 0.733333
174 MAN MAN MAN MAN 0.476923 1
175 MAN MAN BMA MAN 0.476923 1
176 GLA GAL NAG FUC GAL GLC 0.47619 0.717391
177 GAL GAL SO4 0.47619 0.66
178 NAG BMA 0.47619 0.653061
179 GAL NGA 0.47541 0.733333
180 A2G GAL 0.47541 0.733333
181 GAL A2G 0.47541 0.733333
182 GLA BMA 0.472727 1
183 GLC BGC 0.472727 1
184 GAL GAL 0.472727 1
185 GLA GLC 0.472727 1
186 BGC GLA 0.472727 1
187 GAL GLC 0.472727 1
188 GLA BGC 0.472727 1
189 BMA GLA 0.472727 1
190 BMA MAN 0.472727 1
191 MAN MAN 0.472727 1
192 BGC GLC 0.472727 1
193 MLB 0.472727 1
194 GLC GLC 0.472727 1
195 MAN BMA 0.472727 1
196 LAK 0.472727 1
197 NPJ 0.470588 0.622642
198 FUC GAL NAG GAL BGC 0.469136 0.717391
199 GAL GLC NAG GAL FUC 0.469136 0.717391
200 GLC NAG GAL GAL FUC 0.469136 0.717391
201 MAN MAN MAN GLC 0.46875 1
202 ABL 0.466667 0.702128
203 FRU GAL 0.465517 0.842105
204 BMA FRU 0.465517 0.842105
205 DAF BGC 0.464789 0.733333
206 DAF GLC 0.464789 0.733333
207 TM6 0.463768 0.916667
208 BGC SGC BGC SGC BGC SGC BGC SGC 0.463768 0.916667
209 LSE 0.462687 0.6875
210 FUC GLA GLA 0.460317 0.970588
211 GAL GAL FUC 0.460317 0.970588
212 FUC GAL GLA 0.460317 0.970588
213 GLA GLA FUC 0.460317 0.970588
214 GLA GAL FUC 0.460317 0.970588
215 IFM BMA 0.457627 0.711111
216 9MR 0.457627 0.744186
217 IFM BGC 0.457627 0.711111
218 BMA IFM 0.457627 0.711111
219 BGC OXZ 0.457627 0.666667
220 RCB 0.457143 0.622642
221 GLO GLC GLC 0.457143 0.942857
222 MAN MAN MAN 0.45614 1
223 GLC GLC GLC GLC BGC 0.45614 1
224 GLC GLC GLC GLC GLC BGC 0.45614 1
225 BMA MAN MAN 0.45614 1
226 GLC GLC GLC 0.45614 1
227 WOO 0.454545 0.848485
228 GIV 0.454545 0.848485
229 BGC 0.454545 0.848485
230 ALL 0.454545 0.848485
231 GAL 0.454545 0.848485
232 GLA 0.454545 0.848485
233 GLC 0.454545 0.848485
234 GXL 0.454545 0.848485
235 BMA 0.454545 0.848485
236 MAN 0.454545 0.848485
237 ACI GLD GLC GAL 0.453333 0.733333
238 DAF BGC GLC 0.453333 0.733333
239 DAF GLC GLC 0.453333 0.733333
240 MGL SGC BGC BGC 0.450704 0.868421
241 MGL SGC GLC GLC 0.450704 0.868421
242 CM5 0.450704 0.891892
243 MAN MAN MAN BMA MAN 0.450704 1
244 BGC BGC SGC MGL 0.450704 0.868421
245 MAN MNM 0.45 0.702128
246 GLC DMJ 0.45 0.695652
247 A2G GAL BGC FUC 0.45 0.717391
248 NOJ GLC 0.45 0.695652
249 NOY BGC 0.45 0.702128
250 BMA MAN MAN MAN MAN 0.449275 1
251 GCS GCS 0.448276 0.767442
252 PA1 GCS 0.448276 0.767442
253 M5S 0.447761 1
254 MAN BMA MAN MAN MAN 0.447761 1
255 TXT 0.447368 0.767442
256 GAC 0.447368 0.767442
257 GLC GAL NAG GAL FUC FUC 0.447059 0.702128
258 BGC GAL NAG GAL FUC FUC 0.447059 0.702128
259 GAL NAG GAL NAG GAL NAG 0.445946 0.673469
260 NAG GAL GAL NAG GAL 0.445946 0.6875
261 NAG GAL GAL NAG 0.445946 0.6875
262 MA4 0.444444 0.891892
263 QV4 0.444444 0.733333
264 MAN DGO 0.440678 0.914286
265 3SA 0.44 0.733333
266 Z6J 0.439024 0.742857
267 GLC GLC GLC PO4 SGC GLC 0.439024 0.66
268 AHR 0.439024 0.742857
269 RIB 0.439024 0.742857
270 FUB 0.439024 0.742857
271 32O 0.439024 0.742857
272 T6P 0.438596 0.767442
273 MMA 0.4375 0.857143
274 MBG 0.4375 0.857143
275 GYP 0.4375 0.857143
276 AMG 0.4375 0.857143
277 MAN G63 0.435484 0.653061
278 GDQ GLC 0.435484 0.666667
279 4MU BGC BGC 0.434211 0.767442
280 ISX 0.433333 0.761905
281 MAN 7D1 0.431034 0.888889
282 ACR 0.43038 0.733333
283 QPS 0.43038 0.733333
284 GAL MGC 0.428571 0.702128
285 4MU BGC BGC BGC BGC 0.428571 0.767442
286 GAL NDG FUC 0.422535 0.717391
287 FUC NDG GAL 0.422535 0.717391
288 HMC AGL GLC 0.421053 0.717391
289 KHO 0.421053 0.888889
290 GCS GCS GCS 0.419355 0.767442
291 GCS GCS GCS GCS GCS 0.419355 0.767442
292 GCS GCS GCS GCS GCS GCS 0.419355 0.767442
293 GAL NAG GAL 0.418919 0.702128
294 NGT GAL 0.41791 0.66
295 GAL NGT 0.41791 0.66
296 P3M 0.41791 0.767442
297 GLC GAL NAG GAL FUC A2G 0.417582 0.673469
298 A2G GAL NAG FUC GAL GLC 0.417582 0.673469
299 TUR 0.416667 0.842105
300 BTU 0.416667 0.842105
301 GLC FRU 0.416667 0.842105
302 GLA MAN ABE 0.414286 0.916667
303 NAG NAG BMA 0.413333 0.634615
304 NAG NDG BMA 0.413333 0.634615
305 ACR GLC GLC GLC GLC 0.4125 0.702128
306 ACR GLC 0.4125 0.702128
307 AHR AHR AHR AHR AHR AHR 0.410714 0.857143
308 FUB AHR AHR 0.410714 0.857143
309 VAM 0.409836 0.868421
310 GLF B8D 0.409836 0.775
311 DAF GLC DAF GLC GLC 0.409639 0.702128
312 ACI GLD GLC ACI G6D BGC 0.409639 0.702128
313 AC1 GLC AC1 BGC 0.409639 0.702128
314 ACI G6D GLC ACI G6D BGC 0.409639 0.702128
315 BGC GLC AC1 GLC GLC GLC AC1 0.409639 0.702128
316 ACI GLD GLC GLC GLC ACI GLD GLC GAL 0.409639 0.702128
317 MAN MMA MAN 0.409091 0.942857
318 FUB AHR 0.407407 0.857143
319 AHR AHR 0.407407 0.857143
320 G6D GLC ACI GLD GLC ACI GLD GLC BGC 0.406977 0.653061
321 4U0 0.406593 0.66
322 BGC BGC SSG PIH 0.405063 0.767442
323 GLA MAN RAM ABE 0.405063 0.891892
324 G1P 0.403846 0.697674
325 GL1 0.403846 0.697674
326 XGP 0.403846 0.697674
327 M1P 0.403846 0.697674
328 GLC IFM 0.403226 0.727273
329 MAN IFM 0.403226 0.727273
330 MAN MAN MAN MAN MAN MAN MAN 0.402597 1
331 XZZ BGC BGC 0.402439 0.702128
332 ACG 0.402299 0.695652
333 FUC GAL 0.4 0.941176
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4YLZ; Ligand: LAT NAG GAL; Similar sites found with APoc: 377
This union binding pocket(no: 1) in the query (biounit: 4ylz.bio4) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 5V3D FCN None
2 3E8T UQ8 None
3 3RGA LSB None
4 6D6L FY4 None
5 3W9R A8S None
6 5ETR 5RW None
7 5ETR APC None
8 1M5W DXP None
9 4J8T DOG None
10 1EWJ BLM None
11 1DZK PRZ 1.30719
12 3UN3 G16 1.30719
13 1NZY BCA 1.30719
14 1S4M LUM 1.30719
15 3GC8 B45 1.35135
16 5N2D 8J8 1.38889
17 5NIU 8YZ 1.5625
18 5N2F 8HW 1.6129
19 4WN5 MVC 1.73913
20 3N0Y APC 1.96078
21 1ZM1 BGC BGC BGC 1.96078
22 5EPQ OLA 1.96078
23 1GT4 UNA 1.96078
24 1ST0 GTG 1.96078
25 4XIZ LPP 1.96078
26 2OFV 242 1.96078
27 4L4J NAG NAG BMA MAN NAG 1.96078
28 4KU7 PCG 1.96078
29 3KPX CZH 1.96078
30 4IAW LIZ 1.96078
31 5DKK FMN 2.06897
32 2P7Q GG6 2.25564
33 4EES FMN 2.6087
34 4IE6 UN9 2.61438
35 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 2.61438
36 2WLG SOP 2.61438
37 3T4L ZEA 2.61438
38 4RYV ZEA 2.61438
39 2QX0 PH2 2.61438
40 4J7Q B7N 2.61438
41 3W8X FTK 2.61438
42 3PNA CMP 2.61438
43 4HIA FMN 2.61438
44 3PG7 PTY 2.61438
45 4MOB COA 2.61438
46 4RFR RHN 2.61438
47 5H9Y BGC BGC BGC BGC 2.61438
48 5BV6 35G 2.63158
49 2V0U FMN 2.73973
50 5DJU FMN 2.75862
51 5EFW FMN 2.75862
52 6GNO XDI 2.96296
53 6GH1 ARG LEU PRO ALA LYS ALA PRO LEU LEU 3.26797
54 5NKB 8ZT 3.26797
55 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 3.26797
56 4NFN 2KC 3.26797
57 3ILR SGN IXD 3.26797
58 5FP4 YC8 3.26797
59 1PZO CBT 3.26797
60 2IPI AKY 3.26797
61 3PQB VGP 3.26797
62 6G9I CXX 3.26797
63 4U0W 16G 3.26797
64 3KFF XBT 3.26797
65 3KFF ZBT 3.26797
66 3G5D 1N1 3.26797
67 1YKD CMP 3.26797
68 3BJK CIT 3.26797
69 5CJF 520 3.26797
70 3FW4 CAQ 3.26797
71 4XCB HY0 3.26797
72 5MBC FMN 3.26797
73 3E7O 35F 3.26797
74 1Z03 OCH 3.26797
75 5GP0 GPP 3.3557
76 4R38 RBF 3.57143
77 2Z77 HE7 3.59712
78 5FUI APY 3.78788
79 1OGX EQU 3.81679
80 1UYY BGC BGC 3.81679
81 1LFO OLA 3.90625
82 2A1L PCW 3.92157
83 2XMY CDK 3.92157
84 5NBP BGC BGC BGC 3.92157
85 3MF2 AMP 3.92157
86 5IXH OTP 3.92157
87 5TUF TDC 3.92157
88 4P25 FUC GAL NAG FUC 3.92157
89 4QDC ASD 3.92157
90 4QDF 30Q 3.92157
91 2WKQ FMN 3.92157
92 5A65 TPP 3.92157
93 4NV7 COA 3.92157
94 5F3I 5UJ 3.92157
95 3QRC SCR 3.92157
96 3FW3 ETS 3.92157
97 1ERB ETR 3.92157
98 2I74 MAN MAN MAN MAN 3.92157
99 5O9W AKG 3.92157
100 3I3X U22 3.92157
101 3CW9 01A 3.92157
102 1KGI T4A 3.93701
103 1GU3 BGC BGC BGC BGC BGC 4.02685
104 4JH6 FCN 4.34783
105 5FPX GLY SER SER HIS HIS HIS HIS HIS 4.42478
106 1NKI PPF 4.44444
107 5IXG OTP 4.57516
108 1EWF PC1 4.57516
109 4OPC PGT 4.57516
110 4OPC FDA 4.57516
111 6FE1 V14 4.57516
112 5A3T MMK 4.57516
113 4X6F 3XU 4.57516
114 4CQE CQE 4.57516
115 5I8T LAC 4.57516
116 3PP0 03Q 4.57516
117 5FLJ QUE 4.57516
118 4EE7 PIS 4.57516
119 2HFN FMN 4.57516
120 1EX7 5GP 4.57516
121 5EO8 TFU 4.57516
122 3FV3 IVA VAL VAL STA ALA STA 4.57516
123 3THR C2F 4.57516
124 2CM4 RCL 4.66667
125 5FU3 BGC BGC BGC 4.71698
126 3TCT 3MI 4.72441
127 2E56 MYR 4.86111
128 3L5R 47X 4.91803
129 4MUV PCG 4.92958
130 4QPW XYP XYP XYP 4.92958
131 1KJM ALA GLN PHE SER ALA SER ALA SER ARG 5
132 5UMY TNN 5
133 5AYT L6Y 5.03145
134 4MNS 2AX 5.22876
135 4FFG 0U8 5.22876
136 6E08 NAP 5.22876
137 5DRB 5FJ 5.22876
138 4WUP 3UF 5.22876
139 3Q8G PEE 5.22876
140 1ZB6 GST 5.22876
141 1ZB6 DIN 5.22876
142 4X7Y SAH 5.22876
143 3E8N VRA 5.22876
144 3E8N ATP 5.22876
145 4BJZ P3A 5.22876
146 4BJZ FAD 5.22876
147 2VFT SOR 5.22876
148 2J3M PRI 5.22876
149 4WHZ 3NL 5.22876
150 3AMN CBI 5.22876
151 3AMN CBK 5.22876
152 2Y88 2ER 5.22876
153 4WW8 VD9 5.22876
154 4V24 GYR 5.22876
155 1U0A BGC BGC BGC BGC 5.22876
156 2J3M ATP 5.22876
157 3VBK COA 5.22876
158 3TTI KBI 5.22876
159 2OVW CBI 5.22876
160 2Z81 PCJ 5.22876
161 3P7N FMN 5.22876
162 3TAY MN0 5.22876
163 5ML3 DL3 5.36913
164 4RLT FSE 5.44218
165 1UNB PN1 5.88235
166 1UNB AKG 5.88235
167 3K4Z CBI 5.88235
168 1NYW DAU 5.88235
169 4OYA 1VE 5.88235
170 4KYS VIB 5.88235
171 5I0U DCY 5.88235
172 2XK9 XK9 5.88235
173 4H2X G5A 5.88235
174 6EZ6 C5Z 5.88235
175 1QM5 GLC GLC GLC PO4 SGC GLC 5.88235
176 1QM5 PLP 5.88235
177 4OMJ 2TX 5.88235
178 1OLM VTQ 5.88235
179 5BVE 4VG 5.88235
180 2CDO GAL AAL GAL AAL GAL AAL 5.88235
181 3T1A 5MA 5.88235
182 5DEY 59T 5.88235
183 6MPT C30 5.88235
184 4YGF AZM 5.88235
185 4H2W 5GP 5.88235
186 6C1S EFV 5.88235
187 1AJ0 PH2 5.88235
188 1AJ0 SAN 5.88235
189 4H2W AMP 5.88235
190 4NVP 7CH 5.88235
191 3GNE FLC 5.88235
192 3TYZ XHP 5.88235
193 4GJ3 0XP 5.88235
194 2CET PGI 5.88235
195 2HKA C3S 6.15385
196 4H2V AMP 6.36364
197 2AG4 OLA 6.53595
198 2AG4 LP3 6.53595
199 1QIN GIP 6.53595
200 1TYU GLA MAN RAM TYV GLA MAN RAM TYV 6.53595
201 5UC4 83S 6.53595
202 1UU6 BGC BGC BGC BGC 6.53595
203 4HK8 XYP XYP XYP XYP XYP XYP 6.53595
204 5DXT 5H5 6.53595
205 4LA7 A1O 6.53595
206 2IFW ACE PHE LYS PHE PSA LEU AAR 6.53595
207 3ZXR IQ1 6.53595
208 3ZXR P3S 6.53595
209 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 6.53595
210 5XEG AKG 6.53595
211 3WW2 LPK 6.53595
212 2IU8 PLM 6.53595
213 3WDX BGC BGC GLC 6.53595
214 3JRS A8S 6.53595
215 4J1Q NDP 6.53595
216 4WUJ FMN 6.80272
217 5BVB DOG 6.81818
218 2PR5 FMN 6.81818
219 5TBM 79A 6.95652
220 3L9R L9Q 7.14286
221 3L9R L9R 7.14286
222 1IIU RTL 7.18954
223 2BW7 ECS 7.18954
224 5E2N V14 7.18954
225 3KYG 5GP 5GP 7.18954
226 4H6B 10Y 7.18954
227 4H6B 10X 7.18954
228 4D5B ACX 7.18954
229 2PTR 2SA 7.18954
230 5C3R AKG 7.18954
231 5C3R HMU 7.18954
232 5LRT ADP 7.18954
233 2NVA PL2 7.18954
234 4RF7 ARG 7.18954
235 2VRQ XYP XYP AHR 7.18954
236 3E85 BSU 7.84314
237 4QA8 PJZ 7.84314
238 3H5N ATP 7.84314
239 4F7E 0SH 7.84314
240 1URX AAL GAL AAL GLA 7.84314
241 1GP6 QUE 7.84314
242 5JSD ACY 1GN GAL 1GN BGC ACY GAL BGC 7.84314
243 1GP6 SIN 7.84314
244 1GP6 DH2 7.84314
245 1SMR PIV HIS PRO PHE HIS LPL TYR TYR SER 7.84314
246 3O0Q TTP 7.84314
247 3O0Q GDP 7.84314
248 3O0Q ADN 7.84314
249 1URX AAL GAL AAL GAL AAL GAL AAL 7.84314
250 4M1U MBG A2G 7.84314
251 5U98 1KX 7.84314
252 2DQU CPD 7.84314
253 2E9L OLA 7.84314
254 2E9L BGC 7.84314
255 2E9L PLM 7.84314
256 3V91 UPG 7.84314
257 5DZT AMP 7.84314
258 4BVM VCA 8.27068
259 3PFG SAM 8.49673
260 3PFG TLO 8.49673
261 3AGC RCC 8.49673
262 1ODM ASV 8.49673
263 4ZSI GLP 8.49673
264 3FW9 SLX 8.49673
265 4Y8D 49J 8.49673
266 3UH0 TSB 8.49673
267 5W4W 9WG 8.49673
268 4ZSI 4R1 8.49673
269 3HMO STU 8.49673
270 5EH0 5NW 8.49673
271 2HRL SIA GAL SIA BGC NGA CEQ 8.66142
272 1N5S ADL 8.92857
273 5NEA 8V8 9.15033
274 3G08 FEE 9.15033
275 5FKP 6UL 9.15033
276 3LVW GSH 9.15033
277 5KD6 6C7 9.15033
278 5KD6 LBU 9.15033
279 5HA0 LTD 9.15033
280 5AMV ADA ADA ADA 9.15033
281 2DIO EOD 9.15033
282 1KRR ACO 9.15033
283 4Z87 GDP 9.15033
284 2OO8 RAJ 9.15033
285 1KDK DHT 9.15033
286 3ZO7 K6H 9.57447
287 5KEW 6SB 9.72222
288 3VQ2 LP4 LP5 MYR DAO 9.80392
289 5Y72 DST 9.80392
290 1D5Z ACE ALC ARG ALA ODA SER LEU NH2 9.80392
291 2WA4 069 9.80392
292 2GJ5 VD3 9.80392
293 4HWT 1B2 9.80392
294 4P8K 38C 9.80392
295 4P8K FAD 9.80392
296 4Q0P 0MK 9.80392
297 5H2U 1N1 9.80392
298 5VNF VAL THR SER VAL VAL 9.80392
299 1QD1 FON 9.80392
300 4HWS 1B3 10.4575
301 2HZQ STR 10.4575
302 5BU3 4W9 10.4575
303 6GW1 CHO 10.4575
304 2Z6D FMN 10.7692
305 3E2M E2M 11.1111
306 1BGQ RDC 11.1111
307 5DQ8 FLF 11.1111
308 5X7Q GLC GLC GLC GLC GLC 11.1111
309 5X7Q GLC GLC GLC BGC 11.1111
310 5X7Q GLC GLC GLC GLC 11.1111
311 5YBN AKG 11.7647
312 1QY1 PRZ 11.7647
313 5Y4R C2E 11.7647
314 5XVG 8FX 11.7647
315 5XLY C2E 11.7647
316 1MH5 HAL 11.7647
317 2YKL NLD 11.7647
318 6CC0 EWM 12.4183
319 1OJK GLC BGC 12.4183
320 1OJJ GLC GAL 12.4183
321 4ZU5 THM 12.4183
322 3QP8 HL0 12.4183
323 1VA6 P2S 13.0719
324 1VA6 ADP 13.0719
325 3M3R BCD 13.0719
326 5H5A 6OU 13.0719
327 1WLE SRP 13.0719
328 4LED XXR 13.7255
329 5J75 6GQ 13.7255
330 4WVO 3UZ 14.3791
331 5UR6 8KM 14.3791
332 4NZN ANP 14.3791
333 4NZN 2OU 14.3791
334 3W68 VIV 14.3791
335 3A76 SPD 14.3791
336 1DMY AZM 14.3791
337 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 14.4186
338 2YJ0 420 14.4928
339 4ZU4 4TG 14.8649
340 5TZO 7V7 15.0327
341 4PFC 2QX 15.6863
342 4MP8 MLI 15.6863
343 4MP8 NAD 15.6863
344 5EZU MYR 15.7303
345 2OBD 2OB 16.3399
346 3AJH BL3 16.3399
347 1CZI PRO PHI SMC NOR 16.3399
348 2H8H H8H 16.3399
349 1TT8 PHB 16.9935
350 1SDW IYT 16.9935
351 5WL1 D3D 17.6471
352 5WL1 CUY 17.6471
353 5EIB GTP 17.6471
354 1EE0 CAA 17.6471
355 5DJT FMN 18.0328
356 4B7P 9UN 18.3007
357 1DY4 SNP 18.3007
358 1UMZ BGC BGC XYS BGC XYS GAL 18.3007
359 3MTX PGT 18.543
360 3VRY B43 19.6078
361 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 20.202
362 3SCM LGN 20.2614
363 4WO4 JLS 20.2614
364 3QUZ QUV 20.2614
365 3RUG DB6 20.2614
366 5C0C ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 20.2614
367 4L4V 1VY 20.2614
368 1LYB IVA VAL VAL STA ALA STA 20.6186
369 2YG2 S1P 21.5686
370 2YG2 FLC 21.5686
371 4K55 H6P 21.7742
372 4WOE ADP 22.2222
373 1PN0 FAD 23.5294
374 1PN0 IPH 23.5294
375 3M3E GAL A2G NPO 26.1438
376 3B1Q NOS 33.9869
377 3VV1 GAL FUC 39.2157
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